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In Vitro Antimicrobial Properties of Coconut Oil on Candida Species in Ibadan, Nigeria
A.A. Oni,D.O. Ogbolu,O.A. Daini,A.P. Oloko 한국식품영양과학회 2007 Journal of medicinal food Vol.10 No.2
The emergence of antimicrobial resistance, coupled with the availability of fewer antifungal agents with fungi-cidal actions, prompted this present study to characterize Candida species in our environment and determine the effectivenessof virgin coconut oil as an antifungal agent on these species. In 2004, 52 recent isolates of Candida species were obtainedfrom clinical specimens sent to the Medical Microbiology Laboratory, University College Hospital, Ibadan, Nigeria. Theirsusceptibilities to virgin coconut oil and fluconazole were studied by using the agar-well diffusion technique. Candida albi-canswas the most common isolate from clinical specimens (17); others were Candida glabrata(nine), Candida tropicalis(seven), Candida parapsilosis(seven), Candida stellatoidea(six), and Candida krusei(six). C. albicanshad the highest sus-ceptibility to coconut oil (100%), with a minimum inhibitory concentration (MIC) of 25% (1:4 dilution), while fluconazolehad 100% susceptibility at an MIC of 64 .g/mL (1:2 dilution). C. kruseishowed the highest resistance to coconut oil withan MIC of 100% (undiluted), while fluconazole had an MIC of . 128 .g/mL. It is noteworthy that coconut oil was activeagainst species of Candida at 100% concentration compared to fluconazole. Coconut oil should be used in the treatment offungal infections in view of emerging drug-resistant Candida species.