異常分娩(Dystocia)=難産

黃東薰 최신의학사 1979 最新醫學 Vol.22 No.5

갑상선 섭취율 측정에서 선원의 길이와 부피 증가에 따른 영향

황동훈,오신현,김정열,강천구,김재삼,Hwang, Dong Hun,Oh, Shin Hyun,Kim, Jung Yul,Kang, Chun Koo,Kim, Jae Sam 대한핵의학기술학회 2017 핵의학 기술 Vol.21 No.1

방사성 요오드 갑상선 섭취율 검사는 방사성 요오드를 투여하고 일정 시간 후 갑상선의 요오드 방사능치를 측정하여 전반적인 기능 상태를 알아보는 검사법이다. 검사에 영향을 미치는 인자는 매우 다양하다. 본 연구에서는 갑상선의 길이나 두께, 부피에 따른 기하학적 요인이 계수율에 주는 영향을 관찰하고자 한다. 액체상태의 $^{131}I\;185kBq$ ($5{\mu}Ci$)을 지름이 0.5, 1, 1.5, 3 cm 인 주사기에 넣고 길이를 1 cm 간격으로 생리식염수를 추가하여 증가시켰다. 선원을 장비로부터 25 cm 거리에서 횡축방향과 종축방향으로 위치하였을 때 각각의 계수율을 측정하였다. 횡축 방향으로 위치하였을 때, 선원의 길이가 변화하여도 대부분 유의한 차이를 보이지 않았다. 종축 방향으로 위치하였을 때, 곡선추정 회귀분석 결과 복합모형곡선과 높은 상관관계를 보였고($$R^2{\geq_-}0.941$$), 선원의 길이가 증가할수록 계수율은 감소하였다. 따라서 갑상선 섭취율 검사 시, 갑상선의 가로나 세로 방향의 차이에 따른 섭취율의 오차는 적을 것으로 예상되어 지며, 단순한 부피의 차이보다 갑상선의 두께 및 투여 전 선량측정 시의 비커에 따라서 오차가 생길 수 있다고 예상된다. 따라서 오차를 줄이기 위해서는 초음파 등의 영상을 참고하여 두께를 구해 섭취율 수치에 적용하거나, 결과에서 구한 복합방정식을 통해 오차를 예측, 갑상선과 섭취율 장비의 거리를 변화시킨다면 비교적 정확한 계수율을 구할 수 있을 거라 사료 된다. Purpose Radioactive iodine thyroid uptake (RAIU) rate is an examination which determines and seeks about general functions of thyroid gland. The size of thyroid gland is normally different between each person, also patients having thyroid diseases have had a variety of size of thyroid gland compared with others. The purpose of this study will investigate about the counting rate which is effected by the geometric factors through the length and volume changes of the source in RAIU rate. Materials and Methods I-131 185 kBq ($5{\mu}Ci$) were placed in a cylindrical phantom of 0.5 cm, 1 cm, 1.5 cm, and 3 cm in diameter, respectively, and saline was added to gradually increase the length by 1 cm in the horizontal and vertical directions to give a change in volume. The source was measured 20 times for 20 seconds from a distance of 25 cm to $364.4keV{\pm}20%$ energy ROI with Captus 3000 thyroid uptake system (Capintec, NJ, USA). Results When the source was located in the transverse direction of the detector, the consequence of one-way ANOVA is that even though the length of source is increased each diameter, there is mostly no significant difference. When the source was located in the longitudinal direction and the counting rate of length 1 cm at all diameter is set to 100%, the average is 92.57% for length 2 cm, 86.1% for 3 cm, 80.69% for 4 cm, 74.82% for 5 cm, and 69.68% at 6 cm. Conclusion According to this study, it is expected that the gap of RAIU rate has been depended on the thickness of thyroid gland as well as the diameter of the beaker. We know that the change of the volume with the increase of the length of the source had less effect on the change of the counting rate. Thus, in order to reduce the error in the measurement of the counting rate with the thyroid uptake rate equipment, an accurate counting rate can be relatively measured if the counting rate which is measured is corrected by thickness or the distance between the thyroid and the thyroid uptake rate equipment is changed.

임신융모성종양의 화학요법

黃東薰 연세대학교 의과대학 1982 연세의대논문집 Vol.15 No.1

자외선 조사처리에 의한 cryptococcus neoformans의 전자현미경적 관찰

황동훈,고춘명,최태주,류준,Hwang, Dong-Hoon,Koh, Choon, Myung,Choi, Tae-Joo,Lew, Joon 한국미생물학회 1972 미생물학회지 Vol.10 No.1

The present study is of ultra-fine structure of Cryptococcus neoformans by means of electron microscopy and reveals the following : 1) In constrast to the bacteria, the normal Cryptococcus neofrmans contains nuclear enveloped with nuclear menbrane, mitochondria, endoplasmic reticulum, distinct cell wall and cell membrane, vacuoles and storage granules as observed in the eucaryotic cells. 2) In apparent cell walls and cell membrane with the appearance of electron transparent area (ETA) and changes of cell morphology were observed in the ultra-violet ray irradiated cell. 2) In apparent cell walls and cell membrance with the appreance of electron transparent area (ETA) and changes of cell morphology were observed in the ultra-violet ray irradiated cell. 3) Morphology changes and cytoplasmic element abnormality was increased with irradiated time. 4) Increase of electron transparent area was thought to be associated with degradation of cell.

