후두 및 하인두 암종에서 p53단백 발현과 Espstein-Barr Virus 검출

최영환,도남용,나한조,이도용,노용훈,김완수,최종선 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2

Background and Objectives : When p53 cancer suppressor gene, occurs gene deletion or point mutation, malignancy develops by loss of p53 function with abnormal p53 protein. The Epstein-Barr virus (EBV) is the causative agent of certain type of lymphoma and undifferentiated nasopharyngeal carcinoma. However, the role of EBV as a causative factor in other head &eck tumors is not fully elucidated except nasopharyngeal carcinoma. This study, the author examined that p53 expression and detection rate of EBV correlate to development of laryngeal and hypopharyngeal squamous cell carcinoma(SCC) and play the possible role of prognostic indicators. Materials and Methods : Formalin-fixed, paraffin-embedded tissue specimen from 32 cases of larynx and hypopharyngeal squamous cell carcinomas were studied by immunohistochemical staining for p53 and EBV. The results of analysis were compared with clinicopathological parameters. Results : p53 expression was 56.3% (18 cases) and the detection rate of EBV was 43.6% (14 cases) of 32 cases in laryngeal and hypopharyngeal squamous cell carcinomas. p53 expression was correlate with histologic grade (p<05) only. Detection of EBV was not correlate with clinicopathological parmeters. Conclusion : These results suggest p53 expression and the detection of EBV may be related with development of laryngeal and hypopharyngeal squamous cell carcinoma. And, the expression of p53 protein can be used as a prognosticator in laryngeal and hypopharyngeal squamous cell carcinoma under certain limitation.

수중의 영양염류 제거를 위한 세라믹 소재 개발

이용환(Yong-Hwan Lee),최인호(In-Ho Choi) 한국환경관리학회 2006 環境管理學會誌 Vol.12 No.4

본 연구는 수중에 용해된 인과 질소 제거효과를 갖는 세라믹소재를 개발하기 위하여 수행되었다. 감람석을 이용한 인의 제거효과는 “이”와 “최”의 연구에서 수행된바 있으며, 제올라이트를 이용한 질소제거에 관한 연구는 국내외적으로 많이 수행되어 왔다. 본 연구에서는 감람석(Olivine)과 제올라이트(Zeolite)를 서로 다른 부피 혼합비에 따라 혼합한 후 소성하여 얻어진 세라믹을 이용하여 수중에 용해된 총인(Total-Phosphorus)과 총질소(Total-Nitrogen)의 제거효과를 회분식 실험(batch reactor system)을 통해 분석하였다. 연구결과 총인의 경우 감람석과 제올라이트의 부피 혼합비가 1:2의 경우 최고의 제거효율을 보였으며, 시험개시 30분 일 때 96.0%, 4시간일 때 95.1% 의 인이 제거되었다. 총질소의 경우 감람석과 제올라이트가 1:6일 때 시험개시 30분일 때 93.6%, 4시간일 때 97.4%의 질소가 제거되었다. This study was performed to develop ceramic material to be able to eliminate phosphorus and nitrogen in water. Olivine was found to remove phosphorus in aqueous phase, which was demonstrated by Lee and Choi.1) The nitrogen removal using zeolite has been demonstrated by many researchers.2,3) Hence, utilization of mixed-typed material of Olivine and Zeolite is expected to achieve simultaneous elimination of phosphorus and nitrogen in water. In this study, the removal efficiencies of T-P(Total phosphorus) and T-N(Total nitrogen) were investigated using ceramic material in batch reactor system, which was produced by incinerating after mixing Olivine and Zeolite with different ratio. The highest removal efficiency of phosphorus was achieved under the condition of 1: 2 mixing volume ratio of Olivine to Zeolite. The phosphorus of 93.6% and 97.4% (as T-P) was removed for 0.5hr and 4hr, respectively. For the nitrogen, the nitrogen removal efficiencies of 93.6% and 97.4% (as T-N) were obtained under the condition of 1:6 mixing volume ratio of Olivine and Zeolite.

마이크로머시닝을 이용한 Bump형 Probe Card의 제조

최원익,김용대,심준환,이종현 경북대학교 센서기술연구소 1998 센서技術學術大會論文集 Vol.9 No.1

Probe card is the most important part of testing IC chips. This work was related to silicon vertical probe card which enabled to simultaneously test multiple semiconductor chips. We presented Bump-type vertical probe card. It was fabricated by dry etching using RIE technique, isotropic etching, and bulk-micromachining on SDB wafer. The process used in this work was very simple and reproducible, which had good controllability in the probe card dimension and spacing. It is expected that the fabricated probe card can reduce testing time, can promote productivity and enables bum-in test.

용도지역 적용방식별 비교ㆍ평가 연구 : 도시지역내 2이상의 용도지역에 걸치는 대지를 대상으로 A Case of the Lots Divided by Zoning-Line in the Urban Area

최찬환,황용연,최준순 대한건축학회 2004 대한건축학회논문집 Vol.20 No.2

This study is focusing on analyzing the effect and meaning of the zone on the lot divided by zoning line which is run by the current law to get rational solutions. Each evaluation applies to realistic and applicable methods according to regulations. The three ways of application methods on the zone of the selected lot divided by zoning appear are Land Area Method, Building Area Method, and Zone Method. All three ways have their own meanings and limitations to apply, but according to the analysis result, we could decide that Region Method is the most effective way. However, it has sever limitations when we design site plan, building-use and building form in a land, so complements are required for each of provisions. Therefore, We suggest new approach about the building development scale, and for building-use and a right to enjoy sunshine, We suggest complementary methods for each case. First, We apply for a complex method for deciding on the building development scale. Second, for determination of the building uses, We permit the mixed-usage when a building sets on the lot divided by zoning line, and for a right to enjoy sunshine, We select the application method for the bigger land.

