計算機를 活用하여 問題 解決 指導를 위한 資料 開發에 대한 硏究

배종수 서울교육대학교 과학교육연구소 1997 科學과 數學敎育 論文集 Vol.23 No.-

서울敎育大學敎 學內 電算網 構築 方案에 관한 硏究

裵鍾洙,洪命熹,張豪演 서울교육대학교 과학교육연구소 1994 科學과 數學敎育 論文集 Vol.20 No.-

초등교육용 온라인 멀티미디어 코스웨어 개발을 위한 설계 전략

배종수,최성우 서울교육대학교 과학교육연구소 1997 科學과 數學敎育 論文集 Vol.23 No.-

肝吸蟲에 대한 Albendazole의 殺蟲效果에 관한 實驗的 硏究

裵平元,金洙鎭,林漢鍾 고려대학교 의과대학 1984 고려대 의대 잡지 Vol.21 No.3

Newly developed albendazole(zentel®) is a broad spectrum anthelmintic which high activity against intestinal nematodas as well as trematodes and cesstodes infections. The present study was undertaken to evaluato in vitro and in vivo activities of albendazoles against adult worms of clonorchis sinensis. The morphological change of C. sinensis obtained from experimentally infected rats treated with various dosages of albendazole were studied by means of scaning and transmission electron microscope. The results are as follows: 1. The adult worms of C. sinensis were incubated in the medium containing albendazole with various concentrations. By 24 hours after incubation, none of the worms were dead in concentrations of 0.01μg/ml of albendazole. 2. In order to evaluate the effect of albendazole in vivo, experimentally infected rats with 50 metacencariae of C. sinensis each were treated orally with various dosages of albendazole. In the result, anthelmintic effect was confirmed at the dosage of albendazole with 2×25㎎/㎏×2 days (total amounts 100㎎/㎏). 3. Macrocopital examination was to the clonorchis worms which were collected from the bile ducts of the rats autopsied at 24 hours after treatment with albendazole. The lack of intestinal contents was observed in most of worms from the groups treated with 1×200 ㎎/㎏ and 2×25 ㎎/㎏×2 or 4 days, and the elongation of the anterior portion of the worm body was also observed n the worms from the groups treated with 2×25 ㎎/㎏×2 or 4 days. 4. In the scanning electron microscopic observation, many blebs were fromed on the surface of the damaged tegument of the worms at 24 huors after treatment with albendazole(1×200 ㎎/㎏ and 2×25 ㎎/㎏×2 or days). 5. The transmissions electron microscopic observation indicated that degeneration of mitochonriae and destruction of tegumental syncytium of the worms at 24 hours after treatment with albendazole(1×200 ㎎/㎏ and 2×25㎎/㎏ or 4 days). Inaddition to the findings the degeneration of the intestinal lamellae in the caeca was also observed in the worms from the groups treated with same dosages of albendazole.

