청국장의 제조방법에 따른 향미 증진 효과

고한수,조대희,황성연,김영만 한국식품영양학회 1999 韓國食品營養學會誌 Vol.12 No.1

청국장 제조를 위한 분리균은 포자형성율이 높은 Bacillus subtilis로 대사력이 활발한 대수증식기의 것을 콩에 1,000CFU/g 이상의 균수를 접종하여 40℃와 상대습도 90%에서 배양하면 발효가 빠르게 진행되었다. 발효가 종료되면 포자형성율이 95% 이상 되어야 저온의 후숙과정에서 재번식이 쉽게 일어나지 않았으며 발효취는 발효 중에서만 형성되었다. 중립콩과 대립콩의 발효율이 가장 좋았다. 저온의 후숙과정은 5℃에서 1∼2일 후 경과하면 Bacillus subtilis는 더 이상의 증식이 일어나지 않고 발효취가 소멸되므로 저온의 유통과정을 거쳐야 불쾌취가 없는 구수한 청국장의 맛을 유지할 수 있었다. The strain isolated for making chungkuk-jang was Bacillus subtilis, which formed spore with 98% ratio. Logarithmical culture was inoculated (1,000 CFU /g) to the steamed soybeans and at the optimum fermentation conditions(40℃, RH 90%), fermentation progressed very rapidly and synchronously. Fermentation time was 24 hours on the optimum fermentation conditions. During activated fermentation, chungkuk-jang's aroma and flavor created. After finishing the fermentation, the spore forming ratio was 95% and replenishment was not occured easily during aging at the below 5℃.

교육대학생의 학습량 조사 분석 연구 : 과제물의 양과 해결을 중심으로

고대혁,허 숙,한안진,김규환 仁川敎育大學校 1994 論文集 Vol.28 No.2

University education is not enough with only lectures in order to achieve its educational goals. University is, by definition, a place where inividual academic researches and studies of professors and students are to take place. For this purpose, university students are required to do various kinds of home work, individual study, and report writing. This study tries to investigate the types and amount of individual learning tasks which is provided to the students of Inchon National Teachers University. There are various kinds of individual learning tasks : reading books, finding material, observation and experimentation, skill practice, and report writing. As the results of the study, we can find that : (1) Students are required to take more or less than 10 courses in a semester and every course require 2 or 3 reports. (2) Many students feel that the amount of individual tasks are too heavy to solve within the given time. Especially, the most heavy amount of tasks are given during the third year of university curriculum. (3) Most of the students think that individual study tasks are necessary for university education. But they hope the tasks should be inquiry-oriented rather than memory or mechanical work-oriented. (4) Students want to have a space like Curriculum Material Preparation Area(CMPA) in order to make individual learning tasks.

치과용 임플란트로 적용을 위한 스테인리스강 표면의 Ti/TiN film 증착

최한철,고영무,백대화,박영록,박지윤 대한치과기재학회 1999 대한치과재료학회지 Vol.26 No.1

A study on Ti/TiN film coating on stainless steels for application as dental implants have been investigated. The stainless steels containing Ti were solutionized 1050℃ for 1hr. Then the surface was deposited with Ti and TiN by using electron-beam deposition method. The deposited layer and microstructure were analyzed by using XRD, WDX, XPS and SEM. The hardness and wear resistance of deposited surface were examined and corrosion behavior were investigated by using potentiostat, XPS and SEM. The results were as follows: 1. Some defects showed on the deposited surface, such as crater and microdroplet, and surface roughness increased in all specimen after TiN deposition. 2. Ti/TiN deposited layer showed columnar structure which nucleated and grew on the special crystalline direction and plane: Ti/TiN layer TiN(220) and TiN(200). 3. The hardnesses of Ti/TiN layer was higher than that of TiN layer. 4. In case of stainless steel containing high Ti content, Ti/TiN layer showed better wear resistance than that of TiN layer. 5. Pitting potential of TiN film in NaCl solution increased as Ti content increased, but pitting potential of Ti/TiN film were not affected by the Ti content of substrate. Pitting potential of Ti/TiN film showed high value than that of TiN film in NaCl solution. The number and size of pits were apparently decreased by Ti/TiN film deposition on the stainless steel.

