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盧熙悳,金東進 서울대학교 교양과정부 1973 論文集 Vol.5 No.-
In this paper, the present writer compares and analyzes the theories of Western Scholars on Physical Education tobring about better understanding of the role of physical education. The historical and social background which has influenced the usage of technical terms(in physical education) and the ideas which have caused misconception about physical education are examined. And the concept of synonyms that has given rise to confusion in physical education is also discussed.
성기백,진덕희 강릉대학교동해안지역연구소 1999 東海岸硏究 Vol.10 No.1
One synaptic structure which has a regulatory role in synaptic transmission in the postsynaptic density(PSD). Molecular and immunological studies have identified many regulatory proteins in the rat PSD. In this study, we have prepared PSD fractions from salmon(Chum Salmon, Oncorhynchus keta) brain(0.7g brain/3㎏ salmon). About 250㎍ of the crude PSD fraction could be prepared from an salmon brain. To study the protein composition and electrophoretic profiles, the PSD fraction prepared from salmon brains was analyzed in SDS-polyacrylamide gel electrophoresis (SDS-PAGE). When the proteins were electrophoresed in an 6% SDS-gel, about 20 major distinct protein bands of 40-200kDa could be identified with Coomassie stain. In Coomassie stain, the overall protein profiles of salmon and rat PSD fraction were similar, but the concentration of protein bands were different.
해수에서 분리한 Vibrio sp. M-96 균주의 열감수성 alkaline phosphatase 성질
박문경,진덕희,김중균,공인수,김광현,홍용기 동의대학교 기초과학연구소 1997 基礎科學硏究論文集 Vol.7 No.1
A thermolabile alkaline phosphatase has been purified through steps of osmotic shock, ammonium sulfate salting-out, and DEAE-cellulose chromatography from the cultured broth of the marine Vibrio sp. M-96 strain. The optimal temperature for the enzyme activity was 35℃. The optimal pH was pH 11.0, and the range of pH stability was pH 10.4 to 12.0. Thermal inactivation occured within 6 minutes at 60℃. The enzyme was considerably inactivated by 0.1mM concentrations of Hg^2+, Ni^2+ and Zn^2+, whereas activated up to 234% by 1mM of Mn^2+. The activation energy and deactivation energy by the Arrhenius equation were 4.02 Kcal/mol and 9.09 Kcal/mol, respectively. The Km and Vmax values of the enzyme for p-nitrophenylphosphate were found to be 0.0465mM and 0.001335mM/min. respectively. Active from of the enzyme had a molecular weight of 57,000 dalton determined by the Sephadex G-200 gel filtration method.
오승민,남혜윤,김준수,연제덕,신대희,이진영,박대규,조명행,정규혁 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1
The acute and subacute toxicity of New Woohwangchungsimwon(NWCH) which was used l-muscone as substitutive material of musk were investigated in S.D. rats. In intraperitoneal acute toxicity test, rats(Sprague-Dawley, SPF) were injected intraperitoneally with dosages of 0, 540, 750, 1,070, 1,500 and 3,000 ㎎/㎏. Body weights were significantly decreased at 540 ㎎/㎏ dose group in both sexes and abnormal autopsy findings were founded in both sexes at all treated groups. Intraperitoneal LD_50 of NWCH was 812.3 ㎎/㎏ in male and 872.3 ㎎/㎏ in female rats. In the subacute toxicity study, NWCH was administrated orally to both sexes of rats for 4 weeks as several doses(0, 320, 800 and 2,000 ㎎/㎏). There were neither dead animals nor significant changes of body weights during the experimental period. In addition, no differences were found between control and treated groups in clinical signs, urinalysis, hematology, serum biochemical analysis, and other findings. Above data strongly suggest that no observed adverse effect level of NWCH might be over 2,000 ㎎/㎏/day in this study.
