Eosinophilic Mastitis: A Case Report

Hyewon Bang,Kwan Ho Lee,김현숙,민기옥,최승혜 한국유방암학회 2021 Journal of Breast Disease Vol.9 No.2

Eosinophilic mastitis is a rare disease in which eosinophils infiltrate the ducts and lobules of the breast, causing mammary inflammation. Although eosinophilic mastitis is a benign condition, it presents similarly to and is often mistaken for breast cancer. Here we report the first case of eosinophilic mastitis in Korea. A 43-year-old woman presented with redness and swelling in her right breast. A breast ultrasound revealed ill-defined isoechoic and hyperechoic areas in the upper half and lower inner quadrant of the right breast combined with axillary level I lymphadenopathy. A histopathological examination by core needle biopsy demonstrated lymphoplasma cell infiltration with eosinophils. A peripheral blood examination revealed an eosinophil count of 5,000/mm³. The patient was treated with oral steroids, antibiotics, and leukotriene receptor antagonists. Four months later, the eosinophil count had returned to normal, and breast ultrasound exhibited marked improvement.

Metastatic breast cancer from a hepatocellular carcinoma: a case report

Bang Hyewon,Kim Nam-Hee,Choi Seung Hye,Bae Si Hyun,Jung Eun Sun,Min Ki Ouk,Eom Yong Hwa 대한종양외과학회 2022 Korean Journal of Clinical Oncology Vol.18 No.2

Breast metastases from extramammary malignancies are rare. Here, we report a case of breast metastasis from hepatocellular carcinoma (HCC) after breast mass excision in a 63-year-old woman. A new breast nodule was noticed after transarterial chemoembolization, transarterial radioembolization, and stereotactic body radiation therapy for HCC. Breast ultrasound and core needle biopsy were performed to differentiate between the breast tumors. The biopsy result was invasive breast carcinoma, and wide excision of the breast was performed. The final pathological diagnosis was HCC breast metastasis based on histological findings and immunohistochemical staining results. After 9 months of follow-up, HCC and breast metastasis recurred. Despite palliative treatment, the patient died due to complications and general health deterioration. Although breast metastasis due to HCC is very rare, HCC breast metastasis should be considered when a new breast mass is discovered in a patient with a history of HCC for effective treatment and management.

사교육이 고등학생의 수학학업성취도에 미치는 영향 연구: 경향점수매칭과 다층모형 적용

방현주(Bang Hyunjoo),정혜원(Chung Hyewon) 학습자중심교과교육학회 2018 학습자중심교과교육연구 Vol.18 No.22

본 연구는 사교육 참여 여부와 학생 수준, 학교 수준의 요인이 수학학업성취도에 미치는 영향에 대하여 분석하는데 목적이 있다. 분석을 위하여 서울교육종단연구 (Seoul Education Longitudinal Study: SELS) 초4패널, 7차년도 자료(고등학교 1학년, 2016년)를 활용하였다. 사교육 참여 효과의 보다 면밀한 연구를 위하여 사교육과 수학학업성취도에 영향을 미치는 변인으로 기대되는 변인을 공변인으로 투입하고 경향점수매칭을 실시하여 사교육 참여집단과 미참여집단 간 동등성을 확보하였다. 수학학업성취도에 영향을 미치는 학생 수준, 학교 수준의 변인을 탐색하기 위하여 다층모형을 적용하여 분석하였다. 분석결과에 따르면, 학생 수준의 변인 중 학습태도가 좋을수록, 가정 변인 중 부모의 월수입이 높을수록 수학학업성취도와 정적인 관계가 있는 것으로 나타났으며, 사교육 참여 여부 효과를 통제한 후에 사교육 참여여부는 수학학업성취도에 유의한 영향을 미치지 않았으나 방과후 학교와 EBS 참여여부는 정적으로 유의한 영향을 미쳤다. 학교 수준의 변인 중 학생이 재학한 학교가 수준별 이동수업을 실시할수록, 기초학력미달 수학 학생 비율이 높을수록 수학학업 성취도와 부적인 관계가 나타났다. 이러한 연구결과를 토대로 연구의 시사점을 논의 하였다. The purpose of this study was to explore how participation in private tutoring, the student-level and school-level predictors affect on academic achievement of mathematics. For this study, the 7-wave(first grade of academic high school) of the Seoul Education Longitudinal Study(SELS) dataset was used. To eliminate selection biases, propensity scores matching between the participation(private tutoring, treated) group and non-participation(control) group was conducted. Variables which were expected to be influential factors on private tutoring and academic achivement on mathematics, were modeled as covariate variables. Using the propensity score matching method, the homogeneity between the two groups was secured. As a result of the multilevel modeling using homogeneous data, the participation in private tutoring did not have a statistically significant effect on academic achievement on mathematics. On the other hand, the participation of after-school and EBS programs had a significant effect on academic achievement of mathematics. Among student-level variables, the learning attitude and household’s monthly income were positively related to academic achievement of mathematics. Among school-level predictors, the ability grouping on mathematics achievement and the ratio of students who have below-basic academic proficiency level were negatively related to academic achievement of mathematics. Based on these results, the implications of this study were discussed.

