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기관지경검사에서 Midazolam 의 임상적 유용성에 관한 연구
천은미(Eun Mee Cheon),박상준(Sang Joon Park),권오정(O Jung Kwon),김호중(Ho Joong Kim),정만표(Man Pyo Chung),최동철(Dong Chull Choi),이종헌(Chong H . Rhee),한용철(Yong Chol Han) 대한내과학회 1997 대한내과학회지 Vol.53 No.2
Objectives: Although bronchoscopy is an important diagnostic tool for lung disease, patients compliance is low due to discomfort. Recently, midazolam which has a favorable anterograde amnesia effect and short action duration, has been used to relieve patients discomfort during bronchoscopy. Midazolam was investigated in order to see the beneficial effect and safety during bronchoscopy. Methods: The study design was single blind, randomized, prospective. 102 patients were included, in whom bronchoscopy was performed between June, 19% and October, 1995 at Samsung Medical Center. They were categorized into midazolam group and control group. Patients were asked about the amnesic effect, discomfort of procedure and the willingness to repeat procedure. The consciousness level of patients during procedure, patient cooperation during procedure and ease of procedure were also reported by bronchoscopists. Results: 1) The difference of oxygen saturation between two groups : There was no significant difference in oxygen saturation between midazolam group and control group before and after bronchoscopy. During procedure, however, mean oxygen saturations in midazolam group (90±6.4%) was significantly lower than in control group (93±4.7%)(p<0.05). 2) Evaluations by patients (1) Effect of amnesia : 41 patients (82%) in midazolam group could not recall the procedure but 52 patients (100%) recalled the entire procedure in control group. A favorable amnesic effects could be found in midazolam group(p<0.05). {2) The discomfort during the procedure: 43 patents(86%) did not experience discomfort from procedure in midazolam group but 25 patients(48%) complained of discomfort in control group (p<0.05). (3) Most patients except two(96%) were willing to repeat fiberoptic bronchoscopy in midazolam group but 13 patients (25%) answered that they would never repeat bronchoscapy. There was a statistically significant difference between two groups in the willingness to repeat bronchocopy (p<0.05). 3) The evaluations by bronchoscopists Cooperations of the patients and ease of procedure were not different between two groups. The patients in midazolam group except eight could not respond to verbal stimuli but most patients were awakened during procedure in control group(p<0.05). Conclusion: Midazolam is a good sedative agent for a patient to give a favorable amnesia, reduction of discomfort during bronchoscopy. We concluded that midazolam is a safe and useful sedative agent and midazolam may be used routinely during bronchoscopy. Monitoring of oxygen saturation, however, is essential to prevent severe hypoxia during procedure.
고립성폐결절의 진단시 FDG-PET의 임상적 유용성에 관한 연구
천은미 ( Eun Mee Cheon ),김병태 ( Byung Tae Kim ),권오정 ( O. Jung Kwon ),김호중 ( Ho Joong Kim ),정만표 ( Man Pyo Chung ),이종헌 ( Chong H. Rhee ),한용철 ( Yong Chol Han ),이경수 ( Kyung Soo Lee ),심영목 ( Young Mog Shim ),김진국 대한결핵 및 호흡기학회 1996 Tuberculosis and Respiratory Diseases Vol.43 No.6
천은미(Eun Mee Cheon),이가희(Ka Hee Lee),남현석(Hyeon Seok Nam),권교선(Gyo Seon Kwun),김형건(Hyung Gun Kim),유영진(Young Jin Yuh),이상구(Sang Goo Lee),손태용(Tae Yong Son),이진오(Jhin Oh Lee),강태웅(Tae Woong Kang) 대한내과학회 1995 대한내과학회지 Vol.49 No.3
Multiple endocrine neoplasia IIb is diagnosed when medullary thyroid carcinoma, pheochromocytoma and mucosal neuromas are associated, Other features of this syndrome include a marfsnoid habitus, pectus excurvatum and long, thin extremities. We found a patient with these features: medullary thyroid carcinoma pheochromocytoma, mucosal neuromas and marfanoid habitus. A 19-year old female patient was transferred to our department. for the evaluation of fluctuating blood pressure, facial flushing and abdominal pain after total thyroidectomy which revealed medullary thyroid carcinoma in the left lobe of her thyroid gland. She had long and thin extremities and marfanoid habitus. Multiple mucosal nodules were found on the tip of her tongue and pathologically confirmed as mucosal neuromas. 24 hours urine VMA and metanephrine were markedly elevated and bilateral adrenal masses were found on the abdominal CT, Bilateral adrenalectomy was performed after pretreament with phenoxybenzamine for 2 weeks, which confirmed pheochromocytoma. The screening tests of serum calcitonin for her family members were all within normal limits.
