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이경종,고령은,이현,정병호,엄상원,김호중,권오정 대한결핵 및 호흡기학회 2017 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.124 No.-
Background: In patients who have suspected progression of lung cancer after systemic treatment, it is very important to confirm disease progression or mutational re-evaluation for making treatment decision. We investigated the role of rebiopsy by EBUS-TBNA for patients with progressed lung cancer. Methods: We searched EBUS-TBNA registry and found 114 patients who underwent EBUS-TBNA as a rebiopsy procedure between May 2012 and April 2016. Pathologic and mutation success was defined as cases who had tumor cells or detection of any mutations in the EBUS samples. Results: Among 114 patients, 36 patients (31.6%) were for the confirmation of disease progression and 78 patients (68.4%) for molecular and mutational analysis. Overall, Pathologic success rate to acquire tumor tissues by EBUS-TBNA was 82.5%. Mutational success rate including T790M, ROS, cMET, ALK FISH was 82.7%. The failure of mutation analysis resulted from insufficient tissues (n=3), no malignant cells (n=7), EGFR mutation detection failure (n=1), respectively. Success rate for T790M mutation was 85.4% among 48 patients who had EGFR-TKI treatment failure and EGFR T709M mutation was detected in 56.1%. T790M with Exon 19 mutation, Exon 21 mutation was found in 15 patients (36.6%) and 8 patients (19.5%). There was no significant difference between exon 19 and exon 21 mutation for T790M mutation (p=0.093). Mutational discrepancy rate between primary and rebiopsy samples was 5.3%. Conclusion: EBUS-TBNA for rebiopsy was feasible in patients who were necessary to confirm the disease progression or mutational status.
김규상,정호근,노재훈,문영한,이경종 大韓産業醫學會 1993 대한직업환경의학회지 Vol.5 No.1
Group health services for small and medium sized industries have launched in 1989. This study was performed to analyze the relationship between working environments and workers' health status by characteristics of small and medium sized industries. The medical checkup for workers and evaluation of working environments were performed for 205 industries in Inchon area during 1991. The industrial accident rate for general industries was significantly higher than that for special industries. The occurrence rate of occupational diseases for special industries was significantly higher than that for general industries. the frequency of worksite barzards was highest in metal industries. Incidence rate of industrial accidents, general and occupational diseases for workers of manufacturing industries were higher than those of non-manufacturing industries. The incidence rate of occupational diseases among industries have labor union was significantly higher than industries have not. the level of dust, chemicals and heavy metals in workplace were significantly different by industrial classification. The number of workplace which dust level exceeding TLV was the highest in manufacture of chemicals. As we have seen, general characteristics of industries were related with the working environments and workers' health status. Working environments were strongly related with health status of workers. These results may provide information to establish the group health services to improve workers' health status and working environments.