3D billiards game with haptic interface

Seo, Hyewon,Bang, Joon-Won,Park, Ji-Man,Jeon, Soo-Hyun John Wiley Sons, Ltd. 2010 Computer Animation and Virtual Worlds (Print) Vol.21 No.5

<P>Intuitive human-computer interaction has been an active research area with the participation of both academic and industrial groups. It is an important technical and psychological element in computer games, digital product design, cybersports, etc. In this paper, we present our work on a 3D billiards game featuring a haptic interface. Most of the existing games available today concentrate on the development of sophisticated physics engines to obtain realistic motion of billiards balls or of sound engines for realistic sound effect. Our focus in this work is on the improved realism on the hitting action of the game with the aid of haptic device. We do so by computing accurate feedback force on the haptic handle, considering the exact point of contact and physically faithful collision response. Also presented is the physically based modeling of the game environment, including the collision interaction among billiards balls, and between the table and billiards balls. As a result, the players can enjoy a more realistic and pleasurable game compared to other existing 3D billiards games. Copyright © 2010 John Wiley & Sons, Ltd.</P> <B>Graphic Abstract</B> <P>A 3D billiards game featuring a haptic interface has been presented. The focus in this work is on the improved realism on the hitting action of the game with the aid of haptic device. Also presented is the physically based modeling of the game environment, including the collision interaction among billiards balls, and between the table and billiards balls. <img src='wiley_img_2010/15464261-2010-21-5-CAV337-gra001.gif' alt='wiley_img_2010/15464261-2010-21-5-CAV337-gra001'> </P>

Exosomal Proteins in the Aqueous Humor as Novel Biomarkers in Patients with Neovascular Age-related Macular Degeneration

Kang, Gum-Yong,Bang, Joo Young,Choi, Ae Jin,Yoon, Jeehyun,Lee, Won-Chul,Choi, Soyoung,Yoon, Soojin,Kim, Hyung Chan,Baek, Je-Hyun,Park, Hyung Soon,Lim, Hyunjung Jade,Chung, Hyewon American Chemical Society 2014 JOURNAL OF PROTEOME RESEARCH Vol.13 No.2

<P>Age-related macular degeneration (AMD) describes the progressive degeneration of the retinal pigment epithelium (RPE), retina, and choriocapillaris and is the leading cause of blindness in people over 50. The molecular mechanisms underlying this multifactorial disease remain largely unknown. To uncover novel secretory biomarkers related to the pathogenesis of AMD, we adopted an integrated approach to compare the proteins identified in the conditioned medium (CM) of cultured RPE cells and the exosomes derived from CM and from the aqueous humor (AH) of AMD patients by LC–ESI–MS/MS. Finally, LC–MRM was performed on the AH from patients and controls, which revealed that cathepsin D, cytokeratin 8, and four other proteins increased in the AH of AMD patients. The present study has identified potential biomarkers and therapeutic targets for AMD treatment, such as proteins related to the autophagy–lysosomal pathway and epithelial–mesenchymal transition, and demonstrated a novel and effective approach to identifying AMD-associated proteins that might be secreted by RPE in vivo in the form of exosomes. The proteomics-based characterization of this multifactorial disease could help to match a particular marker to particular target-based therapy in AMD patients with various phenotypes.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jprobs/2014/jprobs.2014.13.issue-2/pr400751k/production/images/medium/pr-2013-00751k_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/pr400751k'>ACS Electronic Supporting Info</A></P>

