골수구성 백혈병 환자에게 발생한 결핵성 림프절염

이창섭,송진수,최평균,조재현,방지환,박경화,박완범,김홍빈,김남중,윤성수,박선양,김병국,오명돈,최강원 대한감염학회 2006 감염과 화학요법 Vol.38 No.5

혈액질환 가운데 결핵 발생이 증가한다고 알려진 것은 호지킨 림프종을 포함한 림프증식성질환 그리고 모양세포성 백혈병 등이 있다. 또한 동종 골수이식을 받은 환자에서도 결핵은 증가한다고 알려져있다. Kaplan 등은 골수구성 백혈병 환자에서 결핵 발생이 증가한다고 보고하였다. 그러나 골수구성 백혈병 환자에서 결핵의 발생이 증가하는 이유에 대해서는 아직까지 정확하게 밝혀지지 않았다. 저자들이 2년 동안 후향적으로 조사한 180명의 성인 골수구성 백혈병 환자들 가운데 결핵이 발생한 환자는 4명이었고, 발생 부위는 모두 림프절이었다. 결핵은 골수구성 백혈병의 특정 아형에만 국한되어 발생하지 않았지만, 50%에서 FAB 분류에 의한 M4였다. 림프절이 종대된 골수구성 백혈병 환자에서 특히, 결핵의 유병율이 높은 나라에서는 결핵성 림프절염도 감별진단에 포함시켜야 한다. During the neutropenic phase, leukemia patients receiving chemotherapy are prone to bacterial and, fungal infections; occasionally mycobacterial, viral and protozoal organisms may also cause infections. Mycobacterium tuberculosis infection was reported very rarely in these patients. This report describes four patients with M. tuberculosis infection identified from 185 adult patients who were diagnosed myelogenous leukemia between January 2003, and December 2004. There was no patient with M. tuberculosis infection from 44 lymphoid leukemia and 11 acute biphenotypic leukemia patients. Sites of infection were all lymph nodes. Three among four patients were presented with lymphadenopathy at initial diagnosis of leukemia, and the other one presented with lymphadenopathy after induction chemotherapy. There was no patient presented with lymphadenopathy during the neutropenic phase. Tuberculous lymphadenitis was presented in a patient with three acute myelogenous leukemia (FAB class 2 M4, 1 M2) and a chronic myelogenous leukemia, accelerated phase. An acute myelogenous leukemia patient had a leukemic cell and tubercle bacilli in the same lymph node. Tuberculosis should also be included as a differential diagnosis in myelogenous leukemia patient with lymphadenopathy, especially in the countries in which the disease is endemic.

CORBA를 기반으로 한 XML 정보검색 시스템 통합 구현

이재완,정병인 군산대학교 정보통신기술연구소 2000 情報通信技術硏究論文集 Vol.4 No.-

The Internet is convenient to use and makes possible to utilize the dispersed information source through single/unity interface so that it provides the most effective computing environment since 1990. But the current web reveals the limitation in data control and expansion due to the unstructured character of the HTML. The XML, the next generation language and developed to overcome the limitation of the current web, can make the data controlled and managed very efficiently. With these advantages the XML is now using broadly in the area of electronic commercial transaction, EDI, medical management system, etc. This paper shows that the development of 3-Tier client/server system with the CORBA basis dispersed object technique. It makes use of the advantages of XML and CORBA, which can make the document data access dynamically.

CdS 광도전막의 제조 및 그 응용

최병진,박욱동,이우일,김기완 경북대학교 센서기술연구소 1991 센서技術學術大會論文集 Vol.2 No.1

The Polycrystallized CdS films have been fabricated at the substrate temperature above 200℃ by thermal evaporation method. When the CdS films were annealed at the temperature higher than 400℃, the dark resistivity was increased. From the photoconductive properties of CdS films under 50~1500uW/cm^(2) illumination, the maximum values of I_(p)/I_(d) ratio and photosensitivity were 60dB and 0.82, respectively. The optical properties of CdS films were measured by spectrometer, the optical band gap of CdS film was different with heat treatment, These results show that this evaporated CdS films are expected to be used as photoconductive cells or photoelectric sensors.

