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김도하(Do Ha Kim),박능화(Neung Wha Park),주광로(Kwang Ro Joo),이선호(Seon Ho Lee),김성률(Sung Ryul Kim),유철인(Cheol In Yoo),서재희(Jae Hee Suh),박재후(Jae Hoo Park) 대한소화기학회 2002 대한소화기학회지 Vol.39 No.4
Background/Aims: Enterogastric reflux of bile has been suspected as a risk factor of foregut cancer. Thus, we measured total intragastric bile acid to determine association between duodenogastric reflux and development of intestinal metaplasia known as premalignant gastric mucosal change. Methods: One hundred and three patients with a functional dyspepsia underwent endoscopy. Subsequently, samples of fasting gastric juice were taken from all patients for analysis of total bile acid. With the specimens from 5 sites of the antrum and body, the degree of intestinal metaplasia was evaluated by the update Sydney System and H. pylori infection was evaluated also by Warthin-Starry staining. Results: There was a significant correlation between the total bile acid level and the degree of intestinal metaplasia (r=0.278, p=0.005). Moreover, multiple linear regression test showed that the concentration of total bile acid was one of the independent risk factors for intestinal metaplasia regardless of age and H. pylori infection. Conclusions: These results suggest that intragastric bile acid may affect histologic premalignant changes of the gastric mucosa and thus, duodenogastric reflux may play a role in gastric carcinogenesis. (Korean J Gastroenterol 2002;39:248-253)
김도하 ( Do Ha Kim ),조몽 ( Mong Cho ),김대현 ( Dae Hyun Kim ),주광로 ( Kwang Ro Joo ),박능화 ( Neung Hwa Park ),양웅석 ( Ung Suk Yang ) 대한내과학회 2003 대한내과학회지 Vol.64 No.4
Background : De novo methylation and transcriptional silencing of p16 gene is one of the main pathways in inactivation of p16 gene in colon neoplasm. But there has been no study about that in Korea yet. The aims of this study were to determine p16 methyla
김도하(Do Ha Kim),김홍자(Hong Ja Kim),박능화(Neung Hwa Park),이근찬(Geun Chan Lee),정영화(Young Wha Chung),이영상(Young Sang Lee),구동억(Dong Erk Goo),윤현기(Hyeon Ki Yoon),성규보(Kyu Bo Sung),유은실(Eun Sil Yu),서동진(Dong Jin Suh) 대한내과학회 1998 대한내과학회지 Vol.54 No.2
Objectives : Liver biopsy is an essential tool to confirm suspected diagnosis and to guide specific therapy in patients with liver disease. But, the standard percutaneous needle biopsy is contraindicated in patients with coagulopathy and large amount of ascites. The transjugular approach has been developed for these problem cases, but its efficacy and safety has not been adequately tested in Korea. Methods : We retrospectively analysed 21 transjugular liver biopsy cases, and the success rate of procedure, the adequacy of obtained specimen for diagnosis and procedure related complications were reviewed. Results : The major reasons for trasjugular liver biopsy were coagulopathy(71%) and massive ascites(19%). Liver tissue was obtained successfully in 20 of 21 cases. The mean number of specimens was 3.4±1.1 per case and the mean size of specimen was 1.8±0.7mm Pathologists reviewed and judged as adequate for diagnosis in 13 cases(65%), helpful in 6 cases(30%), and inadequate in 1 case. Minor complications such as neck pain, hematoma at puncture site, or transient fever occurred in 5 cases (23.8%) but there was no major complication or procedure-related mortality. Conclusion: Transjugular liver biopsy is a safe and valuable technique that provides adequate diagnostic informations in about two thirds of patients for whom conventional percutaneous biopsy is contraindicated.
급성 골수성 백혈병에서 고용량 Cytarabine 을 이용한 공고요법
김도하(Do Ha Kim),이규형(Kyoo Hyung Lee),조재근(Jae Kun Cho),김선희(Seon Hee Kim),이제환(Je Hwan Lee),김성배(Sung Bae Kim),김상위(Sang We Kim),서철원(Chul Won Suh),이정신(Jung Shin Lee),김우건(Woo Kun Kim),김상희(Sang Hee Kim) 대한내과학회 1996 대한내과학회지 Vol.51 No.4
Objectives: This study was designed to evaluate the therapeutic efficacy of postremission therapy utilizing high-dose cytarabine in patients with newly diagnosed acute myelogenous leukemia and to assess the toxicities of the therapy. Acute promyelocytic leukemia (FAB M3) is excluded because it has very unique clinicopathologic characteristics. Methods: Those patients who achieved complete remission had first consolidation therapy with conventional dose cytarabine and daunorubicin but second and third consolidation was done with high-dose cytarabine (cytarabine 1gm/㎡ i.v. over 1 hour every 12 hours daily for 5 days) and daunorubicin. Overall survival and disease free survival were compared with previous conventional dose cytarabine and daunorubicin postremission therapy. Results: 1) Complete remission occurred in 62% (28 of 45 patients) and control group 48% (14 of 29 patients) (p=0.15). 2) The median survival of all 45 patients was not different significantly compared with control group (10 months vs 7 months, p=0.08). 3) The median disease free survival of 21 complete responders receiving at least one course of consolidation was 10 months and there was no significant difference compared with control group 7 months (p=0.47). 4) The toxicity including treatment-related motility, neutropenia duration was similar in both groups. Conclusion: Although our high-dose cytarabine consolidation therapy regimen appeared to have acceptable toxicity, its results did not show the superiority to previous conventional dose cytarabine consolidation regimen.
