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Boehmeria nivea Extract Reduces TNF-α/IFN-γ-induced TARC and MDC Expressions in Human Keratinocytes
Boram Go,Sung Chun Kim,Ho Bong Hyun,Hyejin Hyeon,So Yeon Oh,Weon-Jong Yoon,Young-Min Ham,Yong-Hwan Jung 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
Boehmeria nivea leaf extract (BE) has been reported its anti-inflammatory properties. However, there are few studies on its activity for skin inflammatory disorders and the mechanism. Atopic dermatitis (AD) is one of chronic relapsing skin inflammatory condition. This study investigated the inhibitory effects of BE on AD-like inflammatory markers such as macrophage-derived chemokine (MDC/CCL22) and thymus and activation-regulated chemokine (TARC/CCL17) in human keratinocytes. While stimulation with TNF-α/IFN-γ induces TARC and MDC expressions, co-treatment with BE reduced the levels of the chemokines in HaCaT cells. The chemokine quantitation was determined by ELISA methods. To identify which signaling pathways are involved, we performed western blotting. BE inhibited the phosphorylations of STAT1 significantly as well as NF-κB and MAPK. Our results demonstrate that BE inhibits TNF-α/IFN-γ-induced TARC and MDC through regulating the activities of STAT1, NF-κB, and MAPK signaling pathways.
Yi, Boram,Lee, Chang-Yong,Oh, Jin-Hwan,Lee, Boung Jun,Seo, Sungkyu,Yang, Ji-Woon Institute of Electrical and Electronics Engineers 2016 IEEE transactions on electron devices Vol.63 No.10
<P>The transient parasitic bipolar effect in floating-body double-gate FinFETs with low-doped bodies is analytically modeled. The obtained analytical transient bipolar current and charge models have predictive power for various device structures. These models are applicable when the majority carrier concentration in accumulation conditions noticeably exceeds the body doping concentration. The physical insights obtained from the developed current model are used to analyze the transient bipolar current <TEX>$I_{\text {BJT}}(t)$</TEX> for different device structures. It is shown that the gate–body–source capacitive coupling is an important parameter in <TEX>$I_{\text {BJT}}(t)$</TEX> control.</P>
이보람(Boram Lee),오유수(Yoosoo Oh) 한국HCI학회 2016 한국HCI학회 학술대회 Vol.2016 No.1
본 논문에서는 노인의 위급상황을 판단하여 신속한 대처를 돕는 위급상황 모니터링 시스템을 제안한다. 제안된 시스템은 노인을 고려하여 쉽게 착용 가능한 신발 형태로 개발하였다. 제안된 시스템은 노인이 착용하는 웨어러블 슈즈와 보호자의 모니터링 APP으로 구성된다. 웨어러블 슈즈는 온도 센서, 심박 센서, 기울기 센서, 가속도 센서, 자이로 센서가 내장된다. 웨어러블 슈즈에서 측정한 정보들은 APP을 통하여 실시간으로 모니터링이 가능하다. 또한, 제안된 시스템은 노인의 위급상황 발생 시 보호자의 스마트폰으로 SMS와 전화 연결을 수행하여 보호자에게 위급상황을 알린다. 보호자는 모니터링 APP을 통하여 항상 노인의 온도, 심박, 보행 상태 모니터링이 가능하다. In this paper, we propose an emergency monitoring system that can quickly help elderly people with the case of an emergency by analyzing the state of emergency and walking information. We develop the proposed system as the form of wearable shoes that the elderly can easily wear. The proposed system consists of two parts, which are the wearable shoes and a monitoring APP. The wearable shoes system includes the temperature sensor, pulse sensor, tilt sensor, accelerometer, and gyroscope sensors. The measured values of the wearable sensors can be monitored by the APP/WEB in real time. Also, the proposed system analyzes the movement information of the elderly by using accelerometer and gyroscope values. The proposed system informs the emergency situation to guardian as notification messages of a smartphone. The APP of the guardian always monitors the temperature and pulse information of the elderly.