침엽수재(針葉樹材)의 방사조직에 관한 연구 : 방사조직지표치(放射組織指標値)의 상호관련성 Mutural Relation on the Indicators of Wood Rays in Coniferous Woods

이원용 한국목재공학회 1987 목재공학 Vol.15 No.2

In the present paper I described the relations of wood ray indicators such as ray height, ray width, number of rays per 0.25㎟, ray spacing and fusiform ray height on the stem of Pinus koraiensis and Larix leptoltpis grown at the Experiment Forest of Kangweon National University. The results may be summarized as follows. 1. The number of rays and ray spacing were generally decreased with the increase of ray height on the sample woods. 2. According to the tree species the patterns of varition of rap width with the increase of roe height were different, namely the relation between ray width and ray height showed some positive correlation on Pinns korniensis and negative on Larix leptolepis. 3. It was recognized that tire variation of fusiform ray height due to the increase of ray height indicated two patterns(the increasing and constant regions) in sampler woods. This boundary seemed to appear at six cells o ray height on Pinus koraiensis and nine cells on Larix lepolepis. 4. The relation between fusiform ray height and number of rags had a negative correlation on Pinus koraiensis, but this tendancy was not obvious on Larix leptolepis. And ray spacing and ray width due to the increase of fusiform ray height were generally decreased. 5. On the whole the values of ray spacing and width became gradually larger in proportion to the increase of number of rays. 6. According to the increase of ray spacing the values of ray width also increased gradually. But this tendency was more clear on Pinus koraiensis than larix leptolepis.

The Old Man and the Sea의 硏究 : Christian Symbolism을 中心으로

이원용 總神大學校 1987 論文集 Vol.6 No.-

아동의 구강보건에 대한 보호자의 관리태도 및 지식정도에 관한 조사연구

양정강,이원용 大韓小兒齒科學會 1975 大韓小兒齒科學會誌 Vol.2 No.1

The study was performed to evaluate the Parent's knowledge and attitudes concerning the dental health of their children. A questionnaire consisting of 17 questions was given to each of the 664 parents by their children who are attending in primary school and was completely by them. The collected information from the questionnaire was analyzed by the visits to dental clinic, age and education. The results obtained from this study are as follows: 1) The more educated parents were more interested to the dental health of children. 2) In the knowledge concerning the dental health of their children, the parents who were more educated and had visited the dental clinic gave the better responses. 3) There were no clear differences in age groups in the knowledge and attitudes on their children's dental health. 4) The reason for first visiting the dental clinic was dental treatment 43.2%, toothache 35.4%, for the purpose of oral examination 21.2%, and others were 9.2%. 5) 13.1% of the parents who had visited the dental clinic couldn't or didn't follow the recommended treatment because of economic difficulty 53.3%, lack of time 25%, lack of understanding of child's dental needs 18.3%, and other reasons were 3.3%.

Ethane 1,2-Dimethane Sulfonate (EDS)가 성체 흰쥐의 부속생식기관에 미치는 효과 : 조직학적 연구

이원용,이성호 한국발생생물학회 2009 발생과 생식 Vol.13 No.2

알킬화제로 잘 알려진 ethane 1,2-dimethane sulfonate(EDS)는 여러 종에서 선택적인 Leydig 세포(LC) 독성과 정소 기능장애에 연구모델로 널리 사용된다. EDS 투여에 의해 유도된 LC 녹아웃 흰쥐의 경우 부정소와 저정낭과 같은 테스토스테론 의존성 부속생식기관들의 급격한 무게 감소가 초래됨이 이전의 연구들에서 보고되었다. 본 연구는 EDS 투여가 흰쥐 부속생식기관에 미치는 영향에 대해 조사한 것이다. 성체 수컷 흰쥐에 EDS를 1회 주사(75mg/kg, i.p.) 한 후 0, 1, 2, 3, 4, 5, 6, 7주 후에 각각 희생시켰다. 정소와 부정소, 저정낭 그리고 전립선의 무게를 각각 측정하였다. 조직의 변화는 hematoxylin & eosin 염색과 광학현미경을 통하여 분석하였다. 생식소와 그 부속기관의 무게는 EDS 처리 후 3주까지 점진적으로 감소하였고, 이후 서서히 정상으로 회복되었다. 부정소의 무게는 정상 수준의 60%까지 회복되는 양상을 보였다. 조직학적 결과에서 부정소의 상피세포층은 주사 후 1주에서 3주까지 비대해지는 것이 관찰되었다. 저정낭에서는 주사후 1주부터 3주까지 상피세포층의 두께가 감소하였다. 전립선 역시 주사후 1주에서 3주까지 상피세포층의 두께가 감소되고 4주부터 회복되었다. 본 연구는 EDS 주사에 의해 일시적으로 안드로겐 결핍이 일어난 흰쥐에서 부속생식기관에 뚜렷한 조직학적 변화가 일어남을 보였다. EDS 모델을 사용하여 이들 안드로겐 의존적인 부속생식기관의 생리적, 분자적인 조절 기작에 대해 심층 연구할 경우 이들 조직의 정상 및 병리학적 발생과 분화를 이해하는데 도움이 될 것이다.

