抗히스타민劑의 吸光度比法에 의한 定量

李允中,李康春,李東宣,李振九 成均館大學校 1980 論文集 Vol.28 No.-

The absorbance ratio method was applied to the quantitative determination of antihistamines, such as chlorpheniramine maleate(CPM), carbinoxamine maleate(CBM) and diphenhydramine hydrochloride. The influences of indicator and solvent concentration on the precision and accutacy of determination were investigated. And it was found that the effects of temperature and wavelength was negligible in case of averaging conditions. The standard deviations for three antihistamines tested were within 0.13%. As the results, the determination of antihistamines could be carried out easily, rapidly and accurately by the absorbance ratio method.

제29회 베이징 올림픽 탁구남자개인단식 금메달리스트의 대상별 탁구경기전술분석

이동헌(Lee Dong-Heun),정구인(Jung Koo-In),송창훈(Song Chang-Hoon) 한국체육과학회 2010 한국체육과학회지 Vol.19 No.3

This is an analysis of Lee Dong-heun's table tennis tactics(2010) in the 29th Bejing Olympics focusing primarily on Marin's performance in the finals. I searched for Vod materials on the OK ping-pong website, and TV broadcasting materials to obtain the analysis. After analyzing the 3 games of Marin point by point, I came to the following conclusion. First of all, Marin could win the games with his own tactical patterns. On the other hand, Wang Hao and Wang Richin of China also won the games with their own tactical patterns, but they lost the games without their own tactical patterns. Second, Wang Hao(China), Wang Richin(China) and Oh Sang Eun(South Korea) should have increased the frequency of their main scoring tactics and raised their scoring success rate. In other words, Marin(China) had a higher scoring success rate than the others. However, it is natural that Marin(China)'s table tennis tactics were able to block Wang Hao, Wang Richin and Oh Sang Eun's.

당뇨병과 동반된 화농성 간농양의 임상상 및 예후인자

오은숙,강무일,이원영,오기원,임동준,이소영,이정민,고승현,김성래,안유배,손현식,윤건호,차봉연,이광우,손호영,강성구 대한당뇨병학회 2000 임상당뇨병 Vol.1 No.1

