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Park, S R,Kong, S-Y,Nam, B-H,Choi, I J,Kim, C G,Lee, J Y,Cho, S J,Kim, Y W,Ryu, K W,Lee, J H,Rhee, J,Park, Y-I,Kim, N K Nature Publishing Group 2011 The British journal of cancer Vol.104 No.7
<P><B>Background:</B></P><P>We evaluated the association between polymorphisms of cytochrome P450 2A6 (<I>CYP2A6</I>)/excision repair cross-complementation group 1 (<I>ERCC1</I>)/X-ray repair cross-complementing group 1(<I>XRCC1</I>) and treatment outcomes of metastatic gastric cancer (MGC) patients treated with S-1/cisplatin.</P><P><B>Methods:</B></P><P>Among MGC patients (<I>n</I>=108), who received S-1 (40 mg m<SUP>−2</SUP> b.i.d., days 1–14) and cisplatin (60 mg m<SUP>−2</SUP>, day 1) every 3 weeks, we analysed the wild-type allele (<I>W</I>) and variants (<I>V</I>) of <I>CYP2A6</I> (<I>*4</I>, <I>*7, *9, *10</I>), and the polymorphisms of <I>ERCC1</I> (rs11615, rs3212986) and <I>XRCC1</I> (rs25487).</P><P><B>Results:</B></P><P>Patients having fewer <I>CYP2A6</I> variants had better response rates (<I>W</I>/<I>W vs W</I>/<I>V</I> other than <I>*1/*4 vs V</I>/<I>V</I> or <I>*1/*4</I>=66.7 <I>vs</I> 58.3 <I>vs</I> 32.3% <I>P</I>=0.008), time to progression (TTP) (7.2 <I>vs</I> 6.1 <I>vs</I> 3.5 months, <I>P</I>=0.021), and overall survival (23.2 <I>vs</I> 15.4 <I>vs</I> 12.0 months, <I>P</I>=0.004). <I>ERCC1 19442C</I>><I>A</I> (rs3212986) was also associated with response rate (<I>C/C</I>, 46.7% <I>vs C/A</I>, 55.3% <I>vs A/A</I>, 87.5%) (<I>P</I>=0.048) and TTP (4.4 <I>vs</I> 7.6 <I>vs</I> 7.9 months) (<I>P</I>=0.012). Patients carrying both risk genotypes of <I>CYP2A6</I> (<I>V</I>/<I>V</I> or <I>1/*4</I>) and <I>ERCC1 19442C</I>><I>A</I> (<I>C/C</I>) <I>vs</I> those carrying none showed an adjusted odds ratio of 0.113 (<I>P</I>=0.004) for response, and adjusted hazard ratios of 3.748 (<I>P</I>=0.0001) for TTP and 2.961 (<I>P</I>=0.006) for death.</P><P><B>Conclusion:</B></P><P>Polymorphisms of <I>CYP2A6</I> and <I>ERCC1 19442C</I>><I>A</I> correlated with the efficacy of S-1/cisplatin.</P>
31 위점막의 장상피화생 아형에서 trefoil peptide (TFF1, TFF2, TFF3)의 발현
김병욱 ( B. W. Kim ),이아원 ( A. W. Lee ),이교영 ( K. Y. Lee ),김경미 ( K. M. Kim ),김재광 ( J. K. Kim ),이보인 ( B. I. Lee ),최황 ( H. Choi ),조세현 ( S. H. Cho ),최규용 ( K. Y. Choi ),채현석 ( H. S. Chae ),김성수 ( S. S. Kim ),정인식 대한소화기학회 2002 대한소화기학회 추계학술대회 Vol.2002 No.-
김원석 ( W. S. Kim ),이기명 ( K. M. Lee ),차충근 ( C. K. Cha ),김덕기 ( D. K. Kim ),김영배 ( Y. B. Kim ),유병무 ( B. M. Yoo ),김진홍 ( J. H. Kim ),김영수 ( Y. S. Kim ),조성원 ( S. W. Cho ),함기백 ( K. B. Hahm ) 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
위암의 발생에 관여하는 종양 억제 유전자로는 p53이 잘 알려져 있으며, 주요 작용 기전 중의 하나가 apoptosis 장애 및 cell cycle 조절 실패로 보고되고 있다. 그러나 위암에서 p53의 변이는 30-65% 정도로 보고되고 있어 나머지 위암에서 발암 기전은 의문으로 남아있다. 최근에는 pS2/TFF1 단백질의 변이가 암화의 초기에 관여한다는 사실과 pS2/TFF1 knockout mice에서 위암의 발생되었다는 보고로 위암 발생시 pS2/
포스터 발표 : 간 ; HBeAg 음성 만성 B 형 간염 환자에서 precore와 core promoter mutation이 간염의 경과에 미치는 영향 분석
이미경 ( K. M. Lee ),김성우 ( S. W. Kim ),김원석 ( W. S. Kim ),박소윤 ( S. Y. Park ),김영수 ( Y. S. Kim ),함기백 ( K. B. Hahm ),김진홍 ( J. H. Kim ),조성원 ( S. W. Cho ) 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
〈목적〉 만성 B형 간염에서 HBeAg이 음전되면 대부분의 환자에서 바이러스의 증식이 감소되고 간염의 임상 양상이 호전된다고 알려져 있다. 그러나 HBeAg이 음성인 환자에서도 심한 간염이 지속되는 경우가 관찰되고 있으며, 간염 바이러스의 precore 또는 core promoter에 mutation이 있는 경우 HBeAg의 생산에 장애가 초래되고, precore mutation은 간염의 임상 양상에도 영향을 준다는 보고도 있다. 따라서 연자 등은 HB
Paenibacillus pueri sp. nov., isolated from Pu'er tea
