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Protein kinase A-dependent phosphorylation of B/K protein
Chin, Hemin,Choi, Sung-Ho,Jang, Yoon-Seong,Cho, Sung-Min,Kim, Ho-Shik,Lee, Jeong-Hwa,Jeong, Seong-Whan,Kim, In-Kyung,Kim, Grace J,Kwon, Oh-Joo Springer Science and Business Media LLC 2006 Experimental and molecular medicine Vol.38 No.2
<P>We have previously isolated a novel protein 'B/K' that contains two C2-like domains. Here, we report the isolation and mRNA distribution of a human B/K isoform, and protein kinase A (PKA)-dependent phosphorylation of the B/K protein. The 1.5 kb human B/K cDNA clone exhibits 89% and 97% identities with rat B/K in the sequences of nucleotide and amino acid, respectively. Human B/K isoform encodes a 474 amino acid protein and shows structural features similar to the rat counterpart including two C2 domains, three consensus sequences for PKA, absence of a transmembrane region, and conservation of the N-terminal cysteine cluster. On Northern and dot blot analyses, a 3.0 kb B/K transcript was abundantly present in human brain, kidney, and prostate. Among the brain regions, strong signals were observed in the frontal and temporal lobes, the hippocampus, the hypothalamus, the amygdala, the substantia nigra, and the pituitary. Recombinant B/K proteins containing three consensus sites for PKA was very efficiently phosphorylated in vitro by PKA catalytic subunit. B/K protein which was overexpressed in LLC-PK1 cells was also strongly phosphorylated in vivo by vasopressin analog DDAVP, and PKA-specific inhibitor H 89 as well as type 2 vasopressin receptor antagonist specifically suppressed DDAVP-induced B/K phosphorylation. These results suggest that B/K proteins play a role as potential substrates for PKA in the area where they are expressed.</P>
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The Prediction of Eosinophilic Exacerbation by Eosinophil Levels Stratified in Stable COPD
( Chin Kook Rhee ),( Hye Seon Kang ),( Sung Kyoung Kim ),( Yong Hyun Kim ),( Jin Woo Kim ),( Hyung Kyu Yoon ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-
Background Blood eosinophil count may predict treatment response in patients with chronic obstructive pulmonary disease (COPD) during acute exacerbations (AE). However, the ability and thresholds of blood eosinophil counts in stable status to predict eosinophilic AECOPD have not been completely investigated. Methods This was a retrospective multicenter study performed January 2010 to December 2014. COPD subjects hospitalized with exacerbations, were included. Blood samples were obtained at the time of AE and stable disease at outpatient clinic before or after admission. We identified a blood eosinophil count cut-off point at stable COPD, either taken as a percentage or as absolute value, for identification of predicting blood eosinophil count at AECOPD. Results There was significant positive correlation of eosinophil counts between stable COPD and AECOPD (Figure 1). The best cut-off value of blood eosinophil count in stable status for the prediction of eosinophilic COPD exacerbation based on blood eosinophil count ≥2% was 300 cells/μL (area under the ROC curve [AUC] 0.614, P = 0.001, 39% sensitivity, 83.8% specificity). When the eosinophilic COPD exacerbation was based on blood eosinophil count ≥300 cells/μL, the best cut-off value of blood eosinophil count in stable status for the prediction of eosinophilic COPD exacerbation was also 300 cells/uL (AUC 0.634, P = 0.046, 45.8% sensitivity, 80.9% specificity). Conclusions We demonstrated association between blood eosinophil counts at stable COPD and those with AECOPD. The thresholds of blood counts at stable COPD to predict eosinophilic exacerbations was 300 cells/μL. Further and prospective studies in other populations should validate our Results.
