녹동균 세포외막 단백질 백신 CFC-1-101의 안정성 및 면역원성 검토 : 임상 제 Ⅰ/Ⅱa상 시험

장인진,김익상,유경상,임동석,김형기,신상구,장우현,박완제,이나경,정상보,안동호,조양제,안보영,이윤하,김영지,남성우,김현수 대한감염학회 1998 감염 Vol.30 No.3

목적 : 제일제당에서는 녹농균의 세포외막 단밸질을 유효성분으로 하는 백신인 CFC-101을 개발하였으며, 동물시험에서 이 백신의 안전성과 유효성을 입증하였다. 본 연구에서는 이 녹농균 백신의 인체에 대한 안전성과 면역원성을 평가하는 동시에 인체 접종시의 최적 투여 용량을 결정하기 위하여 제 I/Ⅱa상 임상시험을 수행하였다. 방법 : 건강한 성인 남자를 피험자로 선별하여 각 용량군에 백신투여자 6명, 위약투여자 2명을 배정하였다. 백신 투여군은 0.25mg, 0.5mg 또는 1.0mg 용량의 녹농균 백신을 7일 간격으로 3회에 걸쳐 근육주사 하였으며, 위약 투여군에게는 세포외막 단백질을 제외한 동일한 성분을 투여하였다. 백신접종 후 국소적 또는 전신적인 반응의 발생여부를 관찰하고, 혈액시료를 체취하여 백신의 역가와 유효성을 검정하였다. 결과 : 녹농균 백신 CFC-101은 모든 접종자에서 양호한 내약성을 보였다. 또한 0.5mg 과 1.0mg 백신 투여군에서는 100%의 항체양전율을 나타내었다. 생성된 항체는 녹농균 세포외막단백질에 특이성을 보였고, 녹농균 감염에 대해 방어효능이 있었다. 결론 : 이와같은 결과로부터 이 녹농균 백신은 인체에 안전하게 투여할 수 있으며, 높은 항체 생성능으로 감염방어 효능을 보이고 0.5mg과 1.0mg이 최적용량인 것으로 판단되었다. Background : We developed a Pseudomonas aeruginosa outer membrane protein(OMP) vaccine CFC-101, and the prophylactic efficacy of which has been demonstrated in animal models. In order to evaluate the safety and immunogenicity of the P. aeruginosa vaccine, we carried out a phase I/Ⅱa clinical trial in healthy male volunteers. Methods : Groups of eight volunteers, including two placebo subjects, were vaccinated intramuscularly with three doses of 0.25, 0.5 or 1.0 mg of the vaccine at one week intervals. Sings of systemic and local reactions observed after vaccination were recorded for each vaccinee for 5 days. Physical examinations were performed on days 0, 1, 7, 8, 14, 15, 21, and 42, and clinical laboratory tests were done on days 0, 3, and 21. Blood samples for assay of serum antibody levels were obtained up to 42 days after the first vaccination. Results : The vaccine was generally well tolerated by all vaccinees, showing no significant side effects. In the three dosage groups, all vaccinees, except one receiving the 0.25 mg dose, showed significant elevation in serum IgG antibody titers against the vaccine proteins, indicating 100% seroconversion in 0.5 and 1.0 mg groups. The human antibodies induced by the vaccine were specific for P. aeruginosa OMPs, as confirmed by western blot analysis and immunoprecipitation assays. The capacity of the human antisera to enhance opsonophagocytic killing activity by polymorphonuclear leukocytes and to confer protection against P. aeruginosa infections indicates that the antibodies elicited by the vaccine have protective efficacy. Conclusion : We conclude that the P. aeruginosa OMP vaccine is safe and effective for human use and its optimal dose to be 0.5 or 1.0 mg.

