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Bin Li,Yuan Fang,Guoqing Zhang,Rongrong Yu,Miaomiao Lou,Guanlin Xie,Yanli Wang,Guochang Sun 한국식물병리학회 2010 Plant Pathology Journal Vol.26 No.3
The Burkholderia cepacia complex isolates causing bacterial fruit rot of apricot were characterized by speciesspecific PCR tests, recA-HaeIII restriction fragment length polymorphism (RFLP) assays, rep-PCR genomic fingerprinting, recA gene sequencing, and multilocus sequence typing (MLST) analysis. Results indicated that the isolates Bca 0901 and Bca 0902 gave positive amplifications with primers specific for B. vietnamiensis while the two bacterial isolates showed different recARFLP and rep-PCR profiles from those of B. vietnamiensis strains. In addition, the two bacterial isolates had a higher proteolytic activity compared with that of the non-pathogenic B. vietnamiensis strains while no cblA and esmR marker genes were detected for the two bacterial isolates and B. vietnamiensis strains. The two bacterial isolates were identified as Burkholderia seminalis based on recA gene sequence analysis and MLST analysis. Overall, this is the first characterization of B. seminalis that cause bacterial fruit rot of apricot.
An Output Power Prediction Method for Multiple Wind Farms under Energy Internet Environment
Jianlou Lou,Hui Cao,Bin Song,Jizhe Xiao 보안공학연구지원센터 2016 International Journal of Grid and Distributed Comp Vol.9 No.11
Traditional wind power prediction is only applicable to a single wind farm. Aim at this isolated prediction method. In this paper, combing with the information sharing and Interconnection mechanism of energy Internet, we propose an output power prediction method for multiple wind farms based on DBPSO-LSSVM model. Firstly, collect SCADA data of multiple wind farms in different areas. Secondly, delete outliers of different farms based on DBSCAN algorithm and select multiple wind fields training samples. And searching the optimal input parameters of LSSVM based on particle swarm algorithm to construct every wind farm model. Thirdly, predict multiple wind fields power combined with numerical weather prediction system. The method we propose can be used to make the scheduling plan in advance to solve a large number of abandoned wind power rationing problem every year. In experiment, the method we propose has the lowest error rate compares to LSSVM and BP-neural network. It’s more suitable to predict wind fields in different areas.
Liu, Bin,Ho, Hsiang-Ting,Brunello, Lucia,Unudurthi, Sathya D.,Lou, Qing,Belevych, Andriy E.,Qian, Lan,Kim, Do Han,Cho, Chunghee,Janssen, Paul M. L.,Hund, Thomas J.,Knollmann, Bjorn C.,Kranias, Evangel Oxford University Press 2015 Cardiovascular research Vol.108 No.2
<P><B>Aims</B></P><P>Cardiac calsequestrin (CASQ2) and histidine-rich Ca-binding protein (HRC) are sarcoplasmic reticulum (SR) Ca-binding proteins that regulate SR Ca release in mammalian heart. Deletion of either CASQ2 or HRC results in relatively mild phenotypes characterized by preserved cardiac structure and function, although CASQ2 knockout (KO), or Cnull, shows increased arrhythmia burden under conditions of catecholaminergic stress. We hypothesized that given the apparent overlap of functions of CASQ2 and HRC, simultaneous ablation of both would deteriorate the cardiac phenotype compared with the single knockouts.