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病態動物에서 Acetylsalicylic acid의 生物藥劑學的 硏究
李珍煥,崔俊植 조선대학교 약학연구소 1978 藥學硏究誌 Vol.1 No.1
The purpose of this paper was to investigate the bioavailability of acetylsalicylic acid in phathological rabbits pretreated with carbon tetrachloride and mercuric chloride. The results are as follows ; *Blood level of the absorbed acetylsalicylic acid as increased in rabbits damaged liver and kidney as compared with that of normal rabbits. Especially, blood level of acetylsalicylic acid in rabbits damaged kidney was more increased than that of rabbits damaged liver. *Urinary excretion of acetylsalicylic acid in rabbits damaged kidney was more inhibited than that of rabbits damaged kidney. *As the results, it could be considered that increase of blood level of acetylsalicylic acid was due to inhibition of urinary excretion by interaction with carbon tetrachloride and mercuric chloride.
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李鎭煥 부산대학교 학생생활연구소 1981 硏究報 Vol.17 No.1
In this survey research the possibility that how to perceive college departments might have effects on the choice of them was explored. Data were collected from 84 freshmen(49 male, 35 female), but 5 cases which failed to respond to a few items were excluded. Meaning of college departments was measured on the 7-point semantic differential scale which consisted of 12 pairs of adjective. The percepts and impression of college departments were measured through 12 items. And free-association was also used. Major findings were as follows: (1) Among the meaning dimensions-Evaluation, Potency, Activity-Potency Dimension had effect on the choice of college departments. (2) Popularity of college departments might have effect on the choice of them. (3) Family pressure might be a factor in the choice of college departments. (4) College department which was thought to contribute to our society was more favored. (5) Student's knowledge of college departments was found as superficial by the analysis of their free-asscciation contents. (6) There was a tendency to pragmatism to academism.
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이진환,이창현,박호범,이영무 한국고분자학회 2006 Macromolecular Research Vol.14 No.4
Novel sulfonated poly(aryl ether ketones) containing benzoxazole were directly synthesized by aromatic nucleophilic polycondensation using various ratios of 2,2'-bi[2-(4-flurophenyl)benzoxazol-6-yl]hexafluoropropane to sodium 5,5'-carbonylbis(2-fluorobenzenesulfonate). The copolymers were soluble in polar aprotic solvents such as N-methyl-2-pyrrolidone, N,N-dimethylacetamide, and N,N-dimethylformamide at a relatively high solid compo sition (>15wt%) and formed tough, flexible and transparent membranes. The membranes exhibited a degradation temperature of above 290oC. The exact dissolution times of these membranes at 80oC in Fenton's reagent (3wt% H2O2 containing 2ppm FeSO4) were undetectable, confirming their excellent chemical stability in fuel cell application. The membranes showed a moderate increase in water uptake with respect to increasing temperature. The proton conductivities of the membranes were dependent on the composition and ranged from 1.10 10-2 to 5.5010-2 Scm-1 at 80oC and 95% relative humidity (RH). At 120oC without externally humidified conditions, the conductivities increased above 10-2 Scm-1 with respect to increasing benzoxazole content, which suggested that the benzoxazole moieties contributed to the proton conduction.
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이진환,최준식,백채선,범진필 한국약제학회 1989 Journal of Pharmaceutical Investigation Vol.19 No.3
This study was attempted to investigate the dissolution rate and the bioavailability after oral administration of commercially available aspirin tablets in normal volunteers. The dissolution test was conducted in artificial gastric juice using basket method with three aspirin preparations (A, B and C) which were chemically equivalent. The results were as follows; The dissolution rate was higher in the order of three different brand B>A>C. Area under the blood concentration and peak blood concentration were larger in the order of brand A>B>C. Absorption rate constant and peak time were larger in the order of brand B>A>C, and there was a little difference in elimination rate constant and biological half-life. The correlation of the dissolution rate and absorption rate constant, as well as correlation of the dissolution rate and peak time showed significant linear relationship respectively. From the results of this experiment, it can be concluded that the bioavailability of aspirin tablets showed much difference according to commercial preparations, and that the bioavailability of aspirin tablets in human may be predicted from the results of dissolution rate studies.
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이진환 대한약학회 1978 약학회지 Vol.22 No.4
It was to investigate the absorption, excretion, protein binding of ampicillin in the pathological animals pretreated with carbon tetrachloride and mercuric chloride. The absorption of ampicillin was not affected in rats with damaged liver and kidney as compared with that of normal rats. The blood level of ampicillin after oral administration was increased significantly in rabbits with damaged kidney and liver. The blood level of ampicillin in rabbit with damaged kidney was more increased than that in rabbits with damaged liver. In severly damaged rabbits, it was more increased than that of mildly damaged rabbits. Urinary excretion of ampicillin in pathological animals was more inhibited than that of ampicillin in normals. Hepatic excretion of ampicillin was accelerated in rabbits with damaged kidney. However, in rabbits with damaged liver, it was inhibited as compared with that in normals. Protein binding of ampicillin was slightly enhanced by the various concentration of carbon tetrachloride and mercuric chloride, respectively. The results suggest that the increase of blood level of ampicillin in pathological animals was due to the inhibition of renal excretion.
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이진환,이종기 한국약제학회 1987 Journal of Pharmaceutical Investigation Vol.17 No.2
The drug interaction between probenecid and lithium carbonate was studied pharmacokinetically in rabbits. The blood level and the area under the concentration curve (AUC) of lithium carbonate administered orally were elevated by coadministration of probenecid. Probenecid inhibited the urinary excretion of lithium carbonate in rabbits. Biological half-life and t_(max) of lithium carbonate were prolonged by coadministration of probenecid. From these results, dosage regimen of lithium carbonate is considered to be adjusted for effective and safe therapy in the coadministration of probenecid.
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