2003년 국내 중증급성호흡기증후군 진료 현황 및 문제점 분석

이진수,김은실,정문현,백제중,정선화,안주희,최영화,이선희,고철우,김성범,김민자,박승철,기현균,송재훈,최상호,김양수,이상오,조용균,박영훈,정숙인,김연숙,이흥범,손창희,장성희,정희진,김우주 대한감염학회 2004 감염과 화학요법 Vol.36 No.3

목적 : 2002년 말 중국에서 SARS가 발생한 이후 국내에서도 2003년 10월까지 총 3명의 추정환자, 17명의 의심환자가 보고되었다. 향후 추가적인 SARS의 유행이 우려되는 상황에서, 그간의 SARS 환자 진료에 있어서의 실질적인 준비사항, 진료 현황 등에 대한 조사를 통해 문제점을 파악하여, 향후 더 나은 대비가 될 수 있도록 개선점을 제시하고자 하였다. 재료 및 방법 : SARS로 의심되는 환자를 진료 경험이 있는 병원의료진을 대상으로 2003년 10월에 설문조사를 실시하였다. 설문에는 SARS 환자 진료 시의 실질적인 조치, 진료 현황, 병실, 응급실 및 외래에서의 격리 시설과 준비사항, 보건당국의 관리와 지원에 관한 사항을 포함하였다. 결과 : 대상이 되는 22개 병원 중 17개(17/22, 77.2%) 병원이 설문에 응하였다. SARS 환자를 위한 격리실은 응급실, 외래, 일반병실 및 중환자실에서 각각 9개(9/17, 52.9%), 5개(5/17, 29.4%), 15개(15/16, 93.7%), 4개(4/16, 25%) 병원에서 음압처리가 되어있지 않은 일인실 혹은 다인실이 사용되었고, 1개(1/16, 6.3%) 병원에서만 일반병실에서 음압격리실이 운영되었다. 입원환자의 진찰 시 개인보호구의 착용은 거의 모든 의료기관에서 이루어졌다. 보건당국에서 SARS지정병원의 시설 등을 사전에 확인한 곳은 1곳(1/12, 8.3%)이였고, 14개 병원(14/15, 93.3%)에서는 보건당국에 의뢰한 검사결과를 통하 받지 못하였다. 결론 : 의료기관에서 SARS 환자용 격리실뿐만 아니라 기존의 격리실 설비 등이 미흡하였으며, 특히 중환자실 및 외래의 준비가 더욱 부족하였다. 보건당국의 의료기관에 대한 종합적인 지원이 부족하였고, 병원과의 원활한 연계가 잘 이루어지지 않았다. SARS 만이 아닌 격리를 필요로 하는 질환의 적절한 진료를 위해 향후 병원 시설의 정비와 정부차원에서의 보다 구체적이고 실질적인 대책마련이 필요하다. Background : There was an worldwide outbreak of the Severe Acute Respiratory Syndrome (SARS) originated from China in late 2002. During that period three cases of suspected SARS and 17 cases of probable SARS were reported in Korea. With the concerns about the reemergence of SARS-coV transmission, it is important to be prepared for any possibility. So, this study is aimed to analysis the past measures in managing SARS and propose the amendatory plans to improve the preparedness. Materials & Methods : Questionnaires were collected among clinicians with any experience in managing the probable or suspected SARS cases in Oct. 2003. 17 out of 22 hospitals responded to the questionnaire. The contents in the questionnaire were practical activities, personal equipments, response plans, isolation facilities in emergency centers, outpatient clinics, general wards and intensive care units, and relationship with the public health department. Results : The dedicated isolation rooms in emergency centers, outpatient clinics, general wards, and intensive care units were prepared in 9 (9/17, 52.9%), 5 (5/17, 29.4%), 15 (15/16, 93.7%), and 4 (4/16, 25.0%) hospitals, respectively. Except for one hospital that newly made negative pressure room for SARS, single or multi-bed rooms without airborne infection control were used in all the other hospitals. The personal precaution principles were kept quite well in general wards. Before the designation of SARS hospital by the public health department prior evalution to see if the hospital was suitable for managing SARS was conducted in only 1 (1/12, 8.3%) hospital. The results of laboratory diagnosis were reported back in 1 (1/15, 6.6%) hospital. Conclusions : The isolation facilities which can control airborne infection were almost deficient not only for SARS but also for other respiratory transmissible diseases. For the infection control of transmissible diseases including SARS, more investment is needed on medical facilities and comprehensive support from the public health department required.

