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Solu - Cortef 정주후 기관지수축이 발생한 기관지천식 1례
한표성,홍석철,이종진,조해정,김주옥,김선영 대한알레르기학회 1993 천식 및 알레르기 Vol.13 No.2
Corticosteroids are widely used in the treatment of bronchodilator-resistant bronchial asthma and various forms of anaphylaxis because of their antiinflammatory and immunosuppressive properties. Since Hollander reported 4 cases of urticaria out of a total of 10,000 intraarticular injections of hydrocortisone in 1953, several cases of bronchospasm with urticaria and angioedema after intravenous corticosteroids infusion have been reported. We recently experienced a case of bronchospasm after intravenous Solu-Cortef(Solu-Cortef, the Upjohn co., Kalmazoo, Mich.) infusion to 24 year-old female asthmatic patient with aspirin hypersensitivity for the purpose of symptom relief. After intravenous administration of Solu-Cortef 125mg, she complained tachypnea, severe dyspnea, and coughing with chest tightness. Several minutes later, cyanosis appeared. Two times of subcutaneous epinephrine(1: 1,000, 0.3cc) injections and manual bagging with endotracheal intubation were done. She was stabilized by mechanical venulauon 150 minutes after the attack of bronchospasm. And then she was admitted to ICU for mechanical ventilatory care. It was suggested that the bronchospasm be caused by intravenous Solu-Cortef infusion. Therefore, we emphasize the history taking of any corticosteroid hypersensitivity before its clinical use.
PCR을 이용한 Rat 기관지 세척액에서의 Pneumocystis carinii DNA의 검출 : 기초실험 A pilot study
김주옥,홍석철,한표성,이종진,김선영,이영하,신대환 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.1
Background: Pneumocystis carinii (PC) is a opportunistic pathogen causing serious pneumonia (Pneumocystis carinii pneumonia : PCP) in immunosuppressed patients including AIDS. Laboratory diagnosis of PCP is dependent on microscopic demonstration of the PC by using cytochemical staining or by immunocytochemical staining with monoclonal antibodies. However, these staining methods are not highly sensitive. The development of the polymerase chain reaction (PCR) has made it possible to detect very small numbers of pathogens in clinical specimens. To establish the usefulness of PCR for detection of PC DNA, We performed PCR as a pilot study. Methods: PCP was induced on Spraque-Dawley rats with prednisolone 5mg IM twice a week. Bronchial lavages, impression smears, and permanent sections were performed from the 3rd week to 7th week of cortisonized rats. PC DNA was extracted with bead beater / 10% CTAB method. Results: Impression smears showed PC cyst after the 4th week (100%, 28/28 rats), and permanent sections showed 27/28 rats. Control rats showed some PC cysts (2/7). PCR result was positive only one case among the 6th week rats (1/7), But positive 6 cases at the 7th week rats, (6/7). Among control rats. 2 cases were positive (2/7). ??This data is a pilot study for the PC DNA detection using a PCR. PCP were successfully cortisonized rats. If adequate bronchial washing technique will be used, PCR can be a sensitive for PC DNA detection.