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김법완,권태균,노기석,정성광,장세국,정운복,김정완 경북대학교 병원 1997 경북대학교병원의학연구소논문집 Vol.1 No.1
The objective of this study was to characterise the pattern of p53 mutations in bladder turmor. In this study, 25 bladder transitional cell carcinomas were analyed by immunohistochemistry (IHC) for p53 nuclear overexpression, and the results were compared with those of polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP) analysis in exon 5-8 of the p53 gene and DNA sequencing analysis. 15 out of 20 cases (75%) showed p53 nuclear immunoreactivities on IHC. On PCR-SSCP analysis, 10 out of 25 cases(40%) had abnormal shifts on mobility. 62% of the mutations were in exon 8. Direct DNA sequencing analysis were performed in these 10 cases to confirm the presence of mutated p53 genes and to determine the type of mutations. Sixteen point mutations were detected in 10 cases. Tow specimens had double mutations and another two had triple mutations. G:C→A:T transitions were the most frequent patterns (62.5%). One mutation was a premature stop codon and two were silent mutations. There out of 10 had a point mutation at codon 285 (GAG/Glu→AAG/Lys) and two had at codon 280(GAG/Glu→AAG/Lys). One of 16 mutations was transition at hot spot codon 273 with CpG site. These results suggest that altered expressions and point mutations of p53 occured in all grade of bladder cancer, but are more associated with hight grade bladder tumors. To elucidate the carcinogenesis of bladder cancer, further studies should be carried out.
정성광,변진석,백봉수,김법완 大韓成形外科學會 1991 Archives of Plastic Surgery Vol.18 No.2
Reconstruction of the penis is indicated in a traumatic or surgical amputation, congenital penile absence, micropenis, male pseudohermaproditism, or transsexualism. Initially, penile reconstruction has been performed using a local flap, but often failed because of the multiple procedures, fistula or stricture of the urethra, and no sensation of the phallus. Ideally, penile reconstruction should be a one-stage procedure, creating a phallus with both tactile and aerogenous sensibility, water-tight neourethra allowing for voiding while standing, enough bulk with stiffness, and aesthetically acceptable appearance. Since August 1989 we have constructed a penis in 4 patients. We selected the radial forearm flap as a donor site because it offers a reliable artery, veins, nerves, and stiffner. It also offers thin, malleable skin with adequate width and length. We have followed these patients from 5 months to 10 months. All operations were successful except for one fistula formation.
전립선암과 전립선비대증 환자에서 혈청 유리 및 총전립선특이항원 측정의 의의
서혁준,박형민,권태균,정성광,김법완,이재태 경북대학교 의학연구소 2000 경북대학교병원의학연구소논문집 Vol.4 No.1
Purpose: This study was peformed to investigate whether the free to total PSA ratio(F/T PSA ratio) offers a better discriminant for the detection of patient with prostatic cancer(CaP) and those with benign prostatic hyperplasia(BPH) than serum total PSA alone. Materials and Methods: From September 1996 to February 1999, free and total PSA levels were measured on frozen sera samples of 154 men with BPH and 46 with CaP using immunoradiometric assay. Results: In all subjects, the mean total PSA was significantly higher in CaP group(72.57±66.58ng/ml) than BPH group(3.12±4.10ng/ml). The mean PSAD was significantly higher in CaP group(1.64± 1.86) than BPH group(0.08±0.01). The mean F/T PSA ratio was significantly lower in CaP group(0.19± 0.07) than BPH group(0.30±0.13). Among 41 subjects whose total PSA were between 4-20ng/ml, the mean PSAD was significantly higher in CaP group(0.37±7.16) than BPH group(0.17± 0.07), but the mean F/T PSA ratio was not significantly different between CaP(0.19± 0.10) and BPH group(0.25±7.13). By comparing the sensitivity and specificity of total PSA alone, PSAD and F/T PSA ratio on receiver operating characterislic (ROC) Cutie in all subiects and subiects with total PSA between 4-20ng/ml, F/T PSA ratio had no superiority than total PSA alone and PSAD for discrimination between CaP and BPH. Conclusions: We suggest that the F/T PSA ratio is not superior to total PSA alone and FSAD in the detection of prostatic cancer, and further evaluation of the usefulness of F/T PSA ratio should be required.
