한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고

양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.

천측두 동맥의 외상성 가성동맥류 1례

최익수,김기준,전병훈 白中央醫療院 2005 仁濟醫學 Vol.26 No.1

Pseudoaneurysms form when a hemorrhage or hematoma from the injured arterial wall is replaced with an fibrous vessel wall, which is dilated by subsequent pulsating pressure. Recently, we experienced a patient with a pulsatile preauricular mass, measuring about 1.5× 1.5 cm, sustained from blunt trauma by the baseball. The presumptive diagnosis of pseudoaneurysm of the superficial temporal artery was made by Doppler sonography. Under local anesthesia, the aneurysm was excised en bloc following ligation. We report the rare case with a review of literatures.

한국인의 간과 콩팥조직 내 수은 함유량의 참고치

최병선,박영주,권일훈,홍연표,박정덕 한국환경독성학회 2002 환경독성보건학회지 Vol.17 No.2

This study was conducted to investigate the reference value of mercury (Hg) in liver and kidney of Korean population. The mercury concentration in 244 'sudden and unexpected death' autopsies (male: 180, female: 64) aged from 0 to87 years was analyzed. The concentration of mercury was measured by atomic absorption spec(Perkin -Elmer Model 5100) with mercury/hydride generating system (FIAS 400). The contents of mercury in liver and kidney fitted well the log-normal distribution rather than normal distribution. Geometric mean concentration of mercury in liver and kidney was 0.115 ㎍/g wet weight and 0.149 μg/g wet weight, respectively. Geometric mean concentration of mercury in female was higher than in male (p<0.01). The mercury content in liver and kidney increased with age up to the forties and slightly decreased there-after, The regression model of mercury deposit in liver and kidney by age was predicted as the following equation : Log KHg=-1.0576+0.0045·Age -0.0001·Age²+0.0873·Sex, Log KHg=-1.0576+0.0152·Age-0.0002·Age²+0.1935·Sex. The liver burden of mercury was estimated to be 158.3~161.3μg in male and 163.0-166.9 ㎍ in female. The kidney burden of mercury was estimated to be 42.0~42.9 ㎍ in male and 55.5 ∼57.1 μg in female.

연령과 골소주 특성의 골량에 대한 연관관계

최동훈,송영한,윤영남,이완,이병도 대한구강악안면방사선학회 2006 Imaging Science in Dentistry Vol.36 No.2

Purpose : Bony strength is dependent on bone mass and bony structure. So this study was designed to investigate the relationship between the bone mass and bony trabecular characteristics. Subjects and Methods : Study subjects were 51 females (average age 68.6 years) and 20 males (average age 66.4 years). Bone mineral density (BMD, grams/cm²) of proximal femur was measured by a dual energy X-ray absorptiometry (DEXA). Regions of interest (ROIs) were selected from the digitized radiographs of proximal femur. A customized computer program processed morphologic operations (MO) of ROIs. 44 skeletal variables of MO were calculated from ROIs on the Ward’s triangle and greater trochanter of femur. WHO BMD classes were predicted by MO variables of the same ROI. Classification and Regression Tree analysis was used for calculating weighted kappa values, sensitivity and specificity of MO. Results : The discriminating factors of morphologic operation were branch point, branch point [per cm sq]. Age also played important role in distinguishing osteoporotic classes. The sensitivity of MO at Ward’s triangle and Greater Trochanter was 91.8%, 65.6%, respectively. The specificity of MO was 100% at Ward’s triangle and Greater Trochanter. Conclusion : Bony trabecular characteristics obtained using radiological bone morphometric analysis seem to be related to bone mass.

