원위 대퇴골의 고립성 골연골종에서 발생한 속발성 연골 육종 1례 보고

정필현,황장수,강석,김용민,오형호,채동주,김종필 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

연골육종은 비교적 서서히 자라며 늦게 전이하는 악성 연골 종양으로 알려져 있다. 골 연골종에서 발생한 속발성 연골육종은 발생빈도는 드물며 타부위로의 전이가 적고 악성도가 낮은 경우가 많아 적합한 수술적 치료로서 좋은 예후를 보이는 것으로 보고되고 있다. 본 동국대학교 정형외과학 교실에서는 우측 대퇴골 원위부 골간단부에 생긴 고립성 골 연골종에서 이차적으로 발생한 연골육종을 치험한 바 문헌고찰과 함께 보고하는 바이다. A case of Secondary Chondrosarcoma Arising from Solitary Osteochondroma of the Distal Femur Department of Orthopaedic Surgery, College of Medicine, DongGuk University Phil Hyun Chung M.D., Jung Su Hwang M.D., Suk Kang M.D., Yang Mln Kim M.D., Hyung Ho Oh M.D., Dong Ju Chae M.D., Jong Pil Kim M.D. Chondrpsarcoma is a malignant cartilage-forming tumor that grows slowly and metastasis of this tumor occurs in late stage. Secondary chondrosarcomas arising from a solitary osteocartilaginous exostosis are rare and those have a better prognosis than other chondrosarcomas, and they rarely metastasize. We present our experience with a case of secondary chondrpsarcoma arising in solitary osteochondroma of distal metaphysis of right femur with clinical details.

Staphylococcus aureus와 Coagulase-Negative Staphylococcus Species에 대한 Arbekacin의 시험관내 항균력

위성헌,강진한,허동호,이동건,김상일,김양리,최정현,김종현,유진흥,허재균,신완식,강문원 대한감염학회 2001 감염 Vol.33 No.4

Background : Most strains of methicillin-resistant Staphylococcus aureus (MRSA) now exhibit high-level resistance to various antibiotics, such as β -lactam antibiotics, aminoglycosides, macrolides, tetracyclines and quinolones. Recent reports describing the therapeutic failure of vancomycin for MRSA infections have arisen considerable concerns regarding the emergence of MRSA strains, which will require new therapeutic agents. Arbekacin, an aminoglycoside antibiotic, has antibacterial activity against both gram-positive and gram-negative bacteria and is stable in the presence of aminoglycoside inactivating enzymes produced by S. aureus. In this study, we compared the antibacterial activity of arbekacin with those of vancomycin, gentamicin, and amikacin against Staphylococcus aureus (S. aureus) and coagulase-negative staphylococci (CNS). Methods : For a collection of 549 S. aureus and 251 CNS isolates from three Catholic University Hospitals in Korea, minimum inhibitory concentrations (MICs) of arbekacin, vancomycin, amikacin and gentamicin were determined by agar dilution method using Mueller-Hinton agar according to NCCLS (National Committee for Clinical Laboratory Standards, USA)criteria. Results : Among 549 S. aureus isolates, 278 isolates were MRSA and 271 isolates were methicil sensitive S. aureus (MSSA). MIC50 & MIC90 of arbekacin against 549 S. aureus were 0.5 & 1 ㎍/mL, and MIC50 & MIC90 of vancomycin were 1 & 1 ㎍/mL. MIC of arbekacin against 549 S. aureus isolates ranges from 0.03 to 4 ㎍/mL, and MIC of vancomycin against 549 S. aureus ranges from 0.25 to 2 ㎍/mL. MIC90 of amikacin against 549 S. aureus was 32㎍/mL, and that of gentamicin was 128 ㎍/mL. MICs of amikacin and gentamicin were variable, ranging from 0.125 to 256, and otherwise arbekacin and vancomycin revealed relatively narrow range of MICs. MIC90 of arbekacin against 278 MRSA isolates & 271 MSSA were 1 & 0.5 ㎍/mL, and those of vancomycin against MRSA & MSSA were 1 & 1 ㎍/mL. MIC90 of amikacin against 278 MRSA & 271 MSSA isolates were 32 & 4 ㎍/mL, and that of gentamicin against MRSA & MSSA isolates were 128 & 32 ㎍/mL respectively. Among 251 CNS isolates, 122 isolates were MRCNS and 129 were MSCNS. MICSO & MIC90 of arbekacin against 251 CNS isolates were 0.25 & 2 ㎍/mL, and those of vancomycin were 1 & 2 ㎍/mL. MIC of arbekacin against 251 CNS isolates ranges from 0.015 to 32 ㎍/mL, and that of vancomycin isolates ranges from 0.25 to 2 ㎍/mL, MIC90 of arbekacin against 122 MRCNS & 129 MSCNS isolates were 2&0.3 ㎍/ML, and those of vancomycin were 2&s ㎍/ML. MIC90 of amikacin against 251 CNS isolates was 32 ㎍/ML, and that of gentamicin was 128 ㎍/ML for CNS. MIC90 of amikacin against 122 MRCNS & 129 MSCNS isolates were 128 & 8㎍/mL, and those of gentamicin ere 256 & 32 ㎍/mL. Conclusion : Considering above results, arbekacin can be useful agent against most strains of MRSA and MRCMS, which exhibit high-level resistance to amikacin and gentamicin. (Korea J Infect Dis 33:254~260, 2001)

