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RISS 인기검색어
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- 저자 : Ajiboye, Praise Blessing (검색결과 12 건)
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Ajiboye Basiru Olaitan,Oyinloye Babatunji Emmanuel,Essien Precious Ekong,Onikanni Sunday Amos,Ojo Oluwafemi Adeleke,Kappo Abidemi Paul 한국약제학회 2021 Journal of Pharmaceutical Investigation Vol.51 No.1
Purpose The ameliorative potential of aqueous leave extract of Sterculia tragacantha on renal gene expression and biochemical parameters in streptozotocin-induced diabetic rats were assessed. Methods Forty albino rats (out of fifty) were intraperitoneally induced using 35 mg/kg of streptozotocin, and then grouped into normal control, diabetic control, diabetic animals received 150 and 300 mg/kg of aqueous extract of S. tragacantha leaves (AESTL) and diabetic animals placed on 200 mg/kg of metformin. This experiment lasted for two weeks, animals were sacrificed, and a series of biochemical indices were evaluated. Results Diabetic rats receiving AESTL revealed a momentous decline in fasting blood glucose, urea, creatinine, uric acid, and alkaline phosphatase levels. Administration of AESTL to diabetic animals considerably improved the activities of SOD, CAT, GPx, GST, and GSH with a decline in MDA levels. Also, AESTL reversed abnormalities in mRNA gene expressions of IL-1β, TGF-1β, KIM-1, EPO and CASP 6 in diabetic rats placed on AESTL treatment. The excellent results of diabetic rats maintained on AESTL were supported by histological findings in this study. Conclusion Hence, AESTL may have beneficial effects in controlling nephropathy associated with diabetes mellitus.
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Sensitivity study of frictional behavior by dimensional analysis in cold forging
Ajiboye, Joseph S.,Jung, Ki-Ho,Im, Yong-Taek 대한기계학회 2010 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.24 No.1
In metal forming operations, material flow and quality of the product depend on the conditions at the billet/tools interface friction, lubrication, and surface finish. Of these parameters, friction is the most difficult to characterize and its influence is often difficult to predict because of its dependency on a variety of factors. Recently, through a number of investigations conducted, a linear relationship among shear friction factor, dimensionless load and tip distance was obtained. The aim of the present study is to see whether the linear relationship obtained in the previous works was fortuitous or genuine by applying a dimensional analysis introducing processing parameters such as contact pressure, ram velocity, viscosity of the lubricant, load, surface roughness and shear friction factor. From the dimensional analysis based on Buckingham ${\pi}$ theorem and the data obtained from the tip test experiment, the present theoretical work derives dimensionless parameters and analysis of variance determines any correlation between the dimensionless parameters obtained. This work reconfirms the theoretical background of the previous experimental findings in the literature.
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Upper bound analysis of extrusion from square billets through circular and square/rectangular dies
Joseph S. Ajiboye 대한기계학회 2009 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.23 No.2
Upper bound elemental technique (UBET) for prediction of extrusion pressure in three-dimensional forward extrusion process is presented. Using square/rectangular billets, the study of the effect of die land length has been extended for the evaluations of extrusion pressures to extrude sections such as circular, square and rectangular shaped sections with power of deformation due to ironing effect at the die land taken into account. The extrusion pressure contributions due to the die land evaluated theoretically for these shaped sections considered are found to increase with die land lengths for any given percentage reduction and also increase with increasing percentage die reductions at any given die land length. The effect of die land lengths on the extrusion pressures increases with increasing complexity of die openings geometry with rectangular section giving the highest extrusion pressure followed by circular with square section die opening, giving the least extrusion pressure for any given die reduction at any given die land lengths. The proper choice of die land length is imperative if excessive pressure buildup at the emergent section is to be avoided so as to maintain good quality and metallurgical structure of the extrudates.
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Salawu, Sule Ola,Ajiboye, Praise Blessing,Akindahunsi, Akintunde Afolabi,Boligon, Aline Augusti The Korean Society of Food Science and Nutrition 2017 Preventive Nutrition and Food Science Vol.22 No.2
The purpose of this study was to evaluate the antioxidant and anticholinesterase activities of yellow and white bitter yams from South Western Nigeria using methanolic extraction and simulated gastrointestinal digestion models. The phenolic compounds in the bitter yam varieties were evaluated by high performance liquid chromatography with a diode array detector (HPLC-DAD). The total phenolic content of the bitter yams was measured by the Folin-Ciocalteu method, reductive potential by assessing the ability of the bitter yam to reduce $FeCl_3$ solution, and the antioxidant activities were determined by the 2,2-diphenyl-1-picrylhydrazyl radical ($DPPH^{\cdot}$) scavenging activity, 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radical cation ($ABTS^{{\cdot}+}$) scavenging activity, nitric oxide radical ($NO^{\cdot}$) scavenging ability, hydroxyl radical scavenging ability, and ability to inhibit $Fe^{2+}$-induced lipid oxidation. The HPLC-DAD analysis revealed the presence of some phenolic compounds in the studied bitter yam varieties, with varying degree of quantitative changes after cooking. The antioxidant indices (total phenolic content, total flavonoid content, reducing power, $DPPH^{\cdot}$ scavenging activity, $ABTS^{{\cdot}+}$ scavenging activity, and $NO^{\cdot}$ scavenging activity) were higher in the simulated gastrointestinal digestion model compared to the methanolic extract, with the in vitro digested cooked white bitter yam ranking higher. Similarly, the in vitro digested yams had a higher inhibitory action against lipid oxidation compared to the methanolic extracts, with the cooked white bitter yam ranking high. The methanolic extracts and in vitro enzyme digests showed no acetylcholinesterase inhibitory abilities, while methanolic extracts and the in vitro enzyme digest displayed some level of butyrylcholinesterase inhibitory activities. Therefore the studied bitter yams could be considered as possible health supplements.
