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Denis Nchang Che,강현주,조병옥,신재영,장선일 한국식품과학회 2019 Food Science and Biotechnology Vol.28 No.4
The aim of this study was to investigate thecombined effects of Diospyros lotus leaves extracts (DLE)and Muscat Bailey A grape stalk extracts (MGSE) inobesity induced by high-fat diet (HFD) in mice. The micewere fed with HFD and orally administered daily withDLE, MGSE, a mixture of DLE and MGSE, and Garciniacambogia extract over a period of 16 weeks. The resultsrevealed that daily administration of DLE and MGSEmixtures markedly prevented HFD-induced weight gain,plasma lipid profile, hepatic steatosis, hepatic fibrosis,diabetic symptoms, and the risk of developing cardiovasculardiseases. Also, DLE and MGSE mixtures administrationgreatly prevented oxidative stress and liver toxicity. The combined effects of DLE and MGSE mixtures werehigher than effects of the single extracts and of G. cambogia, a plant known for its anti-obesity effects. Insummary, these findings demonstrated that DLE andMGSE mixtures, exhibit anti-obesity activity in HFD-fedmice.
Cho, Byoung Ok,Che, Denis Nchang,Shin, Jae Young,Kang, Hyun Ju,Jang, Seon Il Elsevier 2018 Biomedicine & pharmacotherapy Vol.97 No.-
<P><B>Abstract</B></P> <P>This study analyzed fruit stem extract (MGFE) from Muscat Bailey A grape (<I>Vitis labrusca </I>× <I>Vitis vinifera</I>) for their ameliorative effects on Ultraviolet B (UVB)-induced skin damage in Balb/c mice. Well established <I>in vivo</I> assays were used to determine the biological effects of MGFE upon UVB irradiation of BALB/c mice. The results showed that treatment with MGFE recovered glutathione depletion, prevented lipid peroxidation of tissues and decreased the expression of DNA repair enzyme oxo guanine glycosylase-1. MGFE recovered the skin conditions in UVB-irradiated Balb/c mice. Moreover, MGFE inhibited dermal infiltration of inflammatory cells and reduced serum tumor necrosis factor alpha and interleukin-6 levels. Finally, MGFE treatment inhibited UV<B>B</B>-induced melanin formation and collagen fiber destruction through the inhibition of matrix metalloproteinase-1 expression. Through high-performance liquid chromatography analysis, catechin, epicatechin, and <I>trans</I>-resveratrol were found to be among the main active compounds present in MGFE. Taken together, these results indicated that MGFE has potentials as topical therapeutic materials against skin damage by inhibiting oxidative stress and inflammatory.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Using UVB irradiation, we induced oxidative stress in Balb/c mice skin. </LI> <LI> MGFE recovered skin damages induced by UVB irradiation. </LI> <LI> MGFE has the potential to be a natural candidate agent for the treatment of skin photo damage. </LI> </UL> </P>
Cho, Byoung Ok,Che, Denis Nchang,Yin, Hong Hua,Shin, Jae Young,Jang, Seon Il Elsevier 2017 BIOMEDICINE AND PHARMACOTHERAPY Vol.89 No.-
<P><B>Abstract</B></P> <P>Atopic dermatitis, a chronic relapsing and pruritic inflammation of the skin also thought to be involved in, or caused by immune system destruction is an upsetting health problem due to its continuously increasing incidence especially in developed countries. Mast cell infiltration in atopic dermatitis skin lesions and its IgE-mediated activation releases various cytokines and chemokines that have been implicated in the pathogenesis of atopic dermatitis. This study was aimed at investigating synergistic anti-inflammatory, anti-pruritic and anti-atopic dermatitis effects of <I>Diospyros lotus</I> leaf extract (DLE) and Muscat bailey A grapefruit stem extract (GFSE) in atopic dermatitis-like induced skin lesions in mice. Combinations of DLE and GFSE inhibited TNF-α and IL-6 production more than DLE or GFSE in PMA plus calcium ionophore A23187-activated HMC-1 cells. DLE and GFSE synergistically inhibited compound 48/80-induced dermal infiltration of mast cells and reduced scratching behavior than DLE or GFSE. Furthermore, DLE and GFSE synergistically showed a stronger ameliorative effect in skin lesions by reducing clinical scores; dermal infiltration of mast cells; ear and dorsal skin thickness; serum IgE and IL-4 production in atopic dermatitis-like mice. Collectively, these results suggest that DLE and GFSE synergistically exhibit anti-atopic dermatitis effects in atopic dermatitis-like skin lesions in mice.</P>