瓜蔞枳殼湯과 升發二陳湯의 實驗的 肝纖維化 變化에 對한 效果

崔宰薰,姜秉淇 대한동의병리학회 1997 동의생리병리학회지 Vol.11 No.2

慢性肝疾患 및 肝硬便은 증가하고 있는 추세이며 그중 간경변은 진핵성과정에서의 병리변화로서 정상간 조직의 구조 변형 및 형태이상과 경화를 유발하게 된다. 한의학적면에서 보면 간경변은 氣血이 瘀滯日久하여 肝脾의 脈絡이 壅塞되어 손상된 것이다. 간의 疎泄機能과 條達機能의 실조로 肝氣鬱結이 되면 일신지기의 通暢機能이 장애를 받아 울증이 발생하니 이에 저자는 식울증에 사용하는 과루지각탕과 승발이진탕이 담도결찰 및 Dimethylnitrosamine의 복강주사로 유발된 간경변에 대해 간기능 보호작용이 있는가를 관할하고 한의학적인 병증의 분류에 따라 간질환에 대한 치료의 가능성에 대한 연구를 하였다. This study was to investigate the protective and anticirrhotic effects of Guwarujigaktang and Seungbalrijintang on the liver cirrhosis or fibrosis induced by prolonged bile duct ligation; a new experimental model for cirrhosis and the intraperitoneal injection of dimethylnitrosamine in the rat. The development of fibros is or cirrhosis and its inhibit-ion by the two prescriptions were examined by the chemical analysis of AST, ALT, and hydroxyproline. The results obtained were as follows. 1. The increase of serum asparate aminotransferase induced by bileduct ligation was inhibited by the administration of Guwarujigakt-ang and Seungbalrijintang extract. 2. The increase of serum alanine aminotransferase induced by bile duct ligation was inhibited by the administration of Guwarujigaktang and Seungbalrijintang extract. 3. The increase level of serum AST and ALT induced by the intraperitoneal injection of dimethylnitrosamine was inhibited by the administration of Guwarujigaktang and Seungbalrijintang extract. 4. The increasing level of hydroxyproline volume in the damaged liver tissues in the rat was decreased by the oral administration of Guwarujigaktang and Seungbalrijintang extract. But there were no significant differences in the inhibition rate between the two experimental groups.

詩人 盧天命의 自己認識과 創造過程

崔炳勳,趙斗英 大韓神經精神醫學會 1987 신경정신의학 Vol.26 No.1

Through the anaiysis of Noh chun Myung's first collective poems ‘San Ho Rim’with her life history, the authors wish to observe her selfawareness and poetic creativ process by psychoanalytic approaches. Noh's incomplete selfimage resulted from childhood narcissistic injuries. These injuries were due to her birth destined to feminity, protracted measles at the age of 6, and loss of father at the age of 9, resulted in feminine inferiority, bisexual elements, and incomplete body-image. She made every effort to recover infantile omnipotence and completeness by poetic products as ‘Self-Portrait’,‘Deer’, and ‘Ass’etc. These efforts were associated with her endless loneliness. Another creative process was restoration of the lost objects, which expressed to unavoidable nostalgia, mourning process to parent loss, and eventually fantasy of utopia using revival of scenery of birth place. In addition, restoration fantasy of the lost object was mainly father's fantasy. These poetic efforts overflowed from initial poem ‘Self-Portrait’of ‘San Ho Rim’to last poem ‘Birth Place’, which combined with perfection of poetic form and justice. Therefore she reached intrapsychic completeness and aesthetic pleasure.

퍼지 c-버라이어티 클러스터링 및 적응 표면 복원에 기반한 3차원 물체의 자료 압축 알고리듬

최병걸,강훈,문성환 중앙대학교 생산공학연구소 1998 생산공학연구소 논문집 Vol.7 No.1

3차원 공간 물체의 자료 압축은 거대한 자료 크기, 느린 처리 시간, 잡음 및 측정 오차 등의 불규칙성과 같은 한계를 가지고 있다. 최근 인터넷에서 정보 전달의 활성화와 함께 대용량의 자료 교환이 가능하게 되면서 3차원 정보 처리에 대한 연구는 매우 중요한 문제로 부각되고 있다. 본 논문에서는 우선 3차원 물체를 구성하고 있는 면을 추정하고 이를 FCV(Fuzzy c-Varieties) 클러스터링에 적용하여 3차원 물체의 변(edge)과 정점(Vertex)을 찾는 알고리듬을 이용하여 자료의 양을 줄일 수 있는 방법을 제안하며, 위 알고리듬을 적용한 결과를 보였다. Data compression of 3 dimensional objects has limitations such as large data size, slow processing time, uncertainties of noise and measurement errors. Recently, along with activities of information transmission in internet, the researches in 3 dimensional information processing become a very important issue as the exchanges of large data are available. In this paper, we propose a data compression algorithm which first estimates the surfaces of 3 dimensional objects and then apply them to the FCV(Fuzzy c-Varieties) Clustering to obtain 3 dimensional edges and vertices, and represent the results.