연구배경: 감염질환은 혈관질환과 함께 당뇨병의 중요한 사망원인의 하나이며, 혈당조절이 불량할수록 감염 빈도가 증가됨은 잘 알려져 있다. 간농양의 발생이 있어서도 당뇨병은 중요한 기저질환 중의 하나이다. 일반적으로 간농양의 가장 흔한 원인균은 Escherichi coli라고 알려져 있으나, 최근 당뇨병을 가진 간농양 환자에서 Klesiella pneumoniae의 검출이 증가되고 있다. 또 최근 연구에 의하면 K.pneumonie가 간농양의 가장 흔한 원인균이며, K. pneumoniae에 의한 간농양은 K.pneumoniae 이외의 균주에 의한 간농양보다 당뇨병과 밀접히 관련되어 있다고 보고된 바 있다. 이에 저자들은 간농양 환자를 대상으로 당뇨병환자의 빈도를 알아보고, 그 원인균 및 특징을 비당뇨병 환자들의 경우와 비교해 보고자 하였다. 방법: 1992년 1월부터 1999년 6월까지 방사선학적 검사 혹은 수술에 의해 간농양이 확인되거나, 경피적 천자나 수술을 통한 배농액 배양, 혹은 혈액 검사에서 원인균이 증명된 182명의 환자를 대상으로 후향적 임상고찰을 실시하였다. 결과: 화농성 농양을 가진 167명의 환자(남:94명, 여:73명)중 당뇨병을 가진 환자는 54명 (남:30명, 여:24명)으로 32.3%를 차지하였다. 환자의 평균나이는 당뇨군에서 62.1 ± 13.4세, 비당뇨군에서는 55.1 ±15.5세로 당뇨군에서 높았으며(p=0.0021), 남녀간의 평균나이 비교 시 두 군 모두 여성의 나이가 의미있게 높았다. 비당뇨군에 비하여 당뇨군의 경우 저알부민혈증의 빈도와 aspartate transaminase가 증가되어있었다. 원인균주는 K. pneumoniae (당뇨군54%, 비당뇨군 39.1%), E. coli(당뇨군 17.5%, 비당뇨군 18.8%), Pseudomonas aeruginosa, Streptococcus viridans, Enterococcus 순이었으며 두 군간의 의미는 차이는 없었으나 K. pneumoniae의 경우 다른 균종에 비해 단독감염의 빈도가 높았다(82.8%). 사망률은 당뇨군에서 16.7%, 비당뇨군에서 7.1%로 당뇨군에서 의미있게 높았으며(p=0.019), 당뇨군에서의 사망환자는 모두 패혈증이 동반되어 있었다. 당뇨환자의 사망군은 생존군에 비해 당뇨병 이환기간이 길고 혼합감염의 빈도가 높았다(p=0.046). 검사실 소견에서는 총 빌리루빈 및 알카리성 포스파타제의 증가가 관찰되어 있었다. 결론: E. coli가 간농양의 주된 원인균이라는 기존 보고와는 달리 당뇨군과 비당뇨군 모두 K. pneumoniae가 간농양의 주된 원인균이었다. 또한 당뇨 유병기간이 길고 당뇨조절이 불량한 환자에서 혼합감염이며 총 빌리루빈 및 알카리성 포스파타제의 증가등과 같은 위험인자가 존재할 경우 사망률이 증가될 수 있으므로 이들 군에서는 적극적인 치료가 필요할 것으로 사료된다. Background: Liver abscesses are commonly associated with underlying disease, particularly diabete mellitus. The number of the liver abscesses caused by Klebslella pneumoniae in diabetic patient has been increased in Korea nowadays. This study was conducted to clarify the clinical presentation and prognostic factors of pyogenic liver abscesses, especially in diabetic patients and to determine the proportion of K. pneunomiae as a pathogen in liver abscess in Korea. Methods: Medical records of 167 patients treated for pyogenic liver abscess from January, 1992 through June, 1999 were reviewed retrospectively in detail. Major Pathogenic organism, clinical manifestations, prognostic factors, the importance of diabetes mellilus as an underlying disease and its effect on clinical features and prognosis were analyzed. Results: Among 167 cases of pyogenic liver abscess, underlying diabetes mellitus was present in 32.3%. The mean age of patients was 62.7 13.4 years in diabetic liver abscess group and 55.1 15.5 years in non-diabetic liver abscess group. Most liver abscesses were cryptogenic in origin or secondary to the billary tree diseases. The clinical presentations among the two groups were not significantly different. When compared to patients without diabetes, patients with diabetes had significantly higher proportions of hypoalbuminemia and elevated aspartate transaminase level. The most common organism of the pyogenic abscess was K. pneumoniae in both groups. Percutaneous drainage of the abscess with appropriate antibiotics was the most commonly used therapeutic modality in liver abscess. The mortality rate of diabetic liver abscess is 16.1 % and 7.1% in nondiabetic liver abscess. Complications, especially septicemla, were found more frequently in patients with diabetes than in patients without diabetes (64.8% vs 28.3%, septicemia : 31.5% vs 9.7%). The factors influencing mortality in the diabetic liver abscess were disease duration, mixed infection, presence of septicemia, elevated bilirubin and alkaline phosphatase. Conclusions: In contrast to prior report that the E. coli was the most common pathogen in liver abscess, we found that K. pneumoniae was the most common organism cultured in liver abscess. Diabetic patients have more complications and higher mortality than patients without diabetes. Early detection and proper treatment are needed to improve the outcome for diabetic patient with liver abscess.

니세틸 정(아세틸 - 엘 - 카르니틴 500mg)에 대한 뉴로세틸 정의 생물학적 동등성

조혜영,오인준,이용복,임동구,문재동,심영순,김은아,정현철 한국약제학회 2001 Journal of Pharmaceutical Investigation Vol.31 No.1