Cefotaxime과 Furosemide의 賢排泄 및 血漿蛋白 結合에 미치는 影響

鄭址昌,金載學,韓大燮,高啓昌 慶熙大學校 1984 論文集 Vol.13 No.-

The cephalosporins are eliminated by both glomerular filtration and tubular excretion. Chronic administration of cephalosporins may cause renal tubular necrosis. Cefotaxime is a new semisynthetic cephalosporin antibiotic with an unusually broad antibacterial spectrum. Therefore, to determine whether any variations at plasma protein binding with furosemide by cefotaxime were responsible for its diuretic action of urine volume and electrolytes in rabbits, author studies effects on drug-interaction of cefotaxime and furosemide. The following results were obtained. 1. The group, administrated simultaneously furosemide and cefotaxime, was significantly increased compared with furosemide alone group on the urine volume, urinary electrolytes, because markedly increased the inhibition of Na^+ and Cl^- reabsorption in the renal tubule, and glomerular filtration rate without any differences. 2. Serum concentration of cefotaxime in rabbits was significanly elevated by the combination with furosemide, and markedly inhibited the elimination levels of cefotaxime in urine of rabbits. Conclusion of above results; Synergistic effect of cefotaxime on diuretic action of furosemide showed the comparative inhibition of plasma protein binding with furosemide by cefotaxime, and the continuation of diuretic effect seems excretion of furosemide on the in-hibited by competition between furosemide and cefotaxime in renal tubular excretion.

Ampicillin과 Furosemide의 相互作用에 관한 硏究

李昇宰,鄭址昌,高啓昌,韓大燮 慶熙大學校 1986 論文集 Vol.15 No.-

In order to investigate the durg-interaction between furosemide and ampicillin, the influences of ampicillin on the diuretic action of furosemide and the effects of furosemide on the urinary elimination rate and serum concentration of ampicillin were studied in the rabbits. In comparison of diuretic effects of furosemide alone group with those of furosemide-ampicillin combined group, the furosemide-ampicillin combined group showed significant increase in urine flow and urinary electrolytes amounts. Those findings seem to be resulted chiefly from marked inhibition of sodium and chloride reabsorption in the renal tubule without a little alteration of glomerular filtration rate. Throughout the combined administration of furosemide and ampicillin. the serum concentration of ampicillin were significantly elevated, but the urinary elimination rate of ampicillin were markedly decreased in the observed rabbits. It is concluded from the results that synergistic effect of ampicillin on diuretic action of furosemide might be due to the competitive inhibition of plasma protein binding with furosemide by ampicillin. It is also postulated that the competition between furosemide and ampicillin in renal tubular secretion.

신생아 중증 세균성 감염에 대한 Augmentin(clavulanate potentiated amoxycillin)의 치료효과 및 안전성 연구

성인경,강진한,고대균,이경수 대한감염학회 1995 감염 Vol.27 No.1

Combination therapy of β-lactam antibiotics has been used widely to treat severe infections in neonates. The widespread use of β-lactam antibiotics has resulted in emergence of a broad variety of plasmid or chromosome mediated β-lactamases. Also, there is a great propensity for these enzymes to spread among various species of bacteria. Thus, the use of β-lactamase inhibitor antibiotics may be of great interest and has potential therapeutic value in severe neonatal infections. We tried to find out the efficacy and safety of clavulanate potentiated amoxycillin (Augmentin) in treatment of severe neonatal infections. Total thirty-five neonates with sepsis(26) or severe organ infections(9) were involved. Each 30mg/kg dose of Augmentin was injected at 12hr-or 8hr-or 6hr-intervals according to the age and weight of neonates. Clinically 77.1% of the cases were cured, and microbiologically 80.0% were eliminated. 88.9% of eighteen gram positive organisms(S. aureus, S. epidermidis, a -hemolytic strep., S. pneumoniae , E. faecalis) isolated from study group were susceptible to Augmentin. 47.0% of gram-negative organisms (K. pneumoniae, E.coli, P. mirabilis, S. marcescens, C. freundii) were suceptible. Thus, it was confirmed that Augmentin was very effective in ampicillin-or ceftriaxone-resistant gram positive cocci infections, but less effective in isolated K. pneumoniae and S.marcescens cases. The serum levels of amoxycillin in the neonates were maintined about 6㎍/ml until 1hr. at each injection. We observed that alkaline phosphatase level was elevated above 1,000IU/ℓ in three neonates and that skin rash developed after injection in one neonate. But, these side effects were mild and transient. These results suggest that Augmentin may be tolerable and effective in treating severe gram positive cocci infections in neonates.

