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RISS 인기검색어
- 검색키워드
- 저자 : Anthony J. Afolayan (검색결과 4 건)
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Collise Njume,Anthony J. Afolayan,Anna M. Clarke,Roland N. Ndip 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.7
Problems associated with current treatment regimens have generated a considerable interest in alternative approaches for the eradication of Helicobacter pylori infections using phytochemical compounds. In an attempt to identify potential sources of such compounds, the antimicrobial activity of five solvent extracts of Garcinia kola seeds were investigated against 30 clinical strains of H. pylori and a standard control strain, NCTC 11638, using standard microbiological techniques. Metronidazole and amoxicillin were included in these experiments as positive control antibiotics. All the extracts tested exhibited anti–H. pylori activity with zone diameters of inhibition between 0 and 25 mm. The ethanol extract demonstrated considerable anti–H. pylori activity with a percentage susceptibility of 53.3% and minimum inhibitory concentration for 50% susceptibility (MIC50) values ranging from 0.63 to 5.0 mg/mL. Ranges of MIC50 values for amoxicillin and metronidazole were 0.01–0.63 mg/mL and 0.04–5.0 mg/mL, respectively. The inhibitory activity of the ethanol extract was similar to that of metronidazole (P > .05) as opposed to amoxicillin (P < .05). The extract caused a 12-hour extension of the lag phase of H. pylori at 1.25 mg/mL. The same observations were recorded when this concentration was doubled and quadrupled alongside a killing rate of 80.1% and 93.7%, respectively, after 24 hours and of 100% after 30 hours. These results demonstrate that the ethanol extract of G. kola may contain therapeutically useful compounds against H. pylori.
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Muinat N. Lewu,Musa T. Yakubu,Patrick O. Adebola,Anthony J. Afolayan 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.5
The liver and kidney functional indices of weanling albino rats (Rattus norvegicus) maintained on different accessions (offspring of a variety planted/collected at a specific location and time but differing in certain morphological characteristics) of cooked Colocasia esculenta (cocoyam)-based diets (UFCe1–UFCe7) for 28 days were investigated. All the accessions of C. esculenta-based diets did not significantly (P>.05) alter the serum levels of albumin, globulin, inorganic phosphorus, calcium, magnesium, and uric acid of the animals.The total protein and total bilirubin levels decreased only in the UFCe3- and UFCe4-fed animals, respectively. Whereas UFCe1 and UFCe2 significantly decreased the conjugated bilirubin levels, UFCe3 and UFCe6 increased it. While all the accessions of C. esculenta-based diet decreased the serum alkaline phosphatase activity, γ-glutamyl transferase activity was increased. UFCe1 and UFCe5 increased the serum alanine aminotransferase activity, whereas UFCe4 decreased the activity of the enzyme. Again, UFCe3 and UFCe1 increased the serum creatinine and aspartate aminotransferase activity of the animals. Furthermore, the computed blood urea nitrogen:creatinine ratio was higher in animals maintained on UFCe1-, UFCe3-, UFCe4-, and UFCe5-based diets. Whereas UFCe6 and UFCe7 increased the level of sodium in the serum of the animals, UFCe4 and UFCe5 decreased the chloride level. The serum urea level was decreased by UFCe1, UFCe3, UFCe4, and UFCe5, whereas the potassium level increased in the UFCe4-, UFCe6-, and UFCe7-fed animals. Overall, the results revealed that all the accessions of C. esculenta produced selective effects on the hepatic and renal functional indices of the weanling rats. The highest alterations were produced by UFCe4, whereas the least was from UFCe2. These alterations may have consequential effects on the normal functioning of the liver and kidney of the animals. UFCe2 exhibited the least toxicity risk among the accessions of C. esculenta growing in the KwaZulu-Natal Province of South Africa.
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Muinat N. Lewu,Toyin M. Yakubu,Patrick O. Adebola,Anthony J. Afolayan 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.9
The growth performance of weanling albino rats (Rattus norvegicus) maintained on different accessions (offspring of a variety that was planted/collected at a specific location and time but differing in certain morphologic characteristics) of cooked Colocasia esculenta (cocoyam)–based diets (UFCe1-UFCe7) for 28 days was investigated. Proximate analysis of the formulated diets revealed that UFCe3, UFCe4, UFCe5, UFCe6, and UFCe7 had significantly (P<.05) higher moisture contents than the corn starch–based diet (control). All the accession-based diets of C. esculenta had higher ash contents. Similarly, all the accessions of the C. esculenta–based diet had lower crude lipid content, whereas UFCe3-UFCe7 had significantly lower protein content. Although the crude fiber content was significantly higher in UFCe2, UFCe4, and UFCe5, only UFCe3 had significantly higher carbohydrate content among all the accessions of C. esculenta–based diets. UFCe1, UFCe2, UFCe4, UFCe5, and UFCe6 increased the average weekly water intake, feed consumption, total body weight, liver–body weight ratio, and kidney–body weight ratio of the animals; UFCe3 and UFCe7 decreased these measures. Overall, UFCe1, UFCe2, UFCe4, UFCe5, and UFCe6 are recommended as diets with promise to enhance growth performance in the animals.
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