Acetyl-L-carnitine (ALC), an endogenous component of the L-carnitine family, is naturally occurring molecule synthesized from L-carnitine (LC) by carnitine acetyl transferase. ALC has been shown to improve the cognitive performance of patients suffering from dementia of the Alzheimer's type and proposed for treating Alzheimer's disease in pharmacological doses. The purpose of the present study was to evaluate the bioequivalence of two ALC tablets, Nicetile^(TM) (Dong-A pharmaceutical Co., Ltd.) and Neurocetil^(TM) (Kyung-Dong Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration. Twenty six normal male volunteers, 22.80±2.76 year in age and 63.07±7.98 ㎏ in body weight, were divided into two groups and a randomized 2 × 2 cross-over study was employed. After one tablet containing 500 ㎎ of ALC was orally administered, blood was taken at predetermined time intervals and the concentrations of ALC in serum were determined using HPLC with fluorescence detector. Because of the presence of endogenous ALC, the calibration was performed using dialyzed serum. Pharmacokinetic parameters such as AUC_t, C_(max) and T_(max) were calculated and ANOVA was utilized for the statistical analysis of the parameters. The results showed that the differences in AUC_t, C_(max) and T_(max) between two tablets were 2.72%, -0.65% and -8.42%, respectively, when calculated against the Nicetile^(TM) tablet. The powers (1-β) for AUC_t and C_(max) were 94.87% and 87.17%, respectively. Minimum detectable differences (△) at α=0.05 and 1-β=0.8 were less than 20% (e.g., 15.58% and 19.16% AUC_t and C_(max), respectively). The 90% confidence intervals were within ±20% (e.g., -11.84∼6.41 and -10.57∼11.88 for AUC_t and C_(max), respectively). Two parameters met the criteria of KFDA for bioequivalence, indicating that Neurocetil^(TM) tablet is bioequivalent to Nicetile^(TM) tablet.

니세틸 정(아세틸-엘-카르니틴 500 mg)에 대한 뉴로세틸 정의 생물학적 동등성

조혜영,김은아,정현철,심영순,임동구,오인준,문재동,이용복 전남대학교 약품개발연구소 2001 약품개발연구지 Vol.10 No.-

Acetyl-L-carnitine (ALC), an endogenous component of the L-carnitine family, is naturally occurring molecule synthesized from L-carnitine (LC) by carnitine acetyl transferase. ALC has been shown to improve the cognitive performance of patients suffering from dementia of the Alzheimer's type and proposed for treating Alzheimer's disease in pharmacological doses. The purpose of the present study was to evaluate the bioequivalence of two ALC tablets, Nicetiler^TM (Dong-A pharmaceutical Co., Ltd.) and Neurocetil^TM (Kyung-Dong Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration. Twenty six normal male volunteers, 22.80±2.76 year in age and 63.07 7.98㎏ in body weight, were divided into two groups and a randomized 2×2 cross-over study was employed. After one tablet containing 500㎎ of ALC was orally administered, blood was taken at predetermined time intervals and the concentrations of ALC in serum were determined using HPLC with fluorescence detector. Because of the presence of endogenous ALC, the calibration was performed using dialyzed serum. Pharmacokinetic parameters such as AUC_t, C_max and T_max were calculated and ANOVA was utilized for the statistical analysis of the parameters. The results showed that the differences in AUC_t, C_max and T_max between two tablets were 2.72%, -0.65% and -8.42%, respectively, when calculated against the Nicetile^TM tablet. The powers (1-β) for AUC_t and C_max were 94.87% and 87.17%, respectively. Minimum detectable differences (Δ) at α=0.05 and 1-β=0.8 were less than 20% (e.g., 15.58% and 19.16% AUC_t and C_max, respectively). The 90% confidence intervals were within ±20% (e.g., -11.84∼6.41 and -10.57∼11.88 for AUC_t and C_max, respectively). Two parameters met the criteria of KFDA for bioequivalence, indicating that Neurocetil^TM tablet is bioequivalent to Nicetile^TM tablet.

