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Apoptotic cell death of human leukaemia U937 cells by ubiquinone-9 purified from Pleurotus eryngii
Bae, Jeen-Soo,Park, Jin Wook,Park, So Hyun,Park, Jung Bin,Rho, Yoon-Hwa,Ryu, Young Bae,Lee, Kun-Sik,Park, Ki-Hun,Bae, Young-Seuk Taylor Francis 2009 NATURAL PRODUCT RESEARCH Vol.23 No.12
<P> A chloroform extract of the edible mushroom Pleurotus eryngii showed an inhibitory effect on mammalian DNA topoisomerase I. The topoisomerase I inhibitory compound was purified and identified as ubiquinone-9. Ubiquinone-9 was shown to inhibit the activity of topoisomerase I with IC50 of about 50 µM. Concentration of 110 µM ubiquinone-9 caused 50% growth inhibition of human leukaemia U937 cells, but not that of normal fibroblast NIH3T3 and 3Y1 cells. Ubiquinone-9-induced cell death was characterised with the cleavage of poly (ADP-ribose) polymerase and pro-caspase 3. Furthermore, ubiquinone-9 induced the fragmentation of DNA into an apoptotic DNA ladder, indicating that the inhibitor triggered apoptosis. The induction of apoptosis by ubiquinone-9 was also confirmed using flow cytometry analysis. Taken together, these results suggest that ubiquinone-9 may function by inhibiting oncogenic disease, at least in part, through the inhibition of topoisomerase I activity.</P>
Kyu-Ho Yi(Kyu-Ho Yi),Hyungkyu Bae(Hyungkyu Bae),Soo-Bin Kim(Soo-Bin Kim),Woo-Ram Kim(Woo-Ram Kim),Won Lee(Won Lee),Ji-Soo Kim(Ji-Soo Kim),Hee-Jin Kim(Hee-Jin Kim) 대한해부학회 2024 Anatomy & Cell Biology Vol.57 No.1
Masseter are commonly botulinum neurotoxin targeted muscle for facial contouring in aesthetic field. However, paradoxical masseteric bulging is common adverse effect that has not been discussed with ultrasonographic observations. Retrospective study has been conducted from October, 2021 to January, 2023, out of 324 patients have done blinded botulinum neurotoxin injection in the masseter at the middle and lower portion of the masseter with each side of 25 units (letibotulinum neurotoxin type A), 3 patients demonstrated paradoxical masseteric bulging has been reported and the image observed by ultrasonography by physician. Based on the observations made, we can infer that the function of the moving muscle involves twisting of the muscle fibers during contraction, along with the twisting of the deep inferior tendon, which causes the muscle to be divided into anterior and posterior compartments rather than into superficial and deep compartments of masseter. In ultrasonographic observe the skin surface of a patient with paradoxical masseteric bulging, it is observable that either the anterior or posterior part contracts significantly. The functional units of anterior and posterior compartment are observable as muscular contraction of inward movement of the muscle from either the anterior or posterior functional unit.
Bae Jun-Sang,Oh Soo Bin,Kim Jeongyun,Kim Hoon,Kim Ji Hye,Kim Eun-Hee,Cho Kyong Jin,Mo Ji-Hun 대한천식알레르기학회 2022 Allergy, Asthma & Immunology Research Vol.14 No.1
Purpose: Data on the effects of direct particulate matter (PM) exposure on the eyes and the nose are limited. Here, an interleukin (IL)-17/neutrophil-dominant ovalbumin (OVA)/polyinosinic-polycytidylic acid (Poly(I:C)) mouse model was used to evaluate the effect of different-sized titanium dioxide (TiO2) particles on the eyes and the nose. We also examined whether IL-17-neutralizing antibody (IL-17Ab) treatment could reverse TiO2 effects. Methods: The nasal cavities and conjunctival sacs of each mouse were challenged with OVA and Poly(I:C) to induce neutrophil-dominant inflammation and then exposed to micro- and nano-TiO2. Subsequently, IL-17Ab was administered to investigate the role of IL-17 and inflammatory parameters. Results: Micro- and nano-TiO2 resulted in significant decreases in tear-break-up time and increases in corneal damage. Airborne micro-TiO2 also increased nasal rubbing and sneezing counts compared with the OVA/Poly(I:C). Micro-TiO2 exposure increased infiltration of neutrophils and IL-17A+ cells in the conjunctival tissues and the nasal mucosae. In addition, these increased symptoms and inflammation in the eyes and the nose by micro-TiO2 exposure were inhibited by the IL-17Ab, suggesting IL-17 dependency. Conclusions: TiO2 aggravated IL-17-induced eye and nose inflammation and the IL-17Ab alleviated inflammation in the OVA/Poly(I:C) mouse model. These results may help develop a therapeutic modality for PM exposure and provide evidence for PM-associated diseases.
