Gynecologic manifestation and identification of genetic causes of Klippel-Trenaunay syndrome

( A Mi Roh ),( Sa Ra Lee ),( Young Mee Lim ),( Kyung Ah Jeong ),( Hye Sung Moon ),( Hyewon Chung ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-

Klippel-Trenaunay syndrome (KTS) is a congenital disorder characterized by malformations of the arteries, capillaries, veins and lymphatic system, surrounding soft tissue and bone hypertrophy. A. Timur et al. (2005) and others have reported that AGGF1 gene causes excessive angiogenesis in KTS. In addition, Fabio C. Vicentini (2006) and others introduced cases involving bladder and vulva. However, there has been no genetic study of KTS patients who have invaded the clitoris. In this study, whole genome sequencing of KTS patients and their families involving vulva were performed to identify KTS - related genes and to confirm genetic variants in KTS. A 26 year old woman visited OBGY clinic for protruding vaginal mass. On examination, the purplish protruding anterior vaginal wall was noted and a 1.5 x 1.5 cm sized clitoral mass was also noted. A sessile type elevated skin lesion causing itching and irritation symptom was noted on both buttock. She had suffered heavy menstrual bleeding and on pelvic MRI, a upward displacement of uterus was noted near umbilicus level. NSAIDs prescribed onthe first 3 days of menstruation decreased the menstrual blood loss upto 40percent. In this study, whole genome sequencing of a KTS patient involving vulva was performed to identify KTS - related genes and to confirm genetic variation. The patient's peripheral blood and a sessile mass around buttock was sampled and whole genome sequencing was performed. Most KTS has known to be a sporadic one, however some genetic variants has been reported.

제주도 119구조·구급대의 활성화 및 전문화 방안

고재문,김태민,김효식,이영아 한국응급구조학회 2002 한국응급구조학회지 Vol.6 No.1

Since 1992, conventional fire fighting businesses have been converted into a metropolitan autonomous fire fighting system to be ready for a variety of disasters. However, the corresponding investment has been overlapped due to the non integration of businesses to prevent any potential disasters, and a series of collaborative systems have been not functioning so well. In the meantime, our fire fighting sector has been trying to set up its own clean and faithful position by abolishing any inconvenient system or outsourcing private sectors, and expanded its work scope from conventional fire fighting even to rescue and emergency works. While focusing on handling disaster, the fire fighting sector has been widely trusted and reliable throughout our nation. Moreover, our fire fighting sector has secured nation-wide mobile organizations, technical personnel by field, special equipments and independent communication network. In addition, the fire fighting sector has knowledges, expertise and capabilities required for managing disasters, while in charge of almost every disaster management works including fire, explosion, collapse, disaster and flood. It becomes an organization for comprehensive disaster management under an absolute national trust, which is based on the system for prevention, preparation and countermeasure against a variety of disasters. Thus, our fire fighting sector must make many efforts and try to modernize conventional education and training. The ways to facilitate rescue and emergency works may include the nurture of technical fire fighting personnel along with modernized equipments, the reinforcement of rescue and emergency education, the facilitation of operating civil defense corps, the facilitation of operating volunteer fire fighting corps, the better arrangement of 119 briefing room for public healthcare in provincial offices, the sterilization of rescue instruments and equipments, the better repair education for emergency rescue member, the establishment of regional emergency assistant system and the expansion of fire fighting personnel and equipments. In terms of reinforcing the functions and services of rescue 119 and emergency corps, we must review the following consideration: Building up security system along with operational expansion, building up a system for emergency medical treatment, building up a comprehensive information management system for rescue and emergency, constructing a provincial safety museum and so forth. For the ways to better the works of rescue 119, we can review the following considerations: Improving the education for fire fighting training corps under Jeju Provincial Fire and Disaster Mangement Department, providing rescue members with more opportunities for clinical practices, enhancing the morale of rescue members, installing a comprehensive briefing room for emergency rescue member, building up medical networks along with reasonable policies for information service, operating the consulting system for rescue 119 and so on. If these requirements are met, it is expected that the fire fighting departments in Juju province can cope with every accident and disaster a little more rapidly and quickly in compliance with local needs, so that they can keep their own position as a public fire fighting organization, which may be trusted by the public.

