정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

외 셋업이 가능한 흐름 작업의 Scheduling에 관한 연구

정병희,김진홍 崇實大學校 生産技術硏究所 1992 論文集 Vol.22 No.-

This paper deals with the two-machine flow-shop scheduling problem of minimizing the total elapsed time, where the sequence is independent and the external setup time is allowed. For each job, the setup time, the processing time and the release time are known in advance. To solve the problem, two assumptions are considered. First, the release work of the preceding job on the same machine hasn't influence upon the setup work of the following job on the same machine. Second, after job i is released on machine 1 completely, it can be processed on machine 2. An algorithm which determines an optimal sequence with the external setup time is developed. And an example is illustrated to clarify the algorithm given in this paper.

앙토냉 아르토의 [잔혹의 연극]론 연구

정병희 이화여자대학교 한국문화연구원 1991 韓國文化硏究院 論叢 Vol.59 No.1

Le point de depart de notre reflexion sinscrit dans une quiestion limminaire: pourquoi le theatre chex Arthaud et non un autre genre? A cette question est consacre le chapitre 1. Comme la ecrit Jacques Derrida, le choix du theatre pour Arthaud refe les souffrances de lauteur ressenties tout au long de sa vie, souffrances de labsence de la vie. Le probleme central reside donc pour lui dans la suppression, dans la liberaton de cet etat dame. Le choix dArtaud devient des lors naturel dans la mesure ou le the atre lui permet dentrer en communication directe avec le public. De la sexplique egalement la forme du dialogue dans la plupart de ses ecrits. Lanalyse du theatre et son double, recueil dessais contenant les vues theoriques sur le theatre de la cruaute, occupe le chapitre 2. Ici nous avons insiste sur le sens que revet le terms cruaute ainsi que sur ses rapports avec le terme couble. Ce dernier prend plusieurs sens dont ceux dombre, de fantome et dinvisible et constitue un element de devenir du theatre. Le theatre de la cruaute en tant que double de la force cachee dans le corps de laceur nous apprait comme un corps mouvant emettantn sans cesse cette force. En conclusion, le theatre dArthaud se definit comme une substance cristallisee defforts eternels pour creer a chaque instant du nouveau.

경동맥 내막 절제술 후 발생한 과관류 증후군 1예

송희정,박광열,정진상,조수진,이순정,허승,김동익,이광호,이병붕 대한신경과학회 1999 대한신경과학회지 Vol.17 No.2

衛星通信에 관한 硏究 : Filter의 性能改善을 中心으로 Especially on the Improvement of Filter Performance

鄭憲相,宋鐵,劉炳守,朴暢均,白亨來,鄭鍾熙,李炅燮 조선대학교 동력자원연구소 1986 動力資源硏究所誌 Vol.8 No.2

There are two kinds of data transmission communication method, namely, Analog communication method and Digital communication method. The latter has many excellent characteristics as compared with the former. In order to design excellent Digital Filter, the window function is studied in this paper. The conventional time-domain windowing requires N/2 stored values of the data window and N multiplications. A class of windows, called binary windows, for the frequency-domain implementation of the Discrete Fourier Transform is proposed. They do not require multiplications or stored constants ; rather, they are replaced by shift and add operations. These windows offer excellent sidelobe behavior compared with the conventional windows.

토끼의 만성 뇌혈관연축 모델에서 혈관확장제에 의한 비가역적 혈관수축의 발현시기와 혈관벽의 전자현미경소견상 이상소견이 발현되는 시기와의 시간관계

정천기,조병규,김하영,지제근,김종재,한대희 대한신경외과학회 1995 Journal of Korean neurosurgical society Vol.24 No.11