子官頸部 上皮內癌의 微細構造

李東久 慶北大學校 醫科大學 1980 慶北醫大誌 Vol.21 No.2

著者는 慶北大學校 醫科大學 病理學敎室에서 子官頸部上皮內癌으로 診斷된 83側의 生檢標本으로 組織學的 形態를 區分하고, 各 形態에 대한 微細構造 變化를 比較檢討한 結果를 要約하면 다음과 같다. 年齡約으로는 40代(47%)에서 가장 好發하는 傾向이었으며 30代에서도 多數가 觀察되었다. 組織學約으로 旁基底細胞型이 50.6%로 가장 많았으며 그 다음이 角化細胞型이었다. 腺浸透에 있어서는 各型別로 有意한 差異가 없었다. 그러나 白班症은 角化細胞型 및 旁基底細胞, 角化細胞混合型에서는 80%程度에서 同伴하였으나 多形態細胞型과 小細胞型에서는 全然 볼 수 없었다. 또한 이들 形態의 年齡的인 分布에도 特記할 差異가 없었다. 電子顯微鏡的으로 各型의 細胞들은 共通的으로 核邊緣의 不規則, 核小體의 肥大, 核과 細胞質比의 上昇 및 細胞間隔의 擴張 等의 所見을 보였으며, 各型의 細胞質에서 약간의 差異를 나타내었다. 卽 旁基底細胞型에서는 desmosome의 增加와 mitochondria의 變性이 뚜렷하였으며 角化細胞型에서는 細胞質 全般에 결쳐 張原線條(tonofilament)가 增加하였고 free ribosome은 polysome의 形態로 增加하여 있었다. 多形態細胞型에서는 rER이 잘 發達되어 있었으며 核周邊部에서 張原線條의 增殖을 가끔 블 수 있었다. 小細胞型의 細胞質은 매우 적었으며 free ribosome이 細胞質의 大部分을 占하고 있었다. 以上의 成績으로 보아 子宮頸部上皮內癌은 한 種類以上의 細胞에서 由來할 것으로 推測되며, 그 原因細胞는 본 實驗成續만으로 言及하기는 困難하며 더욱 硏究하여야 할 課題로 생각된다. Study was made to investigate morphological variation and possibly the nature of the carcinoma in situ of the uterine cervix, utilizing materials of Department of Pathology, Kyungpook National University School of Medicine. Eighty-three cases so diagnosed were selected for this purpose. These 83 cases of carcinoma in situ were classified into the following 5 histological groups : Parabasal, mixed parabasal-keratinizing, keratinizing, pleomorphic and small cell type. And then ulirastructural study was carried out on these 5 types to see if there is any interesting findings on electron microscopy. The results obtained through the comparison study of both light and electron microscopy of the carcinema in situ of the uterine cervix are as follows: The highest frequency rate of carcinoma in situ was found among the age group of 40-49(47%) and next high rate was found in the age group of 30-39. Histologically, the parabasal cell type was 50.6%, the highest rate, and keratinizing cell type was next. There was no particular difference in glandular involvement in any type. However, leukoplakia was associated with keratinizing type and mixed parabasal and keratinizing cell type in about 8O%. And there was no leukoplakia in the pleomorphic and small cell type. No particular age difference was noted among these histological types. Electronmicroscopically, all types of cells were commonly noted to have irregularity in nuclear margin, nucleolic hypertrophy, an increase in nucleus and cytoplasmic ratio, intercellular gaps, etc. Some difference was noted in cytoplasm of each type. There were significant increases of desmosome and degeneration of mitochondria in the parabasal cell type, an increased tonofilament in over all cytoplasm and free ribosome increased to form polysome in the keratinizing cell type. It is noted that rER was well developed and an occasional proliferation of tonofilament was seen around all large nuclei in the pleomorphic cell type. Cytoplasm in the small cell type was very scant and free ribosome was seen in most cytoplasm. The above report indicates squamous cell carcinonla in situ of the uterine cervix derives from more than one type of cell and it is very difficult to tell the origin of the cell of the carcinoma in situ. One has to await for further investigation of clarify this point.

국내수집 밀 유전자원의 생육특성 및 분류

이동진,박상구 한국국제농업개발학회 2004 韓國國際農業開發學會誌 Vol.16 No.2

1. 출수기는 4원 25일~4월 30일이 206점으로 공시자원의 72%를 차지했으며, 5월 1일~5월 15일이 78점으로 27%이었음. 2. 간장은 60㎝ 이하의 극단간종이 7점, 61~80㎝의 단간 종이 58점, 장간종이 91점이었음. 3. 수형, 종피색 등 12형질에 의해 4개의 품종군으로 분류 되었음. 4. 그룹별 생육특성을 보면 Ⅰ그룹은 출수 소요일수 181일, 간장 99㎝ 및 수장 9㎝이었으며, Ⅱ그룹은 출수소요일수가 185일 이었고, 간장 114㎝ 및 수장 10.3㎝로서 다른 그룹보 다 다소 길었음. Ⅲ, Ⅳ 그룹은 출수 소요일수(180일)가 짧았으며, 간장(91, 92㎝)도 짧은 경향이었으나, 수장(8.9㎝, 9.0㎝)은 Ⅰ그룹과 비슷하였음. 5. 그룹별 지역분포를 보면 Ⅰ그룹은 충남, 전남·북 및 경남·북 지역에 4~10% 정도 분포하였으며 Ⅱ그룹은 경기, 충청지역에 분포하고 있었고, Ⅲ,Ⅳ그룹은 도별로 32~67%로서 전국적으로 널리 분포하였음. 6. 국내 수집유전자원 285점 중 질적형질에 의해 세분한 결과 104개의 하위그룹(핵심수집종)으로 구분되었음. The present study was carried out to compare the growth characteristic among 285 Korean wheat germplasms collected in Korea. Heading date of tested accessions were shown 206 accessions (72%) in April 25~30 and 78 accessions (27%) in May 1~15, respectively. In culm length, 58 accessions were 61~80cm and 91 accessions were more than 100 ㎝. Especially, 7 accessions had short cuhn length less than 60 ㎝. Based on morphological relationship, the Korean wheat collection were divided into 4 groups. According to the growth relationship, on morphological traits, Group Ⅰ was day to heading (181 day)with culm length (99 ㎝) and spike length (9 ㎝). Group Ⅱ was day to heading (185 day), culm length (114㎝) and spike length (10.3㎝) longer than other groups. Group Ⅲ and Ⅳ were day to heading (185 day), culm length (91, 92 ㎝) shorter than the Groups Ⅰ and Ⅱ. However, their spike lengths (8.9, 9.0㎝) were similar to that of Group Ⅰ. According to 285 accessions by morphological traits divided by 104 core collections. According to the geographic distribution relationship, the Group Ⅰ was 4~10% distributed in Chungnam, Chonnam, Chonbuk, and Kyungnam province. The Group Ⅱ was almost distributed in Chungchong, and Kyunggi province, while Group Ⅲ and Ⅳ were distributed in all of the country.