천은미(Eun Mee Cheon),윤견일(Kyun Il Yoon),강덕희(Duk Hee Kang) 대한내과학회 1995 대한내과학회지 Vol.49 No.3
Objectives: Serotonin (5-hydroxytryptamine) is a vasoactive agent that influence coronary arterial tone during platelet aggregation and deposition, and high levels of serotonin contribute to hypertension in some patients. In addition, serotonin has recently been implicated in the pathogenesis of ischemic heart disease. The serotonin status of patients in chronic renal failure is not clear. Although there were several re- ports about the concentration and role of serotonin in chronic renal failure patients, no concordent data were available only with the results of possible relationship with hypertension and pruritus in these patients. Methods: We studied 55 patients with chronic renal failure (CRF with conservative treatment(n=10), hemodialysis (n=35), continous ambulatory peritoneal dialysis (n=10)), compared to normal healthy groups (n=20) in order to investigate the level of whole blood and serum serotonin according to the different modality of renal replacement therapy and also to know the possible association with the presence of ischemic heart disease and pruritus. Results: 1) The levels of serotonin decreased significantly in hemodialysis patients (serum ; 58±22 ng/ml, whole blood; 5.6±3.6 μg/dl) compared to normal control group (serum ; 151±45ng/ml, whole blood ; 6.8±2.9μpg/dl, p<0.01) and CAPD patients (serum ; 134±26ng/ml, p<0.01). 2) The whole blood serotonin levels in hemodialysis patients showed significant correlation with the peripheral blood platelets count (r=0.3295, p<0.05). 3) In hemodialysis patients, serum serotonin concentration increased significantly with the time of dialysis (p<0.01), although whole blood serotonin concentration showed constant level during dialysis. 4) Whole blood serotonin levels of hemodialysis patients with ischemic heart disease increased significantly compared to the patients without ischemic heart disease (7.1±3.4μg/dl vs. 4.9±2.3μg/dl, p<0.005). 5) There was no statistically significant difference in serotonin concentration in relation to the presence of pruritus. Conclusion. This study suggests that the level of serotonin decreased significantly in hemodialysis patients and serum serotonin concentration increased significantly with the time of hemodialysis.
부갑상샘종 및 부갑상샘 암에 대비되는 비정형 부갑상샘종의 임상병리학적 특성
오은미 ( Eun Mee Oh ),이규언 ( Kyu Eun Lee ),김수진 ( Su Jin Kim ),윤여규 ( Yeo Kyu Youn ),박귀원 ( Kwi Won Park ),오승근 ( Seung Keun Oh ),정경천 ( Kyeong Cheon Jung ),김영태 ( Young Tae Kim ),김광현 ( Kwang Hyun Kim ) 대한임상종양학회 2010 Korean Journal of Clinical Oncology Vol.6 No.2
목적: 일차성 부갑상샘항진증을 일으키는 질환인 부갑상샘종, 비정형 부갑상샘종, 부갑상샘 암 에 대하여 임상병리학적 특징을 후향적으로 분석해보고 특히 비정형 부갑상샘종의 특징에 대하여 알아보고자 하였다. 대상 및 방법: 1993년 1월부터 2008년 12월까지 서울대학교병원에서 일차성 부갑상샘항진증으로 부갑상샘 절제술을 시행한 88명의 부갑상샘종 환자와 10명의 비정형 부갑상샘종 환자, 2명의 부갑상샘 암 환자의 의무기록을 후향적으로 분석하였다. 결과: 비정형 부갑상샘종 군은 남녀 비율이 동일한데에 비하여 부갑상샘종은 여성에서, 부갑상샘 암은 남성에서 호발하였다. 비전형 부갑상생종 군과 부갑상샘종 군의 평균연령은 비슷하였으나 부갑상샘 암 환자는 두 군에 비하여 낮았다 (PA: 50.18±15.07yrs, AA: 49.1±13.76yrs, PC: 44.0±18.39yrs, p= 0.832.) 술전 시행한 혈청 칼슘 (PA: 11.90±1.46mg/dl, AA: 11.96±1.48mg/dl, PC: 14.25±2.76mg/dl, p= 0.091), 이온화 칼슘 (PA: 1.57±0.21mg/dl, AA: 1.54±0.34mg/dl, PC: 2.27mg/dl, p= 0.008)에서는 비전형 부갑상샘종 군과 부갑상샘종 군이 비슷하고 부갑상샘암 환자 군은 더 높았다. 