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- 저자 : Cho Chung-Won (검색결과 2,101 건)
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(Won Bae Kim),(Hyun Kyung Chung),(Young Joo Park),(Do Joon Park),(Hong Kyu Lee),(Bo Youn Cho) 대한내과학회 2001 The Korean Journal of Internal Medicine Vol.16 No.3
N/A Background:It has been widely accepted that the epitope (s) and/or functional characteristics of thyrotropin receptor antibodies (TSHRAb) from Graves` patients are heterogenous among patients. However, the clinical significance of such heterogeneity has not been systematically evaluatedyet. We were to elucidate and find the clinical significance of heterogeneity for TSH receptor antibodies in Graves` disease. Methods:We measured stimulating TSHRAb (TSAb) activities using CHO-hTSHR cells, FRTL-5 cells and chimeric receptor expressing cells (Mc1+2 and Mc2), specific blocking TSHRAb (TSBAb) activities using Mc2 cells and TBII activities using porcine thyroid membrane in 136 patients with untreated hyperthyroid Graves` disease. Results: Based on various TSHRAb activities from each patient, the patients could be categorized into 7 subgroups by cluster analysis; 1) Group 1 (n=41) was characterized by moderate TSAb activities bothin CHO-hTSHR cells and in FRTL-5 cells, typical TSAb epitope, rare blocking antibodies and high TBII activities. 2) Group 2 (n=16) was characterized by the presence of blocking TSHRAb in most patients, albeit the other characteristics were the same as those in Group 1. 3) Group 3 (n=19) patients had low TSAb activities bothin CHO-hTSHR cells and in FRTL-5 cells, seldom had blocking TSHRAb, but they had high TBII activities. 4) Group 4 (n=30) could be categorized as `mild disease` group, as they had low activities in all kinds of TSHRAb assay and had low antim icrosomal antibody activities. 5) Group 5 (n=14) was characterized by moderate TSAb activities with atypical epitope (s), rare blocking TSHRAb and moderate TBII activities. 6) Group 6 (n=10) patients had veryhigh TSAb activities with typical epitopes, seldom blocking TSHRAb and low TBII activities. 7) Group 7 (n=6) was characterized by very high TSAb activities with atypical epitopes and high TBII activities. Pretreatment serum thyroid hormone level was low only in group 4 patients compared to the other 6 groups (p<0.05). The size of goiter was significantly larger in those in group 1 and group 3 (p<0.05) compared to the other 5 groups. The prevalence of clinically significant ophthalmopathy was higher in group 2 patients than the other 6 groups (50%vs.27.5%,p=0.06). Among 6 kinds of TSHRAb activities, only the blocking TSHRAb activity was significantly associated with the presence of ophthalmopathy in multivariate analysis. Conclusion:These results suggest that the differences inepitopes for TSAb or the presence of blocking TSHRAb is not a major factor in determining the degree of thyrotoxicosis in Graves` disease. Although the pathogenic mechanism is not clearyet, we suggest that patients with ophthalmopathy have different TSHRAb repertoire from those without ophthalmopathy in Graves` disease.
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홍정효(Chung-Hyo Hong),조혜원(Hae-Won Cho) 전북대학교 산업경제연구소 2010 아태경상저널 Vol.2 No.1
본 연구는 2000년 1월부터 2008년 말까지 콜금리, 3년물 국채금리, 원달러 외환시장 및 KOSPI자료를 이용하여 원달러 환율 및 장단기 금리 변화량, KOSPI수익률사이의 동적연관성을 실증적으로 분석하였다. 실증분석결과 첫째, 콜금리와 원달러 외환시장사이에는 장기적인 균형관계가 존재하고 있으나, 콜금리와 KOSPI, 원달러와 KOSPI사이에는 장기적인 균형관계가 존재하지 않는 것으로 나타났다. 3년물 국채금리는 콜금리와 공적분관계가 있으나 원달러, KOSPI와는 공적분관계가 존재하지 않는 것으로 나타났다. 둘째, 3년물 국채금리는 KOSPI 및 원달러 환율간에는 피드백적인 관계가 존재하고 있으나, 3년물 국채금리의 KOSPI 및 원달러에 대한 영향력이 그 반대의 경우보다 상대적으로 더 강한 것으로 나타났다. 세째, KOSPI와 원달러 환율사이에도 피드백적인 영향력이 존재하고 있으나 KOSPI의 원달러 환율변화에 대한 영향력이 그 반대의 경우 보다 더 강한 것으로 나타났다. 다섯째, 콜금리는 원달러 외환시장에만 영향력을 미치고 있으며, 장단기 금리사이에는 3년물 국채금리가 콜금리에 대한 영향력을 미치고 있으나 그 반대의 경우는 존재하지 않는 것으로 나타났다. 여섯째, 전반적으로 4가지 금융시계열모두 호재보다는 악재에 더 민감하게 반응하는 정보의 비대칭적인 특성이 존재하는 것으로 나타났다. 이러한 실증분석결과는 투자자들의 투자 및 위험관리전략 수립 뿐 아니라 정책당국자들의 통화 및 금융정책수립에 다소 나마 기여를 할 수 있을 것으로 보여 진다. We try to examine on the short term lead-lag relationship between call, KOSPI and won dollar spot markets with a vector error correction model, Granger causality test and impulse response analysis. This paper uses daily return data covering from January 2000 to December 2008. The major results are as follows; First, according to empirical test based on the Granger causality, the returns of won/dollar spot market Granger causes call market but vice versa. Second, we find a bilateral influence between won/dollar and KOSPI spot markets but the impact of KOSPI is relatively more dominant than of that of won/dollar market. Third, we also find that there is no influence between call and KOSPI markets in a statistically significant level. We hope these kinds of empirical results might be helpful for the investors to set up a asset portfolio and risk management system.
