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( Young Il Jo ),( Ha Young Na ),( Ju Young Moon ),( Sang Woong Han ),( Dong Ho Yang ),( Sang Ho Lee ),( Hyeong Cheon Park ),( Hoon Young Choi ),( So Dug Lim ),( Jeong Hae Kie ),( Yong Kyu Lee ),( Sug 대한내과학회 2016 The Korean Journal of Internal Medicine Vol.31 No.2
Background/Aims: Immunoglobulin A nephropathy (IgAN) is a generally progressive disease, even in patients with favorable prognostic features. In this study, we aimed to investigate the antiproteinuric effect and tolerability of lowdose valsartan (an angiotensin II receptor blocker) therapy in normotensive IgAN patients with minimal proteinuria of less than 0.5 to 1.0 g/day. Methods: Normotensive IgAN patients, who had persistent proteinuria with a spot urine protein-to-creatinine ratio of 0.3 to 1.0 mg/mg creatinine, were recruited from five hospitals and randomly assigned to either 40 mg of valsartan as the low-dose group or 80 mg of valsartan as the regular-dose group. Clinical and laboratory data were collected at baseline, and at 4, 8, 12, and 24 weeks after valsartan therapy. Results: Forty-three patients (low-dose group, n = 23; regular-dose group, n = 20) were enrolled in the study. Proteinuria decreased significantly not only in the regular-dose group but also in the low-dose group. The change in urine protein-to-creatinine ratio at week 24 was -41.3% ± 26.1% (p < 0.001) in the regular- dose group and -21.1% ± 45.1% (p = 0.005) in the low-dose group. In the lowdose group, blood pressure was constant throughout the study period, and there was no symptomatic hypotension. In the regular-dose group, blood pressure decreased at weeks 8 and 12. No significant change in glomerular filtration rate, serum creatinine level, or serum potassium level was observed during the study period. Conclusions: Our results suggest that low-dose valsartan can significantly reduce proteinuria without causing any intolerability in normotensive IgAN patients with minimal proteinuria.
( Jang Soo Han ),( So Dug Lim ),( Won Hyeok Choi ),( Sung Chul Hong ),( Jung Hee Park ),( Eugene Park ),( Mi Jin Hong ),( Cho I Lee ),( Jung Hwan Park ),( Jong Ho Lee ),( Jong Oh Song ),( Young Il Jo 대한신장학회 2013 Kidney Research and Clinical Practice Vol.32 No.1
Immunoglobulin A (IgA) nephropathy associated with cirrhosis is the most common form of secondary IgA nephropathy (IgAN). Cirrhosis-related IgAN is usually clinically silent with a rare occurrence of gross hematuria, unlike in cases of idiopathic IgAN. Especially, acute tubular necrosis (ATN) associated with gross hematuria is very rare in cirrhosis-related IgAN, although acute renal failure is a frequently reported complication in advanced cirrhosis. Herein, we report an unusual case of ATN requiring renal replacement therapy, associated with gross hematuria in a patient with nonalcoholic, hepatitis B virus-associated cirrhosis. Results of a histopathological analysis revealed obstruction of the lumen of renal tubules by red blood cell casts, a marked tubular necrosis, and IgA deposition in the mesangium. The patient`s renal function and gross hematuria were clearly improved after lamivudine treatment.
Identification of differentially expressed proteins in the bacterial biofilm
강치덕,최점일,Kang, Chi-Dug,Choi, Jeam-Il The Korean Academy of Periodontoloy 2005 Journal of Periodontal & Implant Science Vol.35 No.2
본 연구는 치주낭에 biofilm형태로 부착되어 질환을 유발시키고 항생제 빚 항균제에 저항을 일으키는 세균 독성요소를 규명하기 위해 시행된 기초연구이다. 치주질환의 주 병원균의 하나인 Porphyromonas gingivalis 381 biofilm의 세포외막에 특이하게 발현되는 단백질을 규명하기 위한 기초적인 자료를 얻기 위해 시행하였다. Porphyromonas gingivalis 381을 통상적인 세균 배양용 broth를 사용하여 혐기성 세균 배양기로 24시간 배양한 것을 대조군으로 하고, tissue culture plate를 이용하여 혐기성 배양조건 하에서24시간동안 biofilm을 형성하여 실험군으로 설정하였다. 세균을 수획하여 세포외막을 분리하고 isotonic isoelectric focusing을 시행한 결과 주로 약 20-30 kilodaltons에 해당하는 수종의 세균세포막 단백질이biofilm으로 배양한 세균에서 더 상승적으로 발현됨이 관찰되었고, 상이한 수종의 단백질도 planktonic culture broth로 배양한 세균에서 다 상승적으로 발현됨을 관찰할 수 있었다. 이것은 세균의 배양조건과 환경에 따라 그 외막 단백질이 서로 다르게 발현됨을 입증하는 기초적인 자료로서 향후 단백질의 동정과 성격을 규명하는 근간 실험으로 추진할 계획이다.
