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황대성,신은석,김신재,이준호,김종민,이상곤 연세대학교의과대학 2013 Yonsei medical journal Vol.54 No.2
Purpose: The aim of this study was to demonstrate the early effects of statin treatment on plaque composition according to plaque stability on Intravascular Ultrasound-Virtual Histology at 6 months after a coronary event. Previous trials have demonstrated that lipid lowering therapy with statins decreases plaque volume and increases plaque echogenicity in patients with coronary artery disease. Materials and Methods: Fifty-four patients (54 lesions) with acute coronary syndrome were prospectively enrolled. We classified and analyzed the target plaques into two types according to plaque stability: thin-cap fibroatheroma (TCFA, n=14) and non-TCFA (n=40). The primary end point was change in percent necrotic core in the 10-mm subsegment with the most disease. Results: After 6 months of statin therapy, no change was demonstrated in the mean percentage of necrotic core (18.7±8.5% to 20.0±11.0%, p=0.38). There was a significant reduction in necrotic core percentage in patients with TCFA (21.3±7.2% to 14.4±8.9%, p=0.017), but not in patients with non-TCFA. Moreover, change in percent necrotic core was significantly correlated with change in high-sensitivity C-reactive protein levels (r=0.4, p=0.003). Changes in low-density lipoprotein cholesterol levels and lipid core percentage demonstrated no significant associations. Conclusion: A clear reduction of lipid core was observed only for the TCFA plaque type, suggesting that changes in plaque composition following statin therapy might occur earlier in vulnerable plaque than in stable plaque; the effect may be related to the anti-inflammatory effects of statins.
Light-cone Wavefunction Representations of the Sivers and the Boer-Mulders Distribution Functions
황대성 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.62 No.4
We find the light-cone wavefunction representations of the Sivers and the Boer-Mulders distribution functions. A necessary condition for the existence of these representations is that the light-cone wavefunctions have complex phases. We induce the complex phases by incorporating the final-state interactions into the light-cone wavefunctions. For the scalar and the axial-vector diquark models for a nucleon, we calculate explicitly the Sivers and the Boer-Mulders distribution functions from the light-cone wavefunction representations. We obtain the results that the Sivers distribution function has opposite signs with a factor of 3 difference in magnitude for the two models, whereas the Boer-Mulders distribution function has the same sign and magnitude. We can understand these results from the properties of the light-cone wavefunction representations of the Sivers and the Boer-Mulders distribution functions.
황대성,강순애,오광수,김태영 圓光大學校 醫科學硏究所 1992 圓光醫科學 Vol.8 No.1-2
Neurilemmoma is the most frequent solitary tumor of the peripheral nerves, but it is extremely rare in children. It arises from Schwann cells, and has usually benign nature. There is suprisingly good recovery after total removal of the mass in patients with preoperative neurologic deficits. We experienced two cases of neurilemmoma in the spinal cord and report it with a review of the literature.