전류 비유 모델에 의한 초등학생의 전류 개념 변화 분석

유병길,강인석,김병철,남만희,박선희,소하연,윤희정,이영아,이하룡,전병문,정승호 부산교육대학교 과학교육연구소 2000 科學敎育硏究 Vol.25 No.-

There exists a major impediment to learning electricity which may illuminate why direct presentation of scientists' ideas is too aggressive a strategy. This impediment lies in thinking that electricity is used up and in envisaging the light bulb as a consumer. This view is based on a powerful idea which summarises much of our experience; it declares that 'things get used up', 'you cannot get something for nothing', and 'intuitive thinking'. To replace this view with scientific view, we made the analogy model. It is suggested that the analogy model is more effective in teaching electricity circuits than conventional teaching method.

강박장애 환자에서 Sertraline 치료반응의 예측인자에 관한 연구

유은정,우행원,김영철,연규월,김종원,임원정 대한신경정신의학회 2000 신경정신의학 Vol.39 No.2

연구목적: 1980년 중반부터 강박장애의 치료로 SSRIs가 널리 쓰이고 있으나 치료반응의 예측인자에 대한 연구는 미비한 실정이다. 본 연구에서는 sertraline 투여후 호전군과 비호전군의 인구학적 특성, 발병연령, 이환기간, 과거의 강방장애에 대한 투약경력, 정신과 질환의 가족력, 증상의 심각도, 임상양상 등의 변수들을 관찰하여 sertraline 치료반응과의 상관관계를 살펴보았으며 치료방응을 예측 할 수 있는 인자를 알아보았다. 방법: 연구 대상은 이대부속 동대문병원 정신과에 입원 또는 외래치료를 받은 환자들 중 정신과 진단 편람제 4판 진단 기준에 의거하여 강박장애로 진단 받은 31명(남자 10명, 여자 21명)이었다. 연구 방법은 sertraline을 하루 50mg씩 투약하면서 Y-BOCS, NIMHOCS, CGI로 강박증상의 변화를 평가하였고, HAM-A로 불안정도의 변화를 측정하여 투약 전 점수와 비교하였다. 결과: 1) Y-BOCS 점수 40%이상 감소와 함께 CGI 점수 2점 이상 감소를 보인 호전군은 대상환자 31명중 17명(54.8%)이었고, 비호전군은 14명이었다. 호전군이 비호전군에 비해 늦은 나이에 발병하는 경향을보였고(p<0.1), 이환기간이 짧았으며(p<0.05), 과거의 강박장애에 대한 투약경력은 적었다(p<0.05), 정신과 질환의 가족력은 두 집단간에 차이가 없었다. 2) 호전군에서 투약 전 Y-BOCS의 강박행동 점수가 유의하게 낮았으며(p<0.05), 기타 다른 평가척도에서는 두 집단간에 유의한 차이가 없었다. 3) 평균 Y-BOCS 점수는 투약 전에 비해 sertraline 투약 12주째 43.5%가 감소하였다. 투약 전과 비교하여 투약 2주째부터 불안을 평가하는 HAM-A 점수가 유의하게 감소하였고, 투약 4주째부터 Y-BOCS, NIMHOCS, CGI 점수가 유의하게 감소되기 시작하여 12주까지 지속되었다.(p<0.01). 4) 호전군에서 오염에 대한 강박사고와 씻음의 강박행동의 유의하게 많았으며(p<0.05), 셈의 강박행동은 없었다(p<0.05), 병적 의심은 비호전군에서 많은 경향을 보였다(p<0.1). 결론: 이상의 결과를 종합하면, 질병의 이환기간이 짧으며 과거의 강박장애에 대한 투약경력이 적고 투약 전강박행동이 심하지 않으며, 주된 임상양상이 오염에 대한 강박사고와 씻음의 강박행동인 경우 sertra-line에 좋은 치료반응을 보이지만, 셈의 강박행동이 있는 경우에는 치료반응이 좋지 않다고 예측할 수 있다. Objectives: The pharmacologic treatment of obsessive-compulsive disorder(OCD) with serotonergic antidepressant agents is well established in clinical psychiatry on the basis of serotonin hypothesis. Studies on predictive factors of treatment reponse to OCD are relatively scarce. The author compared the demographic factors, age of onset, length of illness, family history of mental illness, previous drug history for OCD, severity and type of symptoms between the drug reponders and non-responders to find out the predicitive factors that may be related to treatment response. Methods: The subjects were 31, both inpatients and outpatients who met the diagnostic criteria for OCD by DSM-IV and scored 20 or higher on the Yale-Brown Obsessive-Com-pulsive Scale(Y-BOCS) completed 12-week trial of sertraline. Y-BOCS, National Institute of Mental Health Obsessive-Compulsive Scale(NIMHOCS), Clinical Global Impression Scale(CGI) were scored to measure the changes of obsessive-compulsive symptoms, and Hamilto Anxiety Scale(HAM-A) was measured at each visit. Results: 1) The responders, defined as achieving at least a 40% decrease in the Y-BOCS total score and more than a 2 point decrease in CGI score, were 17(54.8%), and non-responders were 14(45.2%). Responders tended to show later onset(p<0.1), and shorter duration of illness(p<0.05), and less previous drug therapy for OCD(p<0.05) than non-responders. There were no significant differences in family history of mental illness between the two groups. 2) The basline Y-BOCS compulsive score was significantly lower in responders(p<0.05), although there was no significant difference in the basline severity of other measures. 3) The obsession of contamination and washing behaviors were more frequent, but compulsive counting was not shown, in responders(p<0.05). The pathological doubt tended to be more common in nonresponders(p<0.1). Conclusions: In summary, the patients with shorter duration of illness, less prior drug ther-apy for OCD, and less severe compulsive behaviors, and the obsession of contamination and washing behaviors are expected to be better outcome with sertraline, whereas compulsive counting are the predictor of poor response.