연약해성점토의 깊이별 흡수력 시험과 일축압축시험 결과를 이용한 시료교란도 연구

鄭庸宇,柳完圭,金昞逸,李萬洙 명지대학교 산업기술연구소 2006 産業技術硏究所論文集 Vol.25 No.-

It is important to know the degree of disturbance when evaluating the soil strength parameters from laboratory test. In this study, suction tests and unconfined compression strength tests were carried out to investigate the degree of disturbance of sample with soft marine clay of Kwangyang. Based on the test results, suction test is a good quantitative analysis for the degree of disturbance and shows a similar tendency with the results of unconfined compression strength test.

금형스프링을 이용한 송배전용 연결구조체의 내력실험

김호수,정희범,김진완,이배연,오병훈 청주대학교 산업과학연구소 2016 産業科學硏究 Vol.34 No.1

This study presents an experimental process to secure the capacity of mold spring connection structure for electric distribution cable. To this end, this study evaluates the capacity and safety of connection structure through the capacity experiment according to the various design variables

Survey on Current Status of Laboratory Animal Quality control in GLP institutions for Establishing a National Policy in Korea

Byoung Chun Lee,Mee Kyoung Jang,Young Gil Wang,Chang Jun Bae,Ji Soon Sin,Su Hae Lee,Seung Wan Jee,Sun Bo Shim,Byoung Guk Kim,Dae Youn Hwang,Jung Sik Cho,Kap Ryong Chae,Cheul kyu Kim 한국실험동물학회 2007 한국실험동물학회 학술발표대회 논문집 Vol.2007 No.-

간세포암 진단을 위한 세침흡인 세포학적 검사의 필요성과 안전성

이진오,김창민,김유철,이진옥,유성재,정성문,이병희,정숙향,한철주,이승숙,조경자,송용환,김기환 대한간학회 2000 Clinical and Molecular Hepatology(대한간학회지) Vol.6 No.4

Backgrounds/Aims: The fine-needle aspiration (FNA) is a useful method for diagnosis of hepatocellular carcinoma (HCC). The aims of our study are to assess diagnostic accuracy of FNA, to define proper indications of FNA for diagnosis of HCC, and to evaluate the complications of FNA. Subjects and Methods: To assess diagnostic accuracy we compared the results of preoperative FNA with postoperative pathology in 38 resected cases with primary liver cancer. To define proper indications and complications of FNA, we prospectively followed 138 patients received FNA for their liver tumors which were suspicious of primary liver tumor. Results : The sensitivity, specificity, positive and negative predictive values of FNA were 100%, 97%, 100% and 66% respectively. All patients with serum alpha-fetoprotein (AFP) level over 1000 ng/ml were having HCC on FNA result. Among 36 patients with AFP level ranged 15-1000 ng/ml and hypervascular mass on angiography, 96% were having HCC. Among 50 patients with normal AFP level and hypervascular mass on angiography, 92% were having HCC. The major complications after FNA such as hemoperitoneum, pneumothorax, and iatrogenic arterioportal shunt developed in 2%, 2%, and 7% of subjects, respectively. We did not find any case of needle-tract seeding of cancer during a mean 4.7 months of follow-up. Conclusions: Although the FNA is an accurate method for diagnosis of HCC, FNA was usually not indicated for patients with serum AFP level over 1000 ng/ml or patients with hypervascular mass on angiography when they were suspected of having primary liver cancer. Major complications were hemoperitoneum, pneumothorax and iatrogenic arterioportal shunt. Iatrogenic arterioportal shunt may influence the efficacy of subsequent transcatheter arterial embolization(Korean J Hepatol 2000;6:505-513).

PCR-Based Sensitive Detection and Identification of Xanthomonas oryzae pv. oryzae

Lee, Byoung-Moo,Park, Young-Jin,Park, Dong-Suk,Kim, Jeong-Gu,Kang, Hee-Wan,Noh, Tae-Hwan,Lee, Gil-Bok,Ahn, Joung-Kuk 한국미생물 · 생명공학회 2004 한국미생물·생명공학회지 Vol.32 No.3