안지오텐신 변환효소 억제제와 안지오텐신 II 수용체 차단제 투여 후 발생한 급성 신부전과 폐부종으로 전원된 선천성 단일신 환자의 치료 1예

백두현,김경진,홍성철,강석형,송하응,김혜인,김수현,오현정,강혜원,김서우,유민아,류동열,최규복,강덕희 이화여자대학교 의과대학 2010 EMJ (Ewha medical journal) Vol.33 No.1

Blockers of renin-angiotensin system(RAS) including ACE inhibitor or ARB are one of the most frequently prescribed medications for the treatment of hypertension, heart failure and proteinuria. One of the major side effects of these RAS blockers is the deterioration of renal function, mainly due to a reduction of intraglomerular pressure. Therefore, close monitoring of renal function is recommended when RAS blockers are initially prescribed, especially for the patients with impaired renal function. We report a patient who was transferred to our hospital due to the sudden development of oliguria and dyspnea after treatment for hypertension with ACEi and ARB. She was finally diagnosed as RAS blocker-induced acute renal failure with pulmonary edema complicated on congenital solitary kidney. After hemodialysis and conservative treatment, her renal function was recovered with maintenance of normal urine output. Conclusion:This case highlights the necessity of the functional and structural evaluation of kidney to prevent the serious complication such as acute renal failure before the administration of ACEi and/or ARB.

혈우병 소견을 가진 뇌출혈 환자 치험(治驗) 1례(例)

정인태,서병관,이현종,하지영,강미경,홍장무,백용현,박동석,최도영,Jung, In-tae,Seo, Byung-kwan,Lee, Hyun-jong,Ha, Ji-young,Kang, Mi-kyeong,Hong, Jang-moo,Baek, Yong-hyeon,Park, Dong-suk,Choi, Do-young 대한침구의학회 2003 대한침구의학회지 Vol.20 No.4

Objective : Hemophilia, a genetically determined disorder, is characterized by abnormality of the coagulation mechanism due to functional deficiency of a specific factor, namely VIII or IX. In this study, the effect of Dong-Si acupuncture therapy on the cerebral hemorrhage patient with hemophilia was evaluated. Methods : We treated him with acupuncture by stimulating Dong-Si acupuncture point(Yuk Wan) and assessed the effect by using manual dynamic evaluation of MRC(Medical Research Council) and Modified Barthel Index. Results : After treatment, the bleeding tendency was grossly reduced and bleeding lesion was absorbed gradually. And manual dynamic evaluation of the upper extremity increased from 4 grade to 5 grade. Conclusions : This result suggest that Dong-Si acupuncture therapy on the cerebral hemorrhage patient with hemophilia was effective. And futher studies are required to concretely prove the effectiveness of Dong-Si acupuncture therapy for treating hemorrhagic diseases.