혈액 투석 환자에서 2년간 추적 관찰시 Lipoprotein(a)의 변화에 끼치는 요인의 분석

김경아,송준호,이경주,박영주,이승우,김문재 대한신장학회 2000 대한신장학회잡지 Vol.19 No.4

세침 흡입 생검으로 진단된 간의 혈관근지방종 1 예

이경아,유은실,민영일,김해련,심기남,정훈용,양석균,홍원선,박의련,이문규 대한소화기학회 1999 대한소화기학회지 Vol.33 No.6

Hepatic angiomyolipoma is a rare benign tumor of the liver composed of blood vessel, smooth muscle cells, fat and myelocomponent. The preoperative diagnosed of the lesion is important because of its therapeutic implications. Radiologic findings are not specific because the composed elements are variable in proportion and distribution. Thus, the findings at computed tomography, ultrasono graphy and magnetic resonance imaging may be only suggestive and its definitive diagnosed requires histologic confirmation. We experienced a case of hepatic angiomyolipoma in patient with chronic hepatitis diagnosed preoperatively by fine-needle aspiraton biopsy under ultrasound guidance. To our knowledge, this is the first case of hepatic angiomyolipoma diagnosed preoperatively in Korea. We report it with review of literatures.

Sequence Level Analysis of Recently Duplicated Regions in Soybean [ <i>Glycine max</i> (L.) Merr.] Genome

Van, Kyujung,Kim, Dong Hyun,Cai, Chun Mei,Kim, Moon Young,Shin, Jin Hee,Graham, Michelle A.,Shoemaker, Randy C.,Choi, Beom-Soon,Yang, Tae-Jin,Lee, Suk-Ha Oxford University Press 2008 DNA research Vol.15 No.2

<P>A single recessive gene, <I>rxp</I>, on linkage group (LG) D2 controls bacterial leaf-pustule resistance in soybean. We identified two homoeologous contigs (GmA and GmA′) composed of five bacterial artificial chromosomes (BACs) during the selection of BAC clones around <I>Rxp</I> region. With the recombinant inbred line population from the cross of Pureunkong and Jinpumkong 2, single-nucleotide polymorphism and simple sequence repeat marker genotyping were able to locate GmA′ on LG A1. On the basis of information in the Soybean Breeders Toolbox and our results, parts of LG A1 and LG D2 share duplicated regions. Alignment and annotation revealed that many homoeologous regions contained kinases and proteins related to signal transduction pathway. Interestingly, inserted sequences from GmA and GmA′ had homology with transposase and integrase. Estimation of evolutionary events revealed that speciation of soybean from <I>Medicago</I> and the recent divergence of two soybean homoeologous regions occurred at 60 and 12 million years ago, respectively. Distribution of synonymous substitution patterns, <I>K</I><SUB>s</SUB>, yielded a first secondary peak (mode <I>K</I><SUB>s</SUB> = 0.10–0.15) followed by two smaller bulges were displayed between soybean homologous regions. Thus, diploidized paleopolyploidy of soybean genome was again supported by our study.</P>

Comparison of the Duration of Hamstring Flexibility Improvement Following Termination of Modified Dynamic Stretching, Hold-Relax, and Static Stretching

A-young Moon1,Hee-jin Jang,Hyun-jeong Jang,Suhn-yeop Kim 한국전문물리치료학회 2014 한국전문물리치료학회지 Vol.21 No.1

The aim of this study was to compare the duration of hamstring flexibility improvement after 3 stretching interventions in people with limited hamstring flexibility. Twenty-two subjects (12 men, 10 women) with limited hamstring flexibility of the dominant leg received 3 stretching interventions— modified dynamic stretching (MDS), hold-relax (HR), and static stretching (SS)—in a random order. All the subjects received all 3 interventions at intervals of at least 24 hours to minimize any carry-over effect. Modified dynamic stretching was applied as a closed kinetic chain exercise in the supine position by using the sling suspension system (Redcord Trainer??). The SS and HR interventions were individually performed in the straight leg raising (SLR) position, and all 3 interventions were performed for 3 minutes. Outcome measures included passive knee extension (PKE) measurements. Five post-test measurements were recorded for all subjects at 3, 6, 9, 15, and 30 minutes after the interventions. MDS was associated with a significant increase in knee extension range of motion even at 30 minutes post-treatment. In contrast, the HR and SS stretching methods showed increased hamstring flexibility for only 6 minutes post-treatment. Improvements in the range of motion of knee extension (indicating enhancement in hamstring flexibility) with MDS were maintained longer than those with the HR and SS interventions. Therefore, MDS may be more effective than the other interventions for maintaining hamstring flexibility.

