이달의 쟁점 : IT산업 대북투자 어떻게 볼 것인가 -북 현실 직시하는 신중한 접근 요구된다

황재준 평화문제연구소 2001 통일한국 Vol.210 No.-

S-295 ST 분절의 상승이 없는 심근경색증 환자들의 임상결과

황재준,박창범 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1

배경: ST 분절 상승을 동반하지 않는 심근경색 환자(NSTEMI)의 심전도(ECG)는 다양하게 나타난다. 방법 : 2006년 부터 2013년 까지 본원에 입원하여 관상동맥조영술(coronary angiogram)을 시행받은 345명의 NSTEMI 환자의 인구통계학, 시술특성, 임상결과를 분석하였다. 결과 : 심전도상에서 ST 분절 하강군은 114 명, T-wave inversion 군은 90 명, 변화가 없는 군은 141 명이었다. ST 분절 하강 군은 변화가 없은 군에 비해 나이가 더 많았으며 비흡연자이고 신체질량지수(BMI)가 적게 나가는 여성, 공존질환이 더 많은 양상을 보였다. 또한 높은 Killip class, 낮은 좌심실 구혈률(left ventricular ejection fraction), 높은 벽운동지수(regional wall motion score index), 혈관조영술 상에서 혈관 근위부, 3개 혈관질환(3-vessel coronary artery disease) 발생 비율이 더 높았다. 반면 T-wave inversion 군은 변화가 없는 군과 비슷한 양상을 보였다. 임상결과에서는 심전도상에서 변화가 없었던 군에 비해 ST분절 하강군이 시술 후 30일, 12개월 사망율이 더 높았던 반면 T-wave inversion군은 비슷한 양상을 보였다. 결론: 심전도상에서 변화가 없었던 군에 비해 ST분절 하강군은 공존질환이 더 많았으며 원내 및 12개월 사망율이 더 높았으나 T-wave inversion 군은 비슷한 양상을 보임을 확인할 수 있었다.

BSC와 DEA 결합모델을 이용한 증권사 효율성 분석에 관한 연구

황재준 한국산업경영시스템학회 2012 한국산업경영시스템학회 학술대회 Vol.2012 No.추계

개심술 환자에서의 면역기능의 변화;T lymphocyte subset의 변화에 대한 고찰

황재준 대한흉부심장혈관외과학회 1992 Journal of Chest Surgery (J Chest Surg) Vol.25 No.11

Cell mediated immunity is depressed following surgical procedure and the degree of immunosuppression is directly related to the magintude of the procedure, blood transfusion, and length of operation. So we would expect cardiac operations to be highly immunosuppressive, although little is konwn about their immunosuppressive effect. The nearly complete consumption of complement factors and decreased levels of IgM and IgG resulting in an impaired opsonizing capacity. Additionally, peripheral blood mononuclear cell counts including T-and B-lymphocytes and T-cell subsets are reduced. Depression of cell-mediated immunity following open-heart surgery is potentially detrimental because it could increase the susceptability of patients to viral and bacterial infection. We reviewed 20 patients after cardiac operation to search for changes in peripheral blood lymphocyte subsets. Lymphocyte subsets were measured by flow cytometer and the preoperative values of lymphocyte subsets were compared with those from the first, fourth, and seventh days after operation. After cardiac operation, total mumbers of T lymphocyte was severely depressed on the first postoperative day and returned to the preoperative level by the seventh day after operation. CD3, CD4, and CD8 lymphocytes were decreased on the first postoperative day and returned to the preoperative level by the seventh day also. There was four cases of wound infection and these patients had increased CD4 lympocyte and more decreased CD19 lymphocyte compared with the non-infected group. It is concluded from these data that cell-mediated immunity is significantly depressed for at least one week following open-heart surgery and this result was closely related to the postoperative infection.

