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( Han Wook Chung ),( Yu Jin Ko ),( Sang Wook Lee ),( Hyun Woong Lee ),( Hyung Joon Kim ) 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1
Background/Aims: Quantitative HBsAg (qHBsAg) titers are emerging as useful tools for measuring viral load and predicting predicting virologic response (VR). This study aimed to determine whether serial monitoring of HBsAg levels could predict virologic response to entecavir(ETV) & clevudine(CLV) therapy in treatment-naive patients with CHB Methods: A total of 157 treatment-naive patients with CHB, who visited Chung-Ang University Hospital between January 2007 and December 2008, were enrolled in this study (100 males). 97 patients(69 males, mean age 48) were treated with ETV for average 53 months, and 60 patients (31 males, mean age 43) were treated with CLV for 26months average. HBsAg levels were measured at baseline, week 12, 24, and 48. All patients were assessed for virological response (HBV DNA<140 copies/mL). Serum HBV DNA was quantified using the real time PCR assay (Artus HBV LC PCR Kit, Roche Diagnostics, lower limit of quantification, 140 copies/mL). Results: In 97 ETV-treated patients, the rates of virological response were 56.7% (55/97) at 48months and 60 CLV-treated patients, 30% (18/60) at 24 months, respectively. Mean reduction of baseline HBV DNA was -5.3, and -4.9 log10 copies/mL. In 55 VR patients treated with ETV, 43(78.1%) patients showed early decline of HBsAg titer and 31(56.3%) patients had lower baseline HBsAg levels (< 3.7 log IU/mL). In 18 VR patients treated with CLV, 9(50%) patients showed early decline of HBsAg titer and 11(61.1%) patients had also lower baseline HBsAg levels (< 3.7 log IU/mL) . Conclusions: Early decline of HBsAg was useful for predicting VR, and baseline HBsAg could be indicative as well in CHB patients treated with ETV than patients treated with CLV.
Chung, Jae-Uk,Kim, Su Yeon,Lim, Ju-Ok,Choi, Hyun-Kyung,Kang, Sang-Uk,Yoon, Hae-Seok,Ryu, HyungChul,Kang, Dong Wook,Lee, Jeewoo,Kang, Bomi,Choi, Sun,Toth, Attila,Pearce, Larry V.,Pavlyukovets, Vladimir 이화여자대학교 약학연구소 2008 藥學硏究論文集 Vol.- No.18
A series of α-substituted N-(4-tert-butylbenzyl)-N-[4-(methylsulfonylamino)benzyl]thiourea analogues have been investigated as TRPVl receptor antagonists. α-Methyl substituted analogues showed potent and stereospecific antagonism to the action of capsaicin on rat TRPVl heterologously expressed in Chinese hamster ovary cells, In particular, compounds 14 and 18, which possess the R-configuration, exhibited excellent potencies (respectively, K_(i) = 41 and 39.2 nM and K_(i(ant)) = 4.5 and 37 nM).
A Korean case of neurofibromatosis type 1 with an exonic splicing enhancer site mutation
Sang wook Park,Young Bae Sohn,In Soon Chung,Ji Hee Hong,Eun Jung Jung,Seon Yong Jeong,Hyun Seok Jin 대한의학유전학회 2014 대한의학유전학회지 Vol.11 No.1
Neurofibromatosis type 1 (NF1) is an autosomal dominant disease characterized by neurological, cutaneous, and ophthalmological manifestations. A 33-year-old woman with typical symptoms of NF1 visited Ajou University Hospital. Screening of the whole-messenger RNA region of NF1 at the complementary DNA level by polymerase chain reaction-direct sequencing confirmed the presence of an NF1 mutation at the genomic level. The mutation analysis revealed an in-frame skipping of exon 46 (c.6757_6858del) caused by a point mutation (c. 6792C>A) in exon 46. In this report, we have described the first Korean case of a proband with NF1 that carries an allele with an exon 46 deletion caused by an exonic splicing enhancer site mutation, leading to the skipping of the whole of exon 46 (c.6757_6858del).