포스터 전시 : 상부위장관 ; 드문 임상양상을 보인 십이지장 중복낭(Duodenal Duplication Cyst) 3예
김현수 ( Kim Hyeon Su ),주광로 ( Ju Gwang Lo ),신수진 ( Sin Su Jin ),우순주 ( U Sun Ju ),박종호 ( Park Jong Ho ),신정우 ( Sin Jeong U ),방성조 ( Bang Seong Jo ),김도하 ( Kim Do Ha ),박능화 ( Park Neung Hwa ) 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
위장관 중복낭은 주로 소아에서 발견되는 드문 선천성 기형으로 위장관 어디에서나 발생될 수 있으나 회장 말단이 가장 흔히 발생되는 장소이며 십이지장에서 발생하는 경우는 4~12%로 주로 구부와 2부에 국한되어 발생한다. 임상양상은 장 폐색이 주된 소견이며 이외 폐쇄성 황달, 췌장염, 출혈, 및 천공 등이 드물게 나타날 수 있다. 본 증례는 성인에서 발견되고 병리학적으로 확진된 십이지장 중복낭 3예로 각각 폐쇄성 황달 및 췌장염, 재발성 췌장염, 출혈과 천
연구논문 : 혈청 ALT치가 2배 미만인 HBeAg 양성 만성 B형간염 환자의 라미부딘 치료 효과
한동하 ( Dong Ha Han ),박능화 ( Neung Hwa Park ),신정우 ( Jung Woo Shin ),정석원 ( Seok Won Jung ),황영태 ( Young Tae Hwang ),김현수 ( Hyun Soo Kim ),정인두 ( In Du Jeong ),방성조 ( Sung Jo Bang ),김도하 ( Do Ha Kim ) 대한간학회 2007 Clinical and Molecular Hepatology(대한간학회지) Vol.13 No.2
혈액투석 중 채취한 검체를 이용한 Equilibrated Kt/V 를 예측하는 방법
이종수(Jong Soo Lee),김도하(Do Ha Kim),최승원(Seung Won Choi),김영일(Young Il Kim),박재후(Jae Hoo Park),박수길(Su Kil Park),이상구(Sang Koo Lee),이선호(Seon Ho Lee),김성률(Sung Ryul Kim),박정식(Jung Sik Park) 대한신장학회 2002 Kidney Research and Clinical Practice Vol.21 No.1
목 적 : 단일 구획 요소 역동학 모형에서 투석 직후 혈중 요소질소 농도의 반등(postdialysis urea ebound, PDUR)은 실제 Kt/ V를 과대 평가하게 된다. 본 연구는 투석 후 평형상태의 혈중 요소질소 농도를 가장 잘 반영하는 투석 중의 혈액 검체 채취 시점을 확인하고, 이 검체를 이용하여 계산된 Kt/ V가 요소질소 농도 반등 완료 후의 Kt/V와 일치하는 정도를 알아보고자 하였다. 방 법 : 유지혈액 투석을 받고 있는 21명의 말기 신부전증 환자에서 투석 전, 투석시작 후 80분, 120분, 190분, 200분, 210분, 220분, 투석종료 시점, 투석종료 45분 후 혈액을 채취하여 각각 BUN을 측정하였다. 저자들은 투석종료 45분 후 요소질소 농도 반등이 완료된 시점의 검체를 이용한 Kt/V(eKt/V PDUR)를 참고치로 하여 Smye method, double- pool Daugirdas 공식, Tattersall 공식, 투석 중에 채취한 검체 중 하나를 이용하여 계산한 Kt/V를 각각 비교하였다. 결 과 : 투석 후 평균 요소질소 농도의 반등은 17.2±6%였고 single poool (sp)Kt/ V와 eKt/V는 각각 1.300±0.24, 1.120±0.20으로 spKt/ V는 eKt/ V PDUR를 13.5±4% 과대평가 하였다. 투석 중에 채취한 검체 중 투석종료 40분 전에 채취한 검체가(27.9±9 ㎎/dL) 요소농도 반등후의 평형상태의 혈중요소 질소 농도(28.0±9 ㎎/dL)를 가장 잘 반영하였다. Double- pool Daugirdas 공식의 Kt/V(eKt/V Dau =1.135±0.21, r =0.972, p<0.001), Tattersall 공식의 Kt/V(eKt/ V T at =1.134±0.22, r =0.972, p<0.001), Smye공식의 Kt/ V(eKt/ V Smye=1.156±0.24, r =0.900, p<0.001)는 PDUR eKt/V과 유의한 상관관계를 보였으며, 투석종료 40분 전에 채취한 검체를 이용하여 계산한 Kt/ V(eKt/V T-40 min =1.120±0.20, r =0.984, p<0.001)가 가장 유의한 상관관계를 나타내는 경향을 보였다. Bland- Altman분석에서 Kt/V T - 40 min는 eKt/ V PDUR과 가장 좋은 일치 정도를 보였다. 결 론 : 일반 투석기를 이용한 4시간 동안의 혈액투석에 있어서 spKt/V는 실제 전달된 Kt/V를 평가하는데 부적절하며, 투석종료 40분 전에 채취한 검체를 이용하여 계산한 Kt/V는 요소질소 농도 반등 후의 평형상태의 Kt/ V를 예측하는데 있어서 임상적으로 간단하게 이용할 수 있는 좋은 방법으로 생각된다. Purpose : Postdialysis urea rebound(PDUR) causes the overestimation of actual amount of delivered dialysis in Kt/V from single pool urea kinetic. To correct PDUR and predict equilibrated Kt/V (eKt/V) some methods have suggested by Daugirdas, et al. Smye, et al. and Tattersall, et al. The purposes of this study were to determine the optimum intradialytic urea sample time that fits best with PDUR and to compare calculated Kt/V by this sample with the different other methods. Methods : The subjects were 21 patients who were dialyzed at three times 4 hours weekly, using bicarbonate and cellulosynthetic