허혈성 심질환에서 염증지표에 관한 연구

번정득,권영주,박상호,한대희,이상철,강진환,김명구,심규혁,최병조,온영근,현민수,김성구 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background : Atherosclerosis is the chief underlying cause of ischemic heart disease and there is increasing evidence that inflammation is an important determinant of the development of atherosclerosis. We assessed the levels of inflammatory markers in patients with ischemic heart disease and normal group who has normal coronary angiograms. Materials and Methods : Coronary angiography was performed in 142 patients. 107 patients of ischemic heart disease(stable angina pectoris 58, unstable angina pectoris 30, Acute myocardial infarction 19) and 38 normal control subjects. We assessed the level of inflammatory markers, such as CRP, ESR, fibrinogen and leukocyte. Results : CRP, ESR and fibrinogen values of the patients with stable angina pectoris and unstable angina pectoris were higher than that of normal control group, but there were no statistical significance. Leukocyte value of the patients with unstable angina pectoris(9003.3±701.5/mm^(3)) was significantly higher than that of the patients with stable angina pectoris(6685.5±245.8/mm^(3)) and normal control subjects(6394.3±235.1/mm^(3)). CRP, ESR and fibrinogen values of the patients with acute myocardial infarction were also higher than that of normal control subjects. CRP was 3.88±2.05 mg/dL in acute mocardial infarction group, and 0.29±0.15 mg/dL in normal control subject group(p<0.05). Fibrinogen was 541.6±45.1 mg/dL in acute myocardial infarction group, 321.4±25.6 mg/dL in normal control subject group(p<0.05). Leukocyte was 10942.1±737.6/mm^(3) in acute myocardial infarction group, 6394.3±235.1/mm^(3) in normal control subject group(p<0.05). Conclusions : This study demonstrate that CRP, fibrinogen and leukocyte values of acute myocardial infarction group were significantly higher than that of control group and stable, unstable argina pectoris group. Leucokyte values were significantly elevated in unstable angina group, but CRP values were not in unstable angina group.

관상동맥질환 환자에서 스텐트 시술 후 재협착에 관한 연구

강진환,권영주,박상호,한대희,이상철,김명구,변정득,최병조,심규혁,온영근,현민수,김성구 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background and aims : In the coronary artery disease, a rate of restenosis was much decreased by placement of coronary stent than when percutaneous transluminal coronary angioplasty has been applied, but there are still important clinical problems of restenosis. There has been many progressive studies about various factors contributed to this restenosis. So, we studied a relation between restenosis after placement of coronary stent in the coronary artery disease and many clinical factors, characteristics of stenotic lesion and procedural factors, and also assessed the restenosis rate of various coronary stents. Methods : Total 58 lesions(46 cases of patients ; man 30, woman 16) were evaluated, which has been performed a follow-up coronary angiography after 6 months (mean 188 days) since coronary stent had been placed. Various stents were implanted and assessed a relation between restenosis and many factors. Results : Of 58 lesions were target stenotic studies, there were 22 of restenotic lesions(37.9%), and the restenosis rate wes statistically significant difference in the relation with diabetes mellitus(p<0.05), group of acute myocardial infarction(p<0.05) among clinical diagnosis of ischemic heart disease(stable angina, unstable angina and acute myocardial infarction) in clinical factors and with high dilation pressure of stent(p<0.05) in procedural factors. When the rate of restenosis was evaluated among implanted stents, it was lowest in the Multilink^(®) stent and highest in the Nir Royal^(®) stent(60%). Conclusion : In this study of restenosis and various factors after placement of stents in the coronary artety disease, factors such as diabetes mellitus, group of acute myocardial infarction and a dilation pressure of stent were significant related with restenosis and the restenosis rate of Multilink^(®) stent was lowest and the highest restenosis rate was of Nir Royal^(®) stent.

만성 심부전환자의 혈액에서 측정한 Tumor necrosis factor-α 및 Interleukin-6의 임상적 의의

김명구,김성구,박상호,한대희,강진환,변정득,심규혁,최병조,방덕원,온영근,현민수,권영주 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background and objectives: Many conditions are responsible for the pathophysiology and progressive mechanisms of congestive heart failure. More recently, it has also become evidence that another class of biologycally activated molecules generically reffered to as cytokine these are also over expressed in congestive heart failure. Therefore, the purpose of this study was to measure concentrations of tumor necrosis factor-α(TNF-α), interleukin-6(IL-6) in mild to severe symptoms of heart failure and compare their values with those found in normal control and analysed correlation relationship between cytokine level, clinical findings and hemodynamic indicies. Subjects and Methodology: Levels of TNF-α and IL-6 were measured on pulmonary artery during cardiac catheterization in heart failure patients(n=32) and normal subjects(n=8) as well as physical examination and echocardiogram. Cytokines assay were performed on plasma using commercially available ELISA(Enazyme-Linked Immunosorbent Assay) kits. Results: Although the levels of TNF-α and IL-6 tend to increase in congestive heart failure group, the cytokines level was not made significantly statistical difference between congestive heart failure group and controls. When analyzing the correlation between the levels of PCWP(pulmonary capillary wedge pressure) and cytokines(TNF-α, IL-6), respectively, there were statistically significant correlation coefficient 0.32,(p<0.05), 0.39(p<0.01). The cytokine IL-6 and pressure of pulmonary artery were significant correlation.(correlation coefficient 0.36, p<0.02) More significantly, there was correlated with TNF-α and IL-6.(correlation coefficient 0.57, p<0.001) Conclusions: There was tended toward high concentration of TNF-α & IL-6 in congestive heart failure and significant difference for PCWP between TNF-α & IL-6, thus may be correlated with development and progression in congestive heart failure.

