Antiangiogenic-Like Properties of Fermented Extracts of Ayurvedic Medicinal Plants

Che´rif Rabhi,Guillaume Arcile,Le´on Cariel,Christine Lenoir,Je´rome Bignon,Joanna Wdzieczak-Bakala,Jamal Ouazzani 한국식품영양과학회 2015 Journal of medicinal food Vol.18 No.9

The three ayurvedic medicinal plants, Withania somnifera, Emblica officinalis, and Bacopa monnieri, were extracted by high-pressure static extraction using the Zippertex® technology. The extracts were mixed to reach quantifiable amounts of active compounds identified by high-pressure liquid chromatography-mass spectrometry (HPLC-MS) analysis. The mixture of extracts was incubated with resting cells of the fungus Beauveria bassiana ATCC 7159. The fermentation promoted the fluidization of the starting dense mixture, while HPLC monitoring evidenced the disappearance of glucogallin from E. officinalis extract and the concomitant increase in gallic acid content. Topical exposure of the chick embryo chorioallantoic membrane (CAM) to the nonfermented extract led to the extensive necrosis and destruction of the treated membrane. However, the fermented extract was shown to be free of any toxicity. Furthermore, compared with the untreated CAM, the fermented sample reduced CAM vascularization, suggesting its antiangiogenic potency. The innocuity of the fermented extract was demonstrated using the in vivo LD50 test, the morphological examination of internal organs of treated rats, as well as the evaluation of blood biomarkers of liver damage (aspartate aminotransferase and alanine aminotransferase). The fermented extract was developed as a nutraceutical antiangiogenic treatment of age-related macular degeneration and commercialized in an oral form named Ethnodyne-Visio™.

제주 우수 육상경기 선수들의 년중 훈련효과 분석 및 처방

김철원,임상용,김승곤,오만원,김성찬,이창준,남사웅,이세형,류재청 濟州大學敎 體育科學硏究所 1996 체육과학연구 Vol.2 No.-

The study was undertaken to analysis, evaluate, and prescribe t h e annual effect of training of periodically anaerobic and aerobic motor ability for Che-Ju representive team of elementary, middle and high school athletes. first. the performance can be obtained when it was prescribed proper training after analysis of physical fitness by each events. second, individually fitness. scientific analysis. prescription. proper management of athlete will be necessary to apply. In addition to physiology aspect, it is essential to consider sport biomechanics. sport psychology when we prescribe specific events and necessary approach in demension coach-athlete-researcher for individual.

제주 우수 수영 선수들의 년중 훈련효과 분석 및 처방

김철원,임상용,김승곤,오만원,김성찬,이창준,남사웅,이세형,류재청 濟州大學敎 體育科學硏究所 1996 체육과학연구 Vol.2 No.-

The study was undertaken to analysis, evaluate, and prescribe the annual effect of training of periodically anaerobic and erobic motor ability for Che-Ju representive team of elementary, middle and high school athletes, first the performance can be obtained when it was prescribed proper training after analysis of physical fitness by each events, second individually fitness scientific analysis. prescription. proper management of athlete will be necessary to apply.

의료소비자의 관계혜태 지각이 관계의 질 및 행동의도에 미치는 영향

허철선(Che이-Seon Heo),유광우(Kwang-Woo Yoo) 한국무역연구원 2014 무역연구 Vol.10 No.1

Medical institutions are important to develop and maintain enduring relationship with medical service conswners. So, this research aims to find out the effect of medical service conswners perception of relational benefits on relationship quality and behavioral intention. On the basis of the literature review, the research model is established. This research has been done through the survey utilizing medical service consumers in Gangwondo, and the effective 368 questionnaires are tested for the research model. The main findings are as follows. First, among 5 key dimensions of relational benefits, psychological, customization, economic, and information benefits except social benefits have significant effects on relationship satisfaction. Also, medical institutions type and medical service consumers type as moderating variables are included concurrently, and the significant differences are found in other 4 benefits except relationship between social benefits and relationship satisfaction. Second, relationship satisfaction relates positively to relationship commitment and behavioral intention. But the normative commitment, one of 3 key dimensions of relationship commitment, has no significant effects on recommendation to others. Third, the revisit intention has significant effect on recommendation to others. Finally, the findings reveal that the overall goodness fit index of the model is comparatively good and model set in this research is significant. At the end of the research, managerial implications, limitations and future research directions are suggested.

