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육미지황탕합사백산(六味地黃湯合瀉白散)과 상백피(桑白皮)가 인간 기관지상피세포의 IL-6, IL-8, GM-CSF mRNA level에 미치는 영향
황우석,허태석,정희재,정승기,이형구,주창엽,Hwang, Woo-Suck,Heo, Tae-Seok,Jung, Hee-Jae,Jung, Sung-Ki,Rhee, Hyung-Koo,Ju, Chang-Yeop 대한한방내과학회 2001 大韓韓方內科學會誌 Vol.22 No.3
Objectives: We aimed to identify the dose-dependent inhibitory effects of Yukmijihwang-tang-Hap-Sabaek-san(YMHSB) and Root cortex of Morus alba L.(RCM) on the mRNA expression of Interieukin(IL)-6, IL-S, granulocyte macrophage colony stimulating factor(GM-CSF) involved in the asthma model. Methods: In this study BEAS-2B cell lines, human epithelial cells, were used. These cells were stimulated by tumor necrosis $factor(TNF)-{\alpha},\;IL-1{\beta}$ and histamine for artificial inflammatory expression. ${\beta}-actin$ messenger RNA(mRNA) was used for the internal standard. After each 24 hours of the YMHSB and RCM treatment, total cellular RNAs were collected by treating RNA zol directly on the living cells. Then the transcriptional activities of IL-6, 8 and GM-CSF were measured by RT-PCR with electrophoresis. Results: In the YMHSB study, the mRNA expression of GM-CSF and IL-8 is significantly inhibited compared to that of control group. But the mRNA expression of IL-6 is not significantly inhibited. In the RCM study, the mRNA expression of GM-CSF and IL-S is significantly inhibited compared to that of control group. But the mRNA expression of IL-6 is not significantly inhibited. Conclusions: This study shows that YMHSB and RCM have dose-dependent inhibitory effects on the mRNA expression of IL-S and GMCSF in human epithelial cells. So these herbal medicines may inhibit the inflammatory process of asthma. Advanced studies are required to investigate the mechanisms of inhibition by herbal medicine in the asthma model.
황우석(Woo-seok Hwang),이두호(Doo-ho Lee),이덕영(Dug-young Lee) 한국자동차공학회 2002 한국자동차공학회 지부 학술대회 논문집 Vol.- No.-
The tools to solve the NVH problems in a car are presented. One analysis tool alone cannot verify the mechanism of the complex NVH problems. For example, the transfer path analysis can identify the critical noise transfer path. However, it does not give the answer for why the noise transfer function is so high at that path. The simultaneous application of transfer path analysis, running mode analysis, structural modal analysis, acoustic modal analysis, and panel contribution analysis can verify the mechanism of NVH problems systematically.
황우석(Hwang, Woo-Seok) 한국소음진동공학회 2012 한국소음진동공학회 논문집 Vol.22 No.4
The most common type of the piezoelectric energy harvester is the cantilevered beam since it is attached to the host structure and tuned to the frequency of the base excitation easily. However, the excessive strain at the fixed end of cantilevered beam causes some problems such as fatigue and durability. The use of higher vibration modes of the cantilevered beam may reduce the concentration of the strain at the fixed end since the strains of higher modes are distributed along the span. The results show that the use of high vibration mode is not efficient for power generation, but it reduces the excessive strain lever at typical region to prevent the failure by fatigue.
모달 파라미터를 이용한 동적 시스템의 운동 방정식 구성
황우석(Woo Seok Hwang) 한국항공우주학회 2007 韓國航空宇宙學會誌 Vol.35 No.1
구조물의 모달 해석 또는 모달 시험은 구조물의 동적 특성을 나타내는 모달 파라미터들을 구하는 과정이다. 모달 파라미터에는 고유 진동수, 감쇠율, 진동 모드의 세 가지 값들이 있다. 본 연구에서는 시스템의 개발과정에서 당연히 수행되는 모달 해석의 결과인 모달 파라미터를 활용하여 시스템 방정식을 구하는 방법에 대한 연구를 수행하였다. 상태 방정식의 고유치와 고유 벡터의 상관관계로부터 물리적 시스템 행렬인 질량, 감쇠, 강성 행렬을 각각 구하는 방법을 개발하였다. 간단한 질량-스프링-댐퍼 시스템과 외팔보에 대한 수치 예제를 통하여 개발된 방법의 유용성과 정확도를 검증하였다. Modal analysis or modal test is a routine process to get the modal parameters of a dynamic system. The modal parameters include the natural frequencies, damping ratios and mode shapes. This paper presents a method that can derive the equations of motion for a dynamic system from the modal parameters obtained by the modal analysis or modal test. The present method based on the relation between the eigenvalues and eigenvectors of the state space equation derives the mass, damping and stiffness matrices of the system. The numerical verifications for the simple mass-spring-damper system and the cantilevered beam prove the efficiency and accuracy of the present method.