무궁화 根群 分布에 관한 연구 : 2. 土壤 種類別 實生苗의 根群 分布 2. Root system of seedlings on the soil conditions.

심경구,하유미,김진춘,서병기,강호철 성균관대학교 생명과학자원연구소 1995 生命資源科學硏究 Vol.2 No.1

This study was carried out to examine the characteristics of root system for seedlings of Hibiscus syriacus L. on the different soil conditions as a basic study for the stock of top-root cultivars. The obtained results are summarized as follows; It was significantly different on soil hardness between upland soil with 13 kg f/cm2 until 60 cm depth and waste landfill soil with 5 kg f/cm2 until 5 cm depth. But it was not measured soil hardness under 30 cm of waste landfill soil because of waste base. But soil pH was not different between soil conditions. The root depth of 'SKK 91-3' growing on upland soil was 81.0 cm and it was significantly different as compared with that of 'SKK 91-3' on the waste landfill. In addition, 'SKK 91-3' growing on upland soil had more root weight, root width, root number, main root diameter, and shoot growth than that on the waste landfill. Therefore it was suggested that soil condition affect root growth of seedlings in Hibiscus syriacus L. and then induce top-root system.

Results of the Ground-based Cloud Seeding for Orographic Snow Enhancement at Daegwallyeong During the 2010 Winter

Ha-Young Yang,Chul-kyu Lee,Ki-Ho Chang,Jin-Yim Jeong,Sung-Kyu Seo,Jin-Young Bae,Jae-won Jung,Yoo-Chul Kim,Jeong-Ho Lee,Young-Jean Choi,Joo-Wan Cha,Byung-Gon Kim,Yoo-Jun Kim,Seung-Hee Eun,Chan-Su Ryu 한국기상학회 2011 한국기상학회 학술대회 논문집 Vol.2011 No.4

The quantified EGFR value by PNA clamping can be a predictor within EGFR mutated group

( Ha Young Park ),( Hyung Joo Oh ),( Chul-kyu Park ),( Hong-jun Shin ),( Hee-jung Ban ),( Yong-soo Kwon ),( In-jae Oh ),( Yu-il Kim ),( Sung-chul Lim ),( Young-chul Kim ),( Yoo-duk Choi ) 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1

Background: Epidermal growth factor receptor (EGFR) mutation is a reliable predictive factor for response to EGFR tyrosine kinase inhibitors (TKIs) compared to wild type. We investigated the quantified EGFR value can also predict response and survival within EGFR mutated group. Methods: This was a retrospective study of 836 lung cancer patients performed EGFR mutation test by peptidenucleic acid (PNA)-mediated clamping polymerase chain reaction (PCR) from January 2013 to December 2014. The efficiency of PCR clamping was determined by measuring the cycle threshold (Ct) value and the EGFR quantification was determined by corrected delta Ct (□Ct) value which was subtracted non-PNA corrected sample Ct value from standard Ct value. Results: The positivity of EGFR mutation was 32.3% and there were 235 single activating mutations (131 cases of 19 deletion and 104 cases of L858R). Response to EGFR-TKIs was significantly better in female (p<0.001), non-smoker (p=0.012), EGFR mutation (p<0.001) and first line treatment group (p<0.001). In EGFR single activating mutation group, the mean corrected □Ct value was 6. The high corrected □Ct group was significantly better response (70.9% vs. 54.9%, p=0.022) and median progression-free survival (303.4 days vs. 223.9 days, p=0.05). But overall survival was not different between two groups (379.7 days vs 356.2 days, p=0.655). Conclusions: The quantified EGFR value by PNA-mediated PCR clamping can predict response and progression-free survival of EGFR-TKIs in patients with 19 deletion and L858R mutations.

