Serum TSH Level in Healthy Koreans and the Association of TSH with Serum Lipid Concentration and Metabolic Syndrome

( Yeo Kyung Lee ),( Jo Eun Kim ),( Hyun Ju Oh ),( Kyung Sun Park ),( Soo Kyung Kim ),( Seok Won Park ),( Moon Jong Kim ),( Yong Wook Cho1 ) 대한내과학회 2011 The Korean Journal of Internal Medicine Vol.26 No.4

Background/Aims: The proper treatment of subclinical hypothyroidism and the normal range of serum thyroid stimulating hormone (TSH) concentration are intensely debated. However, few reports have investigated TSH concentrations in Asian ethnic groups. Therefore, the present study was designed to define the TSH reference range in a Korean population and to investigate the metabolic significance of TSH concentration. Methods: We enrolled patients who underwent medical examination at the CHA Bundang Medical Center. Anthropometric data were evaluated, and serum TSH, free T4, and lipid profiles were assayed. Results: A total of 7,270 subjects were included. Mean TSH concentration of the study population was 1.82 ± 0.95 mU/L, and we observed a sex-related difference in TSH concentration (male, 1.67 ± 0.87 mU/L; female, 2.02 ± 1.01 mU/L; p < 0.01). When the 2.5 and 97.5 percentiles were calculated, 95% TSH reference limits were 0.52-4.29 mU/L. TSH concentration was higher in elderly subjects, during winter, in postmenopausal women, and in obese males. Moreover, TSH showed significantly positive correlations with serum total cholesterol, triglyceride, and low density lipoprotein cholesterol regardless of sex, age, season, obesity, or menopausal status (all p < 0.01). Finally, TSH concentration was positively related to the prevalence of metabolic syndrome. Conclusions: We demonstrated the association between TSH concentration within the normal reference range and serum lipid levels. TSH concentration varies according to sex, age, season, and body mass index (only in males). Moreover, high normal TSH levels were significantly associated with an increased prevalence of metabolic syndrome, which may be of importance when evaluating subjects with high normal TSH concentration.

특수학교 교사와 일반학교 교사의 기본심폐소생술 숙련도

오덕자,조경호 釜山大學校 附設 體育科學硏究所 2009 體育科學硏究所 論文集 Vol.25 No.2

본 연구는 특수학교 교사와 일반학교교사의 기본심폐소생술(인공호흡, 심폐소생술) 숙련도를 비교하는데 목적이 있다. 대상자는 특수학교(44명)와 일반학교(48명)에 재직 중인 교사 총 92명으로 선정하였으며, 측정은 마네킨(ResusciAnne w/SkillReporter)을 사용하였다. 자료 처리는 SPSS 12.0 for Windows를 이용하여 측정항목의 평균값(M)과 표준편차(SD)를 구하였고, Komogorov-Smirnov Z-test를 실시하였다. 측정항목의 정확도와 오류율의 차이를 독립표본 t-test와 Mann-Whitney U-test를 실시하였으며, 유의수준(a)은 ,05로 설정하였다. 분석한 결과는 첫째, 교사의 학교구분에 따른 인공호흡 숙련도는 유의한 차이가 없었으며, 교사 성별에 따른 인공호흡 숙련도는 정확도에서 남자가 여자보다 높게 나타났고, 오류는 과다 실시 횟수에서 남자보다 여자가 높게 나타났다. 둘째, 교사의 학교 구분에 따른 심폐소생술 숙련도는 평균 압박속도에서 특수학교 교사가 일반학교 교사보다 빨랐다. 교사 성별에 따른 심폐소생술 숙련도는 유의한 차이가 나타나지 않았다. 이상의 연구에서 볼 때 학교 안전사고를 대비한 학교교사를 대상으로 심폐소생술 교육의 필요성이 강조되어지며, 응급상황시 대처능력을 향상시킬 수 있는 교육프로그램이 마련되어야 된다고 본다.