Bendamustine in heavily pre-treated multiple myeloma patients: Results of a retrospective analysis from the Korean Multiple Myeloma Working Party

김석진,Soo-Mee Bang,최윤석,조덕연,김진석,Hyewon Lee,Hyeon Seok Eom,윤덕현,서철원,이제중,Junshik Hong,이재훈,Youngil Koh,김기현,윤성수,민창기 대한혈액학회 2016 Blood Research Vol.51 No.3

BackgroundBendamustine may be a potential treatment option for patients with myeloma, but little is known about the utility of bendamustine as a salvage treatment, especially in Asian patients.MethodsWe performed a multicenter retrospective study of patients with relapsed or refractory myeloma who received bendamustine and prednisone. ResultsThe records of 65 heavily pre-treated patients, who had undergone bortezomib and lenali-domide treatment (median number of previous treatments: 5), were analyzed. The me-dian time from diagnosis to bendamustine treatment was 3.8 years, and the median pa-tient age was 63 years (range, 38‒77 yr). The responses to the last treatment before bend-amustine were refractory disease (N=52, 80%) or disease progression from partial re-sponse (N=13, 20%). Twenty-three patients responded to the treatment, with an overall response rate of 35% (23/65), and the median number of bendamustine treatment cycles was two (range, 1‒5 cycles). The median overall survival after bendamustine treatment was 5.5 months and the overall survival rate in responders to bendamustine was sig-nificantly better than that in non-responders (P=0.036). ConclusionBendamustine may be a potential salvage treatment to extend survival in a select group of heavily pre-treated patients with relapsed or refractory myeloma.

다변량 잠재성장모형을 활용한 청소년의 자기주도학습능력과 진로성숙도의 종단적 관계

이정민(Lee Jungmin),방현주(Bang Hyunjoo),정혜원(Chung Hyewon) 한국열린교육학회 2017 열린교육연구 Vol.25 No.2

본 연구에서는 다변량 잠재성장모형을 활용하여 청소년의 자기주도학습능력과 진로성숙도의 종단적 관계를 탐색하고자 하였다. 분석을 위하여 서울교육종단연구(Seoul Education Longitudinal Study: SELS) 중1패널 1~6차년도 자료를 활용하였다. 분석결과에 따르면 첫째, 자기주도학습능력과 진로성숙도의 변화 양상은 시간이 지남에 따라 감소했다가 다시 증가하는 이차함수변화 모형이 가장 적합한 것으로 나타났다. 둘째, 초기치인 중1 시기의 자기주도학습능력이 높을수록 같은 시기의 진로성숙도를 높게 하는 것으로 나타났다. 하지만, 중1 시기의 자기주도학습능력이 높을수록 진로성숙도의 변화율을 낮게 하였지만, 오히려 진로성숙도의 2차 변화율은 증가시켰다. 본 연구결과를 통해 자기주도학습능력이 진로성숙도에 미치는 효과가 종단적으로 유의함을 확인하였으며, 이를 토대로 연구의 시사점을 논의하였다. The purpose of this study was to verify the longitudinal relationship between self-directed learning ability and career maturity, using multivariate latent growth modeling. The 6-waves of the Seoul Education Longitudinal Study (SELS) dataset were used. The results of this study are as follows. First, the unconditional model analysis indicated that self-directed learning ability and career maturity’s change patterns were curvelinear (U-shaped). Second, the initial status of the self-directed learning ability was positively related to the initial status of the career maturity. However, the initial status of the self-directed learning ability was negatively related to the growth rate of the career maturity, and was positively related to the quadratic growth rate of the career maturity. The results showed that the effect of the self-directed learning ability on the career maturity was longitudinally significant. Based on these results, the implications of this study were discussed.