membranes. Blood samples to measure BUN were obtained at initiation of dialysis session and then at 80, 120, 180, 200, 210, 220 minutes, and the end of dialysis session times and then at 45 minutes of postdialysis . We compared four different methods of eKt/V with the equilibrated 45-minute PDUR Kt/V (eKt/V PDUR) as the reference method. Results : The mean PDUR was 17.2± 6%. spKt/V and eKt/V PDUR was 1.300±0.24 and 1.120±0.20 respectively, leading to overestimation of actual delivered Kt/V by 13.5±5%. The best time for intradialytic sampling to fit with PDUR BUN w as 40 minute before the end of session. eKt/V by Daugirdas formulae(eKt/V Dau=1.315± 0.21, r=0.972, p<0.001), Tattersal formulae(eKt/V T at=1.134± 0.22, r =0.972, p<0.972, p<0.001) and Smye formulae(eKt/V Smye=1.156± 0.24, r=0.900, p<0.001) showed good correlation with eKt/V PDUR. eKt/V calculated by the sample of 40 minute before end of session (eKt/V T-40=1.120±0.20, r=0.984) had tendency of the best correlation with eKt/V PDUR. Among these different methods, eKt/V T -40 had the best degree of agreement with eKt/V PDUR by Bland-Altman analysis. Conclusion : Our results suggest that the use of spKt/V is not adequate to estimate the amount of delivered hemodialysis dose because of the existence of significant postdialysis urea rebound even conventional 4 hour dialysis. Intradialytic sampling method is a simple and accurate method to predict eKt/V for use in clinical practice.
성인에서 발생한 소장 지방종에 의한 공장-공장 중첩증 1예
김병철 ( Byung Chul Kim ),정석원 ( Seok Won Jung ),권성호 ( Sung Ho Kwon ),박재석 ( Jae Serk Park ),고병균 ( Byung Kyun Ko ),김영민 ( Young Min Kim ),김도하 ( Do Ha Kim ) 대한내과학회 2008 대한내과학회지 Vol.75 No.3
Intussusception is a prolapse of a segment of the intestine into the lumen of the adjacent intestine. The majority of intussusceptions occur in infancy and early childhood. Intussusception arising in adulthood represents only about 5% of all intussusceptions and is usually caused by a malignant small bowel lesion acting as an apex for intussusception. Lipoma is not a common tumor in the gastrointestinal tract, and gastrointestinal lipomas may be submucosal or subserosal. Most of them are asymptomatic, although they may cause abdominal pain, bowel obstruction, and gastrointestinal bleeding. Intestinal intussusception caused by lipoma is uncommon and is particularly rare when the lipoma is located in the small intestine. We report an unusual case of intussusception in an adult male patient, which was caused by a lipomatous lesion located in the proximal jejunum acting as a lead point. (Korean J Med 75:333-336, 2008)
포스터 전시 : 간 ; 자가면역성 간염과 원발성 담즙성 간경변증의 중복 증후군 1예
김병철 ( Byung Choul Kim ),박지현 ( Jee Hyun Park ),정인두 ( In Du Jeung ),서광원 ( Kwang Won Seo ),주광로 ( Kwang Ro Joo ),김도하 ( Do Ha Kim ),박능화 ( Neung Hwa Park ) 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
<서론> 중복증후군이란 자가면역성 간염과 원발성 담즙성 간경변증의 여러 진단의 특징들이 혼재하여 어느 한 질환으로 정의 할 수 없는 경우를 말한다. 국내 문헌에는 이러한 중복증후군의 2예가 보고되었고 저자 등도 이러한 1예를 경험하였기에 보고하는 바이다. <증례> 45세 여자가 내원 2년 전부터 발생한 우상복부 불쾌감을 주소로 개인병원에서 실시한 검사에서 간기능의 이상이 발견되어 내원하였다. 과거력에서 특이 사항 없었고 약물 복용이나 음주력도 없었으며