영지버섯 생장점 단백다당체 GLB의 대식세포 활성화 효과

오정연,조경주,정수현,김진향,Lillehoj, H.S.,정경수 충남대학교 약학대학 의약품개발연구소 1998 藥學論文集 Vol.14 No.-

In the previous study we described the antitumor activity of GLB. a protein-polysaccharide fraction of the growing tips of Ganoderma lucidum, against sarcoma 180 solid tumor in ICR mice. In this study we investigated the stimulatory activity of GLB on macrophages. When analyzed using a flow cytometer. GLB (100 ㎍/㎖) was found to increase the phagocytic activity of the BALB/c mouse peritoneal macrophages as well as chicken macrophage BM2CL cells against FTTC-labeled C. albicans by 55.2% and 21.2%, respectively. GLB also increased the spreading and the expression of MHC class Ⅱ molecules of BM2CL cells as well as the mouse peritoneal macrophages. From these results, it is clear that GLB is a strong stimulator to the macrophages.

다중 제어루프에 의한 자기부상용 DC-DC 전원장치에 관한 연구

조주현,조정민,전기영,이상집,이승환,오봉환,이훈구,한경희 明知大學校 産業技術硏究所 2004 産業技術硏究所論文集 Vol.23 No.-

The author present a modified multi-loop algorithm including feedforward for controlling a 55kW step down chopper in the power supply of Maglev. The control law for the duty cycle consists of three terms. The first is the feedforward term which compensates for variations in the input voltage. The second term consists of the difference between the slowly moving inductor current and output current. The third term consists of proportional and integral terms involving the perturbation in the output voltage. This perturvation is derived by subtracting the desired output voltage from the actual output voltage. The proportional and integral action stabilizes the system and minimizes output voltage error. In order to verify the validity of the proposed multi-loop controller, simulation study was tried using Matlab simulink.

이동 애드 혹 네트워크에서 QoS를 지원하는 AODV 라우팅 프로토콜

吳世德,趙榮泰,丁燦赫,金玄郁,李光培,姜景仁,朴京培,文泰洙,郭承郁,河載承 明知大學校 産業技術硏究所 2003 産業技術硏究所論文集 Vol.22 No.-

Abstract - In this paper, we propose a bidirectional mobile Ad Hoc routing protocol based on AODV(ad-hoc on-demand distance victor routing) with QoS(quality of service) support. At presence, wireless mobile communication focuses on how to efficiently support mobility of users more than QoS guarantee. However, in order to satisfy requirement of various applications which have been or will be served, QoS guarantee between end point is a very important issue. The existing AODV routing protocol is implemented to use only BE (Best Effort) service. However, actual wireless mobile environment requires to reduce a waste of communication resources and meet with the real-time change of data paths by setting up routes with QoS support, considering available communication resources at each node in advance. Therefore, in this thesis, we propose an adaptive QoS support method using hello message in order to rapidly meet with the change of available communication resources and to smoothly perform route maintenance. For performance evaluation, we analyzed the average date reception rate. At that time, we used evaluation parameters such as node's mobility -stop time, hello message period, and packet priority, considering the node's mobility and the number of best effort/QoS data flows. As results, we found that with our proposed method the average data reception rate was increased 16.3% for 0 mobility-stop second case and 4.7% for 300 mobility-stop second case.

겨울철 홍천강의 위생학적 수질조사연구

오덕철,김선균,주왕기,조동현,김우호,윤경민 江原大學校附設體力硏究所 1976 江原大學校附設體育科學硏究所論文集 Vol.- No.1

The water quality of the Hong-Cheon river was investigated during the winter season. The rate of contamination of the low tide was a little more than the high tide. But all values of the analyzed-items were similar to those in the clear water.