의료 화상을 위한 전처리 필터들의 특성에 관한 연구

강명아,최종주,정종필,정채영,정남채 조선대학교 기초과학연구소 1997 自然科學硏究 Vol.20 No.1

There has been no fixed rule of pre-processing course required to do image processing that it was barely possible to find the proper pre-processing course, only to process with experience till now. In this paper, lots of application method of pre-processing algorithm, only available by the non-typified and experiential method, shall quantify and the algorithm method of algorithm according to the rule shall calculate the frequency of the value of each pixel gray level and the histogrm of the image. And then average it to all pixel number and finally set a high-ranking or optional % standardized by the average value in teh standard value. The result of a experiment showed the Median filter is superior to the Mean filter in all image of the smoothing filter. The sobel filter extracted feature. The laplacian filter presented sectional feature which not showed in original image.

제주도 스포츠 산업의 발전 방안

류재청 濟州大學敎 體育科學硏究所 1999 체육과학연구 Vol.5 No.-

The purpose of this Consideration was to suggest basic sports industry guidline and investigate developmental consideration as meca of global sports industry of CheJu-Do. It will be necessary for Cheju-Do's sports industry to develop hardware facilities and software program on the basis of characteristics of clear sky- ocean of 4 plane-mid level altitude area-subtropic area background in terms of farsighting for 21c globalization and meca of sports industry.

두 가지 고장 형태를 가진 제품의 비용모형

김제숭 尙志大學校 生産技術硏究所 2000 生産技術論叢 Vol.8 No.-

This paper is concerned with warranty cost models for a product with two types of failure: type1 failures corrected by minimal repair and type2 failures removed only by replacement. Two warranty policies involving an initial free service period followed by a pro-rata period are considered; the difference is whether the warranty is renewed or not when type2 failure occurs during its free service period. Expected warranty costs under the two policies are obtained, and their behaviors are examined for the case where type 1 and 2 failure distributions are Weibull and exponential, respectively.

신발 힐의 높이에 따른 보행자세의 운동역학적 분석

류재청,안성규 濟州大學敎 體育科學硏究所 1997 체육과학연구 Vol.3 No.-

This study was conducted to discover the maost desirable height for shoe heels. An analysis of human kinematics and gaits according to different kinds of shoe heel heights was carried out. Walking, which is related to the locomotor and nervous systems, is different from running. It has some unique characteristics such as the double-supporing phase and the pelvis-centered smooth connections with tension and flexion which can make it possible to walk comfortably. The specific goals of this study are as follows: 1. To analyze the variables of gait cycles with respect to shoe heel height. 2. To analyze the variables of linear kinematics with respect to shoe heel height. 3. To analyze the variables of anguiar kinematics with respect to shoe heel height. 4. To discover the ideal heel height to promote a comfortable walking style. Limits of this study: 1. The processes of BSP and Yeadon-kwon were used. 2. The shoe heel heights investigated were 1. 0 cm(ie: bare foot) 2. 3cm 3. 5cm 4. 7cm 3. The equipment used in this experiment comprised of : a Panasonic VCR: VCR analyzer and analysis program: a Kwon "3D Mothion Anaysis" package. 4. The subjects of this experiment were 3 female collage students who are not used to wearing high heeled shoes: all are aerobics instuctors. with an exellent sense of equilibrium. The model of the human body is defined as a rigid body system connected by 19 jonts(for the purpose of this experiment the nose included as an imaginative joint to give precise direction). In order to reduce any displacement which may occur during didgitization. Iandmarkers were attatched to each of the 19 body segments of each subject. The subject were then asked to walk firstly in bare feet and then wearing shoes with a 3cm, 5cm, and then 7cm heel. A video camera zoom lens was used to record the subjects' walking patterns(RTD-LTO-LTD-RTO-RTD) for one complete gait cycle and the direction of the subject was defined wsing X and Y axes. After the digitization and interpolation of all frames the linear and angular variables which are necessary for the study were calculated. The results of this study are as follows: 1. The time taken to complete one gait cycle increases or decreases by a negligable amount as heel heights vary. It appears that the higher the heel is, the longer the length of each stride will be and the greater the horizontal displacement at the center of the body. 2. When a higher heel is worn vetical displacement is increased during the initial phaze of each gait cycle however when a lower heel is worn. vertical displacement is increased in the final phaze of the gait cycle. 3. The average horizontal speed of each phase increases, regardless of the height of the heel. 4. The vertical speed decreases. regardless of heel height in any gait cycle, the speed decreases with each consecutive phaze eg: in a cycle consisting of :RTD-LTO-LTD-RTO-RTD. the initial phaze from RTD to LTO will the fastest movement in the cycle. the speed will decrease with each concecutive phaze in the cycle. The second phaze of the gait (LTO to LTD) will be slower than the first, and the the final phaze (LTD to RTO to RTD) being the slowest in the cycle. (Overall. the rate of decrease in speed in the last the last phaze of any gait cycle is always slower than the decrease of the first two phazes. therefore we can put the last two phazes together to make one final phaze (LTD-RTO-RTD) as the decrease in speed is so small.) 5. For each motion variable, the difference in tension and flextion of lower body joints is not apparent, using any heel height. The tension and flextion in the shank and thigh is negligable with a 5cm or 7cm heel. The tension and flextion is the most apparent when using a 3cm heel. 6. The walking speed changes little according to heel height alterations. The common outcome is that there is a slow increase in speed after the LTO phase, so that when supporting body weight on the right foot, it is very hard to move on to a new 'centered' body weight position. No problem appears when using a 3cm-heel. however when walking bare foot. there is more pressure on L5 and on S1 than with a 3cm-heel. this is because walking is a forward-motion and the center of the body is left behind when walking bare foot. In conclusion, it is the 3cm-heeled shoe that is the most suitable height to promote a comfortable forward walking motion.