폐 동정맥루;1례 보고

황재준 대한흉부심장혈관외과학회 1992 Journal of Chest Surgery (J Chest Surg) Vol.25 No.7

In pulmonary arteriovenous fistula, there are abnormal communications between the pulmonary arteries and the pulmonary veins; the capillary networks that normally separate arteries from veins is absent. The only available treatment of this uncommon variety is an excision. We report a case of pulmonary arteriovenous fistula cured by segmentectomy with a review of literatures.

Combination Therapy With Polydeoxyribonucleotide and Pirfenidone Alleviates Symptoms of Acute Respiratory Distress Syndrome in Human Lung Epithelial A549 Cells

황재준,고일규,진준장,황락경,김상훈,전정원,백승숙,장복순,최천웅 대한배뇨장애요실금학회 2020 International Neurourology Journal Vol.24 No.S1

Purpose: Acute respiratory distress syndrome (ARDS) is characterized by its acute onset of symptoms such as bilateral pulmonary infiltrates, severe hypoxemia, and pulmonary edema. Many patients with ARDS survive in the acute phase, but then die from significant lung fibrosis.Methods: The effect of combination therapy with polydeoxyribonucleotide (PDRN) and pirfenidone on ARDS was investigated using human lung epithelial A549 cells. ARDS environment was induced by treatment with lipopolysaccharide and transforming growth factor (TGF)-β. Enzyme-linked immunoassay for connective tissue growth factor (CTGF) and hydroxyproline were conducted. Western blot for collagen type I, fibroblast growth factor (FGF), tumor necrosis factor (TNF)-α, and interleukin (IL)-6 was performed.Results: In this study, 8-μg/mL PDRN enhanced cell viability. Combination therapy with PDRN and pirfenidone and pirfenidone monotherapy suppressed expressions of CTGF and hydroxyproline and inhibited expressions of collagen type I and FGF. Combination therapy with PDRN and pirfenidone and PDRN monotherapy suppressed expression of TNF-α and IL-1β.Conclusions: The combination therapy with PDRN and pirfenidone exerted stronger therapeutic effect against lipopolysaccharide and TGF-β-induced ARDS environment compared to the PDRN monotherapy or pirfenidone monotherapy. The excellent therapeutic effect of combination therapy with PDRN and pirfenidone on ARDS was shown by promoting the rapid anti-inflammatory effect and inhibiting the fibrotic processes.

Hyperuricemia Is Not Predictive of Long- Term Outcome in Patients with Stable Chronic Obstructive Pulmonary Disease

황재준,오연목,Chin Kook Rhee,유광하,박용범,Ho Il Yoon,임성용,Ji-Hyun Lee,김은경,Tae Hyung Kim,Sei Won Lee,Sang Do Lee,이재승,KOLD Group 대한의학회 2020 Journal of Korean medical science Vol.35 No.8

Background: Although the association of hyperuricemia with an increased risk of mortality has been demonstrated in the context of acute exacerbation of chronic obstructive pulmonary disease (COPD), the long-term outcomes of hyperuricemia have not been studied in the case of stable COPD. Methods: We retrospectively analyzed baseline data of 240 men with stable COPD enrolled in the Korea Obstructive Lung Disease cohort. We evaluated associations between serum uric acid levels and clinical parameters, risk factors for all-cause mortality, and acute exacerbation of COPD. Results: The mean age of subjects was 66.4 ± 7.7 years, and the median follow-up time was 5.9 years. We identified no significant difference in terms of lung function or laboratory findings between patients with hyperuricemia and those without. Serum uric acid level was negatively associated with systemic inflammation indicated by neutrophil–lymphocyte ratio (r = −0.211, P = 0.001). Univariate Cox regression analysis revealed hyperuricemia to not be associated with an increased risk of all-cause mortality in men with stable COPD (hazard ratio [HR], 0.580; 95% confidence interval [CI], 0.250–1.370; P = 0.213). In the multivariate Cox regression model, hyperuricemia was not an independent predictor of acute exacerbation (HR, 1.383; 95% CI, 0.977–1.959; P = 0.068). Conclusion: Among men with stable COPD, hyperuricemia is not an independent predictor of all-cause mortality or future acute exacerbation of COPD. These results differ from those of previous studies on patients with acute exacerbation of COPD.

