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기도상피세포에서 식물 에센셜 오일의 인터루킨-8 분비억제 효과
현경희 ( Kyung Hee Hyun ),김윤섭 ( Youn Seup Kim ),서정근 ( Jeung Keun Suh ),한성환 ( Sung Hwahn Hahn ),김도형 ( Do Hyung Kim ),박재석 ( Jae Suk Park ),지영구 ( Young Koo Jee ) 대한천식알레르기학회 2011 천식 및 알레르기 Vol.31 No.4
Background: Neutrophil is an important inflammatory cell in severe asthma and associated with steroid-resistance in asthma therapy. In addition, interleukin (IL)-8 is a key chemokines recruiting and activating neutrophils. Methods: The aim of this study was to explore the therapeutic potential of aromatherapy using essential oils derived from plant extracts in asthma treatment. Essential oils from citron, pine tree, Chamaecyparis pisifera, and Chamaecyparis obtusa were extracted by water-steam distillation. The promoter activity and secretion of IL-8 were measured by using luciferase assay and enzyme-linked immunosorbent assay after pretreatment in tumor necrosis factor-α stimulated A549 and human bronchial epithelial cells (BEAS-2B) cell lines with diluted essential oils. Results: IL-8 transcription was suppressed with 1 : 500 concentration of each essential oil (P<0.05). IL-8 secretion in A549 cell was suppressed with 1 : 1,000 or higher concentrations of oils except from citron (P<0.05). IL-8 secretion in BEAS-2B cells was decreased after exposure to 1 : 500 concentration of pine tree, Chamaecyparis pisifera and 1 : 2,000 or higher concentrations of Chamaecyparis obtusa (P <0.05). Conclusion: Essential oils from pine tree and Chamaecyparis obtusa may have a therapeutic potential for asthma by regulating neutrophil-mediated inflammation. (Korean J Asthma Allergy Clin Immunol 2011;31:272-280)
염증성 장질환 환자에서 Azathioprine 사용방법에 따른 골수억제 부작용의 빈도
현경희 ( Kyung Hee Hyun ),이석호 ( Suck Ho Lee ),신재민 ( Jae Min Shin ),박동일 ( Dong Il Park ),이창균 ( Chang Kyun Lee ),신정은 ( Jeong Eun Shin ),은창수 ( Chang Soo Eun ),허규찬 ( Kyu Chan Huh ),황보영 ( Young Hwangbo ) 대한장연구학회 2012 Intestinal Research Vol.10 No.3
Background/Aims: The most important adverse effect of azathioprine (AZA) is bone marrow toxicity (BMT). Many physicians have preferred a gradual dose increment (GDI) policy for the prevention of BMT. The aim of this study was to evaluate the efficacy of GDI for the prevention of AZA-induced BMT in inflammatory bowel disease (IBD) patients. Methods: The medical records of IBD patients who received AZA in 6 university hospitals were reviewed. The patients were divided into two groups: the GDI group (initial dose <1.5 mg/kg, gradually increased to a therapeutic dose) and the non-GDI group (initial therapeutic dose ≥2 mg/kg). Results: A total of 308 patients were enrolled (male to female ratio, 1:2.3; mean age, 34.91±14.19 years; ulcerative colitis, 43.5%; Crohn`s disease, 55.2%; and intermediate colitis, 1.3%). The overall incidence of BMT was 16.2% (50/308). BMT developed most frequently between fourth to eighth week (26%, 13/50). The rate of BMT of the non-GDI group was significantly higher than that of the GDI group (27.5%, 11/40 vs. 14.6%, 39/268, P=0.038). A multivariate analysis showed that the only factor related to BMT was a non-GDI policy (P=0.036; odds ratio, 2.41; 95% confidence interval, 1.06-5.49). Conclusions: A GDI policy could be useful for reducing AZA-induced BMT in Korean IBD patients. (Intest Res 2012;10:244-250)
김용현 ( Yong Hyun Kim ),박건우 ( Keon Woo Park ),이순일 ( Soon Il Lee ),임도형 ( Do Hyoung Lim ),이현숙 ( Hyun Suk Lee ),현경희 ( Kyung Hee Hyun ) 대한내과학회 2012 대한내과학회지 Vol.82 No.1