간호실무에서 신봉이론(Espoused theories)에 대한 탐색적 연구

서문자,김혜숙,이은희,박영숙,조경숙,강현숙,임난영,김주현,이소우,조복희,이명하,지성애,하양숙,손영희,권성복,김희진,추진아 성인간호학회 2001 성인간호학회지 Vol.13 No.1

As a nursing practice involves nurses' actions in a specific context of health care, this study has focused on exploring the espoused theories in nursing practice within the action science perspectives, Espoused theories are the belief, principles, and rationale expressed by the practitioner as guiding her/his actions in a situation of practice. The data were analysed qualitatively and 25 elements of espoused theories of nursing action were identified and clustered into 6 categories. The 25 elements of espoused theories are as follows: The clinical nurse worked in wholistic and individual nursing, focussed on the patient's needed, comfort and supportive nursing (5 theories of nursing goal) ; excellent skills, knowledge based, assessment and data collection, explaining, educating or a scientific basis(6 theories of nursing intervention): advocacy, value oriented, treatment, account- ability and commitment(4 theories of nursing ethics) ; human respect. partnership, trust(3 theories of patient-nurse relationship) : knowledgable, accumulated clinical experiences and personally lived experiences. positive perspectives(4 theories of nurse), role of intervention. rewarding peer relationship(3 theories of situations) The above mentioned espoused theories are similar to that of nursing textbooks which students learned through basic nursing education and almost the same as the Acts ofa Nurse in Korean. However, we are doubtful whether nurses actually do as they think. Therefore. it is recommended to review the theories-in-use in order to and any discrepancies between the espoused theories and the reality of nursing actions

니세틸 정(아세틸-엘-카르니틴 500 mg)에 대한 뉴로세틸 정의 생물학적 동등성

조혜영,김은아,정현철,심영순,임동구,오인준,문재동,이용복 전남대학교 약품개발연구소 2001 약품개발연구지 Vol.10 No.-

Acetyl-L-carnitine (ALC), an endogenous component of the L-carnitine family, is naturally occurring molecule synthesized from L-carnitine (LC) by carnitine acetyl transferase. ALC has been shown to improve the cognitive performance of patients suffering from dementia of the Alzheimer's type and proposed for treating Alzheimer's disease in pharmacological doses. The purpose of the present study was to evaluate the bioequivalence of two ALC tablets, Nicetiler^TM (Dong-A pharmaceutical Co., Ltd.) and Neurocetil^TM (Kyung-Dong Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration. Twenty six normal male volunteers, 22.80±2.76 year in age and 63.07 7.98㎏ in body weight, were divided into two groups and a randomized 2×2 cross-over study was employed. After one tablet containing 500㎎ of ALC was orally administered, blood was taken at predetermined time intervals and the concentrations of ALC in serum were determined using HPLC with fluorescence detector. Because of the presence of endogenous ALC, the calibration was performed using dialyzed serum. Pharmacokinetic parameters such as AUC_t, C_max and T_max were calculated and ANOVA was utilized for the statistical analysis of the parameters. The results showed that the differences in AUC_t, C_max and T_max between two tablets were 2.72%, -0.65% and -8.42%, respectively, when calculated against the Nicetile^TM tablet. The powers (1-β) for AUC_t and C_max were 94.87% and 87.17%, respectively. Minimum detectable differences (Δ) at α=0.05 and 1-β=0.8 were less than 20% (e.g., 15.58% and 19.16% AUC_t and C_max, respectively). The 90% confidence intervals were within ±20% (e.g., -11.84∼6.41 and -10.57∼11.88 for AUC_t and C_max, respectively). Two parameters met the criteria of KFDA for bioequivalence, indicating that Neurocetil^TM tablet is bioequivalent to Nicetile^TM tablet.

