Surface Crystallinity of Meltspun Isotactic Polypropylene Filaments

Ali Kilic,Keith Jones,심은경,Behnam Pourdeyhimi 한국고분자학회 2016 Macromolecular Research Vol.24 No.1

In this study, surface crystallinity of meltspun polypropylene (PP) filaments was reported. Results obtained from attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy were confirmed with tapping mode atomic force microscopy (TM-AFM) analysis. ATR-FTIR tests were performed directly on longitudinal surfaces of the filaments, where IR radiation penetrates up to a specific depth. TM-AFM measurements were done on microtomed cross-sections of the filaments, which were scanned carefully to investigate stiffness. Annealing enhanced the surface crystallinity of the filaments in a significant way. Interestingly, samples annealed at 70 and 110 oC for 12 h exhibited similar crystallinity on the uppermost 500 nm surface, whereas for the bulk a continuous increase was observed after XRD studies. 12 h annealing at 70 oC modified the endothermic thermogram, while it did not causes significant effect on overall bulk crystallinity. Differences in the behavior of surface and bulk of the fibrous materials should be considered particularly for surface treatment, i.e. plasma, corona discharge, chemical vapor deposition. Results are also pertinent for water and dye absorbency in polymers.

NOTE ON BERTRAND B-PAIRS OF CURVES IN MINKOWSKI 3-SPACE

( Kazim Ilarslan ),( Ali Ucum ),( Nihal Kilic Aslan ),( Emilija Nesovic ) 호남수학회 2018 호남수학학술지 Vol.40 No.3

In this paper, we define null Cartan and pseudo null Bertrand curves in Minkowski space E according to their Bishop frames. We obtain the necessary and sufficient conditions for pseudo null curves to be Bertand B-curves in terms of their Bishop curva-tures. We prove that there are no null Cartan curves in Minkowski 3-space which are Bertrand B-curves, by considering the cases when their Bertrand B-mate curves are spacelike, timelike, null Cartan and pseudo null curves. Finally, we give some examples of pseudo null Bertrand B-curve pairs.

NOTE ON BERTRAND B-PAIRS OF CURVES IN MINKOWSKI 3-SPACE

Ilarslan, Kazim,Ucum, Ali,Aslan, Nihal Kilic,Nesovic, Emilija The Honam Mathematical Society 2018 호남수학학술지 Vol.40 No.3

In this paper, we define null Cartan and pseudo null Bertrand curves in Minkowski space ${\mathbb{E}}^3_1$ according to their Bishop frames. We obtain the necessary and sufficient conditions for pseudo null curves to be Bertand B-curves in terms of their Bishop curvatures. We prove that there are no null Cartan curves in Minkowski 3-space which are Bertrand B-curves, by considering the cases when their Bertrand B-mate curves are spacelike, timelike, null Cartan and pseudo null curves. Finally, we give some examples of pseudo null Bertrand B-curve pairs.

Poster Session : PS 0716 ; Rheumatology ; Ocular Toxicity of Hydroxychloroquine is More Frequent in Male Patients

( Omer Karadag ),( Abdulsamet Erden ),( Levent Kilic ),( Umut Kalyoncu ),( Ali Akdogan ),( Sule Apras Bilgen ),( Sedat Kiraz ),( Ihsan Ertenli ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Hydroxychloroquine(HQ) is widely used to treat for rheumatoid arthritis( RA) and connectice tissue disorders. Due to the potential of ocular toxicity,routine ophtalmological assessment(ROA) is essential for sight safety. Methods: In our outpatient clinic, patients with RA and connective tissue disorders such as systemic lupus erythematosus (SLE), sjogren syndorme (SS) and overlap were assessed consecutively for drug status of HQ by a standard questionnaire between December 2013 and January 2014. Patients who used HQ less than 1 year (13. 6%) were excluded from study. Ocular toxicity was taken from patients` reported. If ophthalmologist advised to cease HQ due to ocular toxicity,we accepted as ocular side effect. Patients with ocular toxicity were not reevaluated by an ophthalmologist. Cumulative HQ dosage and risk factors for ocular toxicity were assessed by using Mann-Whitney U test. Results: A total of 266 patients(90. 6% female) were enrolled. Mean age was 50±13. 5 years and median disease duration was 8 years(1-50). Median duration of HQ treatment was 6 years(1-28) and median dose was 400 mg/day. Of 46(17. 3%) patients were ceased HQ. The reasons of cease of HQ were ocular toxicity 22(47. 8%), patient non-adherence 9(19. 6%),dermatological side effect 3(6. 5%),others 12(26. 1%). 22 of all 266(%8. 3) patients developed ocular toxicity. Ocular toxicity was found more frequently in male 5/20(20%) vs 17/241(7%),p=0. 025). Median cumulative HQ dosage in patients with ocular toxicity was 864 gram (108-2160) in other words 12. 9 gr per kilogram( 1. 2-40). Older age (58±10 vs 50±13,p=0. 008),longer disease duration (14. 8±11. 5 vs 9. 2±7. 1 years,p=0. 013), and longer HQ duration (10±6. 3 vs 7. 1±5. 6 years,p=0. 023)were associated with ocular toxicity. Conclusions: Among regularly follow-up patients, ocular toxicity of HQ was not rare in a rheumatology outpatient clinic. Cumulative toxicity for ocular toxicity was 13 gram/kilogram;however, certain patients developed toxicity in 1 gram/kg/day. Although, important part of our patients was female, ocular toxicity was seen more frequently in male patients. Other risk factors such as longer disease duration,longer HQ usage and older age were also demonstrated in our patients.

