http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Jo, Myungjin,Chung, Ah Young,Yachie, Nozomu,Seo, Minchul,Jeon, Hyejin,Nam, Youngpyo,Seo, Yeojin,Kim, Eunmi,Zhong, Quan,Vidal, Marc,Park, Hae Chul,Roth, Frederick P.,Suk, Kyoungho Cold Spring Harbor Laboratory Press 2017 Genome Research Vol. No.
<P>To understand disease mechanisms, a large-scale analysis of human yeast genetic interactions was performed. Of 1305 human disease genes assayed, 20 genes exhibited strong toxicity in yeast. Human yeast genetic interactions were identified by en masse transformation of the human disease genes into a pool of 4653 homozygous diploid yeast deletion mutants with unique barcode sequences, followed by multiplexed barcode sequencing to identify yeast toxicity modifiers. Subsequent network analyses focusing on amyotrophic lateral sclerosis (ALS)-associated genes, such as optineurin (OPTIV) and angiogenin (ANG), showed that the human orthologs of the yeast toxicity modifiers of these ALS genes are enriched for several biological processes, such as cell death, lipid metabolism, and molecular transport. When yeast genetic interaction partners held in common between human OPTN and ANG were validated in mammalian cells and zebrafish, MAP2K5 kinase emerged as a potential drug target for ALS therapy. The toxicity modifiers identified in this study may deepen our understanding of the pathogenic mechanisms of ALS and other devastating diseases.</P>
Molecular Characterization of Norovirus and Rotavirus in Outbreak of Acute Gastroenteritis in Seoul
Oh, Se-Ah,Park, Sang-Hun,Ham, Hee-Jin,Seung, Hyun-Jung,Jang, Jung-Im,Suh, Sang-Won,Jo, Suk-Ju,Choi, Sung-Min,Jeong, Hae-Sook 대한미생물학회 2013 Journal of Bacteriology and Virology Vol.43 No.4
Norovirus and rotavirus are important causes of acute nonbacterial gastroenteritis in communities worldwide. Genotypes of norovirus and rotavirus in stool samples, which were collected from patients, was determined by RT-PCR and ELISA. A total 4,484 stool samples (461 outbreak cases) collected during January 2010-April 2013 were analyzed. Four hundred thirty eight of samples were positive for norovirus. Twelve samples were positive for Rotavirus. Norovirus genotypes identified were nine kinds of G I genotype (G I-1, G I-2, G I-3, G I-4, G I-6, G I-7, G I-9, G I-12, G I-13) and nine kinds of G II genotype(G II-2, G II-4, G II-5, G II-6, G II-7, G II-11, G II-12, G II-15, G II-16). Rotavirus genotypes were G2P[4]. The results might be useful information for evaluating the epidemiological status of viral diarrhea in Seoul, and providing a strategy to prevent human norovirus, rotavirus and other threats to public health in Korea.
