Antiangiogenic-Like Properties of Fermented Extracts of Ayurvedic Medicinal Plants

Che´rif Rabhi,Guillaume Arcile,Le´on Cariel,Christine Lenoir,Je´rome Bignon,Joanna Wdzieczak-Bakala,Jamal Ouazzani 한국식품영양과학회 2015 Journal of medicinal food Vol.18 No.9

The three ayurvedic medicinal plants, Withania somnifera, Emblica officinalis, and Bacopa monnieri, were extracted by high-pressure static extraction using the Zippertex® technology. The extracts were mixed to reach quantifiable amounts of active compounds identified by high-pressure liquid chromatography-mass spectrometry (HPLC-MS) analysis. The mixture of extracts was incubated with resting cells of the fungus Beauveria bassiana ATCC 7159. The fermentation promoted the fluidization of the starting dense mixture, while HPLC monitoring evidenced the disappearance of glucogallin from E. officinalis extract and the concomitant increase in gallic acid content. Topical exposure of the chick embryo chorioallantoic membrane (CAM) to the nonfermented extract led to the extensive necrosis and destruction of the treated membrane. However, the fermented extract was shown to be free of any toxicity. Furthermore, compared with the untreated CAM, the fermented sample reduced CAM vascularization, suggesting its antiangiogenic potency. The innocuity of the fermented extract was demonstrated using the in vivo LD50 test, the morphological examination of internal organs of treated rats, as well as the evaluation of blood biomarkers of liver damage (aspartate aminotransferase and alanine aminotransferase). The fermented extract was developed as a nutraceutical antiangiogenic treatment of age-related macular degeneration and commercialized in an oral form named Ethnodyne-Visio™.

제주 우수 수영 선수들의 년중 훈련효과 분석 및 처방

김철원,임상용,김승곤,오만원,김성찬,이창준,남사웅,이세형,류재청 濟州大學敎 體育科學硏究所 1996 체육과학연구 Vol.2 No.-

The study was undertaken to analysis, evaluate, and prescribe the annual effect of training of periodically anaerobic and erobic motor ability for Che-Ju representive team of elementary, middle and high school athletes, first the performance can be obtained when it was prescribed proper training after analysis of physical fitness by each events, second individually fitness scientific analysis. prescription. proper management of athlete will be necessary to apply.

제주 우수 육상경기 선수들의 년중 훈련효과 분석 및 처방

김철원,임상용,김승곤,오만원,김성찬,이창준,남사웅,이세형,류재청 濟州大學敎 體育科學硏究所 1996 체육과학연구 Vol.2 No.-

The study was undertaken to analysis, evaluate, and prescribe t h e annual effect of training of periodically anaerobic and aerobic motor ability for Che-Ju representive team of elementary, middle and high school athletes. first. the performance can be obtained when it was prescribed proper training after analysis of physical fitness by each events. second, individually fitness. scientific analysis. prescription. proper management of athlete will be necessary to apply. In addition to physiology aspect, it is essential to consider sport biomechanics. sport psychology when we prescribe specific events and necessary approach in demension coach-athlete-researcher for individual.

의료소비자의 관계혜태 지각이 관계의 질 및 행동의도에 미치는 영향

허철선(Che이-Seon Heo),유광우(Kwang-Woo Yoo) 한국무역연구원 2014 무역연구 Vol.10 No.1

Medical institutions are important to develop and maintain enduring relationship with medical service conswners. So, this research aims to find out the effect of medical service conswners perception of relational benefits on relationship quality and behavioral intention. On the basis of the literature review, the research model is established. This research has been done through the survey utilizing medical service consumers in Gangwondo, and the effective 368 questionnaires are tested for the research model. The main findings are as follows. First, among 5 key dimensions of relational benefits, psychological, customization, economic, and information benefits except social benefits have significant effects on relationship satisfaction. Also, medical institutions type and medical service consumers type as moderating variables are included concurrently, and the significant differences are found in other 4 benefits except relationship between social benefits and relationship satisfaction. Second, relationship satisfaction relates positively to relationship commitment and behavioral intention. But the normative commitment, one of 3 key dimensions of relationship commitment, has no significant effects on recommendation to others. Third, the revisit intention has significant effect on recommendation to others. Finally, the findings reveal that the overall goodness fit index of the model is comparatively good and model set in this research is significant. At the end of the research, managerial implications, limitations and future research directions are suggested.

의료 화상을 위한 전처리 필터들의 특성에 관한 연구

강명아,최종주,정종필,정채영,정남채 조선대학교 기초과학연구소 1997 自然科學硏究 Vol.20 No.1

There has been no fixed rule of pre-processing course required to do image processing that it was barely possible to find the proper pre-processing course, only to process with experience till now. In this paper, lots of application method of pre-processing algorithm, only available by the non-typified and experiential method, shall quantify and the algorithm method of algorithm according to the rule shall calculate the frequency of the value of each pixel gray level and the histogrm of the image. And then average it to all pixel number and finally set a high-ranking or optional % standardized by the average value in teh standard value. The result of a experiment showed the Median filter is superior to the Mean filter in all image of the smoothing filter. The sobel filter extracted feature. The laplacian filter presented sectional feature which not showed in original image.

