연구의 즐거움, 임상의뿌듯함

함기백 생화학분자생물학회 2012 생화학분자생물학회 소식 Vol.32 No.3

위암과 대장암이 병발한 가족성 대장 용종증 1예

함기백,방수관,안용진,백승운,김은주,윤세옥,홍성란,최규식,유승익,차중직 ( Ki Baik Hahm,Soo Kwan Bang,Yong Jin Ahn,Seung Woon Paik,Eun Joo Kim,Se Ok Yoon,Sung Ran Hong,Kyu Shik Choi,Seung Ik Yoo,Joong Jik Cha ) 대한소화기학회 1992 대한소화기학회지 Vol.24 No.1

Familial adenomatious polyposis (FAP) includes early development of up to thousands of colorectal adenoma and of coloaic adenocarcinoma in all untreated cases. Moreover, a variety of extracolonic manifestation are seen. Several reports have demonstrated a high incidence of gastroduodenal polyps in FAP patient. Fundic gland polypois is found in half of polyposis patient, It is an non-geoplastic condition with hundreds of sessile polyps in the gastric fundus consisting of cystic dilated fundic glands without epithelial dyeplasia, In western countries, gastric adenoma and carcinoma are rare findings in FAP patients. Until present time, only 2 cases in western countries and 8 cases in Japanese series were reported in literature. So it is generally suggested that the development of gastric carcinoma is related not only to racial and environmental factors, but also to a genetic effect, this may be the first case-report in Korea. Here we report the case with familial adenomatous polyposis, presenting with gastric and colonic adenocarcinoma.

각종 간질환 환자에서 혈중 lipoprotein ( a ) 농도의 변화

함기백,김원호,한광협,전재윤,강진경,박인서,최홍재 ( Ki Baik Hahm,Won Ho Kim,Kwang Hyub Han,Chae Yoon Chon,Jin Kyung Kang,In Suh Park,Heung Jai Choi ) 대한소화기학회 1992 대한소화기학회지 Vol.24 No.2

Lipoprotein (a) [Lp (a)] is a LDL-like lipoprotein whose concentrations in plasma are significantly are correlated with atherosclerosis. The characteristic protein compoment of Lp (a) is apoliporotein (a) which is linked to apolipoprotein B-100 by disulfide bonds. Although Lp (a) might play an important role in the development of premature atherosclerotic vascular lesions, only scarse information about the metabolism of this lipoprotein is available. The major site of synthesis of Lp (a) appers to be the liver because it was found that a complete conversion of the Lp (a) phenotype of thc receipient to that of the donor occurs after liver transplantation and presence of apo (a) mRNA in human liver and hepatoma cell line. Until the present time, little information is available about determining the influence of liver disease on Lp (a) concentration. This study was designed to find out the changes of Lp (a) concentrations in 88 patients with various liver diseases, diagnosed histologically through the peritoneoscopic liver biopsy. The Lp (a) concentrations were checked by the method of radioimmunoassay. The mean Lp (a) concentrations of CAH with LC (6.1+4.8 mg/ml) and LC group (4.1+2,2 mg/ml) were significantly lower than those of normal control (24.4+19.1 mg/ml), CPH (25.4+18.5mg/ml), and CAH group (16.6+13.7 mg/ml). The Lp (a) concentrations were significantly correlated with serum albumin concentrations (r=0.54 p<0.05) and prothrombin time (r=0.62, p<0.01). There was a significant difference in mean Lp (a) coincentration between the cases with serum albumin above and below 3.0 g/ml in patients with liver cirrhosis. These data suggest that lipoprotein (a) may be secreted frorn the liver in accordance with the capability of liver to synthesize the protein and we find out that as the liver diseases progressed and deteriorated, the levels of Lp (a) concentrations were significantly decreased.

알코올에 의한 간손상시 적혈구막 지질 과산화현상의 역할

함기백,김원호,전재윤,문영명,강진경,박인서,최홍재,장학철,김한수,백승운,신용운 ( Ki Baik Hahm,Won Ho Kim,Chae Yoon Chon,Young Myung Moon,Jin Kyung Kang,In Suh Park,Heung Jai Choi,Hak Chul Jang,Han Soo Kim,Seung Woon Paik,Yong Woon Shin 대한소화기학회 1992 대한소화기학회지 Vol.24 No.2

The question of whether or not ethanol-induced liver injury is related to or accompanied by lipid peroxidation has been a subject of controversy. Short-term ethanol administration was shown by some to produce hepatic lipid peroxidation in rats, but very large doses of ethaol had to be used. Furthermore, some investigators failed to confirm these effects of ethanol. Fewer studies have explored the relationship between alcohol consumption and lipid peroxidation. In order to study this question and clarify the role of oxygen derived free radicals and lipid peroxidation of the RBC in inducing the alcoholic liver diseases, we measured the thiobarbituric acid reactivities in normal controls and patients with alcoholic liver disease. The subjects were divided into three groups according to the liver function tests and the amounts of alcohol drinking: group I-normal controls, group II-cases showing normal liver function test in spite of frequent alcohol drinking over 3 days per week and 45 g alcohol per one time, group III-patients with alcoholic liver disaesae, drinking alcohol over 4 times per week. The thiobarbituric acid reactive substances were measured as a marker of lipid peroxidation by the method of Uchiyama and Mihara. The colorimetric method was used by a measurment of malonyldialdehyde [MDA, nmole/ml (packed cells)] concentration. The results were as follows; (continue...)

