정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

초음파 수침법을 이용한 터빈베어링 Babbitt 금속 박리 검사 기술

정계조,박상기,조용상,박병철,길두송 한국비파괴검사학회 2004 한국비파괴검사학회지 Vol.24 No.4

이 연구는 터빈베어링의 신뢰성을 평가하기 위하여 초음파 C-Scan 방법을 적용한 기술이다. 수침법에 관한 연구는 실험실과 현장검사 적용에 광범위하게 사용되는 기술이다. 여기에서는 C-Scan 방법을 이용하여 베어링의 모재와 Babbitt 금속간 경계부의 상태를 평가하였다. 수침법 C-Scan 방법에 의한 초음파 영상은 베어링 경계부의 상태를 확인하는데 효과적인 방법으로 사용될 수 있었다. 초음파 영상의 분해능을 높이기 위하여 집속형 탐촉지를 사용하고, Babbitt 금속과 베어링 모재간의 접합경계면에서 발생하는 초음파 음압 반사율을 측정하여 결함의 검출과 면적을 추정할 수 있었다. 초음파 수침법은 베어링 접합부의 박리위치와 박리면적의 경계면을 결정하여 크기를 계산하는데 아주 유용하게 사용될 수 있는 기술이며, 이 연구에서 개발된 기술은 화력발전소에서 사용되고 있는 터빈베어링의 건전성을 확보하는데 적용되었다. This study is aimed for the implementation of ultrasonic method to assess the reliability of turbine bearings. A modified ultrasonic immersion technique was carried out in both laboratory experiment and field application. From the laboratory results, we confirmed that the condition of interface layer between the babbitt and base metal be monitored by the C-Scan. The C-Scan image by the ultrasonic immersion test can be used successfully to observe the condition of interface layer. The testing with a focused transducer provides a promising approach for estimating the extent of the damaged region and observing the interface layer effectively. The difference of the ultrasonic reflection ratio between the bonding and debonding area at the interface layer is one of the key parameters for assessing the extent of the damaged area; additionally, the reflection amplitude exhibits a favorable correlation with the overall damage level. The technique developed in this study was applied to the inspection of the turbine bearings at several power plants in Korea whereby the applicability in the filed can be ascertained.

퇴행성 슬관절염 환자의 증상 중증도 지표와 DITI의 상관성 연구

서병관,류성룡,강중원,안경애,이재동,최도영,김건식,이두익,이윤호,이상훈 EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-

Objectives : To investigate the applicability of thermography as severity measurement in the patients with osteoarthritis (OA) of the knee. Methods : Data were obtained from 80 patiens with OA of the knee. They were asked to answer two disease-specific questionnaire (Western Ontario and McMaster Universities (WOMAC) OA index, Lequesne's Functional Index (LFI)), one generic instrument (Korean Health Assessment Questionnaire (KHAQ)), VAS in order to assess the severity of disease, quality of life, degree of pain and taken thermography in standardized environment. Results : The thermal difference between ipsilateral side and contralaterla side of lateral aspect of knee was correlated with that of medial aspect of knee, and the thermal difference of anterior thigh was correlated with that of lateral, medial aspect of knee and patella region. Age, duration of disease, duration of morning stiffness, sex, crepitus, and painful side of knee were not correlated with the thermal differences of each region. LFI, WOMAC, WOMAC pain subscale, WOMAC stiffness subscale, WOMAC physical function, KHAQ,, VAS were not correlated with the thermal differences of each region. Conclusion : Further study on the thermography on OA of the knee in population with appropriate severity grade and the standardization of analysis of thermographic data were recommended.