태권도 소비결정권자의 연령별 마케팅 전략

하제형 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.2

This study was to present a basic data on the marketing activities of Taekwondo training center as analyzing a desire for a training center, the reasons to select Taekwondo, the interest in sports and a continuous training intent of children. The objects of this study have been chosen 233 in total: 170 persons in the 30's and 63 in the 40's who have a child engaged in both Taekwondo training centers and elementary schools. The results that calculates x², t test and correlation factors are as follow: First, the reason to select Taekwondo was mostly to intensify the power of concentration and train their physical strength. The persons is the 30's thought much of the location to select a training center and those in the 40's thought much of notability of coach. Second, the educational purposes of Taekwondo were to intensify the power of spiritual strength in the 30's and maintain their health in the 40's. In the training programs, the leadership program was much preferred in the 30's to the 40's. In the importance of environment and furnishings, there was no significant difference between the 30's and the 40's, however, the 30's thought much of protective equipment than the other. Under these circumstances, it shall set up the suitable marketing strategy to the training center focusing on both the health program required by the 40's and the intensive training of the power of spiritual strength and the art for self-defence by the 30's. on the basis of the good location and facilities, the improvement of capability of coaches.

제주도 스포츠 산업의 발전 방안

류재청 濟州大學敎 體育科學硏究所 1999 체육과학연구 Vol.5 No.-

The purpose of this Consideration was to suggest basic sports industry guidline and investigate developmental consideration as meca of global sports industry of CheJu-Do. It will be necessary for Cheju-Do's sports industry to develop hardware facilities and software program on the basis of characteristics of clear sky- ocean of 4 plane-mid level altitude area-subtropic area background in terms of farsighting for 21c globalization and meca of sports industry.

이차원 보증정책의 비용분석 모형

김제승,이영규 尙志大學校 生産技術硏究所 1999 生産技術論叢 Vol.7 No.-

A two-dimensional warranty policy is characterized by a region in a two-dimensional plane with one axis representing time or age and the other representing item usage, such as the age and mileage of an automobile. This paper proposes a new two-attributes warranty policy that the failed product is free-replaced by producer in the replacement and minimally free-repaired by producer in the repair regions. We obtain expressions for the expected warranty costs under some assumptions about usage and failure and illustrate through numerical examples.

몽골諸語의 現況

鄭堤文 順天大學校 1985 論文集 人文社會科學篇 Vol.4 No.-

This paper aims at describing the present state of the Mongolian languages spoken troughout the Asian Continent. Beginning with the introductory remarks, the writer continues his description of the languages one by one in the order of Y??, Shi-chang(喩世長:1983). This kind of work has been neglected by the academic world of Korean linguistics despite its importance for the genealogical study of our language. The writer wishes to see the better successive wosks in this field in the near future.

Kim,Dong-jo

장재철,김동윤,박영순,전철,김동조 群山大學校 自然科學硏究所 1991 自然科學硏究 Vol.6 No.-

홍삼 추출물이 반치사량정도의 방사선(5Gy)에 조사된 생쥐조직 및 이들 조직에서의 효소활성에 미치는 영향을 관찰하기 위하여 ICR계 생쥐를 대상으로, 생리적 식염수군을 대조구군으로 하여, 홍삼 추출물 투여군과 방사선만을 조사한군 및 홍삼 추출물 투여후 방사선 조사군 등 4군으로 나누어 1일, 4일, 9일, 17일 및 30일 등 5회에 걸쳐 생체의 조직중 비장 및 고환에서의 중량 변화 및 GOT와 GPT의 활성을 측정하여 결과를 얻었다. 비장의 중량변화는 1일째 및 4일째 최소치를 보이다가 이후 증가추세를 보였으며, 고환의 중량 변화는 17일 이후 급격한 감소로 30일에도 증가하지 못했다. GOT의 활성도 변화는 비장에서는 초기에 현저히 증가했으며 이후 회복하는 경향이었다. 방사선 조사군들에서는 홍삼추출물 투여군이 방사선만을 조사한 군보다 빠르게 회복하는 경향이었으며 고환에서의 GOT활성은 매우 불안정하였다. GPT 활성도 변화는 비장, 고환에서 모두 초기에 증가하다가 점차 회복하는 경향이었으며 홍삼 추출물 투여후 방사선 조사군이 방사선만을 조사한군보다 빠르게 회복하는 경향이었다. 이러한 결과로 볼 때 홍삼 추출물은 방사선 조사에 의하여 기인된 비장 및 고환의 GOT와 GPT활성도 증가에 방호효과가 있다고 생각된다. This study was prepared to observe the change of tissues weight, glutamate oxaloacetate transminase(GOT) and glutamate pyruvate transminase(GPT) activities in the spleen and testis treated with red ginseng extract injection in the gamma ray irradiated mice. Groups were divided into control, red ginseng extract injection, irradiation after saline injection and irradiation after red ginseng extract injection. The spleen and testis weights were decreased at 17th day irradiation after saline injection and irradiation after red ginseng extract injection. The GOT activity showed earlier recovery at irradiation after red ginseng extract injection group than irradiation after saline injection group in the spleen. The GPT activity showed earlier recovery at irradiation after red ginseng extract injection group than irradiation after saline injection group in the spleen and testis. The above result suggest that red ginseng extract have the recovery effect on the change GOT and GPT activity after radiation injury in the spleen and testis of mice.