박물관 건설경영에 관한 연구

林采震,文鍾承 홍익대학교환경개발연구원 2001 환경개발연구논문집 Vol.6 No.-

An instance of domestic exhibition facility building case, the shortage of managing personal constructive resulted serious issue on expenses, times, quality, and safty with no satisfaction on its process and result. According to subject's speciality the CM's application methods are varied and because of its speciality, overall process of building an exhibition facility operating by its owner. This study intends to exam a application possibility of CM on exhibition facility construction to make smooth communication among varied area that following to exhibition facility construction.

근로 장애인의 직무만족도에 영향을 주는 심리사회적 변인에 관한 연구

이채식,김명식 한국장애인고용공단 고용개발원 2012 장애와 고용 Vol.22 No.1

This study investigated exploratorily the effect of disability acceptance, job stress, motivation for work, and job attitude influencing the job satisfaction of the working people with disabilities. And it tried to search and suggest the interventions of policy and practice for enhacing their job satisfaction. It used and analyzed the data of 'The 3rd Survey of Employment of the Disabled(2011)" by Korea Employment Promotion Agency for the Disabled. Main results are as follows: The disability acceptance positively influenced the job satisfaction and 'work and interpersonal relation job stress' negatively the job satisfaction, and 'no option' negatively did. The more they perceive their work according with their job aptitudes, the more they perceive their job satisfactions. Therefore its main results will be seem to be used as basic data for suggesting the ways of policy and practice for the disabled. 본 연구는 근로 장애인의 직무만족에 영향을 미치는 요인을 장애수용, 직무 스트레스, 근무동기, 직무적성 등 심리사회적인 변인을 중심으로 구분하여 탐색적으로 검증하고, 본 연구결과를 토대로 근로 장애인의 직무만족도를 높일 수 있는 정책적ㆍ실천적 개입방안을 제시하는데 그 목적이 있다. 이러한 요인을 규명하기 위해 한국장애인고용촉진공단에서 실시한 ‘제3차 장애인고용패널조사(2011)’ 데이터를 활용하였다. 분석결과 장애수용이 직무만족에 긍정적 영향을 주는 것으로 나타났고, 직무스트레스에서는 ‘일과 대인관계’가 직무만족에 부정적 영향을 주는 것으로 나타났다. 또한 근무동기에서는 ‘대안이 없어서’가 직무만족에 부정적 영향을 주며, 직무적성이 직무만족에 주는 영향에서는 직무적성이 일치한다고 지각할수록 직무만족에 긍정적 영향을 주는 것으로 나타났다. 따라서 본 연구 결과는 향후 근로 장애인의 직무만족을 높일 수 있는 정책적ㆍ실천적 개입 방향을 설정하는 데 있어서 중요한 기초자료로 활용될 수 있을 것이다.