만성 심부전환자의 혈액에서 측정한 Tumor necrosis factor-α 및 Interleukin-6의 임상적 의의
김명구,김성구,박상호,한대희,강진환,변정득,심규혁,최병조,방덕원,온영근,현민수,권영주 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2
Background and objectives: Many conditions are responsible for the pathophysiology and progressive mechanisms of congestive heart failure. More recently, it has also become evidence that another class of biologycally activated molecules generically reffered to as cytokine these are also over expressed in congestive heart failure. Therefore, the purpose of this study was to measure concentrations of tumor necrosis factor-α(TNF-α), interleukin-6(IL-6) in mild to severe symptoms of heart failure and compare their values with those found in normal control and analysed correlation relationship between cytokine level, clinical findings and hemodynamic indicies. Subjects and Methodology: Levels of TNF-α and IL-6 were measured on pulmonary artery during cardiac catheterization in heart failure patients(n=32) and normal subjects(n=8) as well as physical examination and echocardiogram. Cytokines assay were performed on plasma using commercially available ELISA(Enazyme-Linked Immunosorbent Assay) kits. Results: Although the levels of TNF-α and IL-6 tend to increase in congestive heart failure group, the cytokines level was not made significantly statistical difference between congestive heart failure group and controls. When analyzing the correlation between the levels of PCWP(pulmonary capillary wedge pressure) and cytokines(TNF-α, IL-6), respectively, there were statistically significant correlation coefficient 0.32,(p<0.05), 0.39(p<0.01). The cytokine IL-6 and pressure of pulmonary artery were significant correlation.(correlation coefficient 0.36, p<0.02) More significantly, there was correlated with TNF-α and IL-6.(correlation coefficient 0.57, p<0.001) Conclusions: There was tended toward high concentration of TNF-α & IL-6 in congestive heart failure and significant difference for PCWP between TNF-α & IL-6, thus may be correlated with development and progression in congestive heart failure.
Encapsulating Peritoneal Sclerosis: A Single-Center Experience
( Kyung Deuk Hong ),( Owen Kwon ),( Jang Hee Cho ),( Mi Kyung Jin ),( Ji Young Choi ),( Se Hee Yoon ),( Chan Duck Kim ),( Yong Lim Kim ),( Sun Hee Park ) 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.1
Background: Encapsulating peritoneal sclerosis (EPS) is a serious and often fatal complication of long-term peritoneal dialysis (PD) with severe malnutrition and poor prognosis. We aimed to investigate the incidence and clinical features of EPS in patients on PD. Methods: The data were collected retrospectively from 603 prevalent PD patients in the Kyungpook National University Hospital between August 2001 and July 2011. EPS was diagnosed by the 2000 criteria of the International Society of Peritoneal Dialysis. Results: Eight patients (1.3%) met the diagnostic criteria of EPS. They had at least one of three symptoms: abdominal pain, vomiting and abdominal distension. Mean age of patients was 48.5 (range: 33 to 65) years and 4 were men. Mean duration on PD was 111.7 (range: 23 to 186) months. Seven patients had chronic glomerulonephritis as underlying renal disease, and one patient hypertensive nephrosclerosis. All patients except one had 2 or more episodes of peritonitis, the peritonitis rate being 1/33.7 patient-months in the 8 EPS patients. Six patients were treated with icodextrin solution. Four patients were treated with beta-blocker (cavedilol, 25-50 mg daily). Total parenteral nutrition was used in all patients. Only one patient had elective surgical intervention, adhesiolysis. Four patients were treated with glucocorticoid (0.5~1 mg/kg/day), three with tamoxifen (10-20 mg daily) and three with both. Of the 8 patients diagnosed with EPS, 6 survived and 2 died, an overall mortality rate being 25%. Conclusion: EPS is rare but a serious life threatening complication in patients on long-term PD. To reduce the incidence and mortality of EPS, careful monitoring and intensive therapy may be needed. Keywords: Encapsulating peritoneal sclerosis, Peritonitis, Continuous ambulatory peritoneal dialysis.