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Sule Ola Salawu,Praise Blessing Ajiboye,Akintunde Afolabi Akindahunsi,Aline Augusti Boligon 한국식품영양과학회 2017 Preventive Nutrition and Food Science Vol.22 No.2
The purpose of this study was to evaluate the antioxidant and anticholinesterase activities of yellow and white bitter yams from South Western Nigeria using methanolic extraction and simulated gastrointestinal digestion models. The phenolic compounds in the bitter yam varieties were evaluated by high performance liquid chromatography with a diode array detector (HPLC-DAD). The total phenolic content of the bitter yams was measured by the Folin-Ciocalteu method, reductive potential by assessing the ability of the bitter yam to reduce FeCl₃ solution, and the antioxidant activities were determined by the 2,2-diphenyl-1-picrylhydrazyl radical (DPPH·) scavenging activity, 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radical cation (ABTS<SUP>·+</SUP>) scavenging activity, nitric oxide radical (NO<SUP>·</SUP>) scavenging ability, hydroxyl radical scavenging ability, and ability to inhibit Fe<SUP>2+</SUP>-induced lipid oxidation. The HPLC-DAD analysis revealed the presence of some phenolic compounds in the studied bitter yam varieties, with varying degree of quantitative changes after cooking. The antioxidant indices (total phenolic content, total flavonoid content, reducing power, DPPH<SUP>·</SUP> scavenging activity, ABTS<SUP>·+</SUP> scavenging activity, and NO<SUP>·</SUP> scavenging activity) were higher in the simulated gastrointestinal digestion model compared to the methanolic extract, with the in vitro digested cooked white bitter yam ranking higher. Similarly, the in vitro digested yams had a higher inhibitory action against lipid oxidation compared to the methanolic extracts, with the cooked white bitter yam ranking high. The methanolic extracts and in vitro enzyme digests showed no acetylcholinesterase inhibitory abilities, while methanolic extracts and the in vitro enzyme digest displayed some level of butyrylcholinesterase inhibitory activities. Therefore the studied bitter yams could be considered as possible health supplements.
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Abdulwasiu O. Adeleye,Taofeek O. Ajiboye,Ganiyat A. Iliasu,Folakemi A. Abdussalam,Abdulazeez Balogun,Oluwayemisi B. Ojewuyi,Musa T. Yakubu 한국식품영양과학회 2014 Journal of medicinal food Vol.17 No.8
This study investigated the effect of Dialium guineense pulp phenolic extract on aflatoxin B1 (AFB1)–induced oxidative imbalance in rat liver. Reactive oxygen species (ROS) scavenging potentials of free and bound phenolic extract of D. guineense (0.2–1.0 mg/mL) were investigated in vitro using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical, superoxide ion (O2-), hydrogen peroxide (H2O2), hydroxyl radical, and ferric ion reducing system. In the in vivo study, 35 animals were randomized into seven groups of five rats each. Free and bound phenolic extract (1 mg/mL) produced 66.42% and 93.08%, 57.1% and 86.0%, 62.0% and 90.05%, and 60.11% and 72.37% scavenging effect on DPPH radical, O2 - radical, H2O2, and hydroxyl radical, while ferric ion was significantly reduced. An AFB1-mediated decrease in the activities of ROS detoxifying enzymes (superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glucose 6 phosphate dehydrogenase) was significantly attenuated (P < .05). AFB1-mediated elevation in the concentrations of oxidative stress biomarkers; malondialdehyde, conjugated dienes, lipid hydroperoxides, protein carbonyl, and percentage DNA fragmentation were significantly lowered by D. guineense phenolic extract (P < .05). Overall, the in vitro and in vivo effects suggest that D. guineense phenolic extract elicited ROS scavenging and detoxification potentials, as well as the capability of preventing lipid peroxidation, protein oxidation, and DNA fragmentation.
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Induction of oxidative stress in Clarias gariepinus from Eleyele River in Nigeria
Arojojoye, Oluwatosin A.,Nwaechefu, Olajumoke O.,Ajiboye, John A.,Akintunde, Jacob K. Techno-Press 2016 Advances in environmental research Vol.5 No.3
This study evaluated some markers of oxidative stress in the organs of African Catfish, Clarias gariepinus from Eleyele River in Oyo State, Nigeria. Clarias gariepinus (250 g-400 g) were collected from Eleyele River (a suspected polluted River) and Clarias gariepinus from a clean fish farm (Durantee fisheries) were used as the control. Levels of Malondialdehyde (index of lipid peroxidation), Glutathione (GSH) and activities of antioxidant enzymes- Superoxide dismutase (SOD), Catalase and Glutathione-S-Transferase (GST) were evaluated in the liver, kidney and gills of the fish. From the results, there were significant (p<0.001) increases in malondialdehyde and GSH levels in the liver, kidney and gills of Clarias gariepinus from Eleyele River compared with control. The activity of GST increased significantly (p<0.05; p<0.001) in the liver and kidney of fish from Eleyele River compared with control. There was a significant decrease (p<0.05; p<0.001) in SOD activity in all the organs of Clarias gariepinus from Eleyele River compared with conrol and also a significant (p<0.001) decrease in catalase activity in the gills and kidney of the fish but catalase activity increased in the liver. Increase in lipid peroxidation and alterations in antioxidant status in Clarias gariepinus from Eleyele River show that the fish were under oxidative stress. These suggest that the River is polluted probably as a result of various wastes frequently discharged into the River. This could pose serious health risks to consumers of water and aquatic organisms from the River.
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