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Immunomodulatory Effects of a Methanol Extract from Opuntia ficus indica on Murine Splenocytes
Ginnae Ahn,Jin Hee Kim,Eunjin Park,Yoon Kyu Lim,You-Jin Jeon,Youngheun Jee 한국식품과학회 2009 Food Science and Biotechnology Vol.18 No.6
Multiple beneficial properties of Opuntia ficus indica (OPF) are well established. In the present study, we have investigated the immunological role of OPF extract (OPFE) on murine splenocytes. OPFE dose- and time-dependently enhanced the proliferation of splenocytes without cytotoxicity. Our results also showed that the number of CD4? helper T cells and CD45R/B220? pan B cells increased markedly, but not CD8? cytotoxic T cells or CD11b? granulocytes/macrophages. In addition, OPFE significantly decreased the production levels of T helper (Th) 1 type cytokines, interferon (IFN)-γ, and tumor necrosis factor (TNF)-α, although had no significantly differences in those of interleukin (IL)-4, a Th2 type cytokine in concanavalin A (Con A)-stimulated blastogenic cells. Furthermore, OPFE alone strongly increased IL-4 production and decreased TNF-α production even in the absence of Con A. On the basis of these results, this study suggests that OPFE enhances immunity by regulating the pro- and anti-inflammatory response, indicating that this extract exerts a marked immunomodulatory effect, confirming its usefulness as therapy for immune-related diseases.
Anti-inflammatory Effects of Enzymatic Extract from Ecklonia cava on TPA-induced Ear Skin Edema
Ginnae Ahn,Eunjin Park,Dae Seung Kim,You-Jin Jeon,Taekyun Shin,Jae Woo Park,Ho-Chun Woo,Ki-Wan Lee,Youngheun Jee 한국식품과학회 2008 Food Science and Biotechnology Vol.17 No.4
Anti-inflammatory potential of the enzymatic extract prepared by Kojizyme (ECK), a component of brown seaweeds Ecklonia cava (Alariaceae, Phaeophyta) in vivo was investigated. For the application of mouse ear edema model, 12-O-tetradecanoylphorbol acetate (TPA) was used, a topical inducer of a long-lasting inflammatory response. Our results demonstrated that ECK inhibited ear edema when topically applied to mouse ear skin. In histological evaluation, the inhibition activity of ECK on TPA-induced inflammation is similar to that of dexamethasone, although less strong. In addition, the mRNA expression levels of IL-1β, IFN-γ, TNF-α, and cyclooxygenase-2 (COX2) and the immunoreactivity to inducible nitric oxide synthase (iNOS) and COX2 expressed mainly in inflammatory cells were down-regulated by ECK. These results indicate that ECK has anti-inflammatory effects through the inhibition of Th1 cytokines and 2 inducers of inflammation in TPA-induced ear skin edema.