기관지 내 연골성 과오종 -1예 보고-

황재준,이송암,김준석,이태훈,임소덕,황은구,김요한 대한흉부외과학회 2006 Journal of Chest Surgery (J Chest Surg) Vol.39 No.3

폐실질 내 과오종은 흔히 볼 수 있는 양성 폐종양이나, 기관지 내 과오종은 드문 종양 중 하나이다. 치료로는 기관지내시경을 이용한 제거나 기관절개 또는 정상적인 폐실질을 보존하기 위해 소매절제를 통한 종양의 제거가 보편적이다. 그러나 만성적인 기관지 폐쇄로 인해 폐실질이 파괴되어 보존이 어려운 경우에는 폐절제술이 필요할 수 있다. 저자는 기관지 내 과오종에 의해 좌상엽의 경화가 진행되어 좌상엽절제술이 필요했던 환자를 보고하는 바이다. 42세 여자가 3주일 전부터 발생한 기침과 좌측 흉통을 주소로 내원하였다. 기관지내시경 소견상 좌상엽기관지의 입구를 완전히 막고 있는 엽성 종괴가 관찰되었고, 생검을 시도하였으나 출혈로 실패하였다. 수술 소견상 만성적인 기관지 폐쇄에 의해 좌상엽의 경화가 심하여 좌상엽절제술을 시행하였다. 환자는 술 후 14일째 퇴원하였다.

결핵성 늑막염의 진단시 늑막액의 Tb PCR 및 ADA활성도에 관한 연구

황재준,최영호,김욱진,신재승,손영상,김학제 대한흉부심장혈관외과학회 2000 Journal of Chest Surgery (J Chest Surg) Vol.33 No.8

Background: Tuberculous pleurisy is the leading cause of pleural effusion in Korea. And differential diagnosis of tuberculous pleurisy with other cause is clinically very important. Traditional diagnostic methods such as routine analysis of pleural fluid, staining for acid-fast bacilli or pleural biopsy have major inherent limitaion. This study was designed to evaluate the significance of pleural fluid polymerase chain reaction(PCR) and adenosine deaminase (ADA) activity in early diagnosis of tuberculous pleurisy. Material and Method: Between March 1996 and July 1997, 198 patients with pleural effusion reviewed retrospectively. The study group included 112 cases with tuberculous effusion and 86 cases with non-tuberculous effusions, whose diagnoses were confirmed by pleural biopsy, microbiological methods, or cytology. We compared the results of PCR and pleural fluid levels of ADA between tuberculous and non-tuberculous effusions. Result: Mean age was 47.54$\pm$19.52 years(range 2 to 85 years). The positive rate of PCR was significantly higher in tuberculous group than non-tuberculous group(p<0.05). The sensitivty, specificity, positive predictive value(PPV), and negative predictive value(NPV) for PCR were 31.7, 90.9, 83.0, and 48.8%, respectively. Mean ADA activity was significantly higher in tuberculous group than non-tuberculous group(83.2 U/L vs 49.8 U/L)(p<0.05). With diagnostic thresholds of 40 U/L, the sensitivity, specificity, PPV, and NPV of ADA for tuberculosis were 75.9, 70.9, 77.3, and 69.3% respectively. At a level of 70 U/L, the sensitivity, specificity, PPV, and NPV of ADA for tuberculosis were 70.1, 75.9, 82.9, and 60.3% respectively. Conclusion: PCR is very highly specific, but less sensitive methods in diagnosis of tuberculous pleurisy. But ADA level of pleural fluid has acceptable sensitivity and specificity in diagnosis of tuberculous pleurisy. ADA activity is more useful test in the evaluation of pleural effusions.

Fair-DEA를 이용한 다국가 임상시험 기관 선정

황재준,최인찬 대한산업공학회 2017 대한산업공학회 춘계학술대회논문집 Vol.2017 No.4