전처리된 하수슬러지와 유기성폐기물의 통합소화를 위한 최적 혼합비율 연구

변병수 ( Byoung Su Byun ),이준상 ( Jun Sng Lee ),배종훈 ( Jong Hun Bae ),송용호 ( Yonh Hyo Song ),전항배 ( Jun Hang Bae ) 한국수처리학회 2014 한국수처리학회지 Vol.22 No.5

In this study, anaerobic co-digestion experiments for mixtures consisting of pre-treatment sewage sludge, food waste and livestock manure conducted to assess the methane yields and the volatile solids (VS) removal rates. simplex centroid design(SCD) was employed to design the mixing rate of organic wastes for the anaerobic co-digestion. presents the results of ANOVA conducted to assess the models of the cumulative methane yield and VS removal rates. The p-values verified the suitability of the model, where the model shows significance since the null hypothesis proves wrong if the p-value is less than 0.05. Three models-the linear, quadratic, and special cubic models-were considered. The p-values of the linear model were 0.012 (for cumulative methane yield) and 0.05 (for VS removal rate), which were both. From the regression analysis, co-digestion with sewage sludge, food waste, and livestock manure resulted a good synergy effect for accumulated methane production and VS decomposition rate. It was observed that incidence rate of sewage sludge was 61.7% and higher the mixing ratio of sewage sludge brought the better result. The optimal mixing ratio of sewage sludge, food waste, and livestock manure was found to be 61.3%, 28.6%, 10.1% as respectively.

Analysis of a 10-year experience in prophylactic salpingectomy for reducing ovarian cancer risk. ; A single center outcome from 2006 to 2016

( Byoung Jin Min ),( Dae Hoon Jeong ),( Kyung Bok Lee ),( Moon Su Sung ),( Jung Mi Byun ),( Young Nam Kim ),( Byung Hee Choi ),( Da Hyun Kim ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-

Objective: High-grade serous ovarian carcinoma(HGSOC) has poor outcome of ovarian cancer, and Serous tubal intraepithelial carcinomas(STIC) may be precursors of HGSOC. In this study, we analyzed the final pathology of salpinx of benign and ovarian cancer surgery which was done 10 years and invastigated the availability of prophylactic salpingectomy of gynecology surgery. Methods: In this retrospective study, we retrived the slapinx pathology about gynecology surgery for 10 years in our center. Specimens were classified by final patholgy of slapinx, especially STIC or fallopian tube lesion. And clinical/pathological featured added: patients' age, final diagnosis of disease, ovarian cancer histologic grade, lymphovascular invasion, lymph node metastasis, and stage. Results: The operations included salpingectomy were done 3266 cases for 10 years. In benign patients, the pathologic of salpinx (unilateral or bilateral) were no diagnostic abnormlities ; 1518 patients (52.3%), inflammation or infection( salpingitis or oophoritis ) ; 728 patients (25.0%), parovarian or paratubal cyst ; 94 patients (3.2%), Tube-ovarian absess or pyosalpinx: 82 patients (2.8%) , hydrosalpinx ; 82 patients (2.8%) and endometriosis ; 22 patients (0.7%). There were 3 patients of lymphangiectasia and 2 patients of serous borderline tumor of fallopian tube and respectively. Hyperplasia of the tubal epithelium were 2 cases , and no STIC was seen. In ovarian cancer patients, of all 346 patients, 183 patients (52.8%) were diagnosed with serous carcinoma, among them 154 patients (44.5%) are HGSOC. In the patients who diagnosed HGSOC, only 2 patients (1.2%) showed STIC in salpinx pathology. Conclusion: The prophylactic salpingectomy for reduced risks of HGSOC is necessary for the patient who suspected ovarian cancer. But our results suggest that the removal of the salpinx in benign operations do not always proceed. Nevertheless, we need to set up a prophylactic salpingectomy indication of gynecology patients through other center studies.

