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1
Anti-Platelet Fraction from Galega officinalis L. Inhibits Platelet Aggregation

Bojidar Tchorbanov,Atanas Todorov Atanasov 한국식품영양과학회 2002 Journal of medicinal food Vol.5 No.4
A fraction from crude extract of Galega officinalis L. was purified by gel filtration on SephadexG-25, Sepharose 4B, and ion-exchange chromatography on diethylaminoethyl (DEAE) cellu-lose. The fraction with molecular weight 10 140 kDa apears to have a polysaccharide na-ture, including protein. The fraction inhibits platelet aggregation initiated by 25 mM adeno-sine 59-diphosphate (ADP), 10 mg/ml collagen, and 0.8 U/ml thrombin with the 50% inhibitingconcentration (IC 50) being 1.2 mg/ml for ADP, and the IC 10 being 15.1 mg/ml for collagenand IC10 19.6 mg/ml for thrombin.29
2
Laparoscopic combined colorectal and liver resections for primary colorectal cancer with synchronous liver metastases

Ivelin Takorov,Nikolay Belev,Tsonka Lukanova,Boiko Atanasov,Georgi Dzharov,Ventzeslav Djurkov,Evelina Odisseeva,Nikola Vladov 한국간담췌외과학회 2016 Annals of hepato-biliary-pancreatic surgery Vol.20 No.4
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- 복사/대출신청
Backgrounds/Aims: Synchronous liver metastases (SLMs) are found in 15-25% of patients at the time of diagnosis with colorectal cancer, which is limited to the liver in 30% of patients. Surgical resection is the most effective and potentially curative therapy for metastatic colorectal carcinoma (CRC) of the liver. The comparison of simultaneous resection of primary CRC and synchronous liver metastases with staged resections is the subject of debate with respect to morbidity. Laparoscopic surgery improves postoperative recovery, diminishes postoperative pain, reduces wound infections, shortens hospitalization, and yields superior cosmetic results, without compromising the oncological outcome. The aim of this study is therefore to evaluate our initial experience with simultaneous laparoscopic resection of primary CRC and SLM. Methods: Currently, laparoscopic resection of primary CRC is performed in more than 53% of all patients in our surgical department. Twenty-six patients with primary CRC and a clinical diagnosis of SLM underwent combined laparoscopic colorectal and liver surgery. Six of them underwent laparoscopic colorectal resection combined with major laparoscopic liver resection. Results: The surgical approaches were total laparoscopic (25 patients) or hybrid technique (1 patients). The incision created for the extraction of the specimen varied between 5 and 8cm. The median operation time was 223 minutes (100 to 415 min.) with a total blood loss of 180 ml (100-300 ml). Postoperative hospital stay was 6.8 days (6-14 days). Postoperative complications were observed in 6 patients (22.2%). Conclusions: Simultaneous laparoscopic colorectal and liver resection appears to be safe, feasible, and with satisfying short-term results in selected patients with CRC and SLM.
3
Therapeutic value of steroidal alkaloids in cancer: Current trends and future perspectives

Dey, Prasanta,Kundu, Amit,Chakraborty, Hirak Jyoti,Kar, Babli,Choi, Wahn Soo,Lee, Byung Mu,Bhakta, Tejendra,Atanasov, Atanas G.,Kim, Hyung Sik Alan R. Liss, Inc 2019 International journal of cancer Vol.145 No.7
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Discovery and development of new potentially selective anticancer agents are necessary to prevent a global cancer health crisis. Currently, alternative medicinal agents derived from plants have been extensively investigated to develop anticancer drugs with fewer adverse effects. Among them, steroidal alkaloids are conventional secondary metabolites that comprise an important class of natural products found in plants, marine organisms and invertebrates, and constitute a judicious choice as potential anti‐cancer leads. Traditional medicine and modern science have shown that representatives from this compound group possess potential antimicrobial, analgesic, anticancer and anti‐inflammatory effects. Therefore, systematic and recapitulated information about the bioactivity of these compounds, with special emphasis on the molecular or cellular mechanisms, is of high interest. In this review, we methodically discuss the in vitro and in vivo potential of the anticancer activity of natural steroidal alkaloids and their synthetic and semi‐synthetic derivatives. This review focuses on cumulative and comprehensive molecular mechanisms, which will help researchers understand the molecular pathways involving steroid alkaloids to generate a selective and safe new lead compound with improved therapeutic applications for cancer prevention and therapy. In vitro and in vivo studies provide evidence about the promising therapeutic potential of steroidal alkaloids in various cancer cell lines, but advanced pharmacokinetic and clinical experiments are required to develop more selective and safe drugs for cancer treatment.