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( Sang-Cheol Bae ),( Jin-Hye Cha ),( Jung-Yoon Choe ),( Sung Jae Choi ),( Soo-Kyung Cho ),( Won-Tae Chung ),( Chung-Il Joung ),( Young-Ok Jung ),( Young Mo Kang ),( Dong-Wook Kim ),( Jinseok Kim ),( Y 대한류마티스학회 2018 대한류마티스학회지 Vol.25 No.2
Objective. Productivity loss was compared by 3-stage of disease activity and associations between higher disease activity and high productivity loss were identified. Methods. Data were extracted from Rheumatoid Arthritis (RA) Patient-reported Outcomes Research, which enrolled 2,000 RA patients (>20-year) on disease-modifying-antirheumatic-drugs (DMARDs) (≥ 6-month) from December 2012 to June 2013. This included 1,457 RA patients with the disease activity score (DAS-28-ESR) in their medical charts. Productivity loss in time and indirect cost was estimated using The World Health Organization Health and Work Performance Questionnaire (HPQ). Baseline characteristics and productivity loss outcomes were compared according to DAS-28-ESR groups. Results. 84.4% were females, 54.2% had low DAS-28-ESR (<3.2), and 38.2% and 7.6% had moderate (3.2∼5.1) and high DAS-28-ESR (>5.1). Patients with moderate to high DAS-28-ESR had higher lost productivity time (LPT) and monthly costs of LPT than those with low DAS-28-ESR (time in hours: 110.0±58.4 vs. 132.4±57.2 vs. 71.5±52.0, p<0.0001; monthly costs of LPT in 1,000 Korean won: 1,097±607 vs. 1,302±554 vs. 741±531, p<0.0001). Multiple regression analyses revealed significant associations with high LPT in high (adjusted odds ratio [OR]=3.87, 95% confidence interval [CI]: 2.18∼6.87) and moderate DAS-28-ESR (adjusted OR=1.88, 95% CI: 1.41∼2.52) compared to low DAS-28-ESR. In addition, positive associations with high monthly costs of LPT were observed in high (adjusted OR=3.45, 95% CI: 1.98∼5.99) and moderate DAS-28-ESR (adjusted OR=1.93, 95% CI: 1.43∼2.54) compared to low DAS-28-ESR. Conclusion. Timely therapeutic strategies should be taken into consideration given that the RA patients with moderate to high DAS-28-ESR showed strong associations with high productivity loss for effective management of RA. (J Rheum Dis 2018;25:122-130)
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우황청심원(牛黃淸心元)이 저산소증 유발 배양신경세포에 미치는 영향
조규선,신길조,문일수,이원철,정승현,Cho, Gyu-Seon,Shin, Gil-Cho,Moon, Il-Soo,Lee, Won-Chul,Chung, Sung-Hyun 대한한방내과학회 2001 大韓韓方內科學會誌 Vol.22 No.2
Objectives : The purpose of this investigation is to evaluate the effects of Woohwangcheongsim-won on neuronal death of hypoxic E18 cortical neuroblast. Methods : To evaluate the effect of Woohwangcheongsim-won on neuronal death caused by hypoxia, the survival rate of E18 cortical neuroblast was measured with MTT assay and the changes of several synaptic proteins and enzymes were investigated with the immunoblot assays. Results : The E18 cortical neuroblasts were added 50, 100, 500, 1,000, and $5,000{\mu}g/ml$ Woohwangcheongsim-won. They showed neurotoxicity, when the concentration of Woohwangcheongsim-won was above $1,000{\mu}g/ml$. The E18 cortical neuroblasts, which were added 50, 100, and $500{\mu}g/ml$ Woohwangcheongsim-won, were exposed 98% $N_2/5%\;CO_2$ for 3 hours to induce hypoxia, 3 days later, the survival rate of $50{\mu}g/ml$ Woohwangcheongsim-won was 141.5% when compared to the control group. On the immuneblot assays, the expressions of ${\alpha}$CaMKII, NR2A, NR28, PDE2, PSD-95, and eEF-$1{\alpha}$ were increased in normoxia, but those of NR2A, NR2B were decreased in hypoxia when compared to the control group. Conclusions : The data shows that the effects of Woohwangcheongsim-won on neuronal death of hypoxic E18 cortical neuroblast is a significant result.