터빈 효율의 열역학 제2법칙적 고찰

오국택,조경철,정평석 嶺南大學校 工業技術硏究所 1998 工業技術硏究所論文集 Vol.26 No.2

Conventional efficiencies of the adiabatic expansion process such as isentropic efficiency and polytropic efficiency can be explained as the special cases of exergetic efficiencies replacing the reference atmospheric temperature with temperatures which can be determined in the process itself. It enables to explain the meaning of the efficiencies more general and, to define other efficiency such as minimum isentropic efficiency by specifying proper reference temperatures.

모근세포의 분리배양과 발모촉진 활성에 대한 연구

오수진,조경혜 서울여자대학교 자연과학연구소 2007 자연과학연구논문집 Vol.19 No.-

The purpose of this study was to establish culture system of dermal papilla (DP) cells which thought to play an essential role in the induction of new hair follicles and the maintenance of hair growth and to investigate the effect of Schizonepeta tenyifotia Briq. and Scutellaria baicalensis Georgi. extracts on maintenance of anagen phase of DP cells. DP cells were isolated from the back skin of the newborn rats and were shown a large round shape at immediately after isolation. The cells were attached to the culture plate with monolayer and fallen with 70-80% confluency on day 4. In order to confirm DP cell biomarkers of the isolated and cultured cells, the gene expression of versican and nexin was analyzed by RT-PCR. The result showed that both genes were highly expressed and DP cell marker enzyme, alkaline phosphatase activity also was strongly increased in these isolated and cultured cells. The effects of the Schizonepeta tenyifolia Briq. and Scutellaria baicalensis Georgi. extracts on the hair-induction ability of cultured DP cells were examined. Because these extracts increased mRNA expression level of VEGF and versican in a dose-dependent manner, these extracts may be involved in inducing or maintaining anagen phase of hair cells. When DP cells were treated with these extracts, the mRNA expressions of IGF and KGF were also upregulated more than that of minoxidil treatment. These results suggest that these extracts may be candidates for helping hair growth promotion. In addition, when DP cells were treated with plant extracts mixture, VEGF and versican mRNA expression was synergistically increased.

대학 부설 환경 연구소의 운영 실태

조병진,오경환,박기민 경상대학교 환경보전연구소 1993 環境保全硏究所報 Vol.1 No.1

The actual administrative conditions of the environment research institutes attached to the universities and colleges were investigated by means of the questionnaire to propose the reference data for the reasonable and effective management of them. The majority of them were established after 1981, and half of them are unregistered. The retention rates of the full-time researchers and the attendants was 55%, and that of the official facilities was high, but the equipments for analysis and measurement were poorly furnished as 15%. Annual mean amounts of the fund for management and research are less than ten million and more than thirty million won, respectively. Therefore their major roles are limited to consultations, supervising academic conferences, and collecting research materials because of the fund limitations. Half of them distribute their own publications, and subscribe for few scientific journals regularly. There are many obstracles in the management of institutes such as lack of funds, deficient administrative support of the college authorities, deficiencies of full-time researchers, attendants, and equipments for analysis and measurement.

抗精神病藥物에 依한 無顆粒細胞症 治驗 1例

吳東財,申榮宇,張煥一,趙京杉,朴康圭 大韓神經精神醫學會 1985 신경정신의학 Vol.24 No.1

The authors experienced a female schizophrenic patient who revealed severely decreased leucocytes (350/㎣) with the manifestation of high fever, chillness and sore throat after the oral administration of neuroleptics. Agranulocytosis induced with the use of neuroleptic drugs has been well known complication in psychiatric practice although it is quite rare. In this case, following the combined use of neuroleptics (thioridazine halopondol and chlorproonazine), severe decrement of leucocytes (mainly lymphocytes with few neutrophils) was noticed on peripheral blood and marked decrement of erythroid series, especially of myeloid series, with decrement of total cellular elements were confirmed through the biopsy of bone marrow. She did not responded at all to the massive administration of antibiotics, but dramatic improvement was noticed both clinically and in the follow-up biopsy findings of bone marrow after two times trial of leukapheresis.