미세가공기술을 위한 규소기판 접합

안근영,정귀상,이경수,윤선진,강상원 경북대학교 센서기술연구소 1992 센서技術學術大會論文集 Vol.3 No.1

외상 후 속발된 주관절 변형에 있어서 운반각의 변화가 척골 근위부 성장에 미치는 영향

안상로,이광진,박원,오기영 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.2

The posttraumatic cubitus varus and valgus deformity is generally caused by malunion of supracondylar and condylar fracture of humerus in growing children. Generally it is known that carrying angle change is benign deformity causing no specific functional disabilities and the correction of the carrying angle change is performed for cosmetic reason. But after corrective osteotomy, there remained some Lasy S deformity on elbow joint. We invesgated the cause of this Lasy S deformity and found that most of deformity is caused by improper osteotomy, but we also found there developed some bowing deformity of the proximal ulnar metaphysic. So we measure the proximal ulnar bowing of 12 cases of cubitus varus and 4 cases of cubitus valgus which were operated on from 1984 to 1994. We also study the correlation between the amount and duration of the carrying angle change which the amount of the proximal ulnar bowing. The amount of carrying angle and carrying angle change correlate with the change of proximal ulnar bowing significantly. There is some correlation with duration of carrying angle change from proximal ulnar bowing.

고관절 전치환술 후 합병된 비구 컵 해리와 동반된 활액낭종 : 증례보고 Case Report

성일보,정국진,박수철,김진호,정형진,황재광,염재광,정병현,안종국 대한고관절학회 2001 Hip and Pelvis Vol.13 No.1

GIS를 이용한 침수구역 예측

안상진,윤석환,곽현구 충북대학교 건설기술연구소 2004 建設技術論文集 Vol.23 No.1

This study is to analyze the flood damages such as an inundation by overflow levee during rainfall duration. HEC-HMS and HEC-RAS are used to analyze rainfall-runoff and inundated area, respectively. Yeongwoon area is a study catchment for runoff effect analysis. As the result, it was understood that inundated area was magnified gradually according to the increase of rainfall recurrence interval in years. Inaddition GIS technique is an effective tool for calculating the exact flood damage area.

1방향 슬래브의 최소두께에 관한 연구

안상호,이화진 신라대학교 자연과학연구소 2000 自然科學論文集 Vol.8 No.-

An iterative procedure is developed to calculate minimum thickness for one-way slabs corresponding to prescribed deflection limits. The minimum thickness obtained are compared with values given by the ACI Code. Result of a parametric study are presented showing the effects of design variables in the calculated minimum thickness. A minimum thickness equation is developed based on code-specified deflection calculation procedures that minimum thickness as a function of the specified deflection limit. The objective of the study described in this paper was to determine limitations of the current tabulated values for application to a range of design conditions and to develop recommendations for minimum thickness values that were consistent with specified limits on calculated deflection and also covered a wide range of design conditions than the current values.

19세기 유럽과 북미의 기독교 사상과 한국 선교 : A Tradition Bypassed in the Korean Protestant Mission

안상진 서울대학교 종교문제연구소 2002 종교와 문화 Vol.0 No.8

토오크리플 저감을 위한 SRM의 전류추종제어

안성호,안진우 慶星大學校 1998 論文集 Vol.19 No.2

세균성 수막염에서 발생한 치명적 뇌경색 1례

안준성,김민아,김상진,김응규 인제대학교 2006 仁濟醫學 Vol.27 No.-

Bacterial meningitis is frequently fetal or lead to severe neurological impairment. Cerebral infarction is a well known sequele of meningitis, occurring in as many as 10-20% of patients. But fetal cerebral infarction in bacterial meningitis is rare. We report a 61 year old woman who was admitted due to fever, headache and mental change for 3 days. On admission 7 days follow up Brain-CT revealed large and massive infarctions on both hemispheres. When bacterial meningitis is caused by Streptococcus pneumonia, there is a high prevalence of cerebral infarctions. The underlying mechanisms of cerebral infarction in bacterial meningitis are vasculitis, thrombosis, arachnoiditis, and compression of the arterial supply at the foramen magnum by herniation of the cerebellar tonsil.