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Sung Yong Park,Young Mo Yoon,M. Wes Schilling,Koo Bok Chin 한국축산식품학회 2009 한국축산식품학회지 Vol.29 No.5
This study was conducted to investigate the effects of heating, fiber type used in solid-phase microextraction (SPME, two phase vs three phase) and storage time on the volatile compounds of porcine M. longissimus dorsi (LD). Volatile compounds were measured using a gas chromatography and mass spectrometry (GC/MS) with a quadrupole mass analyzer. Among the volatile compounds identified, aldehydes (49.33%), alcohols (24.63%) and ketones (9.85%) were higher in pre-heated loins (100oC/30 min), whereas, alcohols (34.33%), hydrocarbons (22.84%) and ketones (16.88%) were higher in non-heated loins. Heating of loins induced the formation of various volatile compounds such as aldehydes (hexanal) and alcohols. The total contents of hydrocarbons, alcohols, and carboxylic acids were higher in two phase fibers, whereas those of esters tended to be higher in three-phase fibers (p<0.05). Most volatile compounds increased (p<0.05) with increased storage time. Thus, the analysis of volatile compounds were affected by the fiber type, while heating and refrigerated storage of pork M. longissimus dorsi increased the volatile compounds derived from lipid oxidation and amino acid catabolism, respectively. This study was conducted to investigate the effects of heating, fiber type used in solid-phase microextraction (SPME, two phase vs three phase) and storage time on the volatile compounds of porcine M. longissimus dorsi (LD). Volatile compounds were measured using a gas chromatography and mass spectrometry (GC/MS) with a quadrupole mass analyzer. Among the volatile compounds identified, aldehydes (49.33%), alcohols (24.63%) and ketones (9.85%) were higher in pre-heated loins (100oC/30 min), whereas, alcohols (34.33%), hydrocarbons (22.84%) and ketones (16.88%) were higher in non-heated loins. Heating of loins induced the formation of various volatile compounds such as aldehydes (hexanal) and alcohols. The total contents of hydrocarbons, alcohols, and carboxylic acids were higher in two phase fibers, whereas those of esters tended to be higher in three-phase fibers (p<0.05). Most volatile compounds increased (p<0.05) with increased storage time. Thus, the analysis of volatile compounds were affected by the fiber type, while heating and refrigerated storage of pork M. longissimus dorsi increased the volatile compounds derived from lipid oxidation and amino acid catabolism, respectively.
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What Are the Risk Factors Associated with Urinary Retention after Orthopaedic Surgery?
Sung, Ki Hyuk,Lee, Kyoung Min,Chung, Chin Youb,Kwon, Soon-Sun,Lee, Seung Yeol,Ban, Yoon Seong,Park, Moon Seok Hindawi Publishing Corporation 2015 BioMed research international Vol.2015 No.-
<P>This study investigates the overall rate of urinary retention in a large cohort of unselected orthopaedic patients who had either general or regional anesthesia and defines the risk factors for postoperative urinary retention in that cohort of patients. A total of 15,681 patients who underwent major orthopaedic surgery with general or spinal/epidural anesthesia were included. Postoperative urinary retention was defined as any patient who required a postoperative consultation to the urologic department regarding voiding difficulty. Age at surgery, sex, type of surgery, medical history including hypertension and diabetes mellitus, and type of anesthesia were analyzed as potential predictor variables. There were 365 postoperative patients who required urology consults for urinary retention (2.3%). Older age at surgery (OR, 1.035; <I>P</I> < 0.0001), male sex (OR, 1.522; <I>P</I> = 0.0004), type of surgery (OR, 1.506; <I>P</I> = 0.0009), history of hypertension (OR, 1.288; <I>P</I> = 0.0436), and history of diabetes mellitus (OR, 2.038; <I>P</I> < 0.0001) were risk factors for urinary retention after orthopaedic surgery. Advanced age, male sex, joint replacement surgery, history of hypertension, and diabetes mellitus significantly increased the risk of urinary retention. In patients with these risk factors, careful postoperative urological management should be performed.</P>
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Summary of Korean Asthma Guideline
( Chin Kook Rhee ),( Ji Yong Moon ),( Hyonsoo Joo ),( Ji Ye Jung ),( Jung-kyu Lee ),( Kyung Hoon Min ),( Hyeon-kyoung Koo ),( Seong Yong Lim ),( Hyoung Kyu Yoon ),( Sang Yeub Lee ) 대한결핵 및 호흡기학회 2023 Tuberculosis and Respiratory Diseases Vol.86 No.3
Asthma is a chronic inflammatory airway disease that is characterized by variable airflow obstruction. The Korean Asthma Study Group of the Korean Academy of Tuberculosis and Respiratory Diseases has recently updated the Korean Asthma Guideline. This review summarizes the updated Korean Asthma Guideline. Asthma prevalence is increasing worldwide, and in Korea. Variable airflow obstruction can be confirmed by bronchodilator response or other tests, and should be established prior to the controller medication. A low-dose inhaled corticosteroid-formoterol is used to alleviate symptoms in all treatment step, and it can be used as a controller as well as reliever in steps 3-5. This approach is preferred, because it reduces the risk of severe exacerbations, compared to the use of short-acting β2-agonist as reliever. In severe asthma, phenotype/ endotype based on the underlying inflammation should be evaluated. For type 2 severe asthma, the biologics should be considered.