Kim, B.-C.,Jeong, W.-J.,Kim, D. Y.,Oh, H.-W.,Kim, H.,Park, D.-S.,Park, H.-M.,Bae, K. S. Microbiology Society 2009 International journal of systematic and evolutiona Vol.59 No.5
<P>Pu'er tea is a fermented drink made from the leaves of the tea plant, Camellia sinensis. Two novel bacteria, designated strains b09i-3(T) and b13i-1, were isolated during the process of fermentation of this tea. These isolates were Gram-positive, endospore-forming, motile rods that grew at 25-42 degrees C and pH 5.5-10.4. The DNA G+C content was 56.6-58.4 mol%, the predominant isoprenoid quinone was MK-7 and the predominant cellular fatty acid was anteiso-C(15 : 0) (49.0-50 % of the total). Phylogenetic analysis based on 16S rRNA gene sequences showed that strains b09i-3(T) and b13i-1 shared 99.9 % similarity and were affiliated with a cluster within the family Paenibacillaceae. Strains b09i-3(T) and b13i-1 were related most closely to Paenibacillus ginsengihumi DCY16(T) (97 % 16S rRNA gene sequence similarity). Levels of DNA-DNA relatedness between the two novel isolates and P. ginsengihumi DCY16(T) were below 56 %. The phylogenetic and phenotypic characteristics of these novel isolates allowed them to be distinguished clearly from recognized species of the genus Paenibacillus. Based on these data, strains b09i-3(T) and b13i-1 are considered to represent a novel species of the genus Paenibacillus, for which the name Paenibacillus pueri sp. nov. is proposed. The type species is b09i-3(T) (=KCTC 13223(T)=CECT 7360(T)).</P>
산란계 개량에 관한 연구 1 . 순계의 생산능력 비교시험
상병찬,강만석,김동곤,한성욱 ( B . C . Sang,M . S . Kang,D . K . Kim,S . W . Han ) 한국축산학회 1980 한국축산학회지 Vol.22 No.5
This experiment was carried out to test performance of the domentic purebred fowl. The purpose of this experiment was to compare the productive performance of the purebred fowl to obtained basic materials for laying performance improvement by means of cross breeding. In this study, 1, 200 chickens was used-that is 6 purebred strains White Leghorns(720 chickens), 1 purebred strain Rhode Island Reds (120 chickens), 1 purebred strain New Hampshires (120 chickens). The results obtained in this study are as follows; 1. The average Viability of brooding, rearing and laying period was best for Rhode Island Reds and E. Strain among White Leghorns. 2. The average body weight at 8 weeks, first egg production days, 500days of age in W. L. was 546.86g. 1431.37g, 1738.34g, respectively, but there was no significant difference among. purebred strains of W. L. 3. The average Sexual maturity of 50% egg production was 170.58 days in W. L., but R. I. R. and S. N. H. were 189.94 days, 182.42days, respectively. There was significant difference at 1 % level among Strains. 4. The average hen-housed egg production was 214.16 eggs in W. L., but R. I. R. and S. N. H. were 214.22 eggs, 196.74 eggs, respectively. There was significant difference at 1% level among Strains, but the highest hen-housed egg production (231.84 eggs) was E. Strain among strains. 5. The average egg weight was 54. 48g in W. L, but R. I. R. and .S. N. H. were 56.12g, 54.90g, respectively, The highest egg weight (57.69g) was Coronial Strain of W. L. among strains. There was significant difference at 1 % Level among strains. 6. The average feed requirement was 3.01 in W. L. but R. I. R. and S. N. H. were 3.23, 3.52, respectively the highest feed requirement (2.79) was Coronial Strain of W. L. among strains. There was significant difference at 1 % level among strains. 7. On the basis of the results of this study, the productive performance was best for C. D. E. strains among W. L. and R. I. R.
