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Boehmeria nivea Extract Reduces TNF-α/IFN-γ-induced TARC and MDC Expressions in Human Keratinocytes
Boram Go,Sung Chun Kim,Ho Bong Hyun,Hyejin Hyeon,So Yeon Oh,Weon-Jong Yoon,Young-Min Ham,Yong-Hwan Jung 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
Boehmeria nivea leaf extract (BE) has been reported its anti-inflammatory properties. However, there are few studies on its activity for skin inflammatory disorders and the mechanism. Atopic dermatitis (AD) is one of chronic relapsing skin inflammatory condition. This study investigated the inhibitory effects of BE on AD-like inflammatory markers such as macrophage-derived chemokine (MDC/CCL22) and thymus and activation-regulated chemokine (TARC/CCL17) in human keratinocytes. While stimulation with TNF-α/IFN-γ induces TARC and MDC expressions, co-treatment with BE reduced the levels of the chemokines in HaCaT cells. The chemokine quantitation was determined by ELISA methods. To identify which signaling pathways are involved, we performed western blotting. BE inhibited the phosphorylations of STAT1 significantly as well as NF-κB and MAPK. Our results demonstrate that BE inhibits TNF-α/IFN-γ-induced TARC and MDC through regulating the activities of STAT1, NF-κB, and MAPK signaling pathways.