Poster Session : PS 0746 ; Rheumatology ; Frequency of Radiological Hip Involvement and total Hip Replacement in A Large Single Center Spondyloarthritis Cohort with Biological Treatments: HUr-BIo Real Life Results.

( Umut Kalyoncu ),( Abdulsamet Erden ),( Omer Karadag ),( Levent Kilic ),( Sule Apras Bilgen ),( Ali Akdogan ),( Ali Ihsan Ertenli ),( Sedat Kiraz ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Total hip replacement (THR) is a favorable treatment option for severe ankylosing spondylitis (AS). Objective of this study was to assess frequency of THR and hip involvement in a single center spondyloarthritis (SpA) biological dataset. Methods: HUR-BIO(Hacettepe University Rheumatology Biologic Registry) is a single center biological registry since 2005. HUR-BIO biological data set included demographic data, co-morbidities, smoking status, baseline and follow-up disease activity parameters (such as BASDAI, BASfi, CRP, ESR). Available digital radiographic imaging of pelvis were reassesed for hip inolvement and THR. Kaplan-Meier plots and log rank tests were used to assess TNfi drug survival. Results: 768 of 1290 (59. 5%) SpA patients had available pelvis radiography. 450 of 768 (58. 6%) patients were male and mean age was 41±11 years old, mean disease duration 8. 6±6. 9 years, mean TNfi duration was 32±29 months. Frequency of hip involvement in spondyloarthritis is in Table 1. Radiological hip involvement and severe hip involvement found in 125 (16. 3%) and 65 (8. 4%) patients, respectively. Patients with severe hip involvement was older age 47±11 vs 41±11, p<0. 001, more disease duration 15±9 vs 8±6 years, p<0. 001, more frequently male 47/65(72. 3%) vs 402/702 (57. 3), p=0. 018), more frequently advanced spinal disease 18/52 (34. 6%) vs 74/576 (12. 8%), p<0. 001. Baseline disease activity parameters were similar with and without severe hip involvement, however, last visit CRP (2. 56±2. 75 vs 1. 06±1. 97 mg/dl, p<0. 001), ESR (24±25 vs 13±14 mm/hour, p<0. 001) and BASfi (4. 7±2. 8 vs 2. 4±2. 1, p<0. 001) were higher in severe hip involvement. Disease duration was found independent risk factor for severe hip inolvement (OR 1. 13(95%CI 1. 09-1. 17). In all spondyloarthritis patients, TNfi drug survival was similar with and without severe hip involvement. Conclusions: Severe hip involvemet was demonstrated either AS or other spondyloarthritis. THR performed almost 5 percent of AS, PsA and enteropathtic arthritis. On the other hand, substantial of AS patients who need THR were not operated yet. The reasons of this delay may be responsible of patients` perspective or physicians. TNfi may not refi ect any major unfavotrable effect of THR.

Obestatin is present in saliva: alterations in obestatin and ghrelin Levels of saliva and serum in ischemic heart disease

Yilmaz Ozbay,Suleyman Aydin,A. Ferda Dag1i,Mehmet Akbulut,Necati Dagli,Nermin Kilic,Ali Rahman,Ibrahim Sahin,Veli Polat,H. Ibrahim Ozercan,Nadi Arslan,Dogan Sensoy 한국생화학분자생물학회 2008 BMB Reports Vol.41 No.1

Efficacy and Safety of Concomitant Chemoradiotherapy with Cisplatin and Docetaxel in Patients with Locally Advanced Squamous Cell Head and Neck Cancers

Baykara, Meltem,Buyukberber, Suleyman,Ozturk, Banu,Coskun, Ugur,Unsal, Diclehan Kilic,Demirci, Umut,Dane, Faysal,Kaplan, Muhammet Ali,Bora, Huseyin,Benekli, Mustafa Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.4

Background: Chemoradiation (CRT) using cisplatin-based regimens has become the standard of care in the treatment of squamous cell head and neck cancers (SCHNC). The impact of taxanes as radiosensitizing agents with concurrent CRT regimens is unknown. We therefore retrospectively evaluated the efficacy and tolerability of a weekly cisplatin+docetaxel combination with CRT in locally advanced SCHNC. Methods: Sixty-six patients with locally advanced SCHNC (39.4% stage IV, 53% stage III, and 7.6% stage II) were assessed retrospectively. Total radiation dose to the PTV of gross disease (primary and/or node) was 70 Gy/35 fractions, 5 fractions per week. Minimum doses of 60 Gy and 50 Gy were administered to PTVs of elective high risk and low risk disease, respectively. Chemotherapy (CT) consisted of weekly cisplatin (20 $mg/m^2$)+docetaxel (20 $mg/m^2$) concurrently with RT. Results: The median age of the patients was 58 years (range, 32-77). Objective response rate was 83.3%. The 2-year progression-free survival (PFS) and overall survival (OS) were 75.7% and 78.3%, respectively. The most common grade 3 and 4 toxicities were mucositis (36.4%), nausea and vomiting (12.1%), neutropenia (4.5%). Conclusion: Weekly cisplatin and docetaxel concurrent with RT for locally advanced SCHNC was found tolerable with high efficacy.