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Batakrishna Jana,진성언,유자형 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.1
Lysosome always remains a powerful organelle and an important target for cancer therapy as cancer cells are greatly dependent on effective lysosomal function. There are very few strategies for selective targeting the lysosome of cancer cells. Here, we show lysosome targeting followed by lyso-assembly of the peptide amphiphiles as a powerful techniques for the development of selective cancer therapeutics and overcome the drug resistance. We have designed a peptide amphiphiles, which specifically target the cancer lysosome, undergoes supramolecular assembly through enzymatic cleavage governed by cathepsin B followed by lysosomal swelling. It induces the lysosomal membrane permeabilization (LMP) and damage and causes the caspase independent apoptotic death of the cancer cells through disruption of plasma membrane. Moreover, the lysosome possess high cancer selectivity and are effective towards drug resistance cancer treatment.
Supramolecular protection-mediated one-pot synthesis of cationic gold nanoparticles
Batakrishna Jana,김성찬,Huyeon Choi,Seongeon Jin,Kibeom Kim,Min Soo Kim,Hyojin Lee,Kwan Hyi Lee,Jungmin Lee,Myoung-Hwan Park,Youngdo Jeong,Ja-Hyoung Ryu,Chaekyu Kim 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.81 No.-
Despite the extended use of cationic gold nanoparticles (AuNPs) in biomedical applications, direct onepotsynthesis of AuNPs with tunable size in aqueous media is limited due to the deleterious electrostaticattraction between AuCl4-anions and positively charged ligands. This paper describes the one-potsynthesis of cationic gold nanoparticles with size tunability based on host-guest chemistry. As the hostmolecule, cucurbit[7]uril inhibits self-aggregation in aqueous solution by threading positively chargedguest ligands, which provides a shielding effect on the ligands. Reduction of the mixtures by directlyadding NaBH4 generates cationic AuNPs with narrow size distributions. Furthermore, their potential inbiomedical applications is demonstrated by siRNA transfection experiments. This approach relying onsupramolecular-mediated interactions may provide new insights into organic/inorganic reactions thatinvolve electrostatic disturbance.
Quaternary ammonium‐based mitochondria targeting anticancer agents with high water solubility
Kim Sangpil,Yoon Nam Gu,Jana Batakrishna,Kang Byoung Heon,Ryu Ja‐Hyoung 대한화학회 2022 Bulletin of the Korean Chemical Society Vol.43 No.3
Triphenylphosphonium derivatives induce mitochondrial dysfunction by inhibiting the respiratory chain, membrane depolarization, and generation of reactive oxygen species. However, the clinical application has been limited due to low aqueous solubility. In this regard, a series of novel mitochondria targeting agents were designed by introducing quaternary ammonium that increases aqueous solubility. Among them, diquaternary ammonium containing triphenylphosphonium molecules specifically inhibited mitochondrial respiratory chain, disrupted mitochondrial proteostasis, and intra-mitochondrial protein in cancer cells, resulting in apoptosis induction. Overall, the high water-soluble mitochondria targeting agents would be a potential anticancer drug.