치아 석회화 단계와 골 성숙도 단계간의 상관관계에 대한 연구

강동균,김태완,김영진,남순현,김현정 大韓小兒齒科學會 2008 大韓小兒齒科學會誌 Vol.35 No.2

본 연구는 성장 중인 부정교합 환자의 진단이나 치료계획의 수립,치료방법 및 시기,예후 등을 결정하는데 중요한 판단 지침이 되는 치아 석회화 단계와 경추 및 수완부골 성숙도간의 연관성을 규명하여 개인의 보다 정확하고 효율적인 사춘기 성장 정도를 평가하기 위해 시행하였다. 전신 질환이 없고 교정 치료 경험이 없는 7-16세의 여아 154명,남아 179 명,총 333명의 파노라마 방사선사진,측모 두부규격 방사선사진,수완부 방사선사진을 분석하여 평가하였다. 연구 결과,파노라마 방사선사진의 치아 석회화 단계를 통하여 사춘기 성장 정도를 평가하는 것은 부정교합 환자의 진단 및 치료계획을 수립하는데 임상적으로 유용한 정보를 제공할 것으로 판단되었다. The purpose of this study was to investigate the relationship between the stages of calcification of various teeth and skeletal maturity stages among Korean individuals. The study subjects consisted 154 female and 179 male ranging from 7 years to 16 years of age. A total of 333 hand-wrist, cephalo-lateral and panoramic radiographs were obtained and analyzed. The tooth development of the mandibular canines, first, second premolars, and second molars were assessed according to the Dermijian' s system. Skeletal maturity stages were determined from hand-wrist radiographs by using the SMI system and cephalo-lateral radiographs by using the CVMS, respectively. The results were as follows 1. The mean ages of each stage of skeletal maturity were consistently younger in female subjects. 2. There was a high correlation between skeletal maturity of hand-wrist and cervical vertebrae in the both sexes. 3. There was a high correlation between skeletal maturity and dental calcification stage of mandibular canines, first premolar, second premolars, and second molar. 4. The mandibular second molar was tooth showing the highest correlation. 5. Percent distributions of the relationship between calcification stages of individual teeth and stages of skeletal maturity were obtained in both sexes. In summary, this suggests that tooth calcification stages from panoramic radiographs might be clinically useful as a maturity indicator of the pubertal growth period.

FIB 신뢰성 평가를 위한 나노패턴의 설계 및 측정

강현욱,이승재,조동우 한국공작기계학회 2005 한국공작기계학회 춘계학술대회논문집 Vol.2005 No.-

FIB (Focused ion beam) system is one of the most important equipments for the nano-scale machining. Various researches have been performed, since it can etch the material and deposit 3-D structure with high-aspect-ratio in the nanometer scale. In spite of those researches, the definite method for the reliability of FIB system has not been reported. In this paper, we proposed the reliability assessment method through nano-pattern fabrication. In the fabricated nano-pattern, the characteristics of FIB system are included. Using this effect, we tried to assess the FIB reliability. First, we suggested reliability assessment items and nano-patterns. And, to know the suitableness of the proposed method, we fabricated several nano-patterns using Nova200(FEI Company) and SMI2050(SEIKO) which are FIB apparatuses. The fabricated nano-patterns are measured with SEM (Scanning Electron Microscope) and compared with designed dimensions. And the compared results showed that the proposed method is suitable for the assessment of FIB system reliability.

마이크로 광 조형 기술을 이용하여 미세 유체 시스템을 개발하기 위한 가상 조립 공정의 개발

강현욱,이인환,조동우 한국공작기계학회 2004 한국공작기계학회 춘계학술대회논문집 Vol.2004 No.-

As it is difficult to construct a micro-fluidic system composed of micro-mixers, micro-channels and/or micro-chambers in a single process, an assembly process is typically used. The assembling and bonding of micro-parts, however, introduces other problems. In this work, a virtual assembly process was developed that can be used to design various micro-fluidic systems before actual fabrication commences. In the process, the information required for the micro-stereolithography process is generated automatically. Consequently, complex micro-fluidic systems can be fabricated in a single process, thereby avoiding the need for additional assembly or bonding processes. Using the developed process, several examples were fabricated.