Bendamustine in heavily pre-treated multiple myeloma patients: Results of a retrospective analysis from the Korean Multiple Myeloma Working Party

김석진,Soo-Mee Bang,최윤석,조덕연,김진석,Hyewon Lee,Hyeon Seok Eom,윤덕현,서철원,이제중,Junshik Hong,이재훈,Youngil Koh,김기현,윤성수,민창기 대한혈액학회 2016 Blood Research Vol.51 No.3

BackgroundBendamustine may be a potential treatment option for patients with myeloma, but little is known about the utility of bendamustine as a salvage treatment, especially in Asian patients.MethodsWe performed a multicenter retrospective study of patients with relapsed or refractory myeloma who received bendamustine and prednisone. ResultsThe records of 65 heavily pre-treated patients, who had undergone bortezomib and lenali-domide treatment (median number of previous treatments: 5), were analyzed. The me-dian time from diagnosis to bendamustine treatment was 3.8 years, and the median pa-tient age was 63 years (range, 38‒77 yr). The responses to the last treatment before bend-amustine were refractory disease (N=52, 80%) or disease progression from partial re-sponse (N=13, 20%). Twenty-three patients responded to the treatment, with an overall response rate of 35% (23/65), and the median number of bendamustine treatment cycles was two (range, 1‒5 cycles). The median overall survival after bendamustine treatment was 5.5 months and the overall survival rate in responders to bendamustine was sig-nificantly better than that in non-responders (P=0.036). ConclusionBendamustine may be a potential salvage treatment to extend survival in a select group of heavily pre-treated patients with relapsed or refractory myeloma.

고해상도 네트워크를 이용한 도로 영역 검출 알고리즘

변승환(Seunghwan Byun),최우철(Woocheol Choi),이재민(Jaemin Lee),방혜원(Hyewon Bang),한영준(Youngjoon Han) 대한전기학회 2020 정보 및 제어 심포지엄 논문집 Vol.2020 No.10

Clinical Factors Associated with Response or Survival after Chemotherapy in Patients with Waldenström Macroglobulinemia in Korea

Lee, Ho Sup,Kim, Kihyun,Yoon, Dok Hyun,Kim, Jin Seok,Bang, Soo-Mee,Lee, Jeong-Ok,Eom, Hyeon Seok,Lee, Hyewon,Kim, Inho,Lee, Won Sik,Bae, Sung Hwa,Kim, Se Hyung,Lee, Mark Hong,Do, Young Rok,Lee, Jae Ho Hindawi Publishing Corporation 2014 BioMed research international Vol.2014 No.-

<P>Waldenström's macroglobulinemia (WM) is a B-cell proliferative malignancy characterized by immunoglobulin M monoclonal gammopathy and bone marrow infiltration by lymphoplasmacytic cells. Clinical features and cytogenetics of WM in Asia including Republic of Korea remain unclear. Moreover, no study has reported treatment outcomes in patients with WM treated with novel agent combined with conventional chemotherapy. This study investigated clinical features and assessed treatment outcomes with novel agent and conventional chemotherapy in Republic of Korea. Data from all (<I>n</I> = 71) patients with newly diagnosed WM at 17 hospitals who received chemotherapy between January 2005 and December 2012 were collected retrospectively. The median age of patients was 66 years (range: 37–92 years) and male to female ratio was 5 : 1. Patients treated with novel agent combined chemotherapy displayed higher overall response rate (ORR) compared to conventional chemotherapy alone (92.9% versus 52.6%, <I>P</I> = 0.006). The 5-year overall survival rate was 62.6% (95% confidence interval: 34.73–111.07). Use of novel agents produced higher ORR but survival benefit was not apparent due to the small number of patients and short follow-up duration. Further studies are needed to confirm the efficacy of novel agents in patients with WM.</P>