韓國農村에 있어서의 蛔蟲感染相

李駿商,金光錄,高大警,成大林,李慈英,林漢鍾 한국농촌보건회 1980 농촌의학·지역보건 Vol.5 No.1

Convolutional Neural Networks for Character-level Classification

Dae-Gun Ko,Su-Han Song,Ki-Min Kang,Seong-Wook Han 대한전자공학회 2017 IEIE Transactions on Smart Processing & Computing Vol.6 No.1

Optical character recognition (OCR) automatically recognizes text in an image. OCR is still a challenging problem in computer vision. A successful solution to OCR has important device applications, such as text-to-speech conversion and automatic document classification. In this work, we analyze character recognition performance using the current state-of-the-art deep-learning structures. One is the AlexNet structure, another is the LeNet structure, and the other one is the SPNet structure. For this, we have built our own dataset that contains digits and upper- and lowercase characters. We experiment in the presence of salt-and-pepper noise or Gaussian noise, and report the performance comparison in terms of recognition error. Experimental results indicate by five-fold cross-validation that the SPNet structure (our approach) outperforms AlexNet and LeNet in recognition error.

A high efficiency dye-sensitized solar cell with a UV-cured polymer gel electrolyte and a nano-gel electrolyte double layer

Han, Dae Man,Ko, Kwan-Woo,Han, Chi-Hwan,Kim, Youn Sang The Royal Society of Chemistry 2013 Journal of materials chemistry. A, Materials for e Vol.1 No.30

위식도역류질환이 의심되는 환자에서 다채널 강내 임피던스-pH 검사의 유용성

한대희 ( Dae Hee Han ),이준성 ( Joon Seong Lee ),김영대 ( Young Dae Kim ),임희혁 ( Hee Hyuk Im ),정윤 ( Yun Jung ),정인섭 ( In Seop Jung ),고봉민 ( Bong Min Ko ),홍수진 ( Su Jin Hong ),류창범 ( Chang Beom Ryu ),김진오 ( Jin Oh Ki 대한소화기기능성질환·운동학회 2006 Journal of Neurogastroenterology and Motility (JNM Vol.12 No.1

목적: 위식도역류질환의 진단에 다채널 강내 임피던스-pH 검사의 유용성을 알아보고자 하였다. 첫째, 위식도역류질환에 대한 다채널 강내 임피던스-pH 검사의 유용성을 알아보고자 하였다. 둘째, 증상지수 양성인 환자를 대상으로 산역류 또는 비산역류와의 증상과의 관련성을 알아보고자 하였다. 대상 및 방법: 위식도역류질환이 의심되는 총 74명의 환자를 대상으로 다채널 강내 임피던스-pH 검사를 시행하고 결과를 분석하였다. 결과: 1) 보행성 24시간 식도 pH 검사상 위식도역류질환 양성인 환자 수는 20예였으며 산에 대한 증상지수 양성 (SI>50%) 환자 수는 15예였다. 나머지 39예 중 다채널 강내 임피던스 pH 검사로 측정한 비산 역류에 의한 증상지수 양성은 9예, 식괴 역류 총 %시간이 증가된 경우 8예로 총 17예가 위식도역류질환으로 추가 진단되었다. 2) 다채널 강내 임피던스 pH 검사로 측정한 증상지수 양성 29명 중에 산성 역류 시에는 산 역류 증상을 더 많이 호소하였고 비산성 역류 시에는 흉부작열감과 비심인성 흉통을 더 많이 호소하였다. 결론: 다채널 강내 임피던스-pH 검사는 위식도역류질환을 진단하는데 예민한 검사법으로 생각할 수 있고 역류물과 증상과의 상호관계를 알 수 있었다. Background/Aims: To investigate the usefulness of multichannel intraluminal impedance-pH metry (MII-pH) as a diagnostic tool for gastroesophageal reflux disease (GERD): 1) the usefulness of MII-pH to increase the diagnostic sensitivity of GERD; and 2) to analyze whether various GERD symptoms were correlated with acid and nonacid reflux in patients with a positive symptom index (SI). Methods: We retrospectively compared the results of pH-metry and the results of MII-pH metry from the data of MII-pH in 74 patients with suspected GERD. Results: 1) Twenty out of 74 patients were diagnosed with GERD by pH monitoring, and an additional 15 cases had a positive SI (> 50%). Out of the remaining 39 patients, a positive SI for nonacid reflux was present in nine patients. A total of 17 cases were added to the GERD diagnosis including eight patients who showed an increase in total bolus reflux time percentage by MII-pH. 2) Regurgitation was more commonly observed with acid reflux in 29 patients with positive SI, but heartburn and noncardiogenic chest pain were more commonly correlated to nonacid reflux. Conclusions: Multichannel intraluminal impedance-pH metry is a sensitive method for the diagnosis of GERD and informs the correlation between symptoms and reflux. (Kor J Neurogastroenterol Motil 2006;12:25-30)