관광객의 대안평가 유형별 추진-유인동기 요인의 차이에 관한 연구

최병길(Byoung Gil Choi),변수녀(Su Nyo Byun),이성은(Sung Eun Lee) 한국관광연구학회 2007 관광연구저널 Vol.21 No.3

1000MW 초초임계압 신보령화력 보일러계통 시뮬레이터 개발

강해수(Hea-Su Kang),마삼선(Sam-Sun Ma),박신열(Shin-Yeol Park),김종안(Jong-An Kim),전원식(Won-Sik Jeon),최인규(In-Kyu Choi),변승현(Seung-Hyun Byun),김병철(Byoung-Chul Kim),신만수(Man-Su Shin) 대한전기학회 2015 정보 및 제어 심포지엄 논문집 Vol.2015 No.10

Prevalence of group B streptococcus colonization in pregnant women in a tertiary care center in Korea

( Da Hyun Kim ),( Byoung Jin Min ),( Eun Jung Jung ),( Jung Mi Byun ),( Dae Hoon Jeong ),( Kyung Bok Lee ),( Moon Su Sung ),( Ki Tae Kim ),( Young Nam Kim ) 대한산부인과학회 2018 Obstetrics & Gynecology Science Vol.61 No.5

Objective The purpose of this study was to evaluate the group B streptococcus (GBS) colonization rate in pregnant Korean women using selective culture media for GBS and to identify obstetrical complications and GBS-induced early-onset neonatal sepsis. Methods We evaluated 1,014 pregnant women who delivered at Busan Paik Hospital between January 2015 and December 2016. GBS colonization was assessed using chromID Strepto B agar. We evaluated GBS colonization in pregnant women, as well as the obstetrical complication and GBS-induced neonatal sepsis rates. Results The total GBS colonization rate was 11.6% (117/1,014). No significant increase was observed in the rate of pregnancy-related complications between the GBS-positive and the GBS-negative groups. Among the 134 neonates born to colonized mothers, early neonatal sepsis was reported in 2 neonates (1.5%); however, these were cases of non-GBS-induced sepsis. Conclusion The GBS colonization rate (using selective culture media) in this study involving pregnant Korean women showed a higher colonization rate than that previously reported in Korea. Therefore, based on this study, we recommend GBS screening and the administration of intrapartum antibiotic prophylaxis in pregnant Korean women.

A Case Report : Primary Extranodal Marginal Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue in the Oral Cavity

Jang Ho Son,Su Won Park,Byoung Hwan Choi,Yeong Cheol Cho,Lel Young Sung,Ki Jeong Byun 大韓顎顔面成形再建外科學會 2009 Maxillofacial Plastic Reconstructive Surgery Vol.31 No.2S

The clinical importance of the para-aortic lymphadenectomy up to the level of the renal vessels in endometrial cancer and ovarian cancer

( Hye Ree Jang ),( Byoung Jin Min ),( Jung Mi Byun ),( Young Nam Kim ),( Kyung Bok Lee ),( Moon Su Sung ),( Ki Tae Kim ),( Dae Hoon Jeong ) 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-

목적: Pelvic, para-aortic lymph node (PALN) evaluation is a major component of the surgical staging procedure for endometrial and ovarian cancer. The surgical goals of the lymph node dissection are to define the extent of disease and to improve survival by removing metastatic lymph nodes. However, there were many controversies upon levels of lymph node dissection. Aim : To evaluate the importance of para-aortic lymphadenectomy (PAL) up to the level of renal vessels, and to determine the extent of PAL with endometrial and ovarian cancer. 방법: A retrospective study about endometrial and ovarian cancer who had underwent surgical staging or debulking surgery between January 2014 and June 2016 at Busan Paik hospital was conducted. 결과: One hundred and twelve patients with endometrial and ovarian cancer underwent PAL as a part of debulking surgery. Twenty patients (17.8%) had pelvic lymph node metastasis; 16 patients (14.2%) had pelvic and PALN metastasis and 4 patients (3.6%) had only pelvic lymph node metastasis. Six patients (5.3%) had no pelvic lymph node metastasis but had PALN metastasis. Forty-six patients within the same group (41%) underwent PAL up to the level of renal vessels and separate lymph node by two groups; upper and lower area of inferior mesenteric artery (IMA). In this group, 9 patients (19.5%) had PALN metastasis; 6 patients (13%) had both upper and lower area of IMA lymph node metastasis (5 ovarian cancer,1 endometrial cancer), 2 patients (4.3%) had no pelvic lymph node metastasis but had lower area of IMA lymph node metastasis (all 2 ovarian cancer) and 1 patient (2.1%) had only upper area of IMA lymph node metastasis(1 ovarian cancer). 결론: PAL up to the renal vessels may help to find gross metastasis and apply appropriate adjuvant treatment. Moreover, some patients turned out to have lymph node metastasis above the level of IMA without metastasis below. In conclusion, the PALN sampling up to the level of the renal vessels is a hard but necessary workup for gynecologist.