제통단이 퇴행성 슬관절염 환자의 삶의 질에 미치는 영향

서병관,류성룡,강중원,우현수,이상훈,이재동,최도영,김건식,이두익,이윤호 EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-

Objectives : to evaluate the effects of Jetongdan, the newly developed herbal medicine, on the quality of life in patients with osteoarthritis of knee Methods : Placebo-controlled, randomized clinical trial on the 80 patients with osteoarthritis of the knee was fulfilled. After enrollment, they took medication as they enrolled. And they were asked to answer the questionnaires (Korean Health Assessment Questionnaire (KHAQ), Lequesne's functional index (LF1), visual analogue scale (VAS)) and analysed with the erythrocyte sedimentation rate (ESR) at baseline, after 4 weeks and 8 weeks of medication. Results : Total KHAQ score, some categories of KHAQ like hygiene, activities were significantly improved after 8 weeks of medication. And the change of the KHAQ score was significantly correlated with the change of VAS. But LFI, VAS, ESR level was not significantly improved, and it was considered because of the short medication period and small size of study population. Conclusion : In conclusion, Jetongdan could improve the health-related quality of life in patients with osteoarthritis of knee. Further study in the large population, in long period were recommended.

CuInSe₂박막의 증착과 표면 형상의 특성

박정혜,정병두 梨花女子大學校 韓國生活科學硏究院 1993 韓國生活科學硏究院 論叢 Vol.52 No.-

Micro Raman Spectroscopy and Auger Electron Spectorscopy have been used to investigate polycrystalline CuInSe_(2) grains of different morphology. The grains larger than 2μm found on films annealed at 315℃ show Raman peaks at 174cm^(-1) and 258cm^(-1). In_(2)O_(3) is found to have formed on the surface and inside the grains the Cu : Se ratio is about 1 : 1. The 258cm^(-1) peak is thought to originate from a copper-selenide phase. 1-2μm size grains found on films annealed at temperatures below 305℃ show a Raman peak at 174cm^(-1) and an additional peak at 186cm^(-1). The Cu : In : Se ratio of these grains is about 1 : 1 : 3-4. The 186cm^(-1) peak is thought to originate from either a Se excessive or a Cu, In deficient phase when compared to stoichiometric CuInSe_(2) in the grain. Considering these properties, the optimum annealing conditions and surface morphology were obtained. Films annealed under such conditions consisted of clusters of crystals smaller than 1μm and showed a clear Raman peak at 174cm^(-1).

퇴행성 슬관절염에 대한 제통단의 안정성과 효능 임상연구

서병관,류성룡,강중원,안경애,이상훈,최도영,김건식,이두익,이윤호,이재동 EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-

Objectives : In order to investigate the efficacy and safety of the newly developed herbal medicine Jetongdan, a placebo-controlled randomized clinical trial of patients with osteoarthriotis of the knee was undertaken. Methods : Data were obtained from 80 patients with OA of the knee. After the enrollment, they were asked to answer a disease-specific questionnaire (Western Ontario and McMaster Universities (WOMAC) OA index) and analyzed with the erythrocyte sedimentation rate (ESR) in order to evaluate the efficacy of Jetongdan, and analyzed for aspartate transaminase (AST) level, alanine transminase (ALT) level, blood urea mitrogen (BUN) level, and creatinine (Cr) level in order to evaluate the safety of Jetongdan. Results : The liver function and renal function did not deteriorate after treatment with Jetongdan. Composite WOMAC score and physical function subscale was improved, but pain subscale, stiffness subscale, and ESR were not improved by Jetongdan. This was possibly because the baseline characteristics of the two groups were not homogenized after randomization. Conclusions : Jetongdan could be a promising treatment option for osteoarthritis of the knee. Further study in a larger population with appropriate severity grades is recommended.

朝鮮朝 儒家의 理想國家觀과 敍事文學的 形象 : 『金鰲新話』를 中心으로

문범두,김정호,조구호,문병우 진주산업대학교 2003 論文集 Vol.42 No.-

Sr·페라이트 본드자석의 자기 특성에 관한 연구

신용진,정병두,문현욱 明知大學校 産業技術硏究所 1996 産業技術硏究所論文集 Vol.15 No.-

In this paper, we mention the magnetic properties of Sr ferrite bonded magnet. In order to compose Sr ferrite, first, a little CaO, SiO2, Na2Si3 and A12O3 are added to SrO n·Fe203(n=5.9). Then, the composition is calcinated at 1225℃ under N2 environment for1 hour with addition of PVA 6wt% solution. The carbon coating method increase grinding effect on powder fabrication. To fabricate anisotropic Sr ferrite bonded magnet 82∼92wt% of Sr ferrite and polyamide12 are kneaded and then 0∼12kOe of magnetic field is allied. On magnet fabrication, an optimal condition of injection mold is obtained under the injection temperature 250℃, the injection pressure 120㎏/cm², the magnetic field 8kOe and magnetic field applied time 8sec. As the results of experiments, we obtain (BH)max=2.09MGoe properly on anisotropic bonded magnet which is fabricated by using injection mold method in magnetic field.