Helicobacter pylori 항원을 이용한 면역우유 생산 및 항체특성에 관한 연구

배만종,김수정,예은주,김병기,박창호,김미경 경산대학교 생명자원개발연구소 2003 생명자원과 산업 Vol.7 No.-

본 연구는 위염, 위궤양, 위림프종 및 위암과 같은 소화기 질환의 원인균으로 알려진 Helicobacter pylori균을 항원으로 하여 젖소에 면역시킨 후 생산된 우유의 anti-H. pylorigkdcp의 생성능을 검토하고, 백신투여량과 항체 생성과의 관계, 항원 항체의 특이성, H. Pylori균 응집력, 항체의 산과 열에 대한 안정성, 그리고 백신투여가 젖소에 미치는 영향을 알아보았다. 1. 백신 투여량에 따른 혈청과 유청내의 anti-H. pylori항체의 함량은 10㎖, 20㎖, 30㎖ 백신투여 모든 군에서 대조구에 비해서 높은 양의 항체 생성을 확인하였다. 유의적인 차이는 없었으나 20㎖투여가 항체 생성이 가장 많은 것으로 조사되었다. 백신 투여량에 따른 유청내의 anti-H. pylori항체 생성량은 혈청에서 나타난 결과와 유사한 양상으로 형성되었다. 2. Anti-H. pylori항체의 SDS-PAGE에 의한 분자량측정 결과 heavy chain은 50kDa정도, light chain은 24kDa정도로 확인 되었다. 3. H. pylori항원 단백질의 분자량측정 결과 12개의 band가 형성되었다. Anti-H. pylori의 항원 특이성을 알아보기 위해 western bloting을 한 결과 혈청, 혈청정제, 유청, 유청 정제 모두 7개의 항원성 물질을 확인할 수 있었고, 주 항 원성 물질은 분자량이 97, 66, 34kDa 이었다. 4. 응집반응결과 유청속의 anti-H. pylori항체가 H. pylori균에 대해 1/10의 응집가를 나타내었다. 5. Anti-H. pylori항체의 산·알칼리에 대한 안정성 실험에서는 pH 5 ∼ pH 10 범위에서 안정한 상태로 100%의 활성을 나타내었다. 6. Anti-H. pylori항체의 열에 대한 안정성 실험에서는 60℃에서 60분간 안정한 상태를 보였고, 70℃에서도 비교적 안정한 상태였으나 60분 경과후 40%정도 활성이 감소하였다. 80℃에서는 4분간 처리했을 때 77%의 활성을 유지하였고, 100℃에서도 1분간은 비교적 안정한 상태였다. 7. 백신투요로 인하여 유량이 12% 감소하는 경향을 나타냈고, 최장 1주일 정도 지나면서 회복되었다. 8. 백신투여 후 젖소의 체온을 측정한 결과 대조구에 비해 정상적인 범위 내에서 체온이 상승하는 경향을 나타내었다. This study has been to examine bio-function of anti-H. pylori antibodies of milk produced from cows immune with antigen germ of Helicobacter pylori and search the relation between vaccine dosage volume and antibody formation, peculiarity of antigen antibody, cohesion of H. pylori germ, stability about add and heat of antibody, and impact of vaccine dosage on cows. The content of serum and Anti-H. pylori antibody within whey in accordance with vaccine dosage volume has confirmed the formation of high-quantified antibody compared to the controlled conditions in all groups vaccine dosages of 10㎖, 20㎖, and 30㎖. It has been turned out that the antibody was farmed most in 20㎖ dosage on while there was no attention difference. The molecular weight of Anti-H. pylori antibody measured by SDS-PAGE were turned out as about 50kDa in the heavy chain and about 24kDa in the light chain. 12 bands were formed as the result of measured molecular weight of antibody protein. The western blotting was performed in order to examine the antigen peculiarity of Anti-H. pylori that all 7 antigen substances including serum, serum refining, whey and whey refining could be confirmed and the main antigen substances were 97, 66, 34kDa of molecular weight. As a result of cohesive response Anti-H. pylori antibody in whey showed 1/10 cohesive rate about H. pylori germ. In stability test about acid and alkali of antibody there was 100% activated in the range of pH 5-pH 10. In stability test about heat it showed stable condition in 60℃: for 60 minutes and comparatively stable condition in 70℃, but reduced activation to 40% after 60 minutes. It maintained 77% activation in 80℃ for 4 minutes and comparatively stable in 100℃ for I minute. It was inclined to reduce to 12% of flow caused by vaccine injection, but recovered after about maximum 1 week. In measurement of body temperature of cows after vaccine injected, it was inclined to rise with the normal scope in comparison with the controlled conditions.

직류전위차법에 의한 피로균열 진전속도 측정시스템의 제작

배성인,차정환,김종섭,최수준 國立 昌原大學校 産業技術硏究所 1995 産技硏論文集 Vol.9 No.-

Automatic fatigue crack length measuring system using DC electrical potential method and the system control program for automatic fatigue testing under random load condition were made in this study. And using these system and control program, fatigue tests were executed under constant and random load condition. As the result, the propagation of crack in random loading can be represented Paris equation and log normal probability function. But, constant and random load test show different crack propagation properties.

數學 및 科學 敎育 授業現場에서의 Portfolio의 適用 : 基礎 硏究(Ⅰ) Preliminary Study(Ⅰ)

裵鐘洙,徐熹愛 서울교육대학교 과학교육연구소 1995 科學과 數學敎育 論文集 Vol.21 No.-

The term portfolio has become a popular word in areas of educational research. Unfortunately, the background of educational theories and philosophical perspectives has not been clearly established to support the effectiveness of the use of portfolios in classrooms. In this study, we have reviewed the definitions of portfolio, have analyzed the effectiveness of portfolio in mathematics and science education, and have discussed suggestions and guidelines for teachers how to use portfolios in their classroom. Further, from this study, we proposed that portfolio is grounded in learning process which aligned with Constructivism and individualized instruction. Learning characteristics of students in portfolio classroom include self-refelction upon their own learing, continuous growth in learning, and self-motivated learning. Students also improve academic, personal management, and teamwork skills in the process of learning. Particularly, the use of portfolio in science and mathematics classrooms enhance student's problem solving skill, creativity, reasoning skill, scientific thinking skill, and ability to apply knowledge to real world. It was recommended that teachers and teacher educators need to understand the nature of portfolio in order to effectively implement portfolios in classrooms. Changes in current classroom culture toward portfolio approach would stimulate more effective student learning and improve science and mathematics education in the country.