Park, Min-Ah,Park, Ik Jae,Park, Sungmin,Kim, Jihye,Jo, William,Son, Hae Jung,Kim, Jin Young ELSEVIER 2018 Current Applied Physics Vol.18 No.supp
<P>We report a suitable Li-doped NiOx hole-extraction layer of p-i-n type planar perovskite solar cell as an alternative to organic material such as PEDOT:PSS. The Li-doped NiOx used as hole-extraction layer can be prepared by facile method of just adding Li source to NiOx precursor solution to form Li-doped NiOx layer. The presence of Li in NiOx layer has an influence on conductivity of the NiOx layer which is evidenced by the conductive AFM. In addition, the NiOx layer with 50 nm thickness prevents a lot of pinholes inside the film and relatively low processing temperature of 200 degrees C has the advantage of wide choice of transparent conduction oxide substrate. As a result, p-i-n type planar perovskite solar cell incorporating the Li-doped NiOx hole-extraction layer is improved with significantly enhanced fill factor leading to increase in conversion efficiency of 15.41%. (C) 2017 Elsevier B.V. All rights reserved.</P>
Seong, Kyeong Ah,Myung, Geumog,Jeong, Hae Jin,Yih, Wonho,Kim, Hyung Seop,Jo, Hyun Jung,Park, Jae Yeon,Yoo, Yeong Du The Korean Society of Phycology 2017 ALGAE Vol.32 No.1
We explored feeding by the mixotrophic ciliate Mesodinium rubrum, heterotrophic nanoflagellates (HNFs), and small ciliates (<$30{\mu}m$ in cell length) on natural populations of heterotrophic bacteria in Masan Bay, Keum River Estuary, and in the coastal waters of the Saemankeum area, Korea when M. rubrum red tides occurred. We also measured ingestion rates of M. rubrum on cultured heterotrophic bacteria as a function of bacterial concentration in the laboratory. The ingestion rates of M. rubrum on natural populations of heterotrophic bacteria (2.3-16.8 bacteria $grazer^{-1}h^{-1}$) were comparable to or lower than those of co-occurring HNFs (10.7-41.7 bacteria $grazer^{-1}h^{-1}$), but much lower than those of co-occurring small ciliates (76.0-462.2 bacteria $grazer^{-1}h^{-1}$). However, the maximum grazing coefficient of M. rubrum ($0.245d^{-1}$) on natural populations of heterotrophic bacteria was much higher than that of small ciliates ($0.089d^{-1}}$), and slightly higher than that of HNFs ($0.204d^{-1}$). With increasing bacterial concentrations, ingestion rates of M. rubrum on cultured heterotrophic bacteria continuously increased, but became saturated at higher prey concentrations over $1-5{\times}10^6cells\;mL^{-1}$. The maximum ingestion rate of M. rubrum on cultured heterotrophic bacteria was 34.4 bacteria $grazer^{-1}h^{-1}$. Based on the present study, it is suggested that M. rubrum may be an important grazer of heterotrophic bacteria and sometimes have considerable grazing impact on natural populations of heterotrophic bacteria.
Evaluation of Acute Toxicity of Daphnia of Natural Pesticides Based on Derris Extract
Hyeon YANG,Ah-Hae JO,Seong-Jun KIM 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
Recently, as the development and distribution of eco-friendly biological pesticides made using natural raw materials without using chemical materials such as organic synthetic pesticides and chemical fertilizers are increasing, it is necessary to evaluate the impact of these natural pesticides on the aquatic ecosystem. Product “B”, which has natural plant extract as its main ingredient, consists of Derris extract, garlic oil, paraffin oil, and supplements. The main ingredients are Rotenone, Diallyl disulfide, Paraffin oil, etc. Rotenone, which acts as an insecticide, contains 2.5%. Rotenone is widely used as a natural herbicide and insecticide, and is known to be particularly toxic to fish. In this study, an acute toxicity test for daphnia using Daphnia magna was performed to evaluate the toxicity that residues of this natural pesticide may have on the aquatic ecosystem. According to the seller’s recommended usage method, it is suggested to dilute the product stock solution 1,000 times for use, so an experiment was conducted to observe the swimming inhibition rate by applying a dilution azeotrope 2 starting from 1,000 times (Rotenone concentration 25,000 ㎍/l), and Sigma-plot was used. As a result, the half effect concentration (48hr EC50) was 18.7 million times dilution (Rotenone concentration 1.33 ㎍/l), and the observed no effect concentration (NOEC) was 80 million times dilution factor (Rotenone concentration 0.31 ㎍/l). The observed minimum effect concentration (LOEC) was 40 million times (Rotenone concentration 0.63 μg/l). Rotenone is a substance that is rapidly decomposed in soil or water and has a half-life of 1 to 3 days, and its insecticidal power decreases with time. It is known, and considering the natural decomposition effect, the amount of crops sprayed, and the dilution by rainfall, the effect on the aquatic ecosystem is thought to be different from the instantaneous toxicity when sprayed.