비정질 와이어의 자기특성 측정시스템

신용진,정병두,진성빈 明知大學校 産業技術硏究所 1996 産業技術硏究所論文集 Vol.15 No.-

In this paper, we mention the implementation and the experiments of a magnetic properties measurement system about amorphous wire in weak magnetic field. By adding an op-amp of high magnification to a traditional properties measurement system the measurement system fully operates the functions in the weak magnetic field less than 0.1[Oe]. As the result we can find large Barkhausen jump

원적외선 광조사에 의한 도핑되지 않은 반절연성 GaAs의 광전류 전이와 열자극 전류

김화민,박승환,김종재,고석중,최병두 대구효성가톨릭대학교 자연과학연구소 1994 基礎科學硏究論集 Vol.1994 No.1

도핑되지 않은 반절연성 GaAs의 광전류 급냉과 열적 회복효과를 조사하기 위하여, 성장 방법이 다른 두개의 반절연성 GaAs시료에 대해 원적외선 영역(hv≤1.12eV)의 광조사에 의한 열자극 전류(TSC)스펙트럼들이 측정되었다. LEC방법에 의하여 성장된 As가 풍부한 반절연성 GaAs시료에 대한 50K에서의 광전류의 급냉 과정은 두 단계로 대별된다. 광전류 값이 최소가 되는 시간으로 전이시간 t_T를 정의할 때, (1) IR 광조사 시간 t<t_T이면, EL2(기저상태)→EL2^*(준안정상태) 전이에 의하여 광전류가 감소하고, (2)t>t_T이면, persistent photocurrent (PPC)효과에 의하여 광전류는 다시 증가하였다. 이러한 차이는 성장 방법과 조성비에 따른 잔류불순물의 농도가 광전류 변화에 영향을 준 때문으로 판단된다. 한편, 광조사 시간에 따른 TSC 피크들의 급냉과 급냉된 피크들의 열적 회복에 대한 온도 의존성은 EL2의 기저상태와 준안정 상태 간의 전이 또는 열적 회복과정과 거의 일치하였다. 따라서, 광전류의 급냉 전과 후에 각각 다른 형태로 관측되는 TSC스펙트럼 구조는 EL2 또는 EL2^*와 직접적인 관련을 갖는 트랩들의 분포에 의해 결정되고, 이 트랩들은 EL2-점결함 또는 EL2-잔류불순물로 형성된 complex에 의한 것으로 추론되었다. To study the photoquenching and thermal recovery effects in undoped semi- insulating (Sl) GaAs,the thermally stimulated current (TSCI) spectra, by illuminating infrared light (hv≤ 1.12 eV), are measured with two different Sl-GaAs samples, grown by the liquid-encapsulated Czochraski (LEC) and the horizontal bridgeman (HB) methods. In the As-riched Sl-GaAs sample by LEC method, the photo-current (I_ph) quenching process at 50 K consists of the following two stages: (1) quenching of I_ph due to the transition EL2→EL2^* before a transition time t_T and (2) enhancement of I_ph due to persistent photocurrent (PPC) after t_T, where t_T is defined as the time in which I_ph becomes minimum. However, neither re-enhancement of I_ph nor PPC are observed in the Sl-GaAs sample by HB method. This distinction results from the difference on the concentration of residual impurities, dependent on the growing method and composition rate, in the above two samples. The illumination time dependence of the quenching of TSC peaks and the temperature dependence of their thermal recovery are nearly fitted into those of the ground-to-metastable-state transition or thermal recovery process of EL2. Asa result, it is inferred that the TSC spectral structure, showing different feature before and after IR-quenching, is determined by the distribution of traps associated directly with EL2 or EL2^* and the traps are originated from a complex of EL2-point defect or EL2-residual impurities.