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Yoon, Myung Hun,Park, Sang Jun,Kim, Chan Yun,Chin, Hee Seung,Kim, Na Rae British Medical Association 2014 British journal of ophthalmology Vol.98 No.3
<P><B>Aims</B></P><P>This study examined the diagnostic value of the perimacular ganglion cell-inner plexiform layer (GCIPL) thickness in the detection of glaucoma according to the optic disc area.</P><P><B>Methods</B></P><P>The participants underwent reliable standard automated perimetry tests and Cirrus optical coherence tomography. The area under the receiver operating characteristic curve (AUC) was used to determine the diagnostic ability of the GCIPL, total macular thickness, retinal nerve fibre layer (RNFL) and optic nerve head parameters. Subsequently, optic disc areas of ≤1.9, ≤2.4 and >2.4 mm<SUP>2</SUP> were chosen arbitrarily, and the AUCs and sensitivities at fixed specificities were compared for each.</P><P><B>Results</B></P><P>87 normal subjects and 96 glaucoma patients were enrolled. The mean GCIPL thickness and RNFL showed similar ability to diagnose glaucoma (p=0.911). The mean GCIPL thickness had higher diagnostic ability than the central retinal subfield thickness (p=0.001), comparable with that of the retinal cube volume (p=0.840) and mean retinal cube thickness (p=0.840). The mean RNFL (0.866), the minimum GCIPL (0.840) and the inferior and inferotemporal (0.853) disc had the highest AUCs for small, medium and large discs, respectively.</P><P><B>Conclusions</B></P><P>The macular GCIPL thickness, total macular cube thickness, circumpapillary RNFL thickness and disc rim area showed similar performance in diagnosing glaucoma, irrespective of the optic disc size.</P>
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Polymorphisms in <i>PDE4D</i> are Associated with a Risk of COPD in Non-Emphysematous Koreans
Yoon, Hyoung-Kyu,Hu, Hae-Jin,Rhee, Chin-Kook,Shin, Seung-Hoon,Oh, Yeon-Mok,Lee, Sang-Do,Jung, Seung-Hyun,Yim, Seon-Hee,Kim, Tae-Min,Chung, Yeun-Jun Informa Healthcare 2014 COPD Vol.11 No.6
<P>Despite extensive effort, only a few chronic obstructive pulmonary disease (COPD)-associated genes have been suggested, indicating that there must be additional risk-associated loci. Here we aimed to identify additional COPD-associated SNPs and to explore the potential relationship between COPD subgroups and the SNPs in the Korean population. We performed a genome-wide association study (GWAS) with 990 Korean individuals; 102 COPD cases and 544 controls for GWAS using Affymetrix SNP array 5.0, and 173 COPD cases and 171 controls for replication. After validating the candidate single nucleotide polymorphisms (SNP), we performed subgroup analysis by disease phenotype. Through GWAS, we identified a novel SNP in the <I>phosphodiesterase-4D</I> (<I>PDE4D</I>) gene [rs16878037 (C>T), <I>p</I> = 1.66 ◊ 10<SUP>−6</SUP>] that was significantly associated with COPD. This signal in <I>PDE4D</I> was successfully replicated in the independent set (<I>p</I> = 0.041). When we combined the discovery and replication data, the association signal became more significant (<I>p</I> = 5.69 ◊ 10<SUP>−7</SUP>). In the COPD subgroup analysis, the T allele of rs16878037 was significantly more frequent in COPD patients without severe diffusion capacity impairment (mild mixed and obstruction-dominant group) than in patients with severe impairment (severe mixed and emphysema-dominant groups). This result supports that <I>PDE4D</I> polymorphisms might be involved in the susceptibility to COPD especially in non-emphysematous individuals and that they could also affect the responsiveness of the PDE4 inhibitor treatment.</P>
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Agraphia in Korean patients with early onset Alzheimer's disease
Yoon, Ji Hye,Suh, Mee Kyung,Jeong, Yong,Ahn, Hyun-Jung,Moon, So Young,Chin, Juhee,Seo, Sang Won,Na, Duk L. Cambridge University Press 2011 INTERNATIONAL PSYCHOGERIATRICS - Vol.23 No.8
<B>ABSTRACT</B><P>Background: Agraphia in Korean patients may be different from agraphia in other patients who use alphabetical writing systems due to the “visuoconstructional script” characteristics of the Korean writing system, Hangul. Patients with early onset Alzheimer's disease (EOAD) have a severe degree of hypometabolism in the parietal area, which is known to be involved in processing visuospatial function. Thus, we explored the diverse error patterns manifested in writing single syllables in Korean patients with EOAD.</P><P>Methods: A study sample of 35 patients with EOAD and 18 healthy controls (HC) performed a Hangul writing task. We analyzed the erroneous responses of the subjects according to visuoconstructional and linguistic characteristics. In addition, we evaluated the relationship between Hangul writing and the neuropsychological variables as well as the severity of dementia.</P><P>Results: When comparing the total number of erroneous responses between EOAD and HC groups, the performances of EOAD patients were significantly worse than those of HC. EOAD patients demonstrated visuoconstructional errors even in the early stages of the disease. Severity of dementia and multiple cognitive domains such as attention, language, immediate memory, and frontal executive functions significantly correlated with the performance of Hangul writing.</P><P>Conclusion: Our findings suggest that patients with EOAD exhibit not only linguistic errors but also visuoconstructional manifestations of agraphia, which are associated with cognitive impairments in the multiple domains.</P>
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