알코올성 위염 발생시 cytokine/chemokine의 발현 및 항산화제에 의한 예방효과
안병옥 ( B. O. An ),이기명 ( K. Y. Lee ),김성우 ( S. W. Kim ),박소윤 ( S. Y. Park ),김정은 ( J. E. Kim ),김영배 ( Y. B. Kim ),오태영 ( T. Y. Oh ),김원배 ( W. B. Kim ),김진홍 ( J. H. Kim ),유병무 ( B. M. Yoo ),조성원 ( S. W. Cho ),함기백 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
<목적> 알코올에 의한 위점막의 손상 기전으로는 nonprotein sulfhydryl 농도의 감소, reduced glutathionine의 감소, 위산분비 증가, 위액 내 prostaglandin의 감소, 산소 라디칼의 증가로 위염 및 위점막 출혈이 발생하고, 이러한 병변이 진행되면서 위미란과 위궤양으로 진전된다. 그러므로 알코올에 의한 위점막 손상시에 염증 정도를 결정할 수 있는 cytokine (IL-1β, TNF-β, IL-3, IL-4, IL
김창주(C . J . Kim),김병완(B . W . Kim) 한국축산학회 1991 한국축산학회지 Vol.33 No.5
This experiment, as a part of tire studies on soiling forage production for the dairy farm in the Taekw-anryong area was curried out to determine the appropriate keel and method of nitrogen application and examine proper level of lime application to the forage rape(Brassica napus Subsp. oleifera) Two cultivars of the forage rape, Akela and Ramon. were sown on the experimental field(840m above sea level) located in Hoengke-2-ri Toam-myon Pyongchang-gun Kangwon-do. Korea. and they were harvested 70 days after the sowing The plot, of nitrogen treatment consisted of three-level plots applied with 80㎏/㏊ 160 ㎏/㏊ and 240㎏/㏊ of nitrogen. respectively and each level of nitrogen was applied through two methods. One of the methods was applying the whole amount of nitrogen us basal fertilizer (treatment mark:B100). and the other was applying one half of the nitrogen as basal fertilizer and the other half as top dressing(treatment mark: B50/T50). the plots of lime treatment consisted 01 three-level plots applied with 0㎏/㏊, 1500㎏/㏊ and 3000㎏/㏊ of lime. respectively. The results obtained were summarized a, follows 1. In plant length in the B100. Ramon marked 41.9㎝ 48.8㎝ and 53.6㎝ in the plots of 80㎏/㏊, 160㎏/㏊ and 240㎏/㏊ of nitrogen level. respectively Akela was shorter than Ramon by 1.9-3.7㎝ and the B50/T50 was shorter than the B1011 by 3.9-4.1㎝ in the both cultivars. Throughout the three level of lime application. tile plant length of Akela and Ramon ranged narrowly in 46.5-47.8㎝ and 49.3-51.1㎝ respectively: differences of plant length found among all the levels of lime application were slight. 2. In fresh forage yield in the B100, Akela and Ramon showed 32.12t/㏊ and 38.61t/㏊. 37.63t/㏊ and 52.08 t/㏊ 43.86 and 59.01t/㏊ in the plots of 80㎏/㏊ 160㎏/㏊ and 240㎏/㏊ of nitrogen level, respectively. Fresh forage yield of the B50/T50 was lower than the B100 by 4.01t/㏊ in Akela, and by 9.52t/㏊ in Ramon. Throughout the three levels of lime application. the fresh forage yield of Akela ranged narrowly in 36.18-36,70t/㏊ and Ramon narrowly in 50.64-50.82t/㏊: the effect of lime application was inconsiderable. 3. In dry matter yield in the B100, Ramon recorded 5.14t/㏊ 6.82t/㏊ and 7.22t/㏊ in the plots of 80㎏/㏊, 160㎏/㏊ and 240㎏/㏊ of nitrogen level respectively: the yield increased remarkably along with the rising level of nitrogen application(p$lt;0.05). Ramon recorded higher dry matter yield than Akela by 16.8%, 5% and 37.0% in the plots of 80㎏/㏊, 160㎏/㏊ and 240㎏/㏊ of nitrogen level, respectively(p$lt;0.05). The B50/T50 was lower in dry matter yield than the B100 by 10.0% in Akela, and by 24.3% in Ramon(p$lt; 0.05). Significant differences were not recognized among all the levels of plot treated by lime, with Akela ranging narrowly in 4.92-5.14t/㏊ and Ramon narrowly in 6.84-7.07t/㏊. 4. It seems that the appropriate level of nitrogen application is 240㎏/㏊ in the Tackwanryong area. 5. It is recommendable that the whole amount of nitrogen should he applied only as basal fertilizer rather than splitting it into one half as basal fertilizer and the other half as top dressing. 6. It is difficult to confirm the necessity of lime application.