</P><P><B>Methods and results</B></P><P>In contrast to this expectation, double knockout (DKO) mice lacking both CASQ2 and HRC exhibited normal cardiac ejection fraction and ultrastructure. Moreover, the predisposition to catecholamine-dependent arrhythmia that characterizes the Cnull phenotype was alleviated in the DKO mice. At the myocyte level, DKO mice displayed Ca transients of normal amplitude; additionally, the frequency of spontaneous Ca waves and sparks in the presence of isoproterenol were decreased markedly compared with Cnull. Furthermore, restitution of SR Ca release was slowed in DKO myocytes compared with Cnull cells.</P><P><B>Conclusion</B></P><P>Our results suggest that rather than being functionally redundant, CASQ2 and HRC modulate cardiac ryanodine receptor-mediated (RyR2) Ca release in an opposing manner. In particular, while CASQ2 stabilizes RyR2 rendering it refractory in the diastolic phase, HRC enhances RyR2 activity facilitating RyR2 recovery from refractoriness.</P>
Li, Bin,Fang, Yuan,Zhang, Guoqing,Yu, Rongrong,Lou, Miaomiao,Xie, Guanlin,Wang, Yanli,Sun, Guochang The Korean Society of Plant Pathology 2010 Plant Pathology Journal Vol.26 No.3
The Burkholderia cepacia complex isolates causing bacterial fruit rot of apricot were characterized by speciesspecific PCR tests, recA-HaeIII restriction fragment length polymorphism (RFLP) assays, rep-PCR genomic fingerprinting, recA gene sequencing, and multilocus sequence typing (MLST) analysis. Results indicated that the isolates Bca 0901 and Bca 0902 gave positive amplifications with primers specific for B. vietnamiensis while the two bacterial isolates showed different recA-RFLP and rep-PCR profiles from those of B. vietnamiensis strains. In addition, the two bacterial isolates had a higher proteolytic activity compared with that of the non-pathogenic B. vietnamiensis strains while no cblA and esmR marker genes were detected for the two bacterial isolates and B. vietnamiensis strains. The two bacterial isolates were identified as Burkholderia seminalis based on recA gene sequence analysis and MLST analysis. Overall, this is the first characterization of B. seminalis that cause bacterial fruit rot of apricot.
GPR48 Promotes Multiple Cancer Cell Proliferation via Activation of Wnt Signaling
Zhu, Yong-Bin,Xu, Lin,Chen, Ming,Ma, Hai-Na,Lou, Fang Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.8
The key signaling networks regulating cancer cell proliferation remain to be defined. The leucine-rich repeat containing G-protein coupled receptor 48 (GPR48) plays an important role in multiple organ development. In the present study, we investigated whether GPR48 functions in cancer cells using MCF-7, HepG2, NCI-N87 and PC-3 cells. We found that GPR48 overexpression promotes while its knockdown using small interfering RNA oligos inhibits cell proliferation. In addition, Wnt/${\beta}$-catenin signaling was activated in cells overexpressing GPR48. Therefore, our results indicated that GPR48 activates Wnt/${\beta}$-catenin signaling to regulate cancer cell proliferation.
Zhang, Genqiang,Wu, Hao Bin,Song, Taeseup,Paik, Ungyu,Lou, Xiong Wen (David) WILEY‐VCH Verlag 2014 Angewandte Chemie Vol.126 No.46
<P><B>Abstract</B></P><P>While the synthesis of TiO<SUB>2</SUB> hollow structures is well‐established, in most cases it is particularly difficult to control the crystallization of TiO<SUB>2</SUB> in solution or by calcination. As a result, TiO<SUB>2</SUB> hollow structures do not really exhibit enhanced lithium storage properties. Herein, we report a simple and cost‐effective template‐assisted method to synthesize anatase TiO<SUB>2</SUB> hollow spheres composed of highly crystalline nanocrystals, in which carbonaceous (C) spheres are chosen as the removable template. The release of gaseous species from the combustion of C spheres may inhibit the growth of TiO<SUB>2</SUB> crystallites so that instead small TiO<SUB>2</SUB> nanocrystals are generated. The small size and high crystallinity of primary TiO<SUB>2</SUB> nanoparticles and the high structural integrity of the hollow spheres gives rise to significant improvements in the cycling stability and rate performance of the TiO<SUB>2</SUB> hollow spheres.</P>
