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Cosmic ray oriented performance studies for the JEM-EUSO first level trigger
Abdellaoui, G.,Abe, S.,Acheli, A.,Adams Jr., J.H.,Ahmad Jr., S.,Ahriche Jr., A.,Albert Jr., J.-N.,Allard Jr., D.,Alonso Jr., G.,Anchordoqui Jr., L.,Andreev Jr., V.,Anzalone Jr., A.,Aouimeur Jr., W.,Ar Elsevier BV * North-Holland 2017 Nuclear Instruments & Methods in Physics Research. Vol. No.
<P><B>Abstract</B></P> <P>JEM-EUSO is a space mission designed to investigate Ultra-High Energy Cosmic Rays and Neutrinos ( E > 5 ⋅ 1 <SUP> 0 19 </SUP> eV ) from the International Space Station (ISS). Looking down from above its wide angle telescope is able to observe their air showers and collect such data from a very wide area. Highly specific trigger algorithms are needed to drastically reduce the data load in the presence of both atmospheric and human activity related background light, yet retain the rare cosmic ray events recorded in the telescope. We report the performance in offline testing of the first level trigger algorithm on data from JEM-EUSO prototypes and laboratory measurements observing different light sources: data taken during a high altitude balloon flight over Canada, laser pulses observed from the ground traversing the real atmosphere, and model landscapes reproducing realistic aspect ratios and light conditions as would be seen from the ISS itself. The first level trigger logic successfully kept the trigger rate within the permissible bounds when challenged with artificially produced as well as naturally encountered night sky background fluctuations and while retaining events with general air-shower characteristics.</P>
Performances of JEM-EUSO: angular reconstruction : The JEM-EUSO Collaboration
Adams Jr., J. H.,Ahmad, S.,Albert, J. -N.,Allard, D.,Anchordoqui, L.,Andreev, V.,Anzalone, A.,Arai, Y.,Asano, K.,Ave Pernas, M.,Baragatti, P.,Barrillon, P.,Batsch, T.,Bayer, J.,Bechini, R.,Belenguer, Springer-Verlag 2015 Experimental astronomy Vol.40 No.1
Bill Roschek Jr.,Ryan C. Fink,Dan Li,Matthew McMichael,Christine M. Tower,Robert D. Smith,Randall S. Alberte 한국식품영양과학회 2009 Journal of medicinal food Vol.12 No.3
Rice bran, the outer bran and germ of the kernel and a by-product of rice milling, is rich in phytonutrients but has been underutilized because of lipid content instability. New methods for the processing of rice bran have yielded a stabilized form that is increasingly used in foods and dietary supplements. Recent studies have documented a role for stabilized rice bran (SRB) in treating diabetes and arthritis, although little is known of the bioactive compounds that impart these health benefits. Here we characterize the chemical composition of three extracts of SRB and identify the functional bioactives contributing to the inhibitory properties against three key pro-inflammatory enzymes (cyclooxygenase [COX] 1, COX2, and 5-lipoxygenase [5-LOX]) that control the inflammatory cascade involved in impaired joint health, pain, and arthritis. One extract (SRB-AI) demonstrated significant COX1 and COX2 inhibitory activities with 50% inhibitory concentration (IC50) values for COX1 and COX2 of 305 and 29μg/mL, respectively, but no 5-LOX inhibition. The second extract (SRB-AII) inhibited COX1, COX2, and 5-LOX with IC50 values of 310, 19, and 396μg/mL, respectively. The third extract (SRB-AIII), a blend of SRB-AI and SRB-AIII, inhibited COX1, COX2, and 5-LOX with respective IC50 values of 48, 11, and 197μg/mL. Analysis of the extracts by direct analysis in real time time of flight-mass spectrometry revealed that SRB-AI, SRB-AII, and SRB-AIII contain over 620, 770, and 810 compounds, respectively. Of these, 17 were identified as key bioactives for COX and/or LOX inhibition. These SRB extracts have applications for functional foods and dietary supplements for control of inflammation and joint health.