A Study on Evaluating Usability of MUI (Multiple User Interface) as Personal Digital Computing Devices : Based on Different User Environment

Chul Ha Yoo,Chung Mo Jung (사)한국디지털디자인협의회 2007 (사)한국디지털디자인협의회 conference Vol.2007 No.1

A New Cultivar ‘Tohagol Red’ with Unique Flower Shape and Color through Interspecific Hybridization of Hibiscus species

Yoo-Mi Ha,Kyung-Ku Shim,Ho-Chul Kang,Ki-Byung Lim 한국화훼산업육성협회 2014 화훼연구 Vol.22 No.4

A new Hibiscus cultivar ‘Tohagol Red’ with unique flower shape and color, uniform growth habit and hardiness was developed through interspecific hybridization between Hibiscus sinosyriacus and H. syriacus. A new cultivar 'Tohagol Red' (Hibiscus × ‘Tohagol Red’) developed after crossing between Hibiscus sinosyriacus ‘Seobong’ ( ♀) with pink flower and Hibiscus syriacus ‘Samchully’ with pink flower to improve flower quality and growth habit in 2002. Hibiscus ‘Tohagol Red’ was preliminarily selected as ‘R 202’ in 2004 for its stable flower quality with rich pink flower and ruffled petals. This cultivar had violet purple, ruffled flowers accented by an intense red eye. Large and showy, the overlapping flower petals formed a complete circle and then named ‘Tohagol Red’ in 2010. The tree showed medium growth habit with slightly upright branch. The selected line was further evaluated for different growth characteristics, leaf shape, leaf size, flowering characteristics, and tested for distinctness, homogeneity, and stability during 2004-2009. In The flowers are medium in size (11 ~ 13 cm) with fan (II-type) petal having width 9.2 cm. Leaves are 7.2 cm long and 5.4 cm wide. After the plant characteristics evaluation for 6 years (2004 ~ 2009), it was registered as a cultivar ‘Tohagol Red’ (3803, No. of plant variety protection rights) in 2011. ‘Tohagol Red’ having violet-purple flower and red eye with ruffled petals is an excellent garden plant.

Feasibility study for the assessment of the exposed dose with TENORM added in consumer products

Yoo, Do Hyeon,Lee, Hyun Cheol,Shin, Wook-Geun,Ha, Wi-Ho,Yoo, Jae Ryong,Yoon, Seok-Won,Lee, Jiyon,Choi, Won-Chul,Min, Chul Hee Oxford University Press 2015 Radiation protection dosimetry Vol.167 No.1

<P>Consumer products including naturally occurring radioactive material have been distributed widely in human life. The potential hazard of the excessively added technically enhanced naturally occurring radioactive material (TENORM) in consumer products should be assessed. The aim of this study is to evaluate the organ equivalent dose and the annual effective dose with the usage of the TENORM added in paints. The activities of gammas emitted from natural radionuclides in the five types of paints were measured with the high-purity germanium detector, and the annual effective dose was assessed with the computational human phantom and the Monte Carlo method. The results show that uranium and thorium series were mainly measured over the five paints. Based on the exposure scenario of the paints in the room, the highest effective dose was evaluated as <1 mSv y<SUP>−1</SUP> of the public dose limit.</P>

A Study on Evaluating Usability of MUI (Multiple User Interface) as Personal Digital Computing Devices

Chul Ha Yoo,Chung Mo Jung 한국디자인지식학회 2007 한국디자인지식학회 Conference Vol.2007 No.8

Kallmann syndrome with a Tyr113His <i>PROKR2</i> mutation

Ha, Jeong-Ha,Lee, Sara,Kim, Youngmoon,Moon, Ji In,Seo, Jongkwon,Jang, Ja-Hyun,Cho, Eun-Hae,Kim, Jung Min,Rhee, Byoung Doo,Ko, Kyung Soo,Yoo, Soo Jin,Won, Jong Chul Williams & Wilkins Co 2017 Medicine Vol.96 No.35

<P><B>Abstract</B></P><P><B>Rational:</B></P><P>Kallmann syndrome (KS) is a genetic gonadotropin-releasing hormone deficiency associated with hyposmia or anosmia and characterized by various modes of inheritance.</P><P><B>Patient concerns:</B></P><P>A 16-year-old male did not reach puberty and was associated with hypogonadotropic hypogonadism and anosmia. His magnetic resonance imaging of brain revealed the absence of the olfactory bulb.</P><P><B>Diagnosis:</B></P><P>His karyotype was 46 XY. Sanger sequencing of the <I>KAL1</I> gene revealed no mutations. Diagnostic exome sequencing identified a prokineticin-receptor 2 (<I>PROKR2</I>) gene variant, c.337T > C (p.Tyr113His), previously reported to be a pathogenic mutation; we confirmed the presence of the mutation via Sanger sequencing of the coding exons of <I>PROKR2</I>. His apparently unaffected mother and sister, but not his father, were heterozygous for the <I>PROKR2</I> Tyr113His mutation.</P><P><B>Lessons:</B></P><P>This work advances our understanding of the role played by PROKR signaling and the mode of inheritance of the gene in patients with KS.</P>