신부전이 동반된 당뇨병 환자에서 발생된 침습성 모균증 : 수술과 Liposomal amphotericin B 및 GM-CSF 병합 요법에 의한 성공적인 치험 1예

이원영,오기원,임국희,장재혁,이동건,최정현,강무일,신완식,차봉연,이광우,손호영,강성구 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.4

저자들은 신부전이 동반된 당뇨병 환자에서 발생된 부비동형 모균증에 대하여 수술과 함께 liposomal amphotericin B 및 GM-CSF의 복합치료를 하여 성공적으로 치료한 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Mucormycosis (zygomycosis) primarily affects diabetic or immunocompromised patients and typically progresses rapidly, necessitating surgical excision and antifungal therapy with amphotericin B. Large doses of amphotericin B are needed for cure, but it has the risk of causing significant renal toxicity. The recent development of liposomal amphotericin B allows antifungal therapy to be administered with potentially improved efficacy and reduced nephrotoxicity. We have experienced a case of paranasal mucormycosis successfully treated with surgery, liposomal amphotericin B and GM-CSF. A 59-year-old male suffering from diabetes mellitus for 6 years was admitted with pain at left maxillary area. He was diagnosed as mucormycosis after cytologic exam on the necrotic nasal mucosa, which showed typical hyphae. He have had diabetic nephropathy with macroproteinuria and had rapidly rising serum creatinine levels with the amphotericin B treatment: creatinine levels reverted to basal level with the use of liposomal amphotericin B. Despite surgical excision and continued antifungal therapy, his infection was not effectively controlled. Therefore, GM-CSF was administered additionally to improve phagocytic activity of leukocytes. He was finally cured after receiving a combination of aggressive surgery, liposomal amphotericin B and GM-CSF. To our knowledge, this is the first detailed clinical description of the treatment of mucormycosis with liposomal amphotericin B in Korea.

고온 실내환경의 자연환기효과에 대한 수치해석 연구

구윤서,신동윤,이정주 용인대학교 자연과학연구소 1998 自然科學硏究所論文誌 Vol.3 No.2

This study was predicted of ventilation effects from natural ventilation using windows at high temperature passage. Predict method was numerical model simulation by using RNG (Renormalization Group) k-ε turbulence model, because well describe in heat turbulent phenomenon. Result of this study, if exclude heat flux and open a all windows, predicted not over 40℃ in passage temperature at outdoor air temperature 34℃ in summer season.

압출성형에 의한 국산 무연탄 활성탄의 세공구조 변화

이송우,문장천,김도한,이창한,최동훈,류동춘,송승구 부산대학교 환경문제연구소 2000 環境硏究報 Vol.18 No.-

The purpose of this study is to investigate the variation of pore size distribution of the coal-based extruded activated carbon. The extruded activated carbon was prepared by extruding the mixture of coal powder and coal tar. Pore size distribution of the extruded activated carbon was compared with that of the extruded coal and the extruded char. Also it was compared with that of the crushed activated carbon, raw coal and char. The extruded coal had coarser surface than that of raw coal. Macropores of the extruded coal were funned near 10,000Å in diameter during carbonization process and steam penetrated easily between particles and were growing between 3,000Å and 20,000Å in diameter during activation process.