본 연구는 벼의 세균병 중 치명적인 흰잎마름병을 유발하는 Xanthomonas oryzae pv. oryzae를 검출할 수 있는 프라이머를 개발하기 위해 실시하였다. X. o. pv. oryzae str. KACC10331의 hpaA유전자 염기서열로부터 흰잎마름병만을 특이적으로 검출할 수 있는 프라이머를 제작하여 중합효소연쇄반응에 사용하였다. 개발된 특이 프라이머는 X. o. pv. oryzae str. KACC10331과 X. campestris pv. vesicatoria, X. campestris pv. campestris, X. axonopodis pv. citri 그리고 X. axonopodis pv. glycines의 phaA유전자 염기서열의 상동성을 비교하여, 그 중 X. o. pv. oryzae만이 가지는 특이적인 부분을 바탕으로 각각 20-mer인 XOF와 XOR를 제작하였다. 제작된 프라이머를 이용하여 중합효소 연쇄반응을 실시한 결과 반응 후 생성된 단편의 크기는 534-bp였다. 반응 후 생성된 단편은 Southern hybridization을 통하여 Xanthomonas 균주들의 hpaA유전자 존재 여부 및 그 상동성을 비교분석하기 위해 사용하였다. 또한 제작된 프라이머를 이용하여 흰잎마름병에 감염된 벼 잎에서의 검출 여부를 확인하였고 X. o. pv. oryzae의 순수 균주 배양액을 중합효소연쇄반응에 이용하여 검출한계를 검정하였다. 본 연구에서 제작된 프라이머를 사용한 중합효소연쇄 반응 방법은 X. o. pv. oryzae의 검출 뿐만 아니라 흰잎마름병의 발생 예찰에 매우 유용할 것으로 판단 되었다. A new primer set was developed for the detection and identification of Xanthomonas oryzae pv. oryzae, the bacterial leaf blight (BLB) pathogen in rice plant. The nucleotide sequence of hpaA gene was determined from X. o. pv. oryzae str. KACC10331, and the sequence information was used to design primers for the application of the polymerase chain reaction (PCR). The nucleotide sequence of hpaA from X. o. pv. oryzae str. KACC 10331 was aligned with those of X. campestris pv. vesicatoria, X. campestris pv. campestris, X. axonopodis pv. citri, and X. axonopodis pv. glycines. Based on these results, a primer set(XOF and XOR) was designed for the specific detection of hpaA in X. o. pv. oryzae. The length of PCR products amplified using the primer set was 534-bp. The PCR product was detected from only X. o. pv. oryzae among other Xanthomonas strains and reference bacteria. This product was used to confirm the conservation of hpaA among Xanthomonas strains by Southern-blotting. Furthermore, PCR amplification with XOF and XOR was used to detect the pathogen in an artificially infected leaf. The sensitivity of PCR detection in the pure culture suspension was also determined. This PCR-based detection methods will be a useful method for the detection and identification of X. o. pv. oryzae as well as disease forecasting.

Hydrostaticity of poly(methyl methacrylate) loaded in a diamond anvil cell for high-pressure study

Byoung Wan Lee,Seonhyeop Shin,Min-Seok Jeong,Jae-Hyeon Ko,Young Ho Koh,김광주 한국물리학회 2016 Current Applied Physics Vol.16 No.12

Hydrostaticity of poly(methyl methacrylate) (PMMA) loaded in a diamond anvil cell (DAC) was investigated up to ~10 GPa under two conditions, i.e., with and without pressure-transmitting medium. When PMMAwas loaded in the DAC without methanol-ethanol mixture, one of the most widely-used pressuretransmitting media, hydrostatic pressure condition was not fulfilled having a pressure gradient. However, the Brillouin frequency shift of the longitudinal acoustic mode of PMMA exhibited nearly the same pressure dependence regardless of the loading condition whether it was loaded with or without the methanol-ethanol mixture. This suggests that the equation of state (pressure-density relationship) of PMMA, which is calculated by using the Brillouin frequency shift, can be obtained reliably without any pressure medium at pressures less than the solidification pressure of the liquid.

Insertional Transposon Mutagenesis of Xanthomonas oryzae pv. oryzae KXO85 by Electroporation

Byoung Moo Lee,Young Jin Park,Dong Suk Park,Hee Wan Kang,Gil Bok Lee,Jang-Ho Hahn 한국식물병리학회 2004 Plant Pathology Journal Vol.20 No.3