불확실한 환경에서 미디어 기업의 전략 변화와 동적역량

김아영(Kim, A-Young),허문구(Huh, Moon-Goo) 한국경영교육학회 2020 경영교육연구 Vol.35 No.6

[연구목적] 본 연구는 단일사례연구를 통해 급변하는 환경에서 기업의 동적역량과 전략선택의 관계를 탐구하고, 더 나아가 기업의 성장단계에 따른 동적역량의 영향을 분석하였다. [연구방법] 사례기업은 방송, 영화, 음악, 공연 등 다양한 미디어 플랫폼 서비스를 제공하는 국내 C기업으로 선정하였다. 사례연구의 신뢰성과 타당성을 높이기 위해 인터뷰, 내부자료, 보도자료, IR 자료 등 다양한 자료원을 활용하였으며, 기업 외부환경의 변화와 내부자원과 역량, 환경 대응을 위한 활동 등을 분석하였다. [연구결과] 본 연구의 결과는 다음과 같다. 첫째, 변화하는 환경에서 동적역량 관점이 기업의 전략선택을 이해, 분석하는데 효과적으로 활용될 수 있다. 둘째, 동적역량의 하위요소인 환경감지, 기회구현, 변형/재구성 역량이 기업의 성장 단계에 따라 기업의 전략선택 및 성과에 차별적 영향을 미치는 것을 확인하였다. [연구의 시사점] 본 연구는 동적역량에 대한 탐색적 연구로, 경영전략의 새로운 패러다임인 동적역량이 불확실한 환경에서 기업의 전략선택과 성과를 설명하는데 유용하게 활용될 수 있다는 것을 확인하였다. 특히 동적역량의 세 가지 하위 역량을 구분하고 각 역량이 어떻게 기업 분석에 적용될 수 있는지를 구체적 명제로 제시하였다는 점에서 의의가 있다. [Purpose] This study aims to analyze the relativeness between dynamic capabilities and choice of stretegies in the context of the growing step of the company through the single case study. [Methodology] In order to do this, this study select C corporation as an example which is providing various media-platform service like broadcasting, movies, music, performances, and so on. To increase validity and reliability. this study uses a variety of sources such as interview, firm data, IR, etc. [Findings] The results are as follows. First, this study suggests that the perspective of the dynamic capabilities is suitable for analyzing the choice of stretegies in an uncertain environment. Second, the sub-elements of the dynamic capabilities(sensing, seizing, transforming) affects the choice of stretegies and performances of the company in accordance with the growing step of company. [Implications] This study is an exploratory study of dynamic capabilities. The results show us that the dynamic capabilities as a new paradigm of business strategy is useful framework to explain the strategic choices and performance of the company in an uncertain environment. Especially, this study reason out several proposition in reference to dynamic capabilities.

행동유형론에 근거한 집단상담이 중학생의 자아존중감과 대인관계에 미치는 효과

문창희(Moon Chang-Hee),이영옥(Lee Young-Ok),이은아(Lee Eun-A),천성문(Cheon Seong-Moon) 경성대학교 인문과학연구소 2009 인문학논총 Vol.14 No.1

본 연구는 행동유형론에 근거한 집단상담이 중학생의 자아존중감과 대인관계에 미치는 효과를 검증하고자 하였다. 연구 대상은 부산 시내 A중학교 3학년 중 본 프로그램에 참여하기를 희망하는 학생 74명 중 37명을 실험집단으로, 나머지 37명은 통제집단으로 배정하였다. 프로그램은 1회기 당 90분씩, 총 10회기로 실시하였으며, 실험ㆍ통제집단의 사후검사를 실시하였다. 또한 양적 분석의 한계를 보완하기 위한 질적 분석으로 마지막 회기 후에 자유 형식으로 쓴 소감문과 프로그램 평가 설문지를 분석하여 제시하였다. 그 결과 첫째, 실험집단이 통제집단보다 자아존중감 향상에 유의미한 효과가 있었다. 둘째, 실험집단이 통제집단보다 대인관계 문제가 유의미하게 개선되었다. 또한 실험집단에 있어서 프로그램 평가 설문지와 소감문을 바탕으로 분석한 결과 자기이해와 타인이해, 대인관계 등에 긍정적인 효과가 있는 것으로 나타났다. 마지막으로 본 연구가 가지는 의의 및 제언을 기술하였다. The purpose of this study was to examine the effect of the group counseling in behavioral typology on middle school students' self-esteen and interpersonal relation. The subject of this study were 74 students of 3rd grade of A middle school in Busan. Of 74 students, 37 students were allocated to the experimental group, and the other 37 students were allocated to the control group. The program was executed totally by 10 times which were alloted each time 90 minutes and the post test of the experimental and control group was executed. The results of students' reports in the last period of the program were analyzed. The questionnaires were also analyzed in order to estimate the students' satisfaction of the group counseling program. The results of this study were as follows: First, the results of self-esteem test showed that the group counseling was effective in the improvement of students' self-esteem. Second, the results showed that the group counseling was effective in the improvement of students' interpersonal relation. And the analysis of program questionnaire and students' reports showed that students in the experimental group understand the characters of themselves and others, and strengthen their positive side to supplement their negative side. In the end, implications and limitations of this study were discussed.