Modified Free Wrap-around flap을 이용한 수무지 재건술

최영화,황치원,정병훈,한명호 대한성형외과학회 1992 Archives of Plastic Surgery Vol.19 No.3

The thumb is the most important part in the hand and its loss results in severely diminished function of the hand for pinch and grasp. There are several microsurgical and other methods to reconstruct and amputated or lost thumb such as toe-to-thumb transfer1)2)9) as well as several varieties of flaps. Among them, a free wrap around flap taken from the big toe, including the nail and an iliac bone graft as the cone of the reconstruction was a quite satisfactory procedure, but there were some problems. We performed a free wrap around flap on traumatically missing thumb with modification to include all part of the distal phalanx without iliac bone graft. The resorption and atrophy of a grafted iliac bone, a constant problem with Morrison's original procedure8), could be prevented by the modified method. The donor site defects were covered by remained medial flap for weight bearing area first, and full thickness skin graft for remained defected area. The results were good cosmetically and functionally without significant problems.

Cone beam CT를 이용한 비글견 발치창 치유과정에 대한 방사선학적 연구

최동훈,이완,김대석,이병도 대한구강악안면방사선학회 2009 Imaging Science in Dentistry Vol.39 No.1

Purpose : To longitudinally observe the healing process of extracted socket and the alterations of the residual ridge in healthy adult dogs using cone beam CT (CBCT). Materials and Methods : The mandibular premolars of two beagle dogs were removed and the extraction sites were covered with the gingival tissue. CBCTs (3D X-ray CT scanner, Alphard vega, Asahi Co.) were taken at baseline and at 1 week interval for 12 weeks. Radiographic density of extracted wounds was measured on normalized images with a custom-made image analysis program. The amount of alveolar crestal resorption after the teeth extraction was measured with a reformatted three-dimensional image using CBCT. Bony healing pattern of extracted wound of each group was also longitudinally observed and analyzed. Results : Dimensional changes occurred during the first 6 weeks following the extraction of dogs’ mandibular premolars. The reduction of the height of residual ridge was more pronounced at the buccal than at the lingual aspect of the extraction socket. Radiographic density of extracted wounds increased by week 4, but the change in density stabilized after week 6. New bone formation was observed at the floor and the peripheral side of extracted socket from week 1. The entrance of extracted socket was sealed by a hard-tissue bridge at week 5. Conclusion : The healing process of extracted wound involved a series of events including new bone formation and residual ridge resorption.

Tubulin Polymerization에 대한 Colchicine의 영향

최병훈,권기량,임규,황병두 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.2

Although the inhibition of microtubule assembly by colchicine is well established, the paradoxical effect of colchicine in the centriole, cilia and basal body is not clear. The microtubule(MADBP^+) was prepared from rabbit brain through 2 cycles of glycerol-and GTP-mediated polymerization and the tubulin without DNA binding protein(MADBP^-) was prepared from MADBP^+ using double strand DNA column chromatography and the properties of these tubulin preparation were compared with those of MADBP^+. The time course of tubulin polymerization was different, with MADBP^+ being sigmoidal and MADBP^- being hyperbolic. MADBP^+ polymerization could be inhibited by colchicine, whereas MADBP^- polymerization could not. There was little difference in colchicine binding activity between MADBP^+ and MADBP^- and the initial binding velocity of MADBP^- was faster than MADBP^-. From the above results, the possible existence of colchicine sensitive protein among microtubule associated DNA binding proteins was discussed.