전립선암 환자에서 Leuprolide Acetate Depot (루피어<SUP>Ⓡ</SUP> 데포주 3.75mg)의 유효성과 안전성 평가를 위한 다기관 임상시험
김형진(Hyung-Jin Kim),유정현(Chong-Hyon Ryu),이영구(Yong-Goo Lee),김청수(Choung-Soo Kim),류수방(Soo-Bang Ryu),김법완(Bup-Wan Kim),장성구(Sung-Goo Chang),김세중(Se-Joong Kim),이현무(Hyun-Moo Lee),최한용(Han-Yong Choi),홍성준(Sung-Joon 대한비뇨기종양학회 2009 대한비뇨기종양학회지 Vol.7 No.1
방광이행세포암종에서 종양억제유전자 부위의 Microsatellite Instability와 p53 유전자의 돌연변이 분석
권태균,정성광,김법완,김진아,김정완 경북대학교 병원 2001 경북대학교병원의학연구소논문집 Vol.5 No.1
Purprose: The objectives of this study is to eveluate the role of microsatellite instability(MI) and p53 gene inactivation in transitional cell carcinoma(TCC) of the bladder. Meterials and Methods: TOtal 31 cases of TCC patients, not treated with radiation or anticancer chemotherapy, were included in this study.Fifteen out of 31 patients were superficial and 16 were invasive TCC according to pathologic stage, while 16 were low grade and 15 were high grade TCC according to Ash grading system.The presence of MI was investigated in 3 loci of 9p site(D9S162, IFNA,D9S1747), and 6 loci of 17p site(D17S261, D17S513, D17S654, D17S695,D17S796, TP53) using a method based on the polymerase chain reaction(PCR).And the p53 point mutations were detected using polymerase chain reaction-single stranded conformation polymorphism(PCR-SSCP)analysis.The p53 protein overexpression was determined by immunohistochemical stain using DO-7 parimary antibody on formalin fixed, paraffin embedded tissue sections. Results: On MI anaylsis, altered band pattern were detected in 16 of 31 case (51.6%) in 9p region and 15 of 31 cases(48.4%) in 17p region.MI of the 9p region showed no association with tumor grade or stage.MI of the 17p site also showed no difference between superficial and invasive tumor group,but were higher in high grade(73.3%) than low grade tumor group(25.0%).On PCR-sscp analysis, total 8 mutations were found in 6 cases(19.4%) and 4 of 8 mutations (50%) were at exon 8.On immunohchemical staining, p53 nuclear overexpressions were found in 18 cases(58.1%)and more common in high grade and invasive tumor group(p<0.05). Fifteen out of 18 cases(83.3%) showed MI of the 9p or 17p regions. Conclusions: These results suggest that the p16 alterations may associated with high grade/invasive tumor.And DNA mismatch repair system may play an important role in tumorigenesis of bladder tumor.MI analysis can be a useful method to detect early genetic alterations in transitional cell carainoma of the bladder.(Korean J Urol 1999;40:1449~58)
가족적으로 발생한 쿠싱증후군 - 색소침착성 다결절성 부신피질 이형성증 3 예 -
하승우(Sung Woo Ha),김신우(Shin Woo Kim),김정국(Jung Guk Kim),서예경(Ye Kyung Seo),김보완(Bo Wan Kim),정성광(Sung Kwang Chung),김법완(Bup Wan Kim),박윤규(Yoon Kyu Park),장세국(Sae Kook Chang),손윤경(Yoon Kyung Sohn),곽정식(Jyung Sik 대한내과학회 1995 대한내과학회지 Vol.49 No.2
Pigmented multinodular adrenocortical dysplasia is a rare cause of Cushing's syndrome in infants, children and young adults. The disease is characterized by an ACTH independent adrenocortical hyperfunction without autonomously functioning adrenocortical neoplasm. Clinical symptoms are features of Cushing's syndrome and spotty facial pigmentation (lentigines and blue nevi). The bio- chemical findings include: 1) no suppression of urinary corticosteroid excretion after administration of dexamethasone. 2) no response to metyrapone or ACTH administraion; and 3) undetectable, low, or normal plasma levels of ACTH. Adrenal glands are normal or slightly enlarged and may or may not have discernible nodules on computed tomography scans. Bilateral total adrenalectomy cures the Cushing's syndrome. The familial occurrence, especially when to be found in combination with extra adrenal disorders, was considered indicative of 'Carney's complex'. Recently we experienced 3 cases of Cushing's syndrome due to pigmented multinodular adrenocortical dysplasia in one family, so we report the cases with a review of literatures.