위내시경에 의한 칫솔제거

최성곤,권영오,김성국,최용환,정준모 慶北大學校 醫科大學 1997 慶北醫大誌 Vol.38 No.1

최근 내시경술의 발전으로 진단적인 측면 뿐 아니라 그 치료적인 면에서도 많이 이용되고 있는 실정이다. 저자들은 오심을 해결하기 위해 칫솔로 설근부를 자극하여 구토를 유발하던 중 우발적으로 연하되어 식도·위 접합부 및 위내에 있다가 내시경으로 제거된 칫솔 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. With the improvement of the technique and instrument, the gastroduodenal endoscope has been used not only in diagnostic purpose but in therapeutic approach. In this case, we removed a swallowed toothbrush in esophagus and stomach with gastroduodenal endoscope and snare without complication.

발프로산나트륨과 페니토인과의 약물상호작용

최준식,유재신,박용채,이진환 朝鮮大學校 1997 藥學硏究誌 Vol.18 No.2

This study was attempted to investigate the pharmacokinetic interaction between sodium valproate (4. 8. 16 ㎎/㎏. i.v.) and phenytoin (4 ㎎/㎏. i.v) in rabbits. The plasma concentration and area under the curve (AUC) of phenytoin were increased significantly (p<0.05. p<0.01) when coadministered with sodium valproate (4. 8. 16 ㎎/㎏) in rabbits. The volume of distribution and total body clearance of phenytoin were decreased significantly (p<0.05. p<0.01) when coadministered with sodium valproate (8. 16 ㎎/㎏) in rabbit. From the results of this experiment. it is desirable that dosage regimen of phenytoin should be adjusted and therapeutic drug monitoring should be performed for reduction of side or toxic effect when phenytoin will be coadministered with sodium valproate in clinical use.

Molecular subtypes of triple-negative breast cancer: understanding of subtype categories and clinical implication

Yong‑Moon Lee,Man Hwan Oh,Jai‑Hyang Go,Kyudong Han,Song‑Yi Choi 한국유전학회 2020 Genes & Genomics Vol.42 No.12

Background: Triple-negative breast cancer (TNBC) is a heterogeneous entity that encompasses several subtypes with distinct molecular characteristics. The patients with TNBCs show unpredictable response to the chemotherapy, and further there is the lack of effective agents. Thus, many studies have been underway to discover targeted therapy suitable for patients with specific genetic alterations in each molecular subtypes. TNBCs are classified as four major molecular subtypes according to the gene expression patterns. These are luminal androgen receptor (LAR), mesenchymal-like, immunomodulatory (IM), and basal-like types. Conclusion: Here, we discuss the unique molecular features of each subtype as well as promising targets for anti-cancer therapy.

부비동 환기의 연구를 위한 인체 비부비동 모형

정용수,김상렬,김동환,정동근,최순섭,정인호,서세훈 대한이비인후과학회 1999 대한이비인후과학회지 두경부외과학 Vol.42 No.9

rhBMP-2가 저칼슘식이 투여 백서의 골결손부 이유에 미치는 영향

최용석,황의환,이상래 大韓口腔顎顔面 放射線學會 2004 Imaging Science in Dentistry Vol.34 No.1

Purpose : To investigate the effect of rhBMP-2 on the healing of bone defect in the low calcium diet rat. Materials and Methods : To prepare the experimental model, control group was fed a normal diet and experimental group was fed a low calcium diet for 3 weeks. And then, 4 mm bicortical perforated bone defect was made on mandibular body of each rats. Experimental group was subdivided into two groups; experimental group 1 (rats given a low calcium diet before and after bone defect) and experimental group 2 (rats given a low calcium diet before and after bone defect with rhBMP-2 application). At 1, 3, 5 and 7 weeks after bone defect formation, the rats Were terminated. The healing of bone defect was assessed by three-dimensional computerized tomography, soft xray radiography, and histopathological examination. Results : The wound healing of the bone defect for control group, experimental group 1, and experimental group 2 showed a increase from 3 weeks after bone defect formation. The experimental group 2 showed a more increase in healing amount than control group and experimental group 1 from 5 weeks after bone defect formation and the experimental group 2 showed a complete recovery of bone defect at 7 weeks after bone defect formation. Conclusion : The healing process of bone defect is accelerated by rhBMP-2 application in the low calcium diet rats.

외부전원 인가시 복합초전도체의 안정도 파라미터에 관한 연구

최용환,고태국 연세대학교 산업기술연구소 1992 논문집 Vol.24 No.1

Stability is a mesure of the ability of a device to spontaneously return to the superconducting state after the passage of a disturbance that had either triggered or driven an excursion into the normal state; this treatise made a study one of stability theories, flux jump stability. Consequently, the stability of superconductor with the condition of transport current flow was improved with considering the heat effect. And this treatise reached the conclusion that the critical current density is uplifted in inverse proportion to the width of superconductor and the volumetic proportion of superconductor.