One of the characteristics of the cerebral vasospasm is its irreversibility with the vasodilators.Under the hypothesis that the irreversibility with vasodilators might be caused by the structural change in the arterial wall, authors examined the chronological relationships between the irreversibility and the electron microscopic findings of the arterial wall in the rabbit chronic vasospasm model. The development of the vasospasm and the irreversibility of the vasospasm with the intra-arterial papaverine were defined angiographically. After the second angiography done in one to 30 days after subarachnoid hemorrhage(SAH), eighteen rabbits were sacrificed, and the basilar artery was examined with electron microscope. Arterial narrowing was the severest one day after SAH(54.1% of the pre-SAH diameter), and was maintained up to 30 days afer SAH. The irreversibility of the arterial constriction with the papaverine developed 5 days after SAH, which had a tendency to recover 6 to 9 days after SAH. However the irreversibility was noted again 16 days after SAH. Electron microscopy revealed the endothelial wrinkling, disorganization of muscle fiber, myonecrosis, thickening of smooth muscle fibers, and increase of connective tissue in the tunica media. These structural changes were severest one day after SAH, and gradually diminished up to 30 days after SAH. These data show that there are no chronological relationships between the irreversibility and the structural change per se. However the fact that the irreversibility developed during the reparative phase of the arterial wall injury by SAH suggests that the chronic vasospasm is not a primary event but a secondary phenomenon following an injury to the cerebral arterial wall.

소화기 Behcet병: 13예의 임상분석

정희원,유빈,문희범,이인철,김병식,박건춘,김진천 대한대장항문학회 1995 Annals of Coloproctolgy Vol.11 No.1

기계, 공구, 생산경로 유연성을 고려한 FMS의 부품이동 최소화 모형

정병희,이경동 崇實大學校 2000 論文集 Vol.30 No.1

Machine, routing and tool flexibilities are the most important elements for performance improvement in flexible manufacturing systems. We deal with a generalized loading problem with an objective of the part movement minimization in an FMS with machine, tool and process flexibilities. This problem can be formulated as a 0-1 mixed integer programming model. The part movement minimization is achieved by assigning the maximum possible number of successive operations of a part type to the same machine subject to several system configuration and operational constraints

급성 카드뮴중독의 치사량과 혈액 및 간 조직에 미치는 영향

정규철,박정덕,조병희 중앙대학교 의과대학 의과학연구소 1988 中央醫大誌 Vol.13 No.1

Cadmium toxicity on lethality and hepatotoxicity in relation to dosage was investigated with Sprague-Dawley rates after single dose of 0.1~0.3% cadmium chloride solutions into peritoneal cavity of each rats. The rates were divided into 7 groups and amount of dose ranged from 1 to 32 mgCd/kg body weight. Lethal dose (LD_50) was calculated by probit method, and found to be 5.71mgCd/kg body weight. In contrast to an average concentration of cadmium in blood for control group was 0.028±0.095 ㎍Cd/ℓ, the blood concentration for a group to which 1 mgCd/kg body weight was given increased to 15.0±3.9 ㎍Cd/ℓ, and fitting the blood concentrations to power function curve on dosage. Cadmium concentrations in hepatic tissue had also the same relationship as blood cadmium concentrations and, in turn, between blood and hepatic concentrations with regression coefficient of 0.707. Minimal toxic dose (TDLo) based on histopathological findings during the course of observation after the dose was revealed to be 2.0 mgCd/kg body weight and the effective dose (ED_50) for inducing inflammatory cell infiltration (L_1 group) and for induction of pyknosis, hyperchromaticity or partial necrosis of hepatic cells (L_2 group) were identical with a value of 3.29 mgCd/kg body weight.

AGV 투입간격을 고려한 Flow Shop형 FMS의 최적 작업순서 결정

정병희,양대용 한국경영과학회 1992 한국경영과학회지 Vol.17 No.3

The purpose of this paper is to improve the operation performance of unit-load Automated Guided Vehicles (AGVs) used as a carrier and mobile workstation in a flow-shop type flexible manufacturing system. An algorithm is developed to determine the optimal job sequence which minimizes the vehicle idle time on the line and the production makespan by the use of the entering interval and travel time between workcenters. An entering times of AGVs and the minimum number of AGVs required are calculated by optimal job sequence. When the number of AGVs is limited, entering times of AGVs are adjusted to maximize the efficient use of vehicles. A numerical example is given to illustrate the application of the algorithm.