Multiple primary neoplasms, defined as the occurrence of multiple malignant neoplasms in the same individual, were first reported by Billroth in 1889. With gradual improvements in diagnostics, and the early detection and effective treatment of malignant neoplasms, the prevalence of multiple primary neoplasms seems to be increasing. Although there have been several reports of triple primary neoplasms in Korea, cases of quadruple neoplasms are rare. Recently, we diagnosed a 69-year-old male with primary neoplasms in the Lung, esophagus, vocal cords, and hypopharynx. The authors report this rare case of four metachronous primary neoplasms and provide a review of the Literature. (Korean J Med 2012;82:110-114)
김경한 ( Kyong Hahn Kim ),현경희 ( Kyung Hee Hyun ),한소현 ( So Hyun Han ),최수정 ( Soo Jeong Choi ),장명희 ( Myung Hee Jang ) 한국외국어대학교 외국어교육연구소 2015 외국어교육연구 Vol.29 No.2
지금까지 우리나라 특성화고의 직업영어 교육은 영어 교수·학습 원리에 대한 고려 없이 전문교과 내용만을 일대일 번역 식으로 가르치는 수업이 지배적이었다. 또한, 특성화고의 직업영어 교육과정은 1학년 기초영어부터 3학년 직업영어까지 위계적이고 체계적으로 구성된 프로그램이라기보다는 보통 영어 교과와 전문교과가 이원화되어 상호 독립적으로 운영되었다. 특히, 기초영어 과정은 일반계 고등학교의 영어 교과서를 그대로 사용함으로써 학생들의 요구, 수준, 진학 등 특성화고의 현실을 반영하지 못하였다. 이제 일반계고와 차별화되고, 영어 교수·학습 원리에 기반하며, 직업 상황에 필요한 의사소통능력 배양에 초점을 둔 직업영어 교육과정, 교재 및 교수법의 개발이 필요한 시점이다. 본 연구는 이러한 시대적 필요성에 입각하여 특성화고 직업영어 교수·학습 모형을 개발하였다. 본 연구에서 개발한 직업영어 교수·학습 모형은 향후 직업영어 교육과정 및 교재개발에 시사점을 제공할 수 있을 것으로 기대된다. 본 연구에서는 특성화고 직업영어 교수·학습 모형을 개발하기 위해 특수목적영어교수법(ESP), 내용중심교수법(CBI), 의사소통중심교수법(CLT)에서 직업영어교육의 이론적 근거를 찾고, 직업영어 교육과정의 방향과 직업영어 교수·학습의 원칙을 확립하였으며, 이를 바탕으로 직업영어 교수·학습 모형을 개발하고 이에 대해 전문가의 타당도 검사를 받아 모형을 수정하였다. 직업영어 교수·학습 모형의 현장적합성을 검토하기 위해서는 인천광역시 소재 특성화고 1학년 30명을 대상으로 4차시의 시험 수업(pilot study)을 실시하였으며, 이에 대한 교사관찰지 및 학생사후반응지를 분석하고 피드백을 반영하여 최종적으로 직업영어 교수·학습 모형을 완성하였다. The Korean national curriculum for English education has so far focused on improving English instruction in academic high schools, while ignoring the particular language needs of vocational high school students. Few vocational high schools use texts specifically designed for vocational students English as a Foreign Language (EFL) needs. Instead texts are used which focus on translation and vocabulary improvement, which do not enhance communicative skills are used. Therefore, it is imperative that new texts be developed, which focus on the particular communicative skills needed to prepare students for careers in various trades. With this unmet need in mind, this study attempts to develop an instructional model for teaching vocational English in Korean EFL contexts. Ideally, vocational English education should be based on English for Specific Purposes (ESP), Content-Based Instruction (CBI), and Communicative Language Teaching (CLT). Drawing from these three approaches, a vocational English curriculum and instructional model was proposed and trialled in classroom settings. Both teachers and students found the instructional model more effective than the current model. This finding suggests that the instructional model could be effective in training teachers to teach EFL in vocational schools, and thus result in an increase in instruction tailored to the specific needs of students in Korean vocational high schools.
권병운 ( Byung Won Kwon ),현경희 ( Kyung Hee Hyun ),한진형 ( Jin Hyung Han ),김소미 ( So Mi Kim ),이상석 ( Sang Seok Lee ),추영광 ( Young Kwang Choo ),이은경 ( Eun Kyoung Lee ) 대한신장학회 2009 Kidney Research and Clinical Practice Vol.28 No.1
Lesch-Nyhan disease is a very rare X-linked recessive disorder characterized by mental retardation, spasticity resembling cerebral palsy, choreoathetosis, self-mutilation and hyperuricemia. Self-mutilative behavior is a hallmark of the disease. The underlying defect is a deficiency of hypoxanthine-guanine phosphoribosyltransferase (HPRT). We report on a fourteen-year-old boy, who manifested gouty arthritis and mild renal insufficiency with Lesch-Nyhan disease, lacking self-mutilative behavior in spite of undetectable HPRT activity. Though there were several reports about some cases of Lesch-Nyhan disease in the past Korean literature, the cases were classic forms with definite neurological manifestation. As far as we know, this is the first case of Lesch-Nyhan disease without self-mutilation in Korea.