다중 개체군 유전자 알고리즘을 이용한 퍼지 규칙 최적화
류시열,장원빈,권기호,Lou, See-Yul,Chang, Won-Bin,Kwon, Key-Ho 대한전자공학회 1999 電子工學會論文誌, C Vol.c36 No.8
본 논문은 퍼지 규칙 베이스와 소속함수의 모양을 결정하기 위해서, 유전적 다양성을 개선시키는 변형 유전자 알고리즘의 하나인 다중 개체군 유전자 알고리즘(MGA)을 적용하였다. 대부분 퍼지 제어를 위한 퍼지 규칙 베이스의 일반화는 전문가의 경험에 의해 많이 좌우된다. 이러한 점을 개선하여 퍼지 규칙을 최적화하기 위한 방법으로 새로운 평가함수를 제안한다. 시뮬레이션 결과는 제안한 방법이 우수함을 보여준다. In this paper, we apply one of modified Genetic Algorithms, a Multi-population Genetic Algorithm(MGA) that improves the genetic diversity to determine the fuzzy rule base and the shape of membership functions. The generation of the fuzzy rule base for fuzzy control, generally, depends on expert's experience. We suggest a new evaluation function to optimize fuzzy rule base. Simulation shows that the proposed method has good result.
Diversity Analysis of Burkholderia cepacia Complex in the Water Bodies of West Lake, Hangzhou, China
Yuan Fang,Guan-lin Xie,Miao-miao Lou,Bin Li,Ibrahim Muhammad 한국미생물학회 2011 The journal of microbiology Vol.49 No.2
A survey of Burkholderia cepacia complex (Bcc) species was conducted in water bodies of West Lake in China. A total of 670 bacterial isolates were recovered on selective media. Out of them, 39.6% (265 isolates)were assigned to the following species: Burkholderia multivorans, Burkholderia cenocepacia recA lineage IIIA,IIIB, Burkholderia stabilis, Burkholderia vietnamiensis, and Burkholderia seminalis while B. cenocepacia is documented as a dominant Bcc species in water of West Lake. In addition, all Bcc isolates tested were PCR negative for the cblA and esmR transmissibility marker genes except B. cenocepacia IIIB A8 which was positive for esmR genelater. The present study raises great concerns on the role of West Lake as a “reservoir” for potential Bcc pathogenic strains.
Li, Xiao-Fei,He, Hua-Bin,Zhu, Yan-Shuang,He, Jin-Ke,Ye, Wei-Wei,Chen, Yong-Xin,Lou, Lian-Qing Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.9
The objective of this study was to evaluate the influence of a genetic variant in the multidrug resistance 1 gene (MDR1) on hepatocellular carcinoma (HCC) risk. This case-control study was conducted in a Chinese population of 645 HCC cases and 658 cancer-free controls. The genotype of the c.3751G>A genetic variant in the MDR1 gene was investigated by created restriction site-polymerase chain reaction (CRS-PCR) and DNA sequencing methods. Our data demonstrated significantly differences detected in the allelic and genotypic frequencies between HCC cases and those of cancer-free controls. Association analyses indicated that there were statistically increased risk of HCC in the homozygote comparison (AA versus (vs.) GG: OR=2.22, 95% CI 1.51-3.27, ${\chi}^2$=16.90, P<0.001), dominant model (AA/GA vs. GG: OR=1.25, 95% CI 1.00-1.55, ${\chi}^2$=3.98, P=0.046), recessive model (AA vs. GA/GG: OR=2.14, 95% CI 1.47-3.09, ${\chi}^2$=16.68, P<0.001) and allele comparison (A vs. G: OR=1.33, 95% CI 1.13-1.57, ${\chi}^2$=11.66, P=0.001). The allele-A and genotype-AA may contribute to HCC susceptibility. These preliminary findings suggest that the c.3751G>A genetic variant in the MDR1 gene is potentially related to HCC susceptibility in a Chinese Han population, and might be used as a molecular marker for evaluating HCC susceptibility.