술전 부갑상샘호르몬은 부갑상샘 암 환자에서 가장 높았고 비전형 부갑생종, 부갑상샘종 환자 순으로 높게 측정되었다. (335.30±465.40pg/ml, AA: 992.88±612.30pg/ml, PC: 1221.00±227.69pg/ml, p< 0.001) 부갑상샘 암 군은 술전 임상증상이 모두 나타났으며 비전형 부갑상샘종 군과 부갑상샘종 환자 군은 증상이 없이 발견된 경우가 많았다. 병변의 크기와 무게는 부갑상샘 암 군에서 가장 높았으며 비전형 부갑상샘종, 부갑상샘종군이 뒤를 이었다. 결론: 비정형 부갑상샘종은 임상병리학적 특성 상 부갑상샘종과 부갑상샘 암의 중간단계에 위치한다고 할 수 있으며 이에 수술 후 면밀한 추적관찰이 필요하다고 할 수 있다. Purpose: The causes of primary hyperparathyroidism include parathyroid adenoma(PA), atypical parathyroid adenoma(AA) and parathyroid carcinoma(PC). This retrospective study aimed to find the clinicopathologic characteristics among these three diseases and unique characteristics of AA. Patients and Methods: One hundred patients who underwent parathyroidectomy due to primary hyperparathyroidism from January 1993 to December 2008 in Seoul National University Hospital were enrolled. The electronic medical records of 88 patients of PA, 10 patients of AA and 2 patients of PC were analyzed retrospectively. Results: Male to female ratio was same in AA group but female predominance was found in PA group and male predominance in PC group. The mean age of AA group was similar to PA group but PC group was younger than other groups (PA: 50.18±15.07yrs, AA: 49.1±13.76yrs, PC: 44.0±18.39yrs, p= 0.832). The patients with PC showed higher preoperative serum calcium (PA: 11.90±1.46mg/dl, AA: 11.96±1.48mg/dl, PC: 14.25±2.76mg/dl, p= 0.091), ionized calcium (PA: 1.57±0.21mg/dl, AA: 1.54±0.34mg/dl, PC: 2.27mg/dl, p= 0.008) than other two groups and PA and AA showed similar results. PC group showed high parathyroid hormone levels than those of AA and PA (PA: 335.30±465.40pg/ml, AA: 992.88±612.30pg/ml, PC: 1221.00±227.69pg/ml, p< 0.001). Clinical symptoms were found more in PC group and majority of other two groups were found asymptomatic. PC group measured heavier and larger than AA and PA. Conclusion: AA might be an intermediate stage between PA and PC. Close follow up might be needed after operation for AA.
Protection of Green Leafy Vegetable Extracts Against Oxidation of Human Low Density Lipoprotein
Cheon Ho Park,Oh Yun Kwon,Hyun Jung Shim,Min Hee Kim,Jeung Hee Lee,Kun Jong Lee,Xi-Wen Liu,Dai-Eun Sok,Mee Ree Kim 한국식품과학회 2008 Food Science and Biotechnology Vol.17 No.1
Oxidation of low density lipoprotein (LDL) is regarded to play an important role in the development of atherosclerosis. In the present study, salad vegetables with a remarkable DPPH radical-scavenging activity were extracted with methanol, and the methanol extracts were evaluated for the inhibition of Cu<sup>2+</sup>-induced oxidation of human LDL. Separately, the amount of total phenolics was determined colorimetrically using Folin-Ciocalteu reagent. The vegetable extracts, expressing a strong inhibition of LDL oxidation (IC<sub>50</sub> values, <100 μg/mL), were from angelica, dandelion, mustard leaf, and water spinach, which contained relatively high level of polyphenol content. Noteworthy, a highly positive correlation was observed between inhibition of LDL oxidation and amount of total polyphenol (p<0.01). Based on these results, it is suggested that salad vegetables, especially angelica, dandelion, and mustard leaf, may be used as easily accessible sources of natural antioxidants, especially in anti-atherosclerosis.