6-hydroxydopamine을 흰쥐 줄무늬체에 투여한 파킨슨병 모델의 행동학적 특성 및 도파민 신경세포의 퇴행 양상

이원용,김경문,이정일 대한신경과학회 2000 대한신경과학회지 Vol.18 No.6

최적의 공중감시를 위한 임무지역 할당 모형

이원용,이문걸 대한산업공학회 2018 대한산업공학회 춘계학술대회논문집 Vol.2018 No.4

최근 우리군은 북한의 핵 미사일 위협에 대비하여 Kill-Chain, KAMD(Korea Air and Missile Defense)을 통한 방어체계를 구축하고 있다. 본 체계 실행의 최우선 단계는 감시정찰 자산은 무인기 및 고성능의 정찰기 등을 포함하고 있으며 이러한 자산의 효율적인 임무수행을 위해서는 무기체계 성능뿐만 아니라 이 성능을 극대화 시켜줄 효과적인 운용계획이 요구되어진다. 따라서 본 연구에서는 공중감시 체계의 레이더 탐지확률과 생존율 등의 불확실성을 포함한 최적의 임무지역 선정을 위한 확률적 최적화 수리모형을 제시한다. 아울러 본 모형을 적용한 사례연구를 통해 효과성에 대해 보여준다.

The transcription factor Batf3 inhibits the differentiation of regulatory T cells in the periphery

이원용,김형수,황수석,이갑열 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-

Naive CD4 T cells activated by antigen-presenting cells (APCs) undergo terminal differentiation in the periphery. Multiple mechanisms determine their fates, that is, whether they differentiate into conventional T (Tconv) cells or regulatory T (Treg) cells. The key event during Treg generation is expression of the transcription factor Foxp3, which is the lineage-determining regulator for Treg differentiation and function. Here we show that the transcription factor Batf3 acts as a fate-decision factor with respect to Tconv versus Tregs by restraining Treg differentiation. Batf3 was preferentially expressed in effector CD4 T cells but not in Treg cells, and ectopic expression of Batf3 inhibited Foxp3 induction. Batf3-deficient CD4 T cells favorably differentiated into Treg cells in vitro and in colonic lamina propria. Batf3 KO mice also showed enhanced Treg function in gut-associated immune disease models (for example, ovalbumin tolerance and inflammatory bowel disease models). Batf3 bound to the CNS1 region of the Foxp3 locus and reduced expression of the gene. Thus, Batf3 is a transcriptional suppressor of Treg differentiation.

Transcriptional regulation and development of regulatory T cells

이원용,이갑열 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-

Regulatory T (Treg) cells are a distinct subset of CD4+ T cells. Instead of triggering adaptive immunity, they suppress immune responses. Small numbers of Treg cells reside within lymphoid organs and peripheral tissues, but their contribution to immune tolerance is so significant that defects in Treg cell function cause catastrophic immune disorders. Since they were first discovered 20 years ago, efforts have been made to understand the differences in developmental processes between Treg cells and conventional T cells that determine the ultimate fate of the overall T-cell population. Transcription factor Foxp3 is crucial for Treg cell differentiation, but it is not the whole story. Owing to recent advances in Treg cell research, we are now on the verge of appreciating the comprehensive mechanisms underlying Treg cell generation. Here, we discuss major discoveries, active study topics and remaining questions regarding Treg cell development.

한우 비육

이원용 경북대학교 농업개발대학원 1996 最高農業經營者課程 論文集 Vol.- No.2

A Convenient and Less Invasive Technique of Labial Minor Salivary Gland Biopsy Using a Minimal Incision With a Needle Tip

이원용,최윤석,안순현,하정훈 대한이비인후과학회 2014 Clinical and Experimental Otorhinolaryngology Vol.7 No.3

Objectives. This study was to show the technique and to compare the usefulness and complications of biopsy using a mini- mal incision with a needle tip of the labial minor salivary glands with those of conventional incisional lip biopsy in the diagnosis of Sjögren’s syndrome. Methods. We retrospectively reviewed the medical records of the patients who had the labial minor salivary gland biopsy for the diagnosis of Sjögren’s syndrome between January 2005 and December 2008. One hundred forty-three pa- tients were enrolled in this study. The yields of diagnostic salivary tissues and complications of the biopsy using a minimal incision with a needle tip and the conventional incisional lip biopsy were compared. Results. Out of 143 patients, 56 patients underwent the conventional incisional lip biopsy and 87 patients received the bi- opsy using a minimal incision with a needle tip. In the biopsy using a minimal incision with a needle tip group, ade- quate salivary gland tissues were obtained in 85 patients out of 87 patients (97.7%). In the conventional incisional lip biopsy group, adequate specimens were acquired in 44 patients out of 56 patients (78.6%). There was no compli- cation after the biopsy using a minimal incision with a needle tip, whereas there was one patient complained tran- sient numbness of the lip after the conventional incisional lip biopsy. Conclusion. The less invasive labial minor salivary gland biopsy using a minimal incision with a needle tip was easy to per- form and safe and showed the better result than the conventional incisional lip biopsy in terms of the adequate speci- men in the diagnosis of Sjögren’s syndrome. So it might be a good alternative to the conventional incisional lip biopsy.