Roschek, Bill Jr.,Fink, Ryan C.,McMichael, Dan Li, Matthew,Tower, Christine M.,Smith, Robert D.,Alberte, Randall S. The Korean Society of Food Science and Nutrition 2009 Journal of medicinal food Vol.12 No.3
Rice bran, the outer bran and germ of the kernel and a by-product of rice milling, is rich in phytonutrients but has been underutilized because of lipid content instability. New methods for the processing of rice bran have yielded a stabilized form that is increasingly used in foods and dietary supplements. Recent studies have documented a role for stabilized rice bran (SRB) in treating diabetes and arthritis, although little is known of the bioactive compounds that impart these health benefits. Here we characterize the chemical composition of three extracts of SRB and identify the functional bioactives contributing to the inhibitory properties against three key pro-inflammatory enzymes (cyclooxygenase [COX] 1, COX2, and 5-lipoxygenase [5-LOX]) that control the inflammatory cascade involved in impaired joint health, pain, and arthritis. One extract (SRB-AI) demonstrated significant COX1 and COX2 inhibitory activities with 50% inhibitory concentration ($IC_{50}$) values for COX1 and COX2 of 305 and $29\;{\mu}g/mL$, respectively, but no 5-LOX inhibition. The second extract (SRB-AII) inhibited COX1, COX2, and 5-LOX with $IC_{50}$ values of 310, 19, and $396\;{\mu}g/mL$, respectively. The third extract (SRB-AIII), a blend of SRB-AI and SRB-AIII, inhibited COX1, COX2, and 5-LOX with respective $IC_{50}$ values of 48, 11, and $197\;{\mu}g/mL$. Analysis of the extracts by direct analysis in real time time of flight-mass spectrometry revealed that SRB-AI, SRB-AII, and SRB-AIII contain over 620, 770, and 810 compounds, respectively. Of these, 17 were identified as key bioactives for COX and/or LOX inhibition. These SRB extracts have applications for functional foods and dietary supplements for control of inflammation and joint health.
Pollack, Samuela,Igo Jr., Robert P.,Jensen, Richard A.,Christiansen, Mark,Li, Xiaohui,Cheng, Ching-Yu,Ng, Maggie C.Y.,Smith, Albert V.,Rossin, Elizabeth J.,Segrè,, Ayellet V.,Davoudi, Samaneh,Ta American Diabetes Association 2019 Diabetes Vol.68 No.2
<P>To identify genetic variants associated with diabetic retinopathy (DR), we performed a large multiethnic genome-wide association study. Discovery included eight European cohorts (<I>n</I> = 3,246) and seven African American cohorts (<I>n</I> = 2,611). We meta-analyzed across cohorts using inverse-variance weighting, with and without liability threshold modeling of glycemic control and duration of diabetes. Variants with a <I>P</I> value <1 × 10<SUP>−5</SUP> were investigated in replication cohorts that included 18,545 European, 16,453 Asian, and 2,710 Hispanic subjects. After correction for multiple testing, the C allele of rs142293996 in an intron of nuclear VCP-like (<I>NVL</I>) was associated with DR in European discovery cohorts (<I>P</I> = 2.1 × 10<SUP>−9</SUP>), but did not reach genome-wide significance after meta-analysis with replication cohorts. We applied the Disease Association Protein-Protein Link Evaluator (DAPPLE) to our discovery results to test for evidence of risk being spread across underlying molecular pathways. One protein–protein interaction network built from genes in regions associated with proliferative DR was found to have significant connectivity (<I>P</I> = 0.0009) and corroborated with gene set enrichment analyses. These findings suggest that genetic variation in <I>NVL,</I> as well as variation within a protein–protein interaction network that includes genes implicated in inflammation, may influence risk for DR.</P>
Lee, Ji-Seon,Lee, Mi-Ok,Moon, Bo-Hyun,Shim, Sung Han,Fornace Jr., Albert J.,Cha, Hyuk-Jin Wiley (John WileySons) 2009 Stem Cells Vol.27 No.8
<P>Human mesenchymal stem cells (hMSCs) have been widely studied as a source of primary adult stem cells for cell therapy because of their multidifferentiation potential; however, the growth arrest (also known as 'premature senescence') often found in hMSCs cultured in vitro has been a major obstacle to the in-depth characterization of these cells. In addition, the inability to maintain constant cell growth hampers the development of additional genetic modifications aimed at achieving desired levels of differentiation to specific tissues; however, the molecular mechanisms that govern this phenomenon remain unclear, with the exception of a few studies demonstrating that induction of p16INK4a is responsible for this senescence-like event. Here, we observed that the premature growth arrest in hMSCs occurs in parallel with the induction of p16INK4a, following abrogation of inhibitory phosphorylation of retinoblastoma protein. These stress responses were concurrent with increased formation of reactive oxygen species (ROSs) from mitochondria and increased p38 mitogen-activated protein kinase (MAPK) activity. The introduction of Wip1 (wild-type p53 inducible phosphatase-1), a well-studied stress modulator, significantly lowered p16INK4a expression and led to p38 MAPK inactivation, although it failed to affect the levels of ROSs. Moreover, the suppression of stress responses by Wip1 apparently extended the life span of hMSCs, compared with control conditions, while maintaining their multilineage differentiation potential. Based on these results, we suggest that senescent growth arrest in hMSCs may result from activation of stress signaling pathways and consequent onset of stress responses, due in part to ROS production during prolonged in vitro culture.</P>