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- 검색키워드
- 저자 : Eliton Chivandi (검색결과 2 건)
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Insulinotropic Effect of S-Allyl Cysteine in Rat Pups
Busisani W. Lembede,Jeanette Joubert,Pilani Nkomozepi,Kennedy H. Erlwanger,Eliton Chivandi 한국식품영양과학회 2018 Preventive Nutrition and Food Science Vol.23 No.1
S-Allyl cysteine (SAC) is found in garlic and has been reported to exert antidiabetic and antiobesity properties in drug-induced adult experimental models of metabolic dysfunction, but its potential beneficial effects in high-fructose diet neonatal rat models have not been determined. This study investigated the potential prophylactic effects of SAC in high-fructose diet fed suckling rat pups modelling human neonates fed a high-fructose diet. Four-day-old male (n=32) and female (n=32) Wistar rat pups, were randomly assigned to and administered the following treatment regimens daily for 15 days: group I, distilled water; group II, 20% fructose solution (FS); group III, SAC; group IV, SAC+FS. The pups’ blood glucose, triglyceride, cholesterol, plasma leptin and insulin concentration, liver lipid content, and liver histology were determined at termination. In female rat pups, orally administered SAC prevented FS-induced hypoinsulinemia but significantly increased (P≤0.05) liver lipid content. Oral administration of SAC significantly increased (P≤0.05) plasma insulin concentration and homeostasis model assessment for insulin resistance in the male pups. The potential sexually dimorphic effects of SAC (insulinotropic effects in male pups and protection of female pups against fructose-induced hypoinsulinemia) suggest that SAC could be potentially exploited as an antidiabetic and insulinotropic agent. Caution should, however, be exercised in the use of SAC during suckling as it could result in excessive liver lipid accumulation and insulin resistance.
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Nontobeko M. Gumede,Busisani W. Lembede,Richard L. Brooksbank,Kennedy H. Erlwanger,Eliton Chivandi 한국식품영양과학회 2020 Journal of medicinal food Vol.23 No.4
Metabolic syndrome (MetS) is a combination of risk factors that include insulin resistance, obesity, dyslipidemia, and hypertension. The consumption of high-fructose diets contributes to the development of MetS. β-sitosterol a naturally occurring phytosterol possesses antiobesogenic and antidiabetic effects. This study evaluated the potential protective effect of β-sitosterol against the development of metabolic dysfunction in growing female rats fed a high-fructose diet, mimicking children fed obesogenic diets. Thirty-five 21-day-old female Sprague Dawley rat pups were randomly allocated to and administered the following treatments: group 1—standard rat chow (SRC) + plain drinking water (PW) + plain gelatine cube (PC); group 2—SRC + 20% w/w fructose solution (FS) as drinking fluid + PC; group 3—SRC + FS + 100 mg/kg fenofibrate in gelatine cubes; group 4—SRC + FS + 20 mg/kg β-sitosterol gelatine cube (Bst); and group 5—SRC + PW + Bst. Following 12 weeks of feeding, the rats were fasted overnight, weighed, and then euthanized. Plasma cholesterol, insulin, glucose, triglyceride, and adiponectin concentrations were determined. Visceral fat was dissected out and weighed. The high-fructose diet increased (P < .05) visceral adiposity and plasma triglyceride concentration but decreased (P < .05) plasma adiponectin concentration. β-sitosterol prevented the high-fructose diet-induced visceral obesity, hypertriglyceridemia, and hypoadiponectinemia. β-sitosterol alone increased plasma adiponectin concentration and reduced plasma insulin concentration and homeostatic model assessment index. In conclusion, β-sitosterol could be potentially used to prevent high-fructose diet-induced metabolic dysfunction.
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