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Chung, Hyung-Koo,Lee, Won-Kyu,Park, Hong-Gyu,Lee, Hak Moo,Jeong, Hae-Chang,Cho, Min-Cha,Seo, Dae-Shik Optical Society of America 2014 Optics express Vol.22 No.18
<P>Uniaxial alignment of liquid crystals (LCs) is prerequisite for a vast number of LC applications. To accomplish stable and uniform LC orientation, an alignment process to orient the LCs is required. Herein, we demonstrate a simple strategy for fabricating novel LC alignment layers that ensures well aligned LC, superior switching without any capacitance hysteresis, low transmittance loss, and high thermal stability with sufficient anchoring action. Thin films of reactive mesogens (RMs) were transferred onto conventional homeotropic polyimides from a UV-cured RM stamp via contact printing. LC displays using defect free RM/PI polymeric stacks exhibited superior electro-optic (EO) properties to those containing rubbed PI layers. This approach allows for the fabrication of various-mode LC displays such as twisted nematic (TN), in-plane switching (IPS), and optically compensated bend (OCB) mode LCDs by changing the combinations of RMs, base PIs and LCs.</P>
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Synthesis and Antitumor Activity of 3-Arylisoquinoline Derivatives
Cho, Won-Jea,Yoo, Su-Jeong,Park, Myun-Ji,Chung, Byung-Ho,Lee, Chong-Ock The Pharmaceutical Society of Korea 1997 Archives of Pharmacal Research Vol.20 No.3
In order to study the structure-activity relationship of 7, 8-dimethoxy-2-methyl-3-(4, 5-methylenedioxy-2-vinylphenyl)isoquinoline-1(2H) -one (2), which has exhibited significant antitumor activity, chemical modifications of 2 were performed to yield the corresponding products (3-7). Further systematic uses of an efficient procedure for the synthesis of 3-arylisoquinoline derivatives produced the substituted compounds (9a-9g), which were tested for in vitro antitumor activity against five different human cancer cell lines.
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Cho, Hye-Yeon,Park, Chung-Mu,Kim, Mi-Jeong,Chinzorig, Radnaabazar,Cho, Chung-Won,Song, Young-Sun The Korean Nutrition Society 2011 Nutrition Research and Practice Vol. No.
We compared the effects of genistein and daidzein on the expression of chemokines, cell adhesion molecules (CAMs), and endothelial nitric oxide synthase (eNOS) in tumor necrosis factor (TNF)-${\alpha}$-stimulated human umbilical vascular endothelial cells (HUVECs). TNF-${\alpha}$ exposure significantly increased expression of monocyte chemoattractant protein (MCP)-l, vascular adhesion molecule (VCAM)-1, and intercellular adhesion molecule-1. Genistein significantly decreased MCP-l and VCAM-l production in a dose-dependent manner, whereas CAM expression was not significantly lowered by genistein treatment. However, daidzein slightly decreased MCP-l production. The effects of genistein and daidzein on MCP-l secretion coincided with mRNA expression. Pre-treatment with either genistein or daidzein elevated eNOS expression and nitric oxide production disturbed by TNF-${\alpha}$ exposure. A low concentration of isoflavones significantly inhibited nuclear factor (NF)${\kappa}$B activation, whereas a high dose slightly ameliorated these inhibitive effects. These results suggest that genistein had a stronger effect on MCP-l and eNOS expression than that of daidzein. Additionally, NF${\kappa}$B transactivation might be partially related to the down-regulation of these mRNAs in TNF-${\alpha}$-stimulated HUVECs.
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