난소에서 발생한 내배엽동 종양 1예

김종수,최승도,선우재근,배동한 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

The endodermal sinus tumor(EST) of ovary is originated from the undifferentiated primitive germ cell of the embryonal stage. This tumor is the third most frequent malignant germ cell tumors of the ovary and highly malignant. About one-third of patients are premenarcheal at the time of diagnosis. Acute abdominal or pelvic pain is the most initial symptom. The treatment of the EST consists of surgical exploration, unilateral salpingo-oophorectomy and a frozen section for diagnosis. All patients with ESTs are treated with either adjuvant or therapeutic chemotherapy. We experienced one case of the endodermal sinus tumor of the ovary in 21 years old women, who had complaint with abdominal distension and pain. So we report the case with brief review of literatures.

Forced eruption을 이용한 매복 전치의 치험례 : FORCED ERUPTION FOR IMPACTED ANTERIOR TOOTH

공석배,김종수,유승훈 大韓小兒齒科學會 2005 大韓小兒齒科學會誌 Vol.32 No.3

영구 전치의 매복은 제 3대구치나 견치에 비해서 드물게 나타나지만 학령기 아동에서 관찰할 수 있다. 매복치아의 원인은 외상, 공간 부족, 치아의 맹출 경로상에 위치하는 과잉치, 유치의 치근단 감염 등 다양하다. 매복된 치아는 부정교합과 인접치아의 치근 흡수, 낭종 등의 병적 변화를 유발할 수 있으므로 임상적 검사와 방사선학적 검사를 통해 정확한 위치를 확인하고, 적절한 치료계획을 통해 정상 맹출을 유도하여야 한다. 매복된 치아가 병적 변화를 일으킨 경우나 인접치에 손상을 주었을 경우에 발치를 시행하게 된다. 그러나 교정적 견인을 통해 기능과 심미성을 회복시켜 줄 수 있으므로 조기 발견과 발견시의 올바른 진단과 치료 계획을 수립하는 것이 중요하다. 교정적 견인시에는 매복치를 배열할 공간의 확보와 고정원에 대한 고려가 선행되어야 한다. 견인시 적절한 방향의 힘을 통해서 치근의 흡수 등의 부작용이 일어나지 않도록 해야 한다. 본 증례는 매복된 전치들을 forced eruption을 통해서 정상적인 맹출 방향으로 유도한 치험례이다. Impaction of permanent incisor occurs rare than the canine & third molar. But it s often observed in school age child. The causes of impaction are trauma, space deficiency, mesiodens, infections of root apex, etc. In spite of elimination of cause, normal eruption of impacted tooth is rare. Though eruption is normal, the position of tooth will be incorrect. Because the impacted tooth results in malocclusion, root resorption of adjacent tooth, pathologic cystic change, it should be confirmed the precise position by clinical and radiographic exam and found the correct location by appropriate treatment plan. In case of pathologic change of impacted tooth and injury to adjacent tooth, it will be extracted. But through orthodontic retraction, the function and esthetics of tooth can be restored. It is important that impacted tooth should be detected early and diagnosed correctly, and appropriate treatment plan should be made. Before impacted tooth is retracted, the considerations of space for alignment and anchorage should be preceded and through appropriate force and mechanics, the side effects, for example, a root resorption should be minimized. In this study, we guided impacted tooth to normal position by using a forced eruption.

산전 초음파로 진단된 척추이분증 1예

김종수,최승도,선우재근,배동한 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Open neural-tube defects are myelomeningocele that are covered by skin. Leakage of α-fetoprotein(AFP) from the cerebrospinal fluid(CSF) into the amniotic fluid results in an increased transport of AFP into the maternal circulation. Screening by maternal serum AFP analysis has results in an increased ability to detect these lesions prenatally. So, the prenatal diagnosis of spina bifida include the fetal sonography and maternal serum α-fetoprotein(MSAFP). Recently, the prenatal sonographic diagnosis of myelomeningocele has been enhanced by recognition of specific grain abnormalities. It is characterized by visualization of the spinal defect and associated cranial abnormalities: ventriculomegaly, small biparietal diameter, microcephaly, obliteration of the cisternal magna and "fruit" sign, which include the lemons sing, and the banana sign. We report one case of spina bifida diagnosed with meningomyelocele at 22weeks of pregnancy by sonograph with a brief review of literatures.