성인 환자에서 자궁근종 수술 후 장유착증과 동반된 Yersinia enterocolitica 장염 1예
김형준 ( Hyung Joon Kim ),김배환 ( Bae Hwan Kim ),신현덕 ( Hyun Duk Shin ),이준혁 ( Joon Hyuk Lee ),신정은 ( Jeong Eun Shin ),전승민 ( Soung Min Jeon ),현경희 ( Kyung Hee Hyun ) 대한내과학회 2012 대한내과학회지 Vol.83 No.6
Yersinia enterocolitica infection in adults in Korea is reported rarely. Therefore, the possibility of Yersinia infection as a cause of abdominal pain may be overlooked. Because its clinical features are similar to those of acute appendicitis or other diseases that require operations, Yersinia enterocolitis should be diagnosed before surgery. We recently experienced a case of Y. enterocolitica enterocolitis accompanied by postoperative colonic adhesion. A 39-year-old female patient with a 5-year history of asymptomatic uterine myoma underwent transabdominal hysterectomy due to abdominal pain. However, the pain worsened. On CT, diffuse swelling of the right colon and adhesion of the sigmoid colon with luminal narrowing were found. Colonoscopy showed multiple aphthous ulcers with mucosal hyperemia from the cecum to the sigmoid colon. Multiplex PCR with stool specimens, a hemagglutination test for Y. enterocolitica O:3, and tissue culture were positive for Y. enterocolitica. After fluids and antibiotic therapy, her symptoms were relieved. (Korean J Med 2012;83:757-763)
천식증상으로 내원한 성인에서 운동유발성 천식과 아토피의 상관관계
한진형 ( Jin Hyung Han ),권병운 ( Byung Woon Kwon ),현경희 ( Kyung Hee Hyun ),김용현 ( Young Hyun Kim ),이현숙 ( Hyun Suk Lee ),김도형 ( Do Hyung Kim ),김윤섭 ( Yon Seop Kim ),박재석 ( Jae Suk Park ),김경묵 ( Kyung Mook Kim ),지 대한내과학회 2011 대한내과학회지 Vol.81 No.6
Background/Aims: Atopy is closely related to asthma and is a risk factor for the development and exacerbation of asthma. The aim of this study was to evaluate the association between exercise-induced asthma (EIA) and atopy in adult patients with asthma-like symptoms. Methods: Forty young male patients with asthma-like symptoms were enrolled. Skin prick, methacholine bronchial provocation, and exercise provocation tests were performed. Current and ex-smokers were excluded. Results: Exercise provocation tests were positive in 21 patients (52.5%). Airway hyperresponsiveness (AHR) to methacholine (85.7% vs. 42.1%, p=0.007) and atopy (85.7% vs. 47.4, p=0.017) was found more frequently in patients with EIA than in those without EIA. EIA was significantly associated with atopy score (16.5±3.0 vs. 6.5±2.0, p=0.011), atopy index (2.1±0.3 vs. 1.0±0.3, p=0.004), and positive responses to Dermatophagoides pteronyssinus (76.2% vs. 42.1%, p=0.028) and Dermatophagoides farinae (76.2% vs. 36.8%, p=0.012), but not with positive responses to pollen allergens. AHR to methacholine (odds ratio [OR]: 14.3, 95% confidence interval [CI]: 1.86-109.4) and atopy (OR: 16.9, 95% CI: 2.04-140.74) were significant risk factors for EIA. Conclusions: Atopy was a risk factor for EIA in young adult men, and sensitization to house dust mites was associated with EIA. (Korean J Med 2011;81:723-728)
이철호(Cherl-Ho Lee),이응호(Eung-Ho Lee),임무현(Moo-Hyun Lim),김수현(Soo-Hyun Kim),채수규(Soo-Kyu Chae),이근우(Keun-Woo Lee),고경희(Kyung-Hee Koh) 군산대학교 수산과학연구소 1994 군산대학교 수산과학연구소 연구논문집 Vol.1 No.-
The evolution of Korean fish fermentation technology was reviewed from the old literature. and the on going proceses were surveyed. The principles involved in the traditional fermentation methods were explained by the recent acientific findings. The fish fermentatlon technology can be classified into two groups: jeot-kal process, where salt is the only material added to the fish for fermentation and aik-hae process, where cooked cereal, garlic and red pepper powder are added to the salted fish. A total of 46 kinds of jeot-kal was identifed in a survey, depending on the raw materials used. The characteristic feature of Korean jeot-kal process is to produce fermented products which still has original shape after 2·3 months of fermentation to be used for add-dishes of rice meal, as well as fish sauce by keeping these products for longer time(over 6 months) for severe enzymematic hydrolysis to be used for the subingredient of Kimchi(Korean fermented vegetable food). The taste of Jeot-kal is formed by the protein hydrolysates due to the action of salt-tolerant Pediococcus, Bacillus, Halobacterium etc. When the taste of joet-kal deteriorates, yeasts appear to dominate. In aki-hae fermentation, the safety of preserved fish is kept by the rapid decrease in pH resulting from the acid fermentation of added cereals. The roles of cid forming bacteria and proteloytic bacteria are important. The fermentation is completed in 2 weeks and the excess production of acid during prolonged storage limits the taste acceptability. The fish fermentation technology in Korea stands at important position in Korean food science and technology, since the processes of jeot-kal and soysauce have same root in the principle of microbial proteolysis and the processes of aik-hae and Kimchi in the microbial acid production principles.