( Soo Min Ahn ),( Yong-gil Kim ),( Seung-hyeon Bae ),( Doo-ho Lim ),( Seokchan Hong ),( Sang Hyoung Park ),( Chang-keun Lee ),( Bin Yoo ) 대한내과학회 2017 The Korean Journal of Internal Medicine Vol.32 No.5
Background/Aims: In some Western countries, up to 50% of patients with anky-losing spondylitis (AS) have subclinical gut inflammation. This study was con-ducted to evaluate the prevalence and severity of gut inflammation and to deter-mine clinical factors associated with colonic inflammation in Korean AS patients who performed ileocolonoscopy without evidence of established inflammatory bowel diseases before. Methods: One hundred and eight AS patients who underwent ileocolonoscopy were included in this study. Patients were divided into two groups based on gross ileocolonoscopic findings; patients with inflammatory lesions, and patients with-out inflammatory lesions. Results: Inflammatory lesions in ileocolonoscopic findings were found in 40 patients. The Ankylosing Spondylitis Disease Activity Score C-reactive protein was higher in the group with inflammatory lesions and gut lesions were found often in the terminal ileum. The risk of inflammatory lesions was higher for AS patients whose symptoms required ileocolonoscopy than for AS patients who un-derwent routine ileocolonoscopy screening (odds ratio, 3.96). However, abnormal lesions were detected also in 17.6% of the patients who underwent ileocolonoscopy for routine screening and most of them were erosion and ulcer. Among patients with inflammatory lesions (n = 40), 23 showed subclinical gut inflammation asso-ciated with AS and 17 were diagnosed finally as Crohn`s disease (n = 12), intestinal tuberculosis (n = 4), and ulcerative colitis (n = 1). Conclusions: Our findings suggest that ileocolonoscopy might be recommended regularly in AS patients even without gastrointestinal symptoms, especially in the patients with high AS activity.
( Soo Min Ahn ),( Yong Gil Kim ),( Bin Yoo ),( Chang Keun Lee ),( Seok Chan Hong ),( Seung Hyeon Bae ),( Doo Ho Lim ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Background: The prevalence of concurrent Ankylosing spondylitis (AS) and Crohn`s disease (CD) or Ulcerative colitis (UC) is estimated at 10%. Up to 50% of patients with AS have subclinical gut infi ammation seen. This study was purposed to evaluate the association between reasons for ileocolonoscopy and the ileocolonoscopic fi ndings in the patients with AS. Methods: The retrospective study has included 108 AS patients who had ileocolonoscopy from January 2000 to April 2014. Patients with a history of CD, UC, intestinal tuberculosis, or colon cancer were excluded. Patients were divided into 2 groups based on ileocolonoscopic results; 1) negative infi ammatory lesions and 2) positive infi ammatory lesions. The clinical features including HLA-B27 profi les, and reasons for ileocolonoscopy including regular health checkup without symptoms, abdominal pain, rectal bleeding, diarrhea, constipation, anemia and positive stool occult blood were evaluated. Results: As shown in Table, infi ammatory lesions in ileocolonoscopic fi ndings were found in 40 patients out of the 108 patients. Mean ESR and mean CRP were signifi - cantly higher in the group with infi ammatory lesions than the group without infi ammatory lesions. Presence of symptoms or signs (n=34) was associated with risk of infi ammatory ileocolonoscopic fi ndings compared to for screening (n=6) (OR=3. 96). Among the patient`s symptoms or signs, abdominal pain (n=13) was associated with infi ammatory ileocolonoscopic fi ndings most importantly (vs. negative abdominal pain (n=20); OR =2. 47). Among 40 patients with infi ammatory lesions, 12 as CD, 1 as UC,and 4 as intestinal tuberculosis were diagnosed fi nally. However, most of them, 23 patients were considered as subclinical gut infi ammation. Conclusions: Considerable proportion of AS patients showed infi ammatory gut lesions, even in the patients without gastrointestinal symptoms. Moreover, abdominal pain increased a possibility of infi ammatory gut lesions in AS patients. Therefore, regular checkup with ileocolonoscopy could be recommended in AS patients.
Soo Woong Jang,Hee Seung Yang,Young Bae Kim,Joo Chul Yang,Kyu Bok Kang,Tae Wan Kim,Kwan Ho Park,Kyung Soo Jeon,Hee Dong Shin,Ye Eun Kim,Han Na Cho,Yun Kyung Lee,Young Lee,Seul Bin Na Lee,Dong Young Ah 대한재활의학회 2021 Annals of Rehabilitation Medicine Vol.45 No.1
Objective To compare the convenience and effectiveness of the existing lumbosacral orthoses (LSO) (classic LSO and Cybertech) and a newly developed LSO (V-LSO) by analyzing postoperative data. Methods This prospective cohort study was performed from May 2019 to November 2019 and enrolled and analyzed 88 patients with degenerative lumbar spine disease scheduled for elective lumbar surgery. Three types of LSO that were provided according to the time of patient registration were applied for 6 weeks. Patients were randomized into the classic LSO group (n=31), Cybertech group (n=26), and V-LSO group (n=31). All patients were assessed using the Oswestry Disability Index (ODI) preoperatively and underwent plain lumbar radiography (anteroposterior and lateral views) 10 days postoperatively. Lumbar lordosis (LS angle) and frontal imbalance were measured with and without LSO. At the sixth postoperative week, a follow-up assessment with the ODI and orthosis questionnaire was conducted. Results No significant differences were found among the three groups in terms of the LS angle, frontal imbalance, ODI, and orthosis questionnaire results. When the change in the LS angle and frontal imbalance toward the reference value was defined as a positive change with and without LSO, the rate of positive change was significantly different in the V-LSO group (LS angle: 41.94% vs. 61.54% vs. 83.87%; p=0.003). Conclusion The newly developed LSO showed no difference regarding its effectiveness and compliance when compared with the existing LSO, but it was more effective in correcting lumbar lordosis.