Park,Jae Hong,Oh,Eun Jin,Choi,Yung Hyun,Kang,Chi Dug,Kang,Ho Sung,Kim,Dong Kyoo,Kang,Kwang Il,Yoo,Mi Ae 한국생명과학회 2001 한국생명과학회 학술발표회 Vol.31 No.-
Previous studies have shown that dexamethasone, a synthetic glucocorticoid, can induce a G1 arrest, however, genistein, a natural isoflavonoid phytoestrogen, induces a G2/M arrest in the cell cycle progression in various cancer cell lines. A block of cell cycle checkpoint by dexamethasone and genistein correlates with a selective induction of cyclin-dependent kinase (Cdk) inhibitor p21^(WAF1/CIP1) in a tumor suppressor p53-independent manner and abolishment of Cdk2 phosphorylation. In the present study, the effects of dexamethasone and genistein (both singly and combined) on the expression of p21 in human hepatocellular Hep G2 and colorectal Colo320 HSR carcinoma cells were evaluated. Whereas dexamethasone mildly induced the level of p21 protein, genistein strongly increased the expression of p21 protein in our experimental condition. Both compounds also activated p21 promoter reporter constructs. The combined effects of dexamethasone and genistein on the induction of p21 protein and activation of p21 promoter were synergistic in both cell lines. These findings indicate that dexamethasone and genistein act in a synergistic fashion and have potential for combination chemotherapy for the treatment of liver and colon cancer.
PARK, JAE-HONG,OH, EUN-JIN,CHOI, YUNG HYUN,KANG, CHI-DUG,KANG, HO SUNG,KIM, DONG-KYOO,KANG, KWANG IL,YOO, MI-AE 부산대학교 유전공학연구소 2001 분자생물학 연구보 Vol.17 No.-
Previous studies have shown that dexamethasone, a synthetic glucocorticoid, can induce a G1 arrest, however, genistein, a natural isoflavonoid phytoestrogen, induces a G2/M arrest in the cell cycle progression in various cancer cell lines. A block of cell cycle checkpoint by dexamethasone and genistein correlates with a selective induction of cyclin-dependent kinase (Cdk) inhibitor p21^WAFI/CIPI in a tumor suppressor p53-independent manner and abolishment of Cdk2 phosphorylation. In the present study, the effects of dexamethasone and genistein (both singly and combined) on the expression of p21 in human hepatocellular Hep G2 and colorectal Colo320 HSR carcinoma cells were evaluated. Whereas dexamethasone mildly induced the level of p21 protein, genistein strongly increased the expression of p21 protein in our experimental condition. Both compounds also activated p21 promoter reporter constructs. The combined effects of dexamethasone and genistein on the induction of p21 protein and activation of p21 promoter were synergistic in both cell lines. These findings indicate that dexamethasone and genistein act in a synergistic fashion and have potential for combination chemotherapy for the treatment of liver and colon cancer.
H.264/AVC용 영상압축을 위한 CAVLC 인코더 구현
정덕영,최덕영,조창석,손승일,Jung Duck Young,Choi Dug Young,Jo Chang-Seok,Sonh Seung Il 한국정보통신학회 2005 한국정보통신학회논문지 Vol.9 No.7
Variable length code is an integral component of many international standards on image and video compression currently. Context-based Adaptive Variable Length Coding(CAVLC) is adopted by the emerging JVT(also called H.264, and AVC in MPEG-4). In this paper, we design an architecture for CAVLC encoder, including a coeff_token encoder, level encoder, total_zeros encoder and run_before encoder. The designed CAVLC encoder can encode one syntax element in one clock cycle. As a result of implementation by Vertex-1000e of Xilinx, its operation frequency is 68MHz. Therefore, it is very suitable for video applications that require high throughput. 가변 길이 부호는 오늘날 이미지 및 비디오에 관한 많은 국제 표준의 통합된 요소이다. 문맥 기반의 가변 길이 코팅(CAVLC)는 오늘날 주목받고 있는 JVT에서 채용되었다. 본 논문에서는 coeff_token 인코더, level 인코더, total_zero 인코더 및 run_before 인코더를 포함하는 CALVC 인코더 아키텍처를 설계한다. 설계된 CAVLC 인코더는 매 사이클마다 하나의 신택스 요소를 부호화할 수 있다. 자일링스 버텍스 1000e를 사용하여 구현한 결과 68MHz로 동작하는 것을 확인하였다. 따라서 본 논문의 CAVLC 인코더는 고속의 쓰루풋을 요하는 비디오 응용에 아주 적합할 것으로 사료된다.