노인성 골다공증성 추체 압박골절 환자에 대한 경피적 척추성형술 후 치료 결과 및 합병증 : Treatment Efficacy and Complications

강동호,김기정,이철희,황수현,김은상,정진명 대한노인병학회 2002 대한노인병학회지 Vol.6 No.3

천궁의 GABAА-Benzodiazepine 수용체 복합체와의 상호작용

강지현,이동웅,하정희 대한생물치료정신의학회 1997 생물치료정신의학 Vol.3 No.2

요약천궁(Cnidium Officinale)는 미나리과 다년생초본식물로서 대뇌 억제 및 진정 작용이 있다는 여러 문헌 등을 참고하여 볼 때 천궁은 항불안작용을 나타낼 가능성이 시사되었다. 이에 본 연구는 천궁을 사용하여 실험 동물에서 천궁의 항불안 작용을 검색하고 그 작용기전의 일부를 밝히고자 천궁을 극성 및 비극성 용매로 추출하여 분획을 만들고 이들 분획의 GABA-benzodiazepine 수용체 복합체 결합반응에 미치는 영향을 관찰하고자 하였다. 실험 결과 천궁 표준추출물 경구투여는 생쥐의 elevated plus maze 검사에서 그 효과는 diazepam 1 mg/kg 투여 후 실시한 elevated plus maze 검사 결과보다 낮았으나, 개방통로에로의 진입회수 및 개방통로에서의 체류시간을 증가시킴으로써 불안해소작용을 나타내었다. 또 천궁의 표준추출물은 benzodiazepine 수용체 길항제인 [3H]Ro15-1788 결합을 억제함으로써 수용체 활성물질의 존재 가능성이 관찰되었다. 이러한 행동검사상의 불안해소작용 및 benzodiazepine 수용체 활성도를 나타내는 구성성분을 추적하고자 천궁의 표준추출물의 분획화를 실시하였는데, 이를 통하여 얻은 각 분획들을 사용하여 수용체 활성도를 검색한 결과, 모든 분획에서 활성도를 나타내었으나 그 중 chloroform분획의 활성도가 crude한 추출물인 methanol 추출물이나 다른분획에 비하여 가장 높은 활성도를 나타냄을 관찰하였다.천궁의 chloroform분획은 [3H]flunitrazepam의 흰쥐대뇌피질조직에 있는 benzodiazepine 수용체에 대한 결합반응을 억제시켰으며, 이러한 억제도는 GABA 및 chloride 존재에 의해 더욱 항진되는 positive GABA shift 현상이 관찰되었다. 이상의 결과를 종합해볼 때, 천궁의 chloroform분획내에는 benzodiazepine 수용체에 대해 효현제 활성을 지니는 물질이 있음을 추측할 수 있으며, 이는 천궁의 항불안작용의 중요한 한 기전으로 생각된다. C. Officinale is a medicinal plant which has been known to have anxiolytic and sedative activity. A survey of the relevant literature has indicated that the putative anxiolytic activity of C. Officinale has not been scientifically investigated. Therefore, the present study was designed to assess anxiolytic property and interaction with benzodiazepine receptor of C. Officinale. The putative anxiolytic activity of methanol extract of C. Officinale was performed in mice using an elevated plus maze paradigm. Chronic oral administration of C. Officinale showed anxiolytic action in mice. The interaction of C. Officinale with benzodiazepine receptor was investigated using rat cortices. Methanol extract of C. Officinale inhibited the binding of [3H] Ro 15-1788, a selective benzodiazepine receptor antagonist to benzodiazepine receptor of rat cortices. Chlorform fraction of methanol extract showed higher binding activity to benzodiazepine receptor than crude extract by methanol. GABA significantly enhanced the potency of C. Officinale in inhibiting [3H] flunitrazepam, a selective benzodiazepine receptor agonist, binding to benzodiazepine receptor. From these findings, it can be concluded that substance or substances with neurochemical properties characteristic of a benzodiazepine receptor agonist may contribute to the anxiolytic property of C. Officinale.

축대칭 렌즈 코어의 초정밀 보정가공에 관한 연구

강상도,김우순,장광호,박순섭,김동현 한국공작기계학회 2005 한국생산제조학회지 Vol.14 No.1

Code V was used to make a plan for collimator lens with aspherical surface in the present study. The acquired optical design data were applied for ultra-precision machining. The optimum properties were determined to find ways to compensate the tool positioning error allowance during the ultra-precision machining. In ultra-precision aspheric machining, figure tolerance corrected by tool positioning error be improved by compensation cycle number.