체외수정의 예후지표로서 정자의 Zona-Free Hamster Ovum Penetration 분석에 관한 연구

황동훈,이윤호,Hwang, Dong-Hoon,Lee, Yoon-Ho 대한생식의학회 1989 Clinical and Experimental Reproductive Medicine Vol.16 No.2

Defective or inadequate semen quality, usually presenting as low sperm count or poor sperm motility , is recognizable by semen analysis. However, the ability of spermatozoa to fertilize an ovum is not determined used in various experiments. In this study, hamster oocyte sperm penetration assay was used to determine the fertilizing capacity of sperms in 20 subjects which divided into two groups, group A with 10 normal fertile men, and group B with 10 infertile men. The % penetration in group A and group B were 61% and 35% respectively, which showed statistically not significant but fertilization index was significantly different between group A(FI=2.24) and group B(FI=O.05). Additionally it seemed that the percentage of sperm penetraton was influenced more by the motility of spermatozoa than by the number.

악성 란소종양의 처치와 그 예후

황동훈 中央醫學社 1983 中央醫學 Vol.44 No.6

Insulin-like Growth Factor-1 Receptor Dictates Beneficial Effects of Treadmill Training by Regulating Survival and Migration of Neural Stem Cell Grafts in the Injured Spinal Cord

황동훈,박희환,신해영,Yuexian Cui,김병곤 한국뇌신경과학회 2018 Experimental Neurobiology Vol.27 No.6

Survival and migration of transplanted neural stem cells (NSCs) are prerequisites for therapeutic benefits in spinal cord injury. We have shown that survival of NSC grafts declines after transplantation into the injured spinal cord, and that combining treadmill training (TMT) enhances NSC survival via insulin-like growth factor-1 (IGF-1). Here, we aimed to obtain genetic evidence that IGF-1 signaling in the transplanted NSCs determines the beneficial effects of TMT. We transplanted NSCs heterozygous (+/-) for Igf1r, the gene encoding IGF-1 receptor, into the mouse spinal cord after injury, with or without combining TMT. We analyzed the influence of genotype and TMT on locomotor recovery and survival and migration of NSC grafts. In vitro experiments were performed to examine the potential roles of IGF-1 signaling in the migratory ability of NSCs. Mice receiving +/- NSC grafts showed impaired locomotor recovery compared with those receiving wild-type (+/+) NSCs. Locomotor improvement by TMT was more pronounced with +/+ grafts. Deficiency of one allele of Igf1r significantly reduced survival and migration of the transplanted NSCs. Although TMT did not significantly influence NSC survival, it substantially enhanced the extent of migration for only +/+ NSCs. Cultured neurospheres exhibited dynamic motility with cytoplasmic protrusions, which was regulated by IGF-1 signaling. IGF-1 signaling in transplanted NSCs may be essential in regulating their survival and migration. Furthermore, TMT may promote NSC graft-mediated locomotor recovery via activation of IGF-1 signaling in transplanted NSCs. Dynamic NSC motility via IGF-1 signaling may be the cellular basis for the TMT-induced enhancement of migration.

원인불명의 반복적 태아손실 기왕력환자에서 면역치료후 출생한 신생아의 합병증 Bayley Development Test를 이용한 정신신체운동 발달상황에 대한 보고

황동훈,이윤호,황홍규,원현주,문태일 대한산부인과학회 1996 Obstetrics & Gynecology Science Vol.39 No.12

Habitual abortion is defined as three or more successive abortions. The pregnancy outcomes were assessed in infants born to women who underwent immunotherapy for recurrent abortion. To determine the newborn the presence of any adverse effects in infants of mothers who received immunotherapy and to evaluate infants using the Bayley developmental test. 11 gravidae with previous history of unexplained recurrent abortion treated by immunotherapy. Immunization with husband`s leukocyte was done before or during pregnancy until 16~18 weeks of gestation. As a result, there were no define abnormal neonatal outcome, neonatal complication, congenital anomalies and intrauterine fetal death. Consequently, there were no define abnormal neonatal outcome as a result of immunization. All psychologic, psychosomatic and physical developments were found to be normal.

妊婦의 急性泄瀉症에 대한 藥物療法

黃東薰 藥業新聞社 1984 (月刊) 醫藥情報 Vol.1984 No.7

姙娠腎疾患의 病態와 治療

黃東薰 藥業新聞社 1985 (月刊) 醫藥情報 Vol.1985 No.8