Early Hemodynamic Changes after Ligation and Reperfusion of Coronary Artery in Dog
Chung, Wook Sung,Hong, Soon Jo CATHOLIC MEDICAL CENTER 1988 Bulletin of the Clinical Research Institute Vol.16/17 No.1
This study was performed to investigate early hemodynamic changes after ligation and reperfusion of anterior descending branch of left coronary artery. The cardiac output was estimated by thermodilution method and the pulmonary arterial pressure was measured through Swan-Ganz catheter. Simultaneously the electrocardiogram was recorded The results were as follows : 1) After coronary artery ligation, the cardiac output was gradually on the decrease, and 2 hrs ligation value was significantly different from control value (P < 0.05). After reperfusion, the cardiac output was gradually on the increase at 1 hr and 2 hrs, but 2 hrs reperfusion value was not significantly different from 2 hrs ligation value. 2) The pulmonary arterial systolic, end-diastolic, and mean pressure did not reveal significant changes during ligation and reperfusion. 3) The incidence of ischemic ventricular fibrillation was 22.2%, and the incidence of reperfusion ventricular fibrillation 14.5%. The changes of ST segment in surface ECG were not revealed during ligation and reperfusion. These results suggest that very early reperfusion of coronary artery can improve ventricular function in acute myocardial infarction .
Anterolateral Portal Is Less Painful than Superolateral Portal in Knee Intra-Articular Injection
( Sung Yup Lee ),( Kiran Kumar Gn Ms (ortho) ),( Byung June Chung ),( Sang Wook Lee ),( Tae Kyun Kim ) 대한슬관절학회 2015 대한슬관절학회지 Vol.27 No.4
Purpose: Intra-articular knee injections are commonly performed in clinical practice for treating various knee joint disorders such as osteoarthritis and rheumatoid arthritis. When selecting the portal for injection, not only intra-articular needle accuracy but also procedural pain should be taken into consideration. The purpose of this study was to determine whether injection through anterolateral portal provokes less pain and provides better pain relief compared to superolateral portal. Materials and Methods: A total of 60 patients with primary osteoarthritis of the knee receiving intra-articular injections were randomized into 2 groups according to the type of portal approach; anterolateral or superolateral. All patients received hyaluronic acid (20 mg) and triamcinolone (40 mg) as the first injection followed by second and third injections of hyaluronic acid on a weekly basis. Underlying knee pain, procedural pain, and knee pain at 4 weeks were evaluated using visual analogue scale (VAS). Results: Injection through anterolateral portal provoked less pain (VAS, 1.5±1.3) than the superolateral portal (VAS, 1.5 vs. 2.7; p=0.004). No differences were found in the degree of pain relief at weeks between the two groups (p=0.517). Conclusions: We recommend the use of anterolateral portal for intra-articular knee injection as it provokes less pain and comparably short-term pain relief than the superolateral portal.
Performance of friction dampers installed between coupling beams of coupled shear wall
Chung, Hee-San,Moon, Byoung-Wook,Lee, Sung-Kyung,Park, Ji-Hun,Min, Kyung-Won 단국대 부설 리모델링연구소 2009 리모델링 연구소 논문집 Vol.7 No.1
High-rise apartments of shear wall system are governed by flexural behavior like a cantilever beam. Installation of the damper-brace system in a structure governed by flexural behavior is not suitable. Because of relatively high lateral stiffness of the shear wall, a load is not concentrate on the brace and the brace cannot perform a role as a damping device. In this paper, a friction damper applying flexibility of shear wall is proposed in order to reduce the deformation of a structure. To evaluate performance of the proposed friction damper, nonlinear time history analysis is executed by SeismoStruct analysis program and MVLEM(Multi Vertical Linear Element Model) be used for simulating flexural behavior of the shear wall. It is found that control performance of the proposed friction damper is superior to one of a coupled wall with rigid beam. In conclusion, this study verified that the optimal control performance of the proposed friction damper is equal to 45% of the maximum shear force inducing in middle-floor beam with rigid beam .