만성 B형 활동성 간염에서 poly ( A ). poly ( U ) 의 치료 효과

함기백,김원호,한광협,임대순,전재윤,문영명,강진경,박인서,최흥재,윤정구 ( Ki Baik Hahm,Won Ho Kim,Kwang Hyub Han,Dae Soon Yim,Chae Yoon Chon,Young Myung Moon,Jin Kyung Kang,In Suh Park,Heung Jai Choi,Jung Koo Youn ) 대한소화기학회 1992 대한소화기학회지 Vol.24 No.3

The two major approaches to the treatment of chronic hepatitis B are 1) directed toward the eradication of the virus and 2) designed to modulate cellular and humoral immunity. Progress has been made in the development of antiviral chemotherapeutic agents for hepatitis B, but as yet no safe and reliably effective treatment or combmations of treatments are available. It has been demonstrated that interferon is useful in suppressing hepatitis B viral replication, but the relatively low response rate of Asian patients to interferon treatment has been documented due to the fact that mostly they acguired infections perinatally or during childhood. Poly(A). poly(U) is a double stranded helical ribopolyuncleotide complex, which stimulates both humoral and cell mediated immune response, and enhances the splenic NK activity as well as induces the production of the interferon. In this study, we have measured sequentially the leveils of alanine aminotransferase (ALT) and 2, 5-oligoadenylate synthetase (2-5 AS) activities and hepatitis B viral markers in patients with histologically proven chronic active heaptitis after weekly intravenous injection of poly(A). poly(U) to find out that poly(A). poly(U) may be used as the therapeutic agent in the treatment of chronic active hepatitis B. The results were as follows: ALT levels after the weekly administrations of poly(A).poly(U) have declined significantly to the normal level except one case as times passed, especially after 5 weeks. Serum 2-5 AS activities were elevated significantly after the administration of poly(A).poly(U). The complete responses were noted in four cases out of eleven cases (36.4%) until 5 months after discontinuance of poly(A).poly(U). The partial responses were noted in five cases (45.5%). No specific side effects were noted except the light-headness just one time in only one case. In conclusion, the administration of poly(A).poly(U) in the patients with chronic active hepatitis B seems to be effective, simple and safe method, although more extensive and detailed immunologic researches are required.

대한내과학회 연구비 결과보고 : 위선암세포주에서 retinoic acid투여가 암세포주성장 및 ornithine decarboxylase 활성도와 superoxide dismutase와의 synergistic 효과 및 heat shock protein 발현에 미치는 영향

함기백 대한내과학회 1999 대한내과학회 춘계학술발표논문집 Vol.56 No.1

Cysteamine 이 백서의 십이지장궤양 형성시 미치는 영향

함기백,이상인,임대순,김원호,전재윤,문영명,강진경,박인서,최홍재,박형우 ( Ki Baik Hahm,Sang In Lee,Dae Soon Yim,Won Ho Kim,Chae Yoon Chon,Young Myung Moon,Jin Kyung Kang,In Suh Park,Heung Jai Choi,Hyung Woo Park ) 대한소화기학회 1992 대한소화기학회지 Vol.24 No.4

The administration of cysteamine is koown to produce duodenal ulcer in rat. Mucosal damage starts to appear in the duodenal bulb after a delay of 4-8 hous after administration of cysteamine, but despite of several studies, the pathogenesis is not fully understood yet. The aim of the present study was to investigate the role of the various factors such as acid, motility, GABA, and primary afferent neuron on cysteamine-induced duodenal ulcer through the experiments using the Sprague-Dawley rats. (continue...)

알코올에 의한 간손상시 적혈구막 지질 과산화현상의 역할

함기백,박인서,김원호,최홍재,전재윤,문영명,강진경,장학철,김한수 大韓消化器病學會 1992 大韓消化器病學會誌 Vol.24 No.2

만성 B형 활동성 간염에서 poly(A) poly(U)의 치료 효과

함기백,김원호,한광협,임대순,전재윤,문영명,강진경,박인서,최홍재 大韓消化器病學會 1992 大韓消化器病學會誌 Vol.24 No.3

Helicobacter pylori 감염과